Abstract：
:Mapping the genes responsible for natural variation and divergence is a challenging task. Many studies have mapped genes to genomic regions or generated lists of candidates, but few studies have implicated specific genes with a high standard of evidence. I propose that combining recent advances in genomic engineering with a modified version of the quantitative complementation test will help turn candidate genes into causal genes. By creating loss-of-function mutations in natural strains, and using these mutations to quantitatively fail-to-complement natural alleles, fine mapping should be greatly facilitated. As an example, I propose that the CRISPR/Cas9 system could be combined with the FLP/FRT system to fine-map genes in the numerous systems where inversions have frustrated these efforts.
journal_name
Mol Ecoljournal_title
Molecular ecologyauthors
Turner TLdoi
10.1111/mec.12719subject
Has Abstractpub_date
2014-05-01 00:00:00pages
2377-82issue
10eissn
0962-1083issn
1365-294Xjournal_volume
23pub_type
杂志文章abstract：:The formal testing of mating system theories with empirical data is important for evaluating the relative importance of different processes in shaping mating systems in wild populations. Here, we present a generally applicable probability modelling framework to test the role of local mate availability in determining a...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2011.05252.x
更新日期：2012-02-01 00:00:00
abstract：:Understanding connectivity of coral populations among and within reefs over ecologically significant timescales is essential for developing evidence-based management strategies, including the design of marineprotected areas. Here, we present the first assessment of contemporary connectivity among populations of two Mo...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.12539
更新日期：2013-12-01 00:00:00
abstract：:One of the major environmental concerns over genetically modified (GM) crops relates to transgene movement into wild relatives. The pattern of hybridization ultimately affects the scale and rapidity of ecological change and the feasibility of containment. A new procedure for quantifying hybrid formation over large are...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.2000.00986.x
更新日期：2000-07-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2007.03672.x
更新日期：2008-03-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.13972
更新日期：2017-02-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.14386
更新日期：2017-12-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294x.1993.tb00105.x
更新日期：1993-06-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2005.02650.x
更新日期：2005-09-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.1998.00411.x
更新日期：1998-07-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.14517
更新日期：2018-03-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2004.02250.x
更新日期：2004-09-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.1999.00792.x
更新日期：1999-12-01 00:00:00
abstract：:The effect of Pleistocene climate change on the organisms of tropical and subtropical regions is rather poorly understood. We therefore studied the land snail genus Mandarina (Bradybaenidae) of oceanic Ogasawara (Bonin Islands, Japan), with the aim of using population genetic data to understand their recent history. O...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2006.02990.x
更新日期：2006-09-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.12699
更新日期：2014-04-01 00:00:00
abstract：:Phylogenetic analyses of ancient DNA data can provide a timeline for evolutionary change even in the absence of fossils. The power to infer the evolutionary rate is, however, highly dependent on the number and age of samples, the information content of the sequence data and the demographic history of the sampled popul...
journal_title：Molecular ecology
pub_type： 评论,杂志文章
doi：10.1111/mec.12621
更新日期：2014-02-01 00:00:00
abstract：:The population structure of the giant mottled eel, Anguilla marmorata, was investigated with mitochondrial and microsatellite DNA analyses using 449 specimens from 13 localities throughout the species range. Control region F-statistics indicated the North Pacific (Japan, Taiwan, Philippines, Sulawesi), South Pacific (...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2008.03822.x
更新日期：2008-07-01 00:00:00
abstract：:Rabbit haemorrhagic disease virus (RHDV) is a highly virulent lagovirus endemic in Europe and Australasian populations of the European rabbit, Oryctolagus cuniculus. It has also caused several unexplained disease outbreaks in domestic European rabbits in North America. Non-pathogenic spread of RHDV leading to persiste...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2011.05466.x
更新日期：2012-03-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2006.02892.x
更新日期：2006-06-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.1999.00721.x
更新日期：1999-09-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.1998.00449.x
更新日期：1998-10-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
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更新日期：2004-03-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.14765
更新日期：2018-08-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.12383
更新日期：2013-08-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.2003.01800.x
更新日期：2003-04-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.15313
更新日期：2020-01-01 00:00:00
abstract：:Metabarcoding has been used in a range of ecological applications such as taxonomic assignment, dietary analysis and the analysis of environmental DNA. However, after a decade of use in these applications there is little consensus on the extent to which proportions of reads generated corresponds to the original propor...
journal_title：Molecular ecology
pub_type： 杂志文章,meta分析
doi：10.1111/mec.14920
更新日期：2019-01-01 00:00:00
abstract：:Discordance between the mitochondrial and nuclear genomes is a prevalent phenomenon in nature, in which the underlying processes responsible are considered to be important in shaping genetic variation in natural populations. Among the evolutionary processes that best explain such genomic mismatches incomplete lineage ...
journal_title：Molecular ecology
pub_type： 评论,杂志文章
doi：10.1111/mec.15568
更新日期：2020-09-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2010.04603.x
更新日期：2010-05-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.12043
更新日期：2012-11-01 00:00:00
