Hyperthermic and endocrine effects of intravenous prostaglandin administration in the pig.

Abstract:

:Experimentally induced fever is accompanied by a variety of hormonal changes, and there is evidence to suggest that some of these responses may be mediated by prostaglandins. However, little is known about the endocrine effects of peripherally administered prostaglandins, especially in domesticated species. In this study, the effects of intravenous prostaglandin E2 (PGE2; 20 micrograms/kg) on deep body temperature and plasma concentrations of cortisol, lysine vasopressin (LVP), and growth hormone were investigated in prepubertal pigs (n = 6) prepared with venous catheters and sampled at 10-min intervals for 3 hr. PGE2-induced hyperthermia, which lasted for the duration of the study, was accompanied by a 70-min increase in cortisol and LVP concentrations. Moreover, this hyperthermic response was checked when LVP levels were high. These results indicate that a fever-inducing intravenous injection of PGE2 produced a marked anterior and posterior pituitary hormone response in growing pigs. Also, the transient increase in LVP may be correlated with a central action of the hormone, limiting the extent of the fever. In addition, because the majority of the animals exhibited mild hyperthermia (0.5 degrees C) under control conditions, the results suggest that, in a given population of pigs, there may be some animals that exhibit stress-induced hyperthermia.

journal_name

Domest Anim Endocrinol

authors

Parrott RF,Vellucci SV,Forsling ML,Goode JA

doi

10.1016/0739-7240(94)00021-r

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

197-205

issue

2

eissn

0739-7240

issn

1879-0054

pii

0739-7240(94)00021-R

journal_volume

12

pub_type

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