Prevention and control of haemoglobinopathies.

Abstract:

:In many developing countries the haemoglobinopathies (thalassaemias and sickle-cell disorder) are so common that they provide a convenient model for working out a genetic approach to control of chronic childhood diseases. At present, about 250 million people (4.5% of the world population) carry a potentially pathological haemoglobinopathy gene. Each year about 300,000 infants are born with major haemoglobinopathies. Haemoglobinopathy control programmes, based on WHO approaches and recommendations, have been established in different countries in all WHO Regions and have been successful in management of the problem. Following WHO recommendations the health burden of hereditary anaemias could be significantly reduced. This article summarizes the presentations and discussion made at a joint WHO/TIF (Thalassaemia International Federation) meeting, held in Cyprus in April 1993, and reviews the experience of programmes in several countries for the control of haemoglobinopathies in the world.

authors

Angastiniotis M,Modell B,Englezos P,Boulyjenkov V

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

375-86

issue

3

eissn

0042-9686

issn

1564-0604

journal_volume

73

pub_type

杂志文章,评审
  • Cholera studies. V. Bacteriophage investigations.

    abstract::This study is devoted to a general discussion of the role of bacteriophagy in cholera. The author examines early and late observations, indicating that a new epoch in the history of the subject began in 1927, when large-scale investigations on cholera bacteriophagy were started in India. The main results are set out u...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: POLLITZER RR

    更新日期:1955-01-01 00:00:00

  • Cost-effectiveness of community health workers in tuberculosis control in Bangladesh.

    abstract:OBJECTIVE:To compare the cost-effectiveness of the tuberculosis (TB) programme run by the Bangladesh Rural Advancement Committee (BRAC), which uses community health workers (CHWs), with that of the government TB programme which does not use CHWs. METHODS:TB control statistics and cost data for July 1996 - June 1997 we...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Islam MA,Wakai S,Ishikawa N,Chowdhury AM,Vaughan JP

    更新日期:2002-01-01 00:00:00

  • Comparative performances, under laboratory conditions, of seven pyrethroid insecticides used for impregnation of mosquito nets.

    abstract:OBJECTIVE:To compare the efficacy of seven pyrethroid insecticides for impregnation of mosquito nets, six currently recommended by WHO and one candidate (bifenthrin), under laboratory conditions. METHODS:Tests were conducted using pyrethroid-susceptible and pyrethroid-resistant strains of Anopheles gambiae and Culex q...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Hougard JM,Duchon S,Darriet F,Zaim M,Rogier C,Guillet P

    更新日期:2003-01-01 00:00:00

  • Using a geographical information system to plan a malaria control programme in South Africa.

    abstract:INTRODUCTION:Sustainable control of malaria in sub-Saharan Africa is jeopardized by dwindling public health resources resulting from competing health priorities that include an overwhelming acquired immunodeficiency syndrome (AIDS) epidemic. In Mpumalanga province, South Africa, rational planning has historically been ...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Booman M,Durrheim DN,La Grange K,Martin C,Mabuza AM,Zitha A,Mbokazi FM,Fraser C,Sharp BL

    更新日期:2000-01-01 00:00:00

  • Validation of community health workers' assessment of neonatal illness in rural Bangladesh.

    abstract:OBJECTIVE:To estimate the validity (sensitivity, specificity, and positive and negative predictive values) of a clinical algorithm as used by community health workers (CHWs) to detect and classify neonatal illness during routine household visits in rural Bangladesh. METHODS:CHWs evaluated breastfeeding and symptoms an...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.2471/blt.07.050666

    authors: Darmstadt GL,Baqui AH,Choi Y,Bari S,Rahman SM,Mannan I,Ahmed AS,Saha SK,Rahman R,Chang S,Winch PJ,Black RE,Santosham M,El Arifeen S,Bangladesh Projahnmo-2 (Mirzapur) Study Group.

    更新日期:2009-01-01 00:00:00

  • Are skilled birth attendants really skilled? A measurement method, some disturbing results and a potential way forward.

    abstract:OBJECTIVE:Delivery by a skilled birth attendant (SBA) serves as an indicator of progress towards reducing maternal mortality worldwide -- the fifth Millennium Development Goal. Though WHO tracks the proportion of women delivered by SBAs, we know little about their competence to manage common life-threatening obstetric ...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.2471/blt.06.038455

    authors: Harvey SA,Blandón YC,McCaw-Binns A,Sandino I,Urbina L,Rodríguez C,Gómez I,Ayabaca P,Djibrina S,Nicaraguan Maternal and Neonatal Health Quality Improvement Group.

    更新日期:2007-10-01 00:00:00

  • Cell-mediated immunological processes in leprosy.

    abstract::A large number of organisms such as viruses, protozoa, helminths, fungi and bacteria, especially mycobacteria, need cell-mediated immunological processes for their elimination. As well as being involved in protection, cell-mediated immunological processes are also involved in a number of allergic reactions to products...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.5935/0305-7518.19700030

    authors: Turk JL

    更新日期:1969-01-01 00:00:00

  • Scientists embrace the "One World" approach.

    abstract::Public and political awareness of emerging infectious diseases is growing, as animal and human health specialists work closer together to avert potential outbreaks. ...

    journal_title:Bulletin of the World Health Organization

    pub_type: 新闻

    doi:10.2471/BLT.11.031211

    authors: Fleck F,Braine T

    更新日期:2011-12-01 00:00:00

  • Three basic convictions: a recipe for preventing child injuries.

    abstract::This paper represents a personal reflection on what is needed worldwide to prevent child injuries. It repeats messages that have been frequently delivered in the past. The main points are: first, the need for everyone to accept the view that, ultimately, injuries are a health problem and health departments must view t...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.2471/blt.08.058024

    authors: Pless IB

    更新日期:2009-05-01 00:00:00

  • Falciparum malaria treated with a fixed combination of mefloquine, sulfadoxine and pyrimethamine: a field study in adults in Burma.

    abstract::In a field study conducted in Burma, 54 semi-immune adults suffering from falciparum malaria (mean parasite count, 15 328/mm(3) before treatment) were given a single dose of a fixed combination of 750 mg mefloquine base, 1500 mg sulfadoxine, and 75 mg pyrimethamine (3 tablets of Fansimef). All these patients were clea...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Tin F,Hlaing N,Tun T,Win S,Lasserre R

    更新日期:1985-01-01 00:00:00

  • T lymphocytes from mice immunized with irradiated sporozoites eliminate malaria from hepatocytes.

    abstract::When mice are immunized with radiation-attenuated sporozoites they are solidly protected against sporozoite challenge by an immune response that has been shown to require CD8+ lymphocytes in several strains of mice. The target of this CD8+ T-cell-dependent immunity has not been established. Immune BALB/c mice were sho...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Hoffman SL,Isenbarger D,Long GW,Sedegah M,Szarfman A,Mellouk S,Ballou WR

    更新日期:1990-01-01 00:00:00

  • Public health significance of intestinal parasitic infections. WHO Expert Committee.

    abstract::Intestinal parasitic infections are distributed virtually throughout the world, with high prevalence rates in many regions. Amoebiasis, ascariasis, hookworm infection and trichuriasis are among the ten most common infections in the world. Other parasitic infections such as abdominal angiostrongyliasis, intestinal capi...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1987-01-01 00:00:00

  • Recent outbreaks of lymphocytic choriomeningitis in the United States of America.

    abstract::Lymphocytic choriomeningitis (LCM) has been rarely reported in the American literature since 1960. It is interesting that each of the 3 epidemics reported since then has been associated with exposure to hamsters. In 1973, 48 cases of LCM spanning the years 1971-1973 occurred at the University of Rochester Medical Scho...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Gregg MB

    更新日期:1975-01-01 00:00:00

  • Viral hepatitis in Israel: the effect of canvassing physicians on notifications and the apparent epidemiological pattern.

    abstract::Notifications of morbidity are frequently incomplete but they represent the only practicable way of carrying out large-scale surveillance. Studies of hepatitis in the Central District of Israel offered an opportunity of assessing the reliability of routine data. The regular canvassing of physicians resulted in a 2-3-f...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Brachott D,Mosley JW

    更新日期:1972-01-01 00:00:00

  • Primary health screening by haemoglobinometry in a tropical community.

    abstract::The usefulness of a recently developed portable haemoglobinometer in primary health care was assessed in a survey of anaemia carried out in an isolated Indian community living in the jungles of northern Peru. This haemoglobinometer requires only one drop of blood to be added to a disposable cuvette without predilution...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Johns WL,Lewis SM

    更新日期:1989-01-01 00:00:00

  • Mobilizing communities to improve maternal health: results of an intervention in rural Zambia.

    abstract:OBJECTIVE:To determine whether a complex community intervention in rural Zambia improved understanding of maternal health and increased use of maternal health-care services. METHODS:The intervention took place in six rural districts selected by the Zambian Ministry of Health. It involved community discussions on safe ...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.2471/BLT.13.122721

    authors: Ensor T,Green C,Quigley P,Badru AR,Kaluba D,Kureya T

    更新日期:2014-01-01 00:00:00

  • Non-specific effect of measles vaccination on overall child mortality in an area of rural India with high vaccination coverage: a population-based case-control study.

    abstract:OBJECTIVE:To determine whether vaccination against measles in a population with sustained high vaccination coverage and relatively low child mortality reduces overall child mortality. METHODS:In April and May 2000, a population-based, case-control study was conducted at Ballabgarh (an area in rural northern India). El...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Kabir Z,Long J,Reddaiah VP,Kevany J,Kapoor SK

    更新日期:2003-01-01 00:00:00

  • Human resources for health and universal health coverage: fostering equity and effective coverage.

    abstract::Achieving universal health coverage (UHC) involves distributing resources, especially human resources for health (HRH), to match population needs. This paper explores the policy lessons on HRH from four countries that have achieved sustained improvements in UHC: Brazil, Ghana, Mexico and Thailand. Its purpose is to in...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.2471/BLT.13.118729

    authors: Campbell J,Buchan J,Cometto G,David B,Dussault G,Fogstad H,Fronteira I,Lozano R,Nyonator F,Pablos-Méndez A,Quain EE,Starrs A,Tangcharoensathien V

    更新日期:2013-11-01 00:00:00

  • Employment and health after retirement in Japanese men.

    abstract:Objective:To estimate the average treatment effect of working past the current retirement age on the health of Japanese men. Methods:We used publicly available data from the National Survey of Japanese Elderly, extracting a sample of 1288 men who were 60 years or older. Survey respondents were followed-up for at most ...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.2471/BLT.18.215764

    authors: Okamoto S,Okamura T,Komamura K

    更新日期:2018-12-01 00:00:00

  • Epidemiology of endemic viral hepatitis in an urban area of India: a retrospective community study in Alwar.

    abstract::In a community study during a reference period of 1 year, 192 cases of jaundice were detected in an urban population of 69,440 in Alwar, Rajasthan. Detected by paramedics and confirmed by physicians, these cases gave an annual incidence of 2.76 (95% CI: 2.37-3.15) per 1000 population. At least one of these patients di...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Singh J,Prakash C,Gupta RS,Bora D,Jain DC,Datta KK

    更新日期:1997-01-01 00:00:00

  • Serological and prophylactic trials of Asian influenza vaccines in Sweden, 1957.

    abstract::A serological trial of a formolized monovalent Asian influenza vaccine of conventional type, using a range of falling vaccine dilutions, showed a satisfactory antihaemagglutinin response in groups of volunteers vaccinated with relatively low numbers of haemagglutinating units (HU) of the vaccine.Booster injections, gi...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: HELLER L,KORLOF B,MORNER J,ZETTERBERG B

    更新日期:1959-01-01 00:00:00

  • Fatal injuries among urban children in South Africa: risk distribution and potential for reduction.

    abstract:OBJECTIVE:To determine the leading causes of fatal injury for urban South African children aged 0-14 years, the distribution of those causes and the current potential for safety improvements. METHODS:We obtained injury surveillance data from the National Injury Mortality Surveillance System 2001-2003 for six major Sou...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:10.2471/BLT.09.068486

    authors: Burrows S,van Niekerk A,Laflamme L

    更新日期:2010-04-01 00:00:00

  • An evaluation of the HemoCue for measuring haemoglobin in field studies in Jamaica.

    abstract::The HemoCue system utilizes the principle of oxidation of haemoglobin to hemiglobin by sodium nitrite and the subsequent conversion of hemiglobin to hemiglobinazide by sodium azide. The reagents for these reactions are contained within a small disposable microcuvette of approximately 10 microliters in volume. A venous...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Hudson-Thomas M,Bingham KC,Simmons WK

    更新日期:1994-01-01 00:00:00

  • American cutaneous leishmaniasis: use of a skin test as a predictor of relapse after treatment.

    abstract::While relapses following clinical cure of American cutaneous leishmaniasis are frequent, no test has been described until now to predict such relapses. A cohort of 318 American cutaneous leishmaniasis patients was followed up for two years after treatment with meglumine antimoniate, during which time 32 relapses occur...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Passos VM,Barreto SM,Romanha AJ,Krettli AU,Volpini AC,Lima e Costa MF

    更新日期:2000-01-01 00:00:00

  • A survey of bacillary dysentery in a rural community in Serbia.

    abstract::The findings from an epidemiological survey of bacillary dysentery in three villages in south-west Serbia are reported. Factors in the transmission of infection-in particular, living conditions and standards of hygiene-are discussed, and an attempt is made to assess the value of various popular remedies, such as herba...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: SNAJDER K

    更新日期:1954-01-01 00:00:00

  • Immunogenicity of oral poliovirus vaccine administered in mass campaigns versus routine immunization programmes.

    abstract::Reported are the results of a study to investigate the immunogenicity of oral poliovirus vaccine (OPV) when administered in mass campaigns compared with that following routine immunization programmes. For this purpose, paired sera were collected from a cohort of children before and after a mass vaccination with OPV in...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Richardson G,Linkins RW,Eames MA,Wood DJ,Campbell PJ,Ankers E,Deniel M,Kabbaj A,Magrath DI,Minor PD

    更新日期:1995-01-01 00:00:00

  • The genus Leishmania.

    abstract::The systematic position of the so-called "species" of Leishmania is examined and an attempt made to determine their phylogenetic relationships. The morphology of the organisms as seen by light- and electron-microscopy is described; neither method provides useful criteria for the determination of species. The behaviour...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Garnham PC

    更新日期:1971-01-01 00:00:00

  • Preliminary investigation on the use of a light-trap for sampling malaria vectors in the Gambia.

    abstract::Light-traps have been used successfully as mechanical sampling tools for insects of agricultural importance but medical entomologists have had only limited success because of the assumption that light-traps would attract vectors, even when sited in open fields well away from hosts. The investigations reported in this ...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Odetoyinbo JA

    更新日期:1969-04-01 00:00:00

  • The efficacy of live influenza vaccines.

    abstract::Administration of live influenza vaccine produces an asymptomatic immunizing infection of the respiratory tract with the appearance of antibodies in the secretions of the respiratory passages.Because of natural variation in the antigenic and biological properties of the influenza virus, new vaccines must be developed ...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: Smorodincev AA

    更新日期:1969-01-01 00:00:00

  • The virulence in the guinea-pig of isoniazid-sensitive tubercle bacilli isolated from South Indian patients before treatment and after three months of chemotherapy.

    abstract::In order to find out whether chemotherapy with isoniazid affects the virulence in the guinea-pig of tubercle bacilli that do not develop resistance to the drug, virulence tests were carried out on isoniazid-sensitive cultures obtained from 20 South Indian tuberculous patients before treatment and after three months of...

    journal_title:Bulletin of the World Health Organization

    pub_type: 杂志文章

    doi:

    authors: SUBBAIAH TV,BHATIA AL,GERAGHTY E,MITCHISON DA,RADHAKRISHNA S,SELKON JB

    更新日期:1961-01-01 00:00:00