A review of invasive Haemophilus influenzae disease in the Indigenous populations of North America.


:Historically, the highest incidence rates of invasive Haemophilus influenzae disease in the world were found in North American and Australian Indigenous children. Although immunization against H. influenzae type b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasive H. influenzae disease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response to H. influenzae infection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasive H. influenzae disease in Indigenous populations in North America. H. influenzae type a (Hia) has emerged as a significant cause of severe disease in North American Indigenous communities. More research is needed to define the genotypic diversity of Hia and the disease burden that it causes in order to determine if a Hia vaccine is required to protect the vulnerable populations.


Epidemiol Infect


Tsang RS,Bruce MG,Lem M,Barreto L,Ulanova M




Has Abstract


2014-07-01 00:00:00














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    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Brett PJ,Deshazer D,Woods DE

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  • Super-shedding cattle and the transmission dynamics of Escherichia coli O157.

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    journal_title:Epidemiology and infection

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    authors: Matthews L,McKendrick IJ,Ternent H,Gunn GJ,Synge B,Woolhouse ME

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  • Test characteristics of the tuberculin skin test and post-mortem examination for bovine tuberculosis diagnosis in cattle in Northern Ireland estimated by Bayesian latent class analysis with adjustments for covariates.

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    journal_title:Epidemiology and infection

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    authors: O'Hagan MJH,Ni H,Menzies FD,Pascual-Linaza AV,Georgaki A,Stegeman JA

    更新日期:2019-01-01 00:00:00

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    authors: Pedersen K,Pabilonia KL,Anderson TD,Bevins SN,Hicks CR,Kloft JM,Deliberto TJ

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  • Measles and rubella seroprevalence among adults in Georgia in 2015: helping guide the elimination efforts.

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    authors: Khetsuriani N,Chitadze N,Russell S,Ben Mamou M

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    authors: Bediako-Bowan AAA,Mølbak K,Kurtzhals JAL,Owusu E,Debrah S,Newman MJ

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    journal_title:Epidemiology and infection

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    authors: Chanda A

    更新日期:2020-08-11 00:00:00

  • Multistate outbreak of Listeria monocytogenes infections linked to whole apples used in commercially produced, prepackaged caramel apples: United States, 2014-2015.

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    更新日期:2017-04-01 00:00:00

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    authors: Irshad H,Cookson AL,Prattley DJ,Dufour M,French NP

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    journal_title:Epidemiology and infection

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    authors: Alfouzan W,Al Fadhli M,Abdo N,Alali W,Dhar R

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    authors: Kivi M,Hofhuis A,Notermans DW,Wannet WJ,Heck ME,Van De Giessen AW,Van Duynhoven YT,Stenvers OF,Bosman A,Van Pelt W

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    authors: Nastasi A,Mammina C,Villafrate MR

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    authors: Alagiozoglou L,Morris L,Bredell H,Martin DJ,Sitas F

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    authors: Acedo L,Díez-Domingo J,Moraño JA,Villanueva RJ

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    authors: McLean AR,Anderson RM

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  • Incidence of childhood pneumonia and serotype and sequence-type distribution in Streptococcus pneumoniae isolates in Japan.

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    journal_title:Epidemiology and infection

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    authors: Tanaka J,Ishiwada N,Wada A,Chang B,Hishiki H,Kurosaki T,Kohno Y

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    authors: Saitoh T,Morita M,Shimada T,Izumiya H,Kanayama A,Oishi K,Ohnishi M,Sunagawa T

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    authors: Biggerstaff M,Jhung MA,Reed C,Garg S,Balluz L,Fry AM,Finelli L

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    authors: Termorshuizen F,Dorigo-Zetsma JW,de Melker HE,van den Hof S,Conyn-Van Spaendonck MA

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    authors: Effelterre TV,Shkedy Z,Aerts M,Molenberghs G,Damme PV,Beutels P

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    pub_type: 杂志文章,评审


    authors: West PA

    更新日期:1989-08-01 00:00:00

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    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: McLauchlin J

    更新日期:1990-04-01 00:00:00

  • A serologically confirmed, case-control study, of a large outbreak of hepatitis A in China, associated with consumption of clams.

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    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Tang YW,Wang JX,Xu ZY,Guo YF,Qian WH,Xu JX

    更新日期:1991-12-01 00:00:00

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    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Espinosa-Gongora C,Larsen J,Moodley A,Nielsen JP,Skov RL,Andreasen M,Guardabassi L

    更新日期:2012-10-01 00:00:00

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    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Bifolchi N,Michel P,Talbot J,Svenson L,Simmonds K,Checkley S,Chui L,Dick P,Wilson JB

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    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Dunn CE,Rowlingson B,Bhopal RS,Diggle P

    更新日期:2013-04-01 00:00:00