Suppression of immune parameters in animal models of morphine dependence.

Abstract:

:Implantation of pellets containing 75 mg of morphine induced short term (4 day) morphine dependence and markedly reduced total number of spleen cells of BALB/c mice, without affecting total body or liver weight. Polyclonal responses induced by anti-CD3 antibodies, Concanavalin A or Escherichia coli lipopolysaccharide in the remaining spleen cells of morphine-treated mice were also inhibited. Cytofluorimetric analysis indicated that the proportion of major functional lymphocyte populations (Ig+, CD3+, CD4+ and CD8+ lymphocytes) were not significantly changed in the spleen from morphine-dependent mice. Furthermore, expression levels of surface Ig, CD3, CD4, and CD8, were similar in spleen cells from control or morphine-treated mice. So, morphine dependence in BALB/c mice under these controlled conditions results in a specific defect in lymphoid cell number and function, with no incidence on body weight or particular lymphocyte subsets.

journal_name

Immunol Invest

authors

Portolés JM,Ojeda G,Ronda M,Leza JC,Rojo JM

doi

10.3109/08820139509066864

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

643-52

issue

4

eissn

0882-0139

issn

1532-4311

journal_volume

24

pub_type

杂志文章
  • Immunological examination of peripheral blood in patients with colorectal cancer compared to healthy controls.

    abstract:BACKGROUND:The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS:Blood samples were collected from 22 colorectal patients and 25 healthy controls before the sta...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2018.1480030

    authors: Spacek J,Vocka M,Netikova I,Skalova H,Dundr P,Konopasek B,Zavadova E,Lubos P

    更新日期:2018-10-01 00:00:00

  • The Ernest Witebsky memorial lecture. Red but not dead: not a hapless sac of hemoglobin.

    abstract::The purpose of this presentation was to demonstrate that the red blood cell is not a hapless sac of hemoglobin and that much research is still needed for better understanding of its complexities. After a brief historical introduction the following subjects are presented: 1). Phosphofructokinase is the rate limiting st...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139509062760

    authors: Greenwalt TJ

    更新日期:1995-01-01 00:00:00

  • Development of an In Vitro Assay to Assess Pharmacological Compounds and Reversion of Tumor-Derived Immunosuppression of Dendritic Cells.

    abstract:BACKGROUND:Cancer immunotherapies have achieved much success and have become the forefront treatment of cancers previously associated with poor prognosis. However, a major challenge in cancer immunotherapies remains the heterogeneity of the immunoregulatory capacities of cancers, and not all patients of a given cancer ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1778024

    authors: Andersen MM,Larsen J,Hansen M,Pedersen AE,Gad M

    更新日期:2020-06-23 00:00:00

  • Generation and Characterization of Human Single-Chain Antibodies Against Polycyclic Aromatic Hydrocarbons.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2015.1043669

    authors: Ustinov VA,Studennikov AE,Vavilov VA,Tyumentseva MA,Morozova VV,Tikunova NV,Glushkov AN

    更新日期:2015-01-01 00:00:00

  • Enhanced antigen-specific antibody and cytokine responses when targeting antigen to human FcGAMMA receptor type I using an anti-human FcGAMMA receptor type I-streptavidin fusion protein in an adjuvant-free system.

    abstract::There is a continuing need for alternatives to current human adjuvants. Recombinant protein vaccines, which target antigen to human Fc gamma receptor type I (hFcgammaRI) on hFcgammaRI-expressing antigen presenting cells, provide one potential alternative. Using a recombinant anti-hFcgammaRI-antigen fusion protein and ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130500265372

    authors: Adamova E,Walsh MC,Gosselin DR,Hale K,Preissler MT,Graziano RF,Gosselin EJ

    更新日期:2005-01-01 00:00:00

  • DFA, EIA, PCR, LCR and other technologies: what tests should be used for diagnosis of chlamydia infections?

    abstract::For many years, isolation in tissue culture (TC) was considered the test of choice for diagnosis of Chlamydia trachomatis infection. Non-culture tests, such as direct fluorescent antibody (DFA) and enzyme immunoassay (EIA) which detected chlamydial antigens in clinical specimens, made chlamydia diagnostic tests more w...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139709048923

    authors: Schachter J

    更新日期:1997-01-01 00:00:00

  • Effects of immunization with B. macacae on induced periodontitis--preliminary findings.

    abstract::This preliminary study examined the effects of immunization with Bacteroides macacae, the monkey equivalent of the human species of B. gingivalis on ligature-induced periodontitis. During a 12 week immunization period, 8 out of the 12 Macacae fasicularis monkeys were immunized weekly with B. macacae washed cells and 4...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909112239

    authors: Nisengard R,Blann D,Zelonis L,McHenry K,Reynolds H,Zambon J

    更新日期:1989-01-01 00:00:00

  • A rapid, quantitative enzyme-linked immunosorbent assay (ELISA) for the immunodiagnosis of Chagas' disease.

    abstract::A rapid, quantitative enzyme-linked immunosorbent assay (ELISA) for the immunodiagnosis of Chagas' disease is described. The ELISA was standardized with the Falcon assay screening test (F.A.S.T.) system using a purified Trypanosoma cruzi epimastigote fraction (PEF) obtained by ion exchange chromatography. The ELISA te...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139809070892

    authors: Partel CD,Rossi CL

    更新日期:1998-01-01 00:00:00

  • Adsorption and helical coiling of amphipathic peptides on lipid vesicles leads to negligible protection from cathepsin B or cathepsin D.

    abstract::The processing of antigenic peptides for presentation by MHC molecules to T cells, may depend upon the function of a second, consensus sequence in or near the T cell-presented epitope. One such processing-regulating sequence appears to be composed of amino acids Leu, Ile, Val, Phe, and Met recurring in a fashion to fo...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139309066191

    authors: Goldschmidt TG,Reyes VE,You G,Nelson DJ,Reisert PS,Anderson J,Mole J,Humphreys RE

    更新日期:1993-02-01 00:00:00

  • Antibodies to lactate dehydrogenase of Plasmodium knowlesi are specific to Plasmodium species.

    abstract::Polyclonal immune monkey serum raised against schizonts of Plasmodium knowlesi (H-strain) showed the presence of antibodies to lactate dehydrogenase (LDH) of P. knowlesi by immunodot enzyme staining method. The anti-LDH antibodies are most probably directed towards an epitope distinct from the catalytic site as shown ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809030584

    authors: Kaushal DC,Watts R,Haider S,Singh N,Kaushal NA,Dutta GP

    更新日期:1988-08-01 00:00:00

  • Comparison of the anti-tumor effects of various whole-body hyperthermia protocols: correlation with HSP 70 expression and composition of splenic lymphocytes.

    abstract::Whole-body hyperthermia (WBH) has been used as an adjunct approach to radio-/ chemotherapy for tumor therapy for many years. However, the molecular mechanism underlying the enhancement of tumor control is not clearly understood. It has been hypothesized that WBH might activate immune system by inducing the expression ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-200064460

    authors: Zhang H,Wang W,Zhang S,Huang W

    更新日期:2005-01-01 00:00:00

  • Pro-inflammatory effects of uric acid in the gastrointestinal tract.

    abstract::Uric acid can be generated in the gastrointestinal (GI) tract from the breakdown of nucleotides ingested in the diet or from purines released from host cells as a result of pathogen-induced cell damage. Xanthine oxidase (XO) is the enzyme that converts hypoxanthine or xanthine into uric acid, a reaction that also gene...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2013.864667

    authors: Crane JK,Mongiardo KM

    更新日期:2014-01-01 00:00:00

  • Expression of Th17 and Treg lymphocyte subsets in hypertrophied adenoids of children and its clinical significance.

    abstract::Adenoid hypertrophy is the most common cause of upper airway obstruction and sleep-disordered breathing in children, yet its pathogenesis remains unclear. The identification of the novel helper T cell subsets, Th17 cells and regulatory T cells (Tregs) could provide new insight into our understanding of the mechanisms ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2011.575426

    authors: Sade K,Fishman G,Kivity S,DeRowe A,Langier S

    更新日期:2011-01-01 00:00:00

  • Bacterial contamination of blood products and the value of pre-transfusion testing.

    abstract::There has been a dramatic increase recently in the number of reports of septic episodes associated with both red cell and platelet concentrate transfusions. These reports suggest that transfusion-associated septic reactions may occur as often as 1 per 4000 platelet transfusions, however, the true incidence of the bact...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139509062770

    authors: Blajchman MA

    更新日期:1995-01-01 00:00:00

  • Cytokine regulation of CD44 expression on rat intestinal epithelial cells.

    abstract::CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820130009060867

    authors: Reid SD,Pockley AG

    更新日期:2000-08-01 00:00:00

  • Synthesis of intestinal basement membrane.

    abstract::The rat small intestinal epithelial cell (enterocyte) has an average life span of 48h. Undifferentiated stem cells in the lower crypt region undergo division and differentiation into enterocytes as the cell moves on a basement membrane up the villus to reach the tip and be extruded into the lumen. The mechanism of thi...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909112253

    authors: Weiser MM,Ryzowicz S,Soroka CJ,Albini B

    更新日期:1989-01-01 00:00:00

  • Association between Vascular Endothelial Growth Factor Gene Polymorphisms and Pre-Eclampsia Susceptibility: An Updated Meta-Analysis.

    abstract::Objectives: The aim of this study was to assess the genetic association between vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of pre-eclampsia (PE).Methods: A systematic literature search of several databases (PubMed, Embase, and the China National Knowledge Infrastructure (CNKI)) was condu...

    journal_title:Immunological investigations

    pub_type: 杂志文章,meta分析

    doi:10.1080/08820139.2019.1659812

    authors: Wang X,Sun T,Chen G,Gao H

    更新日期:2020-02-01 00:00:00

  • Mapping of IgE binding regions in the major rat urinary protein, alpha 2u-globulin, using overlapping peptides.

    abstract::Exposure to laboratory animals poses a hazard for development of occupational allergy. Identification of antigenic determinants of allergenic proteins may be valuable for immunotherapeutic purposes. Overlapping peptides of the major allergen in rat urine, Rat n 1.02, corresponding to the protein alpha2u-globulin were ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139909062266

    authors: Bayard C,Siddique AB,Berzins K,Troye-Blomberg M,Hellman U,Vesterberg O

    更新日期:1999-09-01 00:00:00

  • Cross-binding between Plasmodium falciparum CTL epitopes and HLA class I molecules.

    abstract::Plasmodium falciparum CTL epitope minigenes containing HLA-A2 and HLA-B7 subtype supermotifs were cloned into a plasmid expression vector; this expression was measured in eight human HLA class I molecule specific cell lines. Three assays for in vitro antigen presentation analysis were developed to examine the cross-bi...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-120019206

    authors: Tang Y,Lin Y,Mao Y,Dong M,Wang H

    更新日期:2003-02-01 00:00:00

  • The Association between Interleukin-6 Gene Polymorphisms and Risk of Systemic Lupus Erythematosus: A Meta-analysis with Trial Sequential Analysis.

    abstract:BACKGROUND:Molecular epidemiological studies have sought associations between interleukin-6 (IL-6) polymorphisms and the risk of systemic lupus erythematosus (SLE); however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of th...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1769646

    authors: Liu J,Liao MQ,Cao DF,Yang Y,Yang Y,Liu YH,Zeng FF,Chen XH

    更新日期:2021-02-01 00:00:00

  • miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic smoking-related lung disease associated with higher mortality and morbidity. Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. METHODS:GEO database was applied to fil...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2021.1874977

    authors: Jing X,Luan Z,Liu B

    更新日期:2021-01-17 00:00:00

  • Studies on in vitro production of Paul-Bunnell antibodies.

    abstract::Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138609052952

    authors: Wasik M,Milgrom F

    更新日期:1986-06-01 00:00:00

  • Flow cytometric quantification of T cell proliferation and division kinetics in woodchuck model of hepatitis B.

    abstract::Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:

    authors: Gujar SA,Michalak TI

    更新日期:2005-01-01 00:00:00

  • Benign monoclonal gammopathy: a reassessment of the problem.

    abstract::Disease associations of clonally restricted serum immunoglobulin (Ig) abnormalities were examined using methods for detecting and characterizing homogeneous Ig that are approximately forty times more sensitive than either cellulose acetate zone electrophoresis or immunoelectrophoresis. Medical records of three hundred...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138509076143

    authors: Kelly RH,Hardy TJ,Shah PM

    更新日期:1985-06-01 00:00:00

  • Impact of IL12B Polymorphisms on Genetic Susceptibility and IL-12p40 and IL-23 Serum Levels in Rheumatoid Arthritis.

    abstract::The aim of this study was to evaluate the possible association of IL12B gene polymorphisms with serum levels of IL-12p40, IL-23 and genetic susceptibility to rheumatoid arthritis (RA) in the Bulgarian population. Genotyping for IL12Bpro (rs17860508) and IL12B A/C - 3' UTR (rs3212227) polymorphisms was performed by pol...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1622561

    authors: Manolova I,Ivanova M,Vasilev G,Stoilov R,Miteva L,Stanilova S

    更新日期:2020-02-01 00:00:00

  • Decreased levels of TNF-beta in cultured PBLs from HIV+ patients occur concomitantly to increased apoptosis and impaired PWM-induced proliferation and dehydrogenase activity.

    abstract::The occurrence of apoptosis in cultured blood cells from HIV+ patients is well-documented. However, the relationship of this process to cytokine production is still undefined. We measured the production of TNF-beta by mitogen-stimulated PBLs from 33 HIV+ patients, while simultaneously assessing their development of ap...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139609059311

    authors: Lavergne JA,Zorrilla C,del Llano AM

    更新日期:1996-07-01 00:00:00

  • Differential transcriptional control of the H-2K and H-2D loci of the major histocompatibility complex in fibrosarcoma cells.

    abstract::In this study we demonstrate a differential transcription of H-2K and H-2D class-I genes in two different tumor cell clones; one is highly metastatic (IE-7) and the other is not metastatic (IC-9), both derived from the same fibrosarcoma, T-10, induced in an (H-2b x H-2k)F1 mouse. The expression of the two parental H-2...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109082628

    authors: Aboud M,Amitai H,Huleihel M,Har-vardi I,Gopas J,Segal S

    更新日期:1991-08-01 00:00:00

  • Association between Monocyte Chemoattractant Protein-1 -2518 (A/G) Single Nucleotide Polymorphism and Chronic Periodontitis in End-stage Renal Disease Patients - A Case-control Study.

    abstract::Monocyte chemoattractant protein 1 (MCP-1) plays an important role in the development of periodontitis. The purpose of this investigation was to evaluate association of the  MCP-1 gene polymorphism with chronic periodontitis in patients with end-stage renal disease (ESRD). One hundred fifty ESRD patients with chronic ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1702052

    authors: Ksiazek K,Buraczynska M

    更新日期:2020-11-01 00:00:00

  • Modulation of B cell stimulation by maternal serum.

    abstract::Anti-IgM stimulation of B cells is decreased in the presence of maternal serum as compared to control media. This inhibiting influence of maternal serum is observed during the priming of the B cells. The progression of B cells into cellular proliferation was not influenced by maternal serum. At the level of the immuno...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109026231

    authors: Vanderbeeken YE,Duchateau J,Gregoire M,Vandermeersch B,Collet H,Lucas A

    更新日期:1991-06-01 00:00:00

  • Ontogeny of Tumor-associated CD4+CD25+Foxp3+ T-regulatory Cells.

    abstract::The critical contribution of CD4+CD25+Foxp3+ T-regulatory cells (Treg) to immune suppression in the tumor microenvironment is well-established. Whereas the mechanisms that drive the generation and accumulation of Treg in tumors have been an active area of study, the information on their origin and population dynamics ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2016.1220390

    authors: Li Q,Egilmez NK

    更新日期:2016-11-01 00:00:00