Suppression of immune parameters in animal models of morphine dependence.

Abstract:

:Implantation of pellets containing 75 mg of morphine induced short term (4 day) morphine dependence and markedly reduced total number of spleen cells of BALB/c mice, without affecting total body or liver weight. Polyclonal responses induced by anti-CD3 antibodies, Concanavalin A or Escherichia coli lipopolysaccharide in the remaining spleen cells of morphine-treated mice were also inhibited. Cytofluorimetric analysis indicated that the proportion of major functional lymphocyte populations (Ig+, CD3+, CD4+ and CD8+ lymphocytes) were not significantly changed in the spleen from morphine-dependent mice. Furthermore, expression levels of surface Ig, CD3, CD4, and CD8, were similar in spleen cells from control or morphine-treated mice. So, morphine dependence in BALB/c mice under these controlled conditions results in a specific defect in lymphoid cell number and function, with no incidence on body weight or particular lymphocyte subsets.

journal_name

Immunol Invest

authors

Portolés JM,Ojeda G,Ronda M,Leza JC,Rojo JM

doi

10.3109/08820139509066864

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

643-52

issue

4

eissn

0882-0139

issn

1532-4311

journal_volume

24

pub_type

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