Suppression of immune parameters in animal models of morphine dependence.


:Implantation of pellets containing 75 mg of morphine induced short term (4 day) morphine dependence and markedly reduced total number of spleen cells of BALB/c mice, without affecting total body or liver weight. Polyclonal responses induced by anti-CD3 antibodies, Concanavalin A or Escherichia coli lipopolysaccharide in the remaining spleen cells of morphine-treated mice were also inhibited. Cytofluorimetric analysis indicated that the proportion of major functional lymphocyte populations (Ig+, CD3+, CD4+ and CD8+ lymphocytes) were not significantly changed in the spleen from morphine-dependent mice. Furthermore, expression levels of surface Ig, CD3, CD4, and CD8, were similar in spleen cells from control or morphine-treated mice. So, morphine dependence in BALB/c mice under these controlled conditions results in a specific defect in lymphoid cell number and function, with no incidence on body weight or particular lymphocyte subsets.


Immunol Invest


Portolés JM,Ojeda G,Ronda M,Leza JC,Rojo JM




Has Abstract


1995-05-01 00:00:00












  • Repeated treatment with S. aureus superantigens expands the survival rate of Ehrlich ascites tumor bearing mice.

    abstract::The bacterial superantigen Staphylococcal enterotoxin-A (SEA), produced by some strains of Staphylococcus aureus, causes proliferation of cytotoxic T-lymphocytes and cytokine production in vivo. SEA has been shown to be highly efficient for antibody-targeted superantegen immunotherapy for different tumor models. A can...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Mondal TK,Bhatta D,Biswas S,Pal P

    更新日期:2002-02-01 00:00:00

  • Production and characterization of an anti-idiotypic single chain Fv that recognizes an anti-DNA antibody.

    abstract::A well-characterized recombinant anti-idiotype to an anti-DNA antibody can be useful for studies of the regulation of anti-DNA-producing B cells. Using a hybridoma technique, a monoclonal anti-idiotypic antibody, designated O2F3, was obtained, and its scFv gene was constructed. O2F3 single chain Fv (scFv) was produced...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Kwon MH,Lee MS,Kim KH,Park S,Shin HJ,Jang YJ,Kim HI

    更新日期:2002-08-01 00:00:00

  • Anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis.

    abstract::The objectives were to determine the prevalence and clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA). Anti-CCP antibodies were checked by ELISA in 68 children with JIA, 38 males and 30 females with mean age of 10.6 (+/-4.02) years and...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Habib HM,Mosaad YM,Youssef HM

    更新日期:2008-01-01 00:00:00

  • Implication of Increased Serum IL-31 for Primary Biliary Cholangitis.

    abstract::Interleukin-31 (IL-31) has diverse biological functions. Increased IL-31 has been found in some skin and autoimmune diseases. There has been no study reporting the association between IL-31 and primary biliary cholangitis (PBC). This study was designed to determine serum IL-31 level and to explore its diagnostic value...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Mu N,Lin F,Jiang Z,Liang Y,Yang Z

    更新日期:2020-07-02 00:00:00

  • Review on therapeutic options in HIV associated thrombocytopenia with emphasis on i.v. immunoglobulin treatment.

    abstract::Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审


    authors: Nydegger UE,Castelli D

    更新日期:1991-04-01 00:00:00

  • The role of the PI3K/mTOR signaling pathway in Staphylococcus epidermidis small colony variants intracellular survival.

    abstract::The objective of this study was to analyze how Staphylococcus epidermidis SCV and WT strains manipulate the PI3K/Akt/mTOR signaling pathway. Six S. epidermidis strains with normal phenotype (WT) and six S. epidermidis strains with SCV phenotype were isolated in parallel from six patients with the prosthetic hip joint ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Magryś A,Bogut A,Kiełbus M,Olender A

    更新日期:2018-04-01 00:00:00

  • Association of IL17 and IL23R gene polymorphisms with rheumatic heart disease in South Indian population.

    abstract:BACKGROUND:IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular les...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Poomarimuthu M,Elango S,Solomon PR,Soundrapandian S,Mariakuttikan J

    更新日期:2018-10-01 00:00:00

  • Dysregulated proteolysis in AIDS.

    abstract::Plasmin activity induced by different concentrations of added urokinase (UK) in serum from 20 patients with AIDS (P) and 10 healthy control (HC) subjects was measured using the fibrin plate assay. 125I-fibrin coated 24 well plates were exposed to UK (0.34-6.8 ng/ml) or to trypsin (T) (2.5 micrograms/ml) in the presenc...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Auci DL,Durkin HG,Murali MR

    更新日期:1992-07-01 00:00:00

  • Benign monoclonal gammopathy: a reassessment of the problem.

    abstract::Disease associations of clonally restricted serum immunoglobulin (Ig) abnormalities were examined using methods for detecting and characterizing homogeneous Ig that are approximately forty times more sensitive than either cellulose acetate zone electrophoresis or immunoelectrophoresis. Medical records of three hundred...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Kelly RH,Hardy TJ,Shah PM

    更新日期:1985-06-01 00:00:00

  • Cyclosporine and dexamethasone inhibit T-lymphocyte MHC class II antigens and IL-2 receptor expression in experimental autoimmune uveitis.

    abstract::Results of recent studies indicated that a monoclonal ART18 antibody recognizes the receptor sites or closely related structures for IL-2 on activated rat T-cells. The major histocompatibility complex (MHC) class II (Ia) antigens (RT1B and RT1D in rat), detected with OX6 antibody, and OX17 antibody, may be present on ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Chan CC,Caspi R,Mochizuki M,Diamantstein T,Gery I,Nussenblatt RB

    更新日期:1987-06-01 00:00:00

  • CellVue Claret, a new far-red dye, facilitates polychromatic assessment of immune cell proliferation.

    abstract::Flow cytometric analyses of immune cell proliferation, differentiation, and function are limited by the number of different fluorochromes that can be resolved simultaneously. Additional colors to expand functional analytic capability will facilitate higher dimensional analyses of heterogeneous cell populations by basi...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Bantly AD,Gray BD,Breslin E,Weinstein EG,Muirhead KA,Ohlsson-Wilhelm BM,Moore JS

    更新日期:2007-01-01 00:00:00

  • Mapping of IgE binding regions in the major rat urinary protein, alpha 2u-globulin, using overlapping peptides.

    abstract::Exposure to laboratory animals poses a hazard for development of occupational allergy. Identification of antigenic determinants of allergenic proteins may be valuable for immunotherapeutic purposes. Overlapping peptides of the major allergen in rat urine, Rat n 1.02, corresponding to the protein alpha2u-globulin were ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Bayard C,Siddique AB,Berzins K,Troye-Blomberg M,Hellman U,Vesterberg O

    更新日期:1999-09-01 00:00:00

  • The Inhibitory Effects of Pentacyclic Triterpenes from Loquat Leaf against Th17 Differentiation.

    abstract:BACKGROUND:Loquat leaf is an herb that is commonly used in traditional Chinese medicine (TCM) for its anti-inflammatory properties. Numerous studies have demonstrated that Th17 cells play a fundamental role in mediating SLE pathological deterioration. In our study, we investigated the inhibitory effect of pentacyclic t...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Zhou X,Chen H,Wei F,Zhao Q,Su Q,Lei Y,Yin M,Tian X,Liu Z,Yu B,Bai C,He X,Huang Z

    更新日期:2020-08-01 00:00:00

  • Expression of Th17 and Treg lymphocyte subsets in hypertrophied adenoids of children and its clinical significance.

    abstract::Adenoid hypertrophy is the most common cause of upper airway obstruction and sleep-disordered breathing in children, yet its pathogenesis remains unclear. The identification of the novel helper T cell subsets, Th17 cells and regulatory T cells (Tregs) could provide new insight into our understanding of the mechanisms ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Sade K,Fishman G,Kivity S,DeRowe A,Langier S

    更新日期:2011-01-01 00:00:00

  • Association between Monocyte Chemoattractant Protein-1 -2518 (A/G) Single Nucleotide Polymorphism and Chronic Periodontitis in End-stage Renal Disease Patients - A Case-control Study.

    abstract::Monocyte chemoattractant protein 1 (MCP-1) plays an important role in the development of periodontitis. The purpose of this investigation was to evaluate association of the  MCP-1 gene polymorphism with chronic periodontitis in patients with end-stage renal disease (ESRD). One hundred fifty ESRD patients with chronic ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Ksiazek K,Buraczynska M

    更新日期:2020-11-01 00:00:00

  • Poly(vinyl alcohol) as a blocking agent in enzyme immunoassays.

    abstract::We examined the blocking ability of poly(vinyl alcohol) (PVA) in enzyme immunoassays by coating polystyrene microtiter wells with PVA of different molecular weights (MW) and percent hydrolysis (%Hyd). Blocking ability was measured by the differences in non-specific binding of an anti-rabbit IgG-horseradish peroxidase ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Rodda DJ,Yamazaki H

    更新日期:1994-11-01 00:00:00

  • Analysis of human peripheral blood T lymphocytes proliferating in response to sensitizing antigens: effect of interleukin-2 (IL-2)-responsive bystander cells.

    abstract::The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Sia DY,Chou JL

    更新日期:1988-03-01 00:00:00

  • Association of VDR ApaI and TaqI Gene Polymorphisms with the Risk of Scleroderma and Behçet's Disease.

    abstract::Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma i...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Kamal A,Gamal SM,Elgengehy FT,Alkemary AK,Siam I

    更新日期:2016-08-01 00:00:00

  • T cell receptor V-segment frequencies in peripheral CD8+ T cells in aging.

    abstract::Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Esparza B,Rodriguez A,Puente M,Sabino E,Merino F

    更新日期:1998-07-01 00:00:00

  • Development of an In Vitro Assay to Assess Pharmacological Compounds and Reversion of Tumor-Derived Immunosuppression of Dendritic Cells.

    abstract:BACKGROUND:Cancer immunotherapies have achieved much success and have become the forefront treatment of cancers previously associated with poor prognosis. However, a major challenge in cancer immunotherapies remains the heterogeneity of the immunoregulatory capacities of cancers, and not all patients of a given cancer ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Andersen MM,Larsen J,Hansen M,Pedersen AE,Gad M

    更新日期:2020-06-23 00:00:00

  • Which allergen extract for grass pollen immunotherapy? An in vitro study.

    abstract:BACKGROUND:Grass pollen is a major cause of allergy throughout the world. The only treatment targeting the causes and not only the symptoms of allergy is specific immunotherapy (IT). A number of controlled trials demonstrated the efficacy of IT in grass pollen allergic subjects, most using extracts of multiple grasses ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Marcucci F,Sensi L,Di Cara G,Incorvaia C,Puccinelli P,Scurati S,Frati F

    更新日期:2010-01-01 00:00:00

  • miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic smoking-related lung disease associated with higher mortality and morbidity. Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. METHODS:GEO database was applied to fil...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Jing X,Luan Z,Liu B

    更新日期:2021-01-17 00:00:00

  • Meta-Analysis of the Relationship between TNF-α (-308G/A) and IL-10 (-819C/T) Gene Polymorphisms and Susceptibility to Dengue.

    abstract:OBJECTIVE:This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS:a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. ...

    journal_title:Immunological investigations

    pub_type: 杂志文章,meta分析


    authors: Santos AC,de Moura EL,Ferreira JM,Santos BR,Alves VM,de Farias KF,de Souza Figueiredo EV

    更新日期:2017-02-01 00:00:00

  • Impact of IL12B Polymorphisms on Genetic Susceptibility and IL-12p40 and IL-23 Serum Levels in Rheumatoid Arthritis.

    abstract::The aim of this study was to evaluate the possible association of IL12B gene polymorphisms with serum levels of IL-12p40, IL-23 and genetic susceptibility to rheumatoid arthritis (RA) in the Bulgarian population. Genotyping for IL12Bpro (rs17860508) and IL12B A/C - 3' UTR (rs3212227) polymorphisms was performed by pol...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Manolova I,Ivanova M,Vasilev G,Stoilov R,Miteva L,Stanilova S

    更新日期:2020-02-01 00:00:00

  • Identification of individuals at increased risk for AIDS among clinically asymptomatic homosexuals and abusers of intravenous drugs.

    abstract::Immunological parameters previously shown to constitute an increased risk for progression towards AIDS have been observed in clinically asymptomatic individuals considered to be at risk for this syndrome. These parameters include severely decreased numbers of T helper cells (count below 400/mm3 blood for CD4+ cells we...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Mannhalter JW,Wolf HM,Pum M,Banekovich M,Hutterer J,Brandstätter R,Eibl MM

    更新日期:1988-04-01 00:00:00

  • A multi-laboratory evaluation of an enzyme-linked immunoassay quantitating human antibodies to Streptococcus pneumoniae polysaccharides.

    abstract::An enzyme-linked immunoassay (EIA) is described and evaluated which quantitates human antibodies to serotype specific S. pneumoniae polysaccharide (PnPs) in human sera. Based on the observations previously described by Koskela (1), native PnPs are used as coating antigens and sera are absorbed with a soluble pneumococ...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Quataert S,Martin D,Anderson P,Giebink GS,Henrichsen J,Leinonen M,Granoff DM,Russell H,Siber G,Faden H,Barnes D,Madore DV

    更新日期:2001-08-01 00:00:00

  • Safety aspects of intravenous immunoglobulins.

    abstract::Seven commercially available intravenous immunoglobulins (IVIG) preparations, a gamma globulin prepared by ethanol fractionation, and an experimental IgG isolated by a chromatographic procedure were compared in several tests. Split products were present in preparations manufactured by procedures involving protease tre...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Medgyesi GA,Kovács J,Füst G,Merétey K

    更新日期:1988-04-01 00:00:00

  • Stimulator T-cells and the regulation of growth factors produced in the murine mixed leukocyte reaction.

    abstract::Previous work had implicated T cells within the stimulating population as having a significant role in the MLR. We now report that depletion of T cells from the stimulators caused a reduction in proliferative response in mixed leukocyte reaction (MLR) by 50% or more. This response could be restored by adding T-enriche...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Roy C,Brown DL,Kaplan JG

    更新日期:1986-03-01 00:00:00

  • Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells.

    abstract::The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmu...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Chen J,Yang W,Yu C,Li Y

    更新日期:2008-01-01 00:00:00

  • Phenotyping of immune cell infiltrates in breast and colorectal tumours.

    abstract::White cell infiltration of solid tumors is an important prognostic indicator in malignant disease. Although macrophage infiltration is associated with good outcome in colorectal cancer, a high macrophage content is associated with poor prognosis in breast cancer. Suppressor macrophages prevent T cell activation in nor...

    journal_title:Immunological investigations

    pub_type: 杂志文章


    authors: Toomey D,Harmey J,Condron C,Kay E,Bouchier-Hayes D

    更新日期:1999-01-01 00:00:00