Repeated exposure to silicone gel can induce delayed hypersensitivity.


:The possible immunologic reactivity of silicone gel remains speculative and controversial. In this laboratory, a quantitative lymphocyte localization assay has been developed and well studied using pure lymphocytes collected by the technique of lymph vessel cannulation in sheep. The kinetics of antigen-specific immune responses (e.g., tuberculin reaction) in this model are well described and accepted. Using the known parameters regarding the response to purified protein derivative and the classic adjuvant Freund's Complete Adjuvant, this study was designed to identify the possible antigen-specific immunologic response, in the form of delayed-type hypersensitivity, after repeated exposure to silicone gel. Pure lymphocytes were collected by cannulating the efferent vessel of a subcutaneous lymph node in four groups of primed sheep which, 30 days previously, had received intradermal injections of 0.9% saline (negative controls; n = 6), Freund's Complete Adjuvant only (positive controls; n = 6), silicone gel (n = 7), or Freund's Complete Adjuvant homogenized with silicone gel (n = 7) in an attempt to induce sensitization. Multiple (1040) intradermal skin tests were performed using silicone gel, purified protein derivative, and 0.9% saline. After the skin lesions had developed for 48 hours, 5 x 10(8) lymphocytes were labeled in vitro with indium-111, returned intravenously, and allowed to circulate for 3 hours. Sheep were euthanized, the skin lesions were removed, and the radioactivity was counted in a gamma spectrometer. The radioactivity in each skin lesion is considered a measure of lymphocyte accumulation. The occurrence of augmented accumulation after reexposure to an antigen is a hallmark of delayed-type hypersensitivity. The purified protein derivative and saline lesions functioned as positive and negative controls, with counts per minute (cpm +/- standard error) of 2404 +/- 478 (Freund's Complete Adjuvant group) and 149 +/- 21 (saline group), respectively. Significantly greater (p = 0.0021) radioactivity was found in the silicone gel sites (310 +/- 35) in the silicone gel-primed group and the Freund's Complete Adjuvant plus silicone gel group (453 +/- 44; p = 0.0004) than in normal skin in each group. These data suggest that it may be possible to induce an antigen-specific lymphocyte-mediated response to silicone gel.


Plast Reconstr Surg


Narini PP,Semple JL,Hay JB




Has Abstract


1995-08-01 00:00:00












  • Optimal Use of Surgical Drains: Evidence-Based Strategies.

    abstract:BACKGROUND:Closed-suction drains are widely used to reduce the incidence of seroma whenever potential spaces are surgically created. However, few studies have examined the parameters that affect drain efficacy. METHODS:An in vitro model was created to assess the effects of tubing length, tubing size, tubing type, flui...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Khansa I,Khansa L,Meyerson J,Janis JE

    更新日期:2018-06-01 00:00:00

  • Preaponeurotic fat advancement in levator recession for treatment of upper eyelid retraction.

    abstract:BACKGROUND:Postoperative cosmetic deformities can be encountered after surgical treatments for upper eyelid retraction. The authors described a preaponeurotic fat advancement technique and investigated the effectiveness in patients who underwent levator recession for upper lid retraction. METHODS:This retrospective co...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Lee JH,Kim YD,Woo KI,Johnson ON 3rd

    更新日期:2015-04-01 00:00:00

  • Hyperbaric oxygen therapy for cutaneous/soft-tissue zygomycosis complicating diabetes mellitus.

    abstract::A 24-year-old female diabetic patient was hospitalized because of ketoacidosis and a necrotic wound on the hand. Debridement and antibiotic therapy failed to halt the process. After demonstration of Mucor in cultures from the wound, the patient underwent extensive surgery and amphotericin B was administered. When the ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bentur Y,Shupak A,Ramon Y,Abramovich A,Wolfin G,Stein H,Krivoi N

    更新日期:1998-09-01 00:00:00

  • A new concept in the tip plasty of Asian rhinoplasty: the flag technique by use of only a septal cartilage.

    abstract:BACKGROUND:To achieve the desired refinements in Asian patients, sufficient septal cartilage is needed for ideal tip projection and lengthening of the nose by the septal extension supported by the stable septum. There are many cases of insufficient septal cartilage in Asian patients. For optimal outcome, the author pro...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kim CH

    更新日期:2015-04-01 00:00:00

  • Treatment of keloids and hypertrophic scars with bleomycin and electroporation.

    abstract:BACKGROUND:Keloids and hypertrophic scars are the result of abnormal healing responses and dermal tissue proliferation; current surgical procedures can give rise to exuberant scarring and permanent functional loss or disfigurement. Considering the promising results reported when treating keloids and hypertrophic scars ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章


    authors: Manca G,Pandolfi P,Gregorelli C,Cadossi M,de Terlizzi F

    更新日期:2013-10-01 00:00:00

  • Quantitative evaluation of volume augmentation in the tear trough with a hyaluronic Acid-based filler: a three-dimensional analysis.

    abstract:BACKGROUND:Despite the prevalent use of hyaluronic acid-based filling materials for facial soft-tissue augmentation and favorable reports of durability in the infraorbital region, no quantitative data exist on the long-term durability of these products following injection. This study represents the first attempt to use...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Donath AS,Glasgold RA,Meier J,Glasgold MJ

    更新日期:2010-05-01 00:00:00

  • Growth Hormone Therapy Accelerates Axonal Regeneration, Promotes Motor Reinnervation, and Reduces Muscle Atrophy following Peripheral Nerve Injury.

    abstract:BACKGROUND:Therapies to improve outcomes following peripheral nerve injury are lacking. Prolonged denervation of muscle and Schwann cells contributes to poor outcomes. In this study, the authors assess the effects of growth hormone therapy on axonal regeneration, Schwann cell and muscle maintenance, and end-organ reinn...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Tuffaha SH,Budihardjo JD,Sarhane KA,Khusheim M,Song D,Broyles JM,Salvatori R,Means KR Jr,Higgins JP,Shores JT,Cooney DS,Hoke A,Lee WPA,Brandacher G

    更新日期:2016-06-01 00:00:00

  • Fat Grafting in Hollow Upper Eyelids and Volumetric Upper Blepharoplasty.

    abstract:BACKGROUND:Periorbital volume loss creates a shadow frame, and traditional excisional blepharoplasties may aggravate the situation. Divergence in filling treatments establishes a demand for simple and reproducible techniques to achieve consistent results. Here, the author's hollow upper eyelid evaluation and treatment ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Ramil ME

    更新日期:2017-11-01 00:00:00

  • Easy orientation of the cut ends for nerve suture.

    abstract::A technique for orienting cut nerve ends for suturing is presented. A mirror is used to reflect one end, making its image identical to that of the other end--so that proper orientation is greatly facilitated. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Vickers DW

    更新日期:1979-01-01 00:00:00

  • Advancements in free flap monitoring in the last decade: a critical review.

    abstract:BACKGROUND:The authors conducted a review of the recent literature on the monitoring of free flaps to create an overview of the current monitoring devices and their potential as an ideal monitoring method. METHODS:A literature-based study was conducted using the PubMed and Cochrane databases. The following search term...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Smit JM,Zeebregts CJ,Acosta R,Werker PMN

    更新日期:2010-01-01 00:00:00

  • Megavolume autologous fat transfer: part II. Practice and techniques.

    abstract::The authors describe the techniques that use the principles of fat grafting to allow them to successfully graft megavolumes (250-ml range) of autologous fat into breasts. The Brava external volume expansion device preoperatively increases the volume and vascularity of the recipient site. Low-pressure liposuction and m...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Khouri RK,Rigotti G,Cardoso E,Khouri RK Jr,Biggs TM

    更新日期:2014-06-01 00:00:00

  • A study of the supraorbital nerve.

    abstract::A detailed description of the anatomical relationships of the supraorbital nerve as it courses across the forehead and under the scalp cannot be found in most anatomy textbooks, and illustrations of the nerve beyond the superior orbital rim frequently misrepresent its course. Because the supraorbital nerve is a struct...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Knize DM

    更新日期:1995-09-01 00:00:00

  • Video microsurgery: evaluation of standard laparoscopic equipment for the practice of microsurgery.

    abstract::Traditional microsurgery involves the use of bulky and expensive stereo microscopes that have limited portability. Recent advances in video technology have enabled the exploration of alternative visualization methods. The purpose of this study was to evaluate standard laparoscopic equipment for microvascular anastomos...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Gorman PJ,Mackay DR,Kutz RH,Banducci DR,Haluck RS

    更新日期:2001-09-15 00:00:00

  • Significance of shoulder function in the reconstruction of prehension with double free-muscle transfer after complete paralysis of the brachial plexus.

    abstract::Reconstruction of shoulder stability and movement in cases with complete paralysis of the brachial plexus was performed to improve the outcomes for universal function of prehension after double free-muscle transfer (Doi's procedure). In cases in which the C5 or C6 nerve root was available as a donor, neurotization of ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Doi K,Hattori Y,Ikeda K,Dhawan V

    更新日期:2003-11-01 00:00:00

  • The cost effectiveness of the DIEP flap relative to the muscle-sparing TRAM flap in postmastectomy breast reconstruction.

    abstract:BACKGROUND:The deep inferior epigastric perforator (DIEP) flap has gained notoriety because of its proposed benefit in decreasing donor-site morbidity but has been associated with longer operative times, higher perfusion-related complications, and increased cost relative to muscle-sparing free transverse rectus abdomin...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Krishnan NM,Purnell C,Nahabedian MY,Freed GL,Nigriny JF,Rosen JM,Rosson GD

    更新日期:2015-04-01 00:00:00

  • The sandwich temporoparietal free fascial flap for tendon gliding.

    abstract::Microsurgical transfer of the superficial and deep temporal fascia based on the superficial temporal vessels has been documented. This article analyzes the functional recovery when each layer of this facial flap is placed on either side of reconstructed or repaired tendons, to recreate a gliding environment. This fasc...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Biswas G,Lohani I,Chari PS

    更新日期:2001-11-01 00:00:00

  • Health risks of failed silicone gel breast implants: a 30-year clinical experience.

    abstract::The purpose of this paper is an assessment of clinically evident systemic health problems associated with failed silicone gel breast implants. A computer search of the medical records of 2033 patients receiving implants in the years 1962-1992 revealed that between 1970 and 1992, 200 women 14 to 75 years of age underwe...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Duffy MJ,Woods JE

    更新日期:1994-08-01 00:00:00

  • Septum-Based Nasal Tip Plasty: A Comparative Study between Septal Extension Graft and Double-Layered Conchal Cartilage Extension Graft.

    abstract:BACKGROUND:The septal extension graft is currently the most commonly used primary and secondary rhinoplasty technique in Asia because it provides maximal tip projection and rotational controllability. The authors compared the tip projection amount and rotational controllability of the tip support between the septal ext...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Suh YC,Jeong WS,Choi JW

    更新日期:2018-01-01 00:00:00

  • Facial Nerve Danger Zones.

    abstract::Facial nerve injury is one of the most feared complications in surgical rejuvenation of the aging face. Understanding the three-dimensional architecture of the facial soft tissue, the fascial planes that exist within this architectural arrangement, and the danger zones where the facial nerve is situated superficial an...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Stuzin JM,Rohrich RJ

    更新日期:2020-01-01 00:00:00

  • The Influence of Insurance Type on Management of Carpal Tunnel Syndrome: An Analysis of Nationwide Practice Trends.

    abstract:BACKGROUND:The purpose of this study was to evaluate the impact of insurance type on use of diagnostic testing, treatments, and the efficiency of care for patients with carpal tunnel syndrome. METHODS:The 2009 to 2013 Truven MarketScan Databases were used to identify adult patients with carpal tunnel syndrome. Insuran...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Sears ED,Swiatek PR,Hou H,Chung KC

    更新日期:2016-11-01 00:00:00

  • Comparison of free and reversed pedicled posterior interosseous cutaneous flaps.

    abstract::The posterior interosseous cutaneous flap is characterized by its thinness and the adjustable length of its vascular pedicle. This flap can be used both as a free and reversed vascular pedicled flap. We applied the free flap mostly for reconstruction of the digits, and the reversed vascular pedicled flap for soft-tiss...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Shibata M,Iwabuchi Y,Kubota S,Matsuzaki H

    更新日期:1997-03-01 00:00:00

  • Anatomical study of factors contributing to zygomatic complex fracture instability in human cadavers.

    abstract:BACKGROUND:Stable reduction of fractures of the zygomatic complex is essential to avoid long-term aesthetic, sensory, and ocular consequences. Delayed collapse or relapse after reduction of fractures of the zygomatic complex is attributed to muscle forces, when there has been no additional trauma. A number of studies h...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Barry CP,Ryan WJ,Stassen LF

    更新日期:2007-02-01 00:00:00

  • Evaluation of the scratch collapse test in peroneal nerve compression.

    abstract:BACKGROUND:The scratch collapse test is a recently described provocative test for diagnosis of peripheral nerve compression. METHODS:The scratch collapse test was studied prospectively in 24 consecutive patients with a diagnosis of common peroneal nerve compression neuropathy. The diagnosis was confirmed by history, p...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Gillenwater J,Cheng J,Mackinnon SE

    更新日期:2011-10-01 00:00:00

  • Anchor-line abdominoplasty: a comprehensive approach to abdominal wall reconstruction and body contouring.

    abstract:BACKGROUND:Classic abdominoplasty leads to disappointing aesthetic results in patients with preexisting supraumbilical scars. Various techniques involving vertical and horizontal incisions have been described. The authors point out the validity of the "anchor-line" approach. METHODS:In a retrospective study, the autho...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Persichetti P,Simone P,Scuderi N

    更新日期:2005-07-01 00:00:00

  • Delayed cranial vault reconstruction for sagittal synostosis in older children: an algorithm for tailoring the reconstructive approach to the craniofacial deformity.

    abstract::An algorithm for the management of sagittal synostosis in older children who underwent delayed cranial vault reconstruction is presented. This algorithm tailors the surgical approach to the specific craniofacial deformity present in each case. The scaphocephalic deformity characteristic of sagittal synostosis varies s...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Weinzweig J,Baker SB,Whitaker LA,Sutton LN,Bartlett SP

    更新日期:2002-08-01 00:00:00

  • Short-scar face lift with extended SMAS platysma dissection and lifting and limited skin undermining.

    abstract::In the past 8 years, short-scar cervicofacial rhytidectomy has been used with great success and a high level of patient satisfaction. The operation involves limited incisions in the sideburn and preauricular areas, extending just around the fold of the ear lobule. Extensive undermining of the superficial musculoaponeu...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Massiha H

    更新日期:2003-08-01 00:00:00

  • The psychological aspects of cosmetic breast augmentation.

    abstract:BACKGROUND:The psychological aspects of cosmetic breast augmentation have been the focus of a great deal of empiric study over the past 40 years. METHODS:Studies investigating the preoperative characteristics and psychosocial status of women interested in breast augmentation are reviewed. Investigations of postoperati...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Sarwer DB

    更新日期:2007-12-01 00:00:00

  • Live demonstration of microcirculation in the deep fascia and its implication.

    abstract::The rich vascular network in the deep fascia has been emphasized by various scientists, but the actual demonstration of live circulation in the deep fascia has not previously been witnessed. Encouraged by the sight of live circulation in the web membrane of toad hind limb, a successful attempt was made to demonstrate ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bhattacharya V,Watts RK,Reddy GR

    更新日期:2005-02-01 00:00:00

  • The effect of unilateral partial facial paralysis on nasofrontal sutural growth: an experimental study in the rabbit.

    abstract::In a previous study in the rabbit, it was demonstrated that paralysis of the midfacial musculature results in decreased anteroposterior growth of the snout. At the end of growth, these animals showed macroscopically striking similarities to animals with unilateral fusion of the nasofrontal suture. In this study, wheth...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Sinsel NK,Guelinckx PJ,Opdebeeck H

    更新日期:1999-06-01 00:00:00

  • Prevention of flap necrosis by chlorpromazine.

    abstract::Chlorpromazine administered to Sprague-Dawley rats 30 minutes prior to elevation of McFarlane back flaps and continued 14 days thereafter resulted in near complete flap survival, compared with 48 percent necrosis in control animals. Chlorpromazine demonstrates a wide variety of actions that appear to meet all presentl...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bibi R,Ferder M,Strauch B

    更新日期:1986-06-01 00:00:00