Early-life vitamin D deficiency and childhood-onset coeliac disease.

Abstract:

:Many studies have investigated the aetiological roles of genetic and environmental factors in coeliac disease (CD) with the long-term goal of developing an effective primary prevention strategy. CD is a condition with dysregulated systemic and intestinal mucosal immune responses to dietary gluten proteins among genetically predisposed individuals. We recently described spring birth as a novel risk factor for CD in children. We believe that the association between season of birth and CD is due to seasonal differences in sunlight exposure and subsequent vitamin D status. Concomitant with global increases in CD prevalence, vitamin D deficiency also is increasingly recognized in children worldwide. Recent studies have shown that vitamin D deficiency can cause improper immune responses, abnormal intestinal mucosal integrity and impaired local defence to pathogenic microbial agents. In conjunction with other potential aetiological factors, we propose a hypothesis model of early-life vitamin D deficiency in the pathogenesis of childhood-onset CD.

journal_name

Public Health Nutr

journal_title

Public health nutrition

authors

Tanpowpong P,Camargo CA

doi

10.1017/S1368980013003510

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

823-6

issue

4

eissn

1368-9800

issn

1475-2727

pii

S1368980013003510

journal_volume

17

pub_type

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