A study of hepcidin and monocyte chemoattractant protein-1 in Egyptian females with systemic lupus erythematosus.

Abstract:

BACKGROUND:Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus (SLE). Novel biomarkers are necessary to enhance the diagnostic accuracy, prognostic stratification, monitoring of treatment response, and detection of early renal flares. METHODS:Our study was conducted on 90 participants. They were divided into three groups, group I (controls) encompassed 30 ages and sex-matched healthy personnel. Group II included 30 non-nephritic SLE patients and finally group III included 30 SLE nephritic patients. Urinary monocyte chemoattractant protein-1 (UMCP-1) and hepcidin were evaluated by ELISA technique, compared and correlated in different groups, with each other and with other routine variables and with renal biopsy done to study group (III). RESULTS:Both UMCP-1 and hepcidin in group III showed significant increase compared to other two groups (controls and group II) (468 ± 128, 111 ± 12, 252 ± 56 pg/ml, respectively, for UMCP-1 and 40 ± 12, 11 ± 2, 20 ± 5 ng/ml, respectively, for hepcidin, P < 0.01). Also both UMCP-1 and hepcidin in group III showed significant increase in diffuse proliferative subgroup compared to focal proliferative and mesangioproliferative subgroups (580 ± 43, 502 ± 46, and 352.6 ± 100 pg/ml, respectively, for UMCP-1 and 47.8 ± 9.5, 41.4 ± 6, and 32.9 ± 10.8 ng/ml, respectively, for urinary hepcidin, P < 0.05). CONCLUSION:UMCP-1 and hepcidin could be associated with the susceptibility of lupus nephritis.

journal_name

J Clin Lab Anal

authors

Mohammed MF,Belal D,Bakry S,Marie MA,Rashed L,Eldin RE,El-Hamid SA

doi

10.1002/jcla.21685

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

306-9

issue

4

eissn

0887-8013

issn

1098-2825

journal_volume

28

pub_type

杂志文章
  • Comparison of prostate acid phosphatase with acid phosphatase isoenzymes from the lung and spleen.

    abstract::Acid phosphatase was purified to electrophoretic homogeneity from human normal lung and spleen and was characterized biochemically and immunologically in comparison with prostate acid phosphatase (PAP). The apparent MW of lung acid phosphatase (LAP) and spleen acid phosphatase (SAP) was 110,000 and 100,000, respective...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860040606

    authors: Lin MF,Li SS,Chu TM,Lee CL

    更新日期:1990-01-01 00:00:00

  • Hepatitis E antibody profiles in serum and urine.

    abstract::The aim of this study was to evaluate anti-HEV antibody profiles in urine specimens in comparison to corresponding serum samples to assess the utility of urine as a clinical specimen. Paired serum and urine specimens from 71 hepatitis E patients, 33 non-E hepatitis patients, 63 patients with nonhepatic diseases, and 2...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.10027

    authors: Joshi MS,Walimbe AM,Arankalle VA,Chadha MS,Chitambar SD

    更新日期:2002-01-01 00:00:00

  • Importance of detecting multidrug resistance proteins in acute leukemia prognosis and therapy.

    abstract::Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice o...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章,评审

    doi:10.1002/jcla.21563

    authors: de Moraes AC,Maranho CK,Rauber GS,Santos-Silva MC

    更新日期:2013-01-01 00:00:00

  • Predictive value of the serum level of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein in left ventricular remodeling after acute myocardial infarction.

    abstract::This study was designed to measure the correlation between left ventricular (LV) remodeling 3 months after successful reperfusion therapy, and the levels of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) at 3 days after acute myocardial infarction (AMI), and...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20094

    authors: Xiaozhou H,Jie Z,Li Z,Liyan C

    更新日期:2006-01-01 00:00:00

  • Establishment of monoclonal antibody against human Apo B-48 and measurement of Apo B-48 in serum by ELISA method.

    abstract::The elevation of chylomicrons and chylomicron remnants in plasma would lead to hyperlipidemia and other complications. Apo B-48, which is translated and produced in the adult intestine from the same gene as Apo B-100, is considered to be an essential component of chylomicrons and chylomicron remnants. Using a peptide ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-2825(1998)12:5<289::aid-jcla7>3

    authors: Uchida Y,Kurano Y,Ito S

    更新日期:1998-01-01 00:00:00

  • Association between serum ferritin and the severity of drug eruptions.

    abstract:BACKGROUND:Early recognition and treatment for severe drug eruption are important in improving clinical outcomes. A few studies have reported laboratory parameters to evaluate the severity of drug eruptions. This study aimed to determine the association between serum ferritin and the severity of drug eruptions. METHOD...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23043

    authors: Pan Y,Tang S,Zheng S,Li S,Zhu D,Fang H,Qiao J

    更新日期:2020-02-01 00:00:00

  • Diurnal variation of biopyrrin excretion in random urine specimens is not corrected by creatinine.

    abstract::Circulating bilirubin is thought to function as a physiological antioxidant. One of the decomposition products of this process is the biopyrrins, which include two regioisomers: biotripyrrin-a (1,14,15,17-tetrahydro-2,7,13-trimethyl-1,14-deoxy-3-vinyl-16H-tripyrrin-8,12-dipropionic acid) and biotripyrrin-b (1,14,15,17...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20157

    authors: Ihara H,Matsumoto T,Morita Y,Hirano A,Okada M,Hashizume N,Shioji I,Yoshimura H

    更新日期:2007-01-01 00:00:00

  • Rhabdomyosarcoma cell line can be used for the isolation of soluble acetylcholine receptor and for assaying blocking and modulating autoantibodies.

    abstract::We found that the Rhabdomyosarcoma (RD) cell line expresses human acetylcholine receptor (AChR) based on the following evidences: 1. Soluble AChR can be isolated from RD cells following the isolation procedure for AChR from human muscle; 2. Intact RD cells bind to alpha-bungarotoxin (alpha Butx) in a time-dependent an...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860070104

    authors: Wu JT,Astill M,Lloyd C,Salmon VC

    更新日期:1993-01-01 00:00:00

  • Evaluation of a bench-top nephelometric immunoassay analyzer.

    abstract::We evaluated the Technicon DPA-1 immunoassay analyzer on its analytical characteristics. Therefore we studied three assays: albumin in cerebrospinal fluid and IgG and transferrin in serum. When tested with the Cusum test for linearity albumin, IgG, and transferrin measurements showed no deviation from linearity. Close...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860050103

    authors: van Rijn JL,van Landeghem AA,Goldschmidt HM

    更新日期:1991-01-01 00:00:00

  • Histocompatibility screening by molecular techniques: use of polymerase chain reaction products and heteroduplex formation.

    abstract::Novel molecular approaches have recently become available allowing improved major histocompatibility complex (MHC) matching of potential allogeneic bone marrow donors and recipients. Current cellular and serological assays are hindered by aberrant cell populations and limited reagents which only detect an individuals'...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860060515

    authors: Rubocki RJ,Wisecarver JL,Hook DD,Cox SM,Beisel KW

    更新日期:1992-01-01 00:00:00

  • Automated chemiluminescent assay for C-peptide.

    abstract::C-peptide is secreted in equimolar concentrations with insulin, and is often measured to assess pancreatic beta-cell function. C-peptide analysis is most often performed by radioimmunoassay (RIA) which has several disadvantages. We evaluated an automated, chemiluminescent immunoassay for C-peptide in terms of precisio...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:

    authors: Hardy RW,Cohn M,Konrad RJ

    更新日期:2000-01-01 00:00:00

  • How useful is bone marrow study as an initial investigative tool without lymph node biopsy in malignant lymphoma?: Eleven years of experience at a single institution.

    abstract:BACKGROUND:Bone marrow (BM) study plays an important role as initial investigation specimen of lymphoma as well as staging lymphoma. This study aimed to investigate the utility of BM studies for classification of lymphoma and evaluate features of BM involvement by lymphoma over a period of 11 years. METHODS:A total of...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22841

    authors: Kwoun WJ,Ahn JY,Park PW,Seo YH,Kim KH,Seo JY,Lee HT,Yoo KH

    更新日期:2019-05-01 00:00:00

  • MicroRNA-132 suppresses migration and invasion of renal carcinoma cells.

    abstract:BACKGROUND:The aim of this study was to explain the effects of microRNA-132 in renal cell carcinoma by regulating FOXM1 expression. METHODS:Thirty patients with renal cell carcinoma admitted to our hospital were enrolled, and their adjacent normal tissues and cancer tissues were taken. The expression of microRNA-132 w...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22969

    authors: Yu Y,Lu W,Zhou X,Huang H,Shen S,Guo L

    更新日期:2020-01-01 00:00:00

  • Does cigarette smoking affect the diagnostic reliability of hemoglobin alpha 2 delta 2 (HbA2)?

    abstract::Quantitation of hemoglobin alpha 2 delta 2 (HbA2) is a basic and confirmatory test in diagnosing the carrier state of beta-thalassemia. The present study was designed to investigate the effect of cigarette smoking on the diagnostic reliability of HbA2. A total of 2,867 (654 smokers and 2,213 never smokers) male subjec...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20228

    authors: Tarazi IS,Sirdah MM,El Jeadi H,Al Haddad RM

    更新日期:2008-01-01 00:00:00

  • M30 does not predict the severity of hepatosteatosis, whereas adiponectin level declined with increase of ALT and the severity of hepatic steatosis.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is an emerging problem all over the world. Because NAFLD and polycystic ovary syndrome (PCOS) are both closely related with insulin resistance, it would be necessary to determine the rate of presence of NAFLD in PCOS patients. So, this study aimed to investigate the u...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21697

    authors: Caner S,Altınbaş A,Saykı M,Büyükcam F,Yılmaz B,Çakal E,Çoban Ş,Delibaşı T

    更新日期:2014-09-01 00:00:00

  • Flow cytometric analysis of lymphocyte subpopulations in infants with congenital heart disease.

    abstract::Premortem diagnosis of the DiGeorge syndrome and its partial variants relies on the demonstration of a primary defect in cell-mediated immunity, generally in the setting of an infant with congenital heart disease, hypocalcemia, absence of a thymic shadow, and typical dysmorphic features. Although T-cell enumeration is...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860030105

    authors: Slade HB,Greenwood JH,Beekman RH 3rd,McCoy JP Jr,Hudson JL,Pahwa S,Schwartz SA

    更新日期:1989-01-01 00:00:00

  • Age-dependent decreases in serum soluble interleukin-1 receptor type I (sIL-1RI) in healthy individuals: a population study of serum sIL-1RI levels in Japanese subjects.

    abstract::The levels of several soluble cytokine receptors in body fluids of healthy individuals change with age. Clinical application of the measurement of the serum soluble interleukin-1 receptor type I (sIL-1RI) level depends critically on the samples used as the controls. At present, there is no information regarding the le...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20315

    authors: Okamoto Y,Tanaka M,Miyahara N,Tanabe M,Gotoh Y,Nagai T,Fujita N,Fukui T,Masuzawa T

    更新日期:2009-01-01 00:00:00

  • Diagnostic value of ganglioside patterns in plasma of human diseases.

    abstract::A method that could be facilitated for the quantitation and qualitation of gangliosides in human plasma was developed and applied in the present study for characterization of ganglioside patterns in plasmas of patients with neoplastic diseases including gastric cancer, adult T-cell leukemia (ATL), and acute lymphocyti...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860030508

    authors: Ayabe M,Shichijo S,Yokoyama MM

    更新日期:1989-01-01 00:00:00

  • Development and Validation of Liquid Chromatography/Tandem Mass Spectrometry Analysis for Therapeutic Drug Monitoring of Risperidone and 9-Hydroxyrisperidone in Pediatric Patients with Autism Spectrum Disorders.

    abstract:BACKGROUND:Risperidone (RIS) is a widely used atypical antipsychotic drug. We developed and validated a sensitive and accurate LC-MS/MS method, which requires a small-volume of plasma and small-volume injection for measurement of RIS levels in ASD pediatric patients. We also investigated the relationship between RIS le...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22009

    authors: Vanwong N,Prommas S,Puangpetch A,Hongkaew Y,Nuntamool N,Nakorn CN,Ngamsamut N,Limsila P,Sukasem C

    更新日期:2016-11-01 00:00:00

  • Multiple cutaneous infections caused by Prototheca wickerhamii.

    abstract:BACKGROUND:Prototheca species are a group of organisms ubiquitously existing in nature but have become a pathogenic threat to public health, which has aroused wide attention. Species identification and antifungal susceptibility have essential and valuable meanings to clinical diagnosis and treatment. METHODS:A case of...

    journal_title:Journal of clinical laboratory analysis

    pub_type:

    doi:10.1002/jcla.23492

    authors: Zhao F,Chen M,Fu Y

    更新日期:2020-11-01 00:00:00

  • Virulence factors impair epithelial junctions during bacterial infection.

    abstract::Epithelial cells are typically connected through different types of cell junctions that are localized from the apical membrane to the basal surface. In this way, epithelium cells form the first barrier against pathogenic microorganisms and prevent their entry into internal organs and the circulatory system. Recent stu...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章,评审

    doi:10.1002/jcla.23627

    authors: Zheng M,Sun S,Zhou J,Liu M

    更新日期:2020-10-17 00:00:00

  • Cost-Effective In-House Neutralization Assay for the Confirmation of HBeAg.

    abstract:BACKGROUND & AIM:Hepatitis B virus-e-antigen (HBeAg) is an affordable viral marker to assess viral replication kinetics and response to antiviral therapy. In the absence of confirmatory assays, discrepant or false-positive HBeAg results are resolved by screening for other HBV markers. We standardized an in-house HBeAg ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21995

    authors: Fletcher GJ,Anantharam R,Radhakrishnan K,Karunakaran A,Abraham P

    更新日期:2016-11-01 00:00:00

  • Analysis of serum gastrin-17 and Helicobacter pylori antibody in healthy Chinese population.

    abstract:BACKGROUND:Gastrin-17 (G-17) and Helicobacter pylori (H pylori) antibody are widely used in the screening of gastric diseases, especially in gastric cancer. In this study, we aimed to evaluate the value of G-17 and H pylori antibody in gastric disease screening. METHODS:Healthy males and females (1368 and 1212, respec...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23518

    authors: Liu W,Sun Y,Yuan Y

    更新日期:2020-08-30 00:00:00

  • Association of TLX1 gene polymorphisms with the risk of acute lymphoblastic leukemia and B lineage acute lymphoblastic leukemia in Han Chinese children.

    abstract:BACKGROUND:Studies on gene polymorphism association are centered on childhood acute lymphoblastic leukemia (ALL), a common hematological malignancy in children younger than 16 years. Single-nucleotide polymorphisms (SNPs) in some genes, such as ARID5B and CDKN2B, are associated with the risk of childhood ALL. T-cell le...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23414

    authors: Mei E,Wei X,Gao J,Tian X,Li W,Liu L,Qian C

    更新日期:2020-09-01 00:00:00

  • Use of Chernoff faces to follow trends in laboratory data.

    abstract::Graphical representation of laboratory data speeds up recognition of abnormalities. The Chernoff face is an excellent tool to represent patient data; the human eye and mind are exquisitely sensitive to subtle changes in facial appearances and expression. One of the best uses of the faces is in illustrating trends in t...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860040112

    authors: Lott JA,Durbridge TC

    更新日期:1990-01-01 00:00:00

  • Angiotoxicity and atherogenicity of cholesterol oxides.

    abstract::Cholesterol in the diet can readily autoxidize and be absorbed and transported in plasma lipoproteins. Cholesterol oxides can also be endogenously produced in tissues via free-radical-induced reactions. Some cholesterol oxides, notably cholestane-3 beta, 5 alpha, 6 beta-triol and 25-hydroxycholesterol, have been shown...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章,评审

    doi:10.1002/jcla.1860050212

    authors: Peng SK,Hu B,Morin RJ

    更新日期:1991-01-01 00:00:00

  • Different patterns of serum chromogranin A in patients with prostate cancer with and without undergoing hormonal therapy.

    abstract::Elevated serum chromogranin A (CgA) levels have been detected in patients with prostate cancer who have developed resistance to hormonal therapy. We would like to reexamine these cases by using serial specimens to determine whether such elevated levels are also detectable in prostate cancer patients not undergoing hor...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:

    authors: Wu JT,Wu TL,Chang CP,Tsao KC,Sun CF

    更新日期:1999-01-01 00:00:00

  • Relative quantification of collagen mRNA in fibroblasts by a radioactive polymerase chain reaction technique.

    abstract::A radioactive polymerase chain reaction (PCR) method has been developed for the relative quantification of the human alpha-2 chain of type I collagen [hu alpha-2(I)] in cells. cDNAs generated by reverse transcription from the total pool of cytoplasmic RNA serve as a template for polymerase chain reaction amplification...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860050407

    authors: Yu YL,Golden JA,Migchielsen AA,Goetzl EJ,Turck CW

    更新日期:1991-01-01 00:00:00

  • Free circulating tumor DNA as a diagnostic marker for breast cancer.

    abstract:BACKGROUND:Cell-free DNA (cfDNA) in the plasma of patients with both malignant and benign breast lesions was analyzed to determine whether the findings may have diagnostic and prognostic implications and to analyze the association between the levels of cfDNA and prognostic parameters. METHODS:Plasma samples were obtai...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21548

    authors: Hashad D,Sorour A,Ghazal A,Talaat I

    更新日期:2012-11-01 00:00:00

  • Comparison of RNA extraction methods to augment the sensitivity for the differentiation of vesicular stomatitis virus Indiana1 and New Jersey.

    abstract::Two methods for the extraction of RNA of vesicular stomatitis virus (VSV) Indiana1 and New Jersey and their simultaneous amplification by one-step polymerase chain reaction using reverse transcriptase were evaluated. A guanidine-thiocyanate-based RNA extraction (Qiagen RNeasy Mini Kit, Qiagen, Valencia, CA ) followed ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20439

    authors: Arshed MJ,Magnuson RJ,Triantis J,Abubakar M,Van Campen H,Salman M

    更新日期:2011-01-01 00:00:00