Is melatonin ready to be used in preterm infants as a neuroprotectant?

Abstract:

:The prevention of neurological disabilities following preterm birth remains a major public health challenge and efforts are still needed to test the neuroprotective properties of candidate molecules. Melatonin serves as a neuroprotectant in adult models of cerebral ischemia through its potent antioxidant and anti-inflammatory effects. An increasing number of preclinical studies have consistently demonstrated that melatonin protects the damaged developing brain by preventing abnormal myelination and an inflammatory glial reaction, a major cause of white matter injury. The main questions asked in this review are whether preclinical data on the neuroprotective properties of melatonin are sufficient to translate this concept into the clinical setting, and whether melatonin can reduce white matter damage in preterm infants. This review provides support for our view that melatonin is now ready to be tested in human preterm neonates, and discusses ongoing and planned clinical trials.

journal_name

Dev Med Child Neurol

authors

Biran V,Phan Duy A,Decobert F,Bednarek N,Alberti C,Baud O

doi

10.1111/dmcn.12415

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

717-23

issue

8

eissn

0012-1622

issn

1469-8749

journal_volume

56

pub_type

杂志文章,评审
  • Relaxation prophylaxis for childhood migraine: a randomized placebo-controlled trial.

    abstract::A randomized controlled trial was used to evaluate the effectiveness of relaxation training in the treatment of paediatric migraine. Relaxation training was compared with-two control groups (psychological placebo and 'own best efforts') in a total of 99 children and adolescents with frequent migraine. Daily recording ...

    journal_title:Developmental medicine and child neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1469-8749.1988.tb04800.x

    authors: McGrath PJ,Humphreys P,Goodman JT,Keene D,Firestone P,Jacob P,Cunningham SJ

    更新日期:1988-10-01 00:00:00

  • Language lateralization in children using functional transcranial Doppler sonography.

    abstract:AIM:Language lateralization with functional transcranial Doppler sonography (fTCD) and lexical word generation has been shown to have high concordance with the Wada test and functional magnetic resonance imaging in adults. We evaluated a nonlexical paradigm to determine language dominance in children. METHOD:In 23 rig...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2009.03362.x

    authors: Haag A,Moeller N,Knake S,Hermsen A,Oertel WH,Rosenow F,Hamer HM

    更新日期:2010-04-01 00:00:00

  • Transient dystonias revisited: a comparative study of preterm and term children at 2 1/2 years of age.

    abstract::Minor neurological dysfunctions (MND) have frequently been reported as an outcome of preterm birth. Behavioural and learning difficulties are a known feature, but coordination problems are especially described in preterm infants at later ages. All preterm infants in our study were born with a gestational age of <32 we...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162201002298

    authors: de Vries AM,de Groot L

    更新日期:2002-06-01 00:00:00

  • Prevalence and selected characteristics of childhood vision impairment.

    abstract::The objective of this study was to examine the descriptive epidemiology of vision impairment among 6- to 10-year-old children in metropolitan Atlanta, Georgia, USA. Children with vision impairment (n=310; 42% black, 56% white; 57% male, 43% female), defined as a best corrected visual acuity in the better eye of 20/70 ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162201002523

    authors: Mervis CA,Boyle CA,Yeargin-Allsopp M

    更新日期:2002-08-01 00:00:00

  • Efficacy of interventions to improve motor performance in children with developmental coordination disorder: a combined systematic review and meta-analysis.

    abstract:AIM:The aim of this study was to review systematically evidence about the efficacy of motor interventions for children with developmental coordination disorder (DCD), and to quantify treatment effects using meta-analysis. METHOD:Included were all studies published between 1995 and 2011 that described a systematic revi...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/dmcn.12008

    authors: Smits-Engelsman BC,Blank R,van der Kaay AC,Mosterd-van der Meijs R,Vlugt-van den Brand E,Polatajko HJ,Wilson PH

    更新日期:2013-03-01 00:00:00

  • Changes in clinical presentation of term infants with intracranial hemorrhage.

    abstract::The clinical course and outcome of eight term infants with intracranial hemorrhage are reported. Before computerized tomography became available, term infants with intracranial hemorrhage were usually diagnosed only at autopsy and the hemorrhage was associated with a trauamtic birth or severe asphyxia. In contrast, si...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1979.tb01694.x

    authors: Cartwright GW,Culbertson K,Schreiner RL,Garg BP

    更新日期:1979-12-01 00:00:00

  • Anxiety and depression in children and adolescents with spinal cord injuries.

    abstract::Aim To determine the levels of anxiety and depression in young people with spinal cord injuries (SCI) and their associated factors and outcomes. Method Children and adolescents aged 7 to 17 years at interview who had sustained SCI at least 1 year before the study were assessed using the Children's Depression Inventory...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2009.03268.x

    authors: Anderson CJ,Kelly EH,Klaas SJ,Russell H,Daharsh E,Vogel LC

    更新日期:2009-10-01 00:00:00

  • A novel neurological disorder with progressive CNS calcification, deafness, renal tubular acidosis, and microcytic anemia.

    abstract::Progressive calcification of the brain and the spinal cord at early infantile onset was observed in two siblings. They showed growth failure, psychomotor deterioration, deafness, vestibular dysfunction, microcytic hypochromic anemia, abnormal ratios of lymphocyte subpopulations, and slightly decreased bicarbonate on b...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1997.tb07410.x

    authors: Yoshimura M,Hara T,Maegaki Y,Koeda T,Okubo K,Hamasaki N,Sly WS,Takeshita K

    更新日期:1997-03-01 00:00:00

  • Cerebral palsy among children born moderately preterm or at moderately low birthweight between 1980 and 1998: a European register-based study.

    abstract:AIM:The aim of this study was to describe trends in prevalence, subtypes, and severity among children with cerebral palsy (CP) born moderately preterm (MPT; (gestational age 32-36 wks) or at moderately low birthweight (MLBW; 1500-2499 g) in Europe. METHOD:We conducted trend analyses of data from 903 children with CP b...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1469-8749.2011.04079.x

    authors: Andersen GL,Romundstad P,De La Cruz J,Himmelmann K,Sellier E,Cans C,Kurinczuk JJ,Vik T

    更新日期:2011-10-01 00:00:00

  • Electromyographic studies on flexor hypertonia of the extremities of newborn infants.

    abstract::In order to investigate flexor hypertonia of the extremities in newborns, a neurological examination and superficial electromyogram (EMG) recordings were carried out on 50 full-term infants both before and after the first 48 hours of life (the 'birth-shock period). EMG amplituds on the flexor side of the upper arm in ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1975.tb03495.x

    authors: Maekawa K,Ochiai Y

    更新日期:1975-08-01 00:00:00

  • Hemispheric specialization using SPECT and stimulation tasks in children with dysphasia and dystrophia.

    abstract::Developmental dysphasia, a severe childhood learning disorder, is thought to result from problems in hemispheric specialization involving both left and right cerebral hemispheres. Regional cerebral blood flow (rCBF) was measured at rest and during stimulation of both hemispheres independently: dichotic listening for t...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162299001139

    authors: Chiron C,Pinton F,Masure MC,Duvelleroy-Hommet C,Leon F,Billard C

    更新日期:1999-08-01 00:00:00

  • Long-term safety and efficacy of continuous intrathecal baclofen.

    abstract::Long-term continuous intrathecal baclofen (CITB) infusion is a treatment option used to manage otherwise intractable spasticity and is delivered via an implantable pump. The purpose of this single-center multidisciplinary review was to report on the long-term safety and efficacy of CITB in the treatment of 21 children...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162201002729

    authors: Campbell WM,Ferrel A,McLaughlin JF,Grant GA,Loeser JD,Graubert C,Bjornson K

    更新日期:2002-10-01 00:00:00

  • Human herpesvirus-6 associated encephalitis with subsequent infantile spasms and cerebellar astrocytoma.

    abstract::A 14-month-old girl presented after 3 days of fever, floppiness, and diffuse urticarial exanthem. She developed encephalitis and carditis and 1 week later, intractable seizures. Initial CT and MRI showed no changes in the brain parenchyma. On days 14 and 34 after the onset of symptoms, a human herpesvirus-6 (HHV-6) ge...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162200000773

    authors: Rantala H,Mannonen L,Ahtiluoto S,Linnavuori K,Herva R,Vaheri A,Koskiniemi M

    更新日期:2000-06-01 00:00:00

  • Musculoskeletal modelling in determining the effect of botulinum toxin on the hamstrings of patients with crouch gait.

    abstract::This study aimed to determine the effect of hamstring botulinum toxin A (Btx-A) injection in 10 children with crouch gait in terms of changes in muscle length and lower-limb kinematics. Before Btx-A injection limb kinematics were recorded. Maximum hamstring lengths and excursions were calculated by computer modelling ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1998.tb15428.x

    authors: Thompson NS,Baker RJ,Cosgrove AP,Corry IS,Graham HK

    更新日期:1998-09-01 00:00:00

  • The impact on socio-emotional development and quality of life of language impairment in 8-year-old children.

    abstract:AIM:To estimate the impact of different types of language disorders on socio-emotional development and health-related quality of life (HRQOL) in 8-year-old children. METHOD:In a prospective cohort including 13 427 newborns, of 10 911 eligible children (66 excluded because of intellectual disability or foreign language...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2010.03794.x

    authors: Van Agt H,Verhoeven L,Van Den Brink G,De Koning H

    更新日期:2011-01-01 00:00:00

  • Practice considerations for the introduction and use of power mobility for children.

    abstract:AIM:The aim of the study was to support clinicians in recommending and justifying power mobility for children of different ages and abilities, and with different needs. The study comprised three distinct parts: a literature review; a Delphi consensus; and clinical practice considerations. METHOD:A scoping review of ei...

    journal_title:Developmental medicine and child neurology

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1111/dmcn.12245

    authors: Livingstone R,Paleg G

    更新日期:2014-03-01 00:00:00

  • Obstetric history and the heart-rate response of newborns to sound.

    abstract::Two groups of clinically normal newborns, differing in the number of non-optimal factors in their obstetric history, were compared by measuring heart-rate response to a series of auditory stimuli. There was a significant difference between the groups in the direction of the average heart-rate response. The high risk" ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1976.tb03685.x

    authors: Kittner S,Lipsitt LP

    更新日期:1976-08-01 00:00:00

  • Preliminary support for the oral administration of valine, isoleucine and leucine for phenylketonuria.

    abstract::Recent behavioral data have demonstrated the importance of maintaining low phenylalanine concentrations beyond early childhood in patients with phenylketonuria, which can be a difficult task, particularly during adolescence. Administration of certain large neutral amino-acids (valine, isoleucine, leucine--VIL) appears...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1985.tb04522.x

    authors: Jordan MK,Brunner RL,Hunt MM,Berry HK

    更新日期:1985-02-01 00:00:00

  • Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes.

    abstract::Nine children (five males, four females; age range 6 years 1 month to 11 years 1 month) affected by benign epilepsy of childhood with centrotemporal or Rolandic spikes (BECRS) with EEG evidence of marked activation of interictal epileptic discharges (IEDs) during sleep, and nine unaffected control children matched for...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162201000755

    authors: Baglietto MG,Battaglia FM,Nobili L,Tortorelli S,De Negri E,Calevo MG,Veneselli E,De Negri M

    更新日期:2001-06-01 00:00:00

  • Power mobility skill progression for children and adolescents: a systematic review of measures and their clinical application.

    abstract:AIM:To identify and critically appraise standardized measures of power mobility skill used with children (18y or younger) with mobility limitations and explore the measures' application for 'exploratory', 'operational', and 'functional' learners. METHOD:Five electronic databases were searched along with hand-searching...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/dmcn.13709

    authors: Field DA,Livingstone RW

    更新日期:2018-10-01 00:00:00

  • IQ and its predictors in childhood hemiplegia.

    abstract::In a population-based sample of 149 children with hemiplegia, IQ was highly correlated with a simple-to-calculate index of neurological severity. Performance IQ was an average of 13 points lower then verbal IQ-a difference that seemed to reflect specific visuospatial difficulties rather than an effect of the motor dis...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1996.tb15045.x

    authors: Goodman R,Yude C

    更新日期:1996-10-01 00:00:00

  • Psychometric properties of functional mobility tools in hereditary spastic paraplegia and other childhood neurological conditions.

    abstract:AIM:To evaluate studies on the psychometric properties of measurement tools used to quantify functional mobility in children with hereditary spastic paraplegia (HSP) and other childhood neurological conditions. METHOD:Two independent reviewers identified measures previously used by clinicians to quantify functional mo...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-8749.2012.04284.x

    authors: Adair B,Said CM,Rodda J,Morris ME

    更新日期:2012-07-01 00:00:00

  • Pons tumour behind a phenotypic Rett syndrome presentation.

    abstract::We describe a girl with a brain-stem tumour and symptoms very similar to those of Rett syndrome (RS). Her early history was uneventful and development was normal (except for hypotonia). At the age of 6 months her development slowed. Subsequently, deterioration occurred and the features characteristic of RS were seen: ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1998.tb12361.x

    authors: Vanhala R,Gaily E,Paetau A,Riikonen R

    更新日期:1998-12-01 00:00:00

  • Low to moderate maternal alcohol use before and during pregnancy, and neurobehavioural outcome in the newborn infant.

    abstract::Of 2002 randomly selected pregnant women recruited prospectively over a three-year period for an extensive questionnaire survey, a stratified subsample of 665 mothers was selected for mother-infant follow-up on the basis of pre-pregnancy alcohol intake. Infant outcome was assessed by detailed clinical examination and ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1991.tb14796.x

    authors: Walpole I,Zubrick S,Pontré J,Lawrence C

    更新日期:1991-10-01 00:00:00

  • Goldenhar syndrome and autistic behaviour.

    abstract::Two girls with concomitant Goldenhar syndrome (oculo-auriculovertebral spectrum disorder) and autistic disorder are described. One was diagnosed as having Goldenhar syndrome in the first few weeks of life and as having autistic disorder in her fifth year; the other was diagnosed as having Goldenhar syndrome when she w...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1992.tb11405.x

    authors: Landgren M,Gillberg C,Strömland K

    更新日期:1992-11-01 00:00:00

  • Management of apnea in infants with trisomy 18.

    abstract::This case series aimed to characterize the clinical features, management, and outcomes of apnea in infants with trisomy 18. Participants in this study were infants with trisomy 18 who were born alive and admitted to the neonatal intensive care unit in Kyushu University Hospital from 2000 to 2018. Retrospective analysi...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.14403

    authors: Taira R,Inoue H,Sawano T,Fujiyoshi J,Ichimiya Y,Torio M,Sanefuji M,Ochiai M,Sakai Y,Ohga S

    更新日期:2020-07-01 00:00:00

  • Postural sway and gait of children with convergent strabismus.

    abstract::Postural sway and gait of 35 children with convergent strabismus were tested and compared with those of a control group. They were found to have a short stride-length and single-limb support time in walking, particularly at slow speeds. The girls had a large postural sway, but not the boys. The results suggest a commo...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1984.tb04477.x

    authors: Odenrick P,Sandstedt P,Lennerstrand G

    更新日期:1984-08-01 00:00:00

  • Childhood nocturnal enuresis: factors associated with outcome of treatment with an enuresis alarm.

    abstract::A study was carried out to assess the factors that may affect the outcome of a single course of treatment for childhood nocturnal enuresis by use of an enuresis alarm. 113 children were treated and followed up; those showing failure of initial arrest of wetting, relapse and longterm successful outcome were analysed se...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1983.tb13723.x

    authors: Dische S,Yule W,Corbett J,Hand D

    更新日期:1983-02-01 00:00:00

  • Rethinking preventive post-discharge intervention programmes for very preterm infants and their parents.

    abstract::Post-discharge preventive intervention programmes with involvement of the parent may support the resilience and developmental outcomes of infants born very preterm. Randomized controlled trials of home-based family-centred intervention programmes in very preterm infants that aimed to improve cognitive outcome, at leas...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/dmcn.13049

    authors: van Wassenaer-Leemhuis AG,Jeukens-Visser M,van Hus JW,Meijssen D,Wolf MJ,Kok JH,Nollet F,Koldewijn K

    更新日期:2016-03-01 00:00:00

  • Mechanical ventilation for respiratory failure in children with severe neurological impairment: is it futile medical treatment?

    abstract:AIM:To assess outcome for children with severe neurological impairment receiving invasive mechanical ventilation for respiratory failure. METHOD:Medical charts for all such children treated in our intensive care unit (ICU) between January 2003 and July 2008 were reviewed. Outcomes were compared with those for children...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2009.03582.x

    authors: van Gestel JP,Robroch AH,Bollen CW,Van Der Ent CK,Van Vught AJ

    更新日期:2010-05-01 00:00:00