Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes.


AIMS:Whereas endogenous carbon monoxide (CO) is cytoprotective at physiologic levels, excess CO concentrations are associated with cardiometabolic risk and may represent an important marker of progression from subclinical to clinical cardiovascular disease (CVD). METHODS AND RESULTS:In 1926 participants of the Framingham Offspring Study (aged 57 ± 10 years, 46% women), we investigated the relationship of exhaled CO, a surrogate of blood CO concentration, with both prevalent subclinical CVD and incident clinical CVD events. Presence of subclinical CVD was determined using a comprehensive panel of diagnostic tests used to assess cardiac and vascular structure and function. Individuals with the highest (>5 p.p.m.) compared with lowest (≤4 p.p.m.) CO exposure were more likely to have subclinical CVD [odds ratios (OR): 1.67, 95% CI: 1.32-2.12; P < 0.001]. During the follow-up period (mean 5 ± 3 years), 193 individuals developed overt CVD. Individuals with both high CO levels and any baseline subclinical CVD developed overt CVD at an almost four-fold higher rate compared with those with low CO levels and no subclinical disease (22.1 vs. 6.3%). Notably, elevated CO was associated with incident CVD in the presence [hazards ration (HR): 1.83, 95% CI: 1.08-3.11; P = 0.026] but not in the absence (HR: 0.80, 95% CI: 0.42-1.53; P = 0.51) of subclinical CVD (Pinteraction = 0.019). Similarly, subclinical CVD was associated with incident CVD in the presence of high but not low CO exposure. CONCLUSION:Our findings in a community-based sample suggest that elevated CO is a marker of greater subclinical CVD burden and, furthermore, a potential key component in the progression from subclinical to clinical CVD.


Eur Heart J


European heart journal


Cheng S,Enserro D,Xanthakis V,Sullivan LM,Murabito JM,Benjamin EJ,Polak JF,O'Donnell CJ,Wolf PA,O'Connor GT,Keaney JF,Vasan RS




Has Abstract


2014-11-07 00:00:00














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    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2004-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Rosengren A,Spetz CL,Köster M,Hammar N,Alfredsson L,Rosén M

    更新日期:2001-02-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:1993-04-01 00:00:00

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    更新日期:2013-06-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章


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    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:European heart journal

    pub_type: 杂志文章


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    更新日期:2003-07-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Rogg H,de Gasparo M,Graedel E,Stulz P,Burkart F,Eberhard M,Erne P

    更新日期:1996-07-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章


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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dunselman P,Liem AH,Verdel G,Kragten H,Bosma A,Bernink P

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