Abstract:
AIMS:Whereas endogenous carbon monoxide (CO) is cytoprotective at physiologic levels, excess CO concentrations are associated with cardiometabolic risk and may represent an important marker of progression from subclinical to clinical cardiovascular disease (CVD). METHODS AND RESULTS:In 1926 participants of the Framingham Offspring Study (aged 57 ± 10 years, 46% women), we investigated the relationship of exhaled CO, a surrogate of blood CO concentration, with both prevalent subclinical CVD and incident clinical CVD events. Presence of subclinical CVD was determined using a comprehensive panel of diagnostic tests used to assess cardiac and vascular structure and function. Individuals with the highest (>5 p.p.m.) compared with lowest (≤4 p.p.m.) CO exposure were more likely to have subclinical CVD [odds ratios (OR): 1.67, 95% CI: 1.32-2.12; P < 0.001]. During the follow-up period (mean 5 ± 3 years), 193 individuals developed overt CVD. Individuals with both high CO levels and any baseline subclinical CVD developed overt CVD at an almost four-fold higher rate compared with those with low CO levels and no subclinical disease (22.1 vs. 6.3%). Notably, elevated CO was associated with incident CVD in the presence [hazards ration (HR): 1.83, 95% CI: 1.08-3.11; P = 0.026] but not in the absence (HR: 0.80, 95% CI: 0.42-1.53; P = 0.51) of subclinical CVD (Pinteraction = 0.019). Similarly, subclinical CVD was associated with incident CVD in the presence of high but not low CO exposure. CONCLUSION:Our findings in a community-based sample suggest that elevated CO is a marker of greater subclinical CVD burden and, furthermore, a potential key component in the progression from subclinical to clinical CVD.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Cheng S,Enserro D,Xanthakis V,Sullivan LM,Murabito JM,Benjamin EJ,Polak JF,O'Donnell CJ,Wolf PA,O'Connor GT,Keaney JF,Vasan RSdoi
10.1093/eurheartj/ehu052subject
Has Abstractpub_date
2014-11-07 00:00:00pages
2980-7issue
42eissn
0195-668Xissn
1522-9645pii
ehu052journal_volume
35pub_type
杂志文章abstract:AIMS:The aim of this study was to assess whether perioperative N-acetylcysteine (NAC), an antioxidant, prevents acute renal injury (ARI) after cardiac surgery. METHODS AND RESULTS:We performed a systematic review of randomized controlled trials (RCTs) of NAC in adult cardiac surgery patients. The RCTs were identified ...
journal_title:European heart journal
pub_type: 杂志文章,meta分析,评审
doi:10.1093/eurheartj/ehp053
更新日期:2009-08-01 00:00:00
abstract:AIMS:This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). METHODS AND RESULTS:Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. I...
journal_title:European heart journal
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doi:10.1016/j.ehj.2004.06.024
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abstract::Glycaemic control is an inadequate surrogate marker of cardiovascular event reduction in patients with type 2 diabetes. Clinical trials to date have been unsuccessful in identifying a therapeutic approach that addresses the underlying problem in diabetes (glycaemic control) and reduces cardiovascular risk. The potenti...
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061452
更新日期:1983-04-01 00:00:00
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doi:10.1093/eurheartj/6.suppl_d.15
更新日期:1985-11-01 00:00:00
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更新日期:2007-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1999.1867
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015079
更新日期:1996-09-01 00:00:00
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doi:10.1093/oxfordjournals.eurheartj.a015314
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062543
更新日期:1988-05-01 00:00:00
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doi:10.1016/j.ehj.2003.09.016
更新日期:2003-12-01 00:00:00
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更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2006-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
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更新日期:2013-04-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/euhj.2000.2242
更新日期:2000-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061894
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014717
更新日期:1996-10-01 00:00:00
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更新日期:2009-09-01 00:00:00
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更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
abstract::In the adult cardiac myocyte the functional and structural integrity of the sarcolemma depends on the presence of calcium ions in the extracellular fluid. Ultrastructural damage to the myocardial cell after Ca is repleted following brief periods of Ca depletion includes (1) sarcolemmal disruption, (2) mitochondrial da...
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pub_type: 杂志文章
doi:10.1093/eurheartj/4.suppl_h.23
更新日期:1983-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
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更新日期:2008-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1997.0823
更新日期:1998-01-01 00:00:00
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doi:10.1093/eurheartj/ehq436
更新日期:2011-08-01 00:00:00