Measurements of placental, decidual, and fetal proteins before and after chorionic villus sampling.


:Circulating placental [human chorionic gonadotrophin (hCG), Schwangerschafts protein 1 (SP1), pregnancy-associated plasma protein A (PAPP-A), decidual (pregnancy protein 12 (PP12), and fetal alphafetoprotein (AFP)] proteins were measured immediately before and within 1 h in 18 women undergoing diagnostic chorionic villus sampling (CVS) in the first trimester. An elevation of serum AFP levels was consistently seen, while fluctuations in excess of 10 per cent of the pre-CVS levels of SP1 and PP12 were seen in the majority of patients. Fluctuations in hCG and PAPP-A were consistently less than 10 per cent of pre-CVS values. Post-CVS changes in levels were not apparently associated with any feature of the technique, the pregnancy, or its outcome (one missed abortion). As feto-maternal haemorrhage is a common event, anti-D should be offered to rhesus-negative women undergoing CVS. In the prediction of subsequent miscarriage, only hCG and PAPP-A measurements should be considered.


Prenat Diagn


Prenatal diagnosis


Stabile I,Warren R,Rodeck C,Grudzinskas JG




Has Abstract


1988-06-01 00:00:00












  • Fetus with long QT syndrome manifested by tachyarrhythmia: a case report.

    abstract::We encountered a fetus who exhibited transient (at most 30 s), repeated episodes of tachyarrhythmia (240 bpm). This female neonate was born at 36 weeks of gestation and showed a markedly prolonged QT interval and transient, repeated episodes of polymorphic ventricular tachycardia. Congenital long QT syndrome was diagn...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Ohkuchi A,Shiraishi H,Minakami H,Eguchi Y,Izumi A,Sato I

    更新日期:1999-10-01 00:00:00

  • Management of red cell alloimmunisation in pregnancy: the non-invasive monitoring of the disease.

    abstract::Haemolytic disease of the fetus and newborn (HDFN) due to red cell alloimmunization was a significant cause of fetal and neonatal morbidity and mortality until the introduction of anti-D immunoglobulin, which has dramatically changed the incidence of the disease. However, it is still a major problem in affected pregna...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,评审


    authors: Illanes S,Soothill P

    更新日期:2010-07-01 00:00:00

  • Calcification of the fetal heart--four case reports and a literature review.

    abstract::Calcification of the heart and vessels in fetuses is a rare condition. It may be dystrophic or metastatic. An extremely rare form of vascular calcification has been termed 'idiopathic arterial calcification of infancy', which is inherited in an autosomal recessive pattern. We report four cases of myocardial calcificat...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,评审


    authors: Hajdu J,Marton T,Papp C,Hruby E,Papp Z

    更新日期:1998-11-01 00:00:00

  • Cervical teratoma: prenatal diagnosis and long-term follow-up.

    abstract::Cervical teratomas are rare tumours which are the result of abnormal prenatal development. They are usually detected at birth, but can occasionally remain silent until adulthood. Obstruction of the airway is the major challenge in the neonatal period. Prenatal diagnosis allows for early consultation with paediatric su...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Kerner B,Flaum E,Mathews H,Carlson DE,Pepkowitz SH,Hixon H,Graham JM Jr

    更新日期:1998-01-01 00:00:00

  • Amniotic fluid fibrinolytic system in fetal neural tube defects.

    abstract::Second trimester amniotic fluid fibrinolytic system was examined in normal pregnancies and those complicated by anencephaly, spina bifida and fetal chromosome abnormalities. No significant difference was demonstrated between the fibrinolytic systems from normal pregnancies and those complicated by fetal chromosome abn...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Legge M

    更新日期:1983-04-01 00:00:00

  • Psychological impact of the detection of soft markers on routine ultrasound scanning: a pilot study investigating the modifying role of information.

    abstract:OBJECTIVES:To determine the impact on maternal anxiety of detecting a soft marker, and the association between anxiety and the information given during the scan. METHODS:Routine 20-week fetal anomaly scans were audiotaped in the obstetric ultrasound unit of a London teaching hospital, across a four month study period....

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Watson MS,Hall S,Langford K,Marteau TM

    更新日期:2002-07-01 00:00:00

  • The association of increased fetal nuchal translucency and spinal muscular atrophy type I.

    abstract::We report a fetus with spinal muscular atrophy type I, who presented with an increased nuchal translucency at 13 weeks' gestation. A review of the literature reveals additional cases of spinal muscular atrophy type I associated with increased nuchal translucency and suggests increased nuchal translucency may be an ear...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,评审


    authors: Stiller RJ,Lieberson D,Herzlinger R,Siddiqui D,Laifer SA,Whetham JC

    更新日期:1999-06-01 00:00:00

  • Association of maternal serum PAPP-A levels, nuchal translucency and crown-rump length in first trimester with adverse pregnancy outcomes: retrospective cohort study.

    abstract:OBJECTIVE:Are first trimester serum pregnancy-associated plasma protein-A (PAPP-A), nuchal translucency (NT) and crown-rump length (CRL) prognostic factors for adverse pregnancy outcomes? METHOD:Retrospective cohort, women, singleton pregnancies (UK 2011-2015). Unadjusted and multivariable logistic regression. OUTCOM...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Bilagi A,Burke DL,Riley RD,Mills I,Kilby MD,Katie Morris R

    更新日期:2017-07-01 00:00:00

  • Evaluation of regional left ventricular longitudinal function in 151 normal fetuses using velocity vector imaging.

    abstract:OBJECTIVE:The purpose of this study was to investigate the clinical value of velocity vector imaging (VVI) in the assessment of normal fetal regional myocardial performance and to establish a normative data set for normal Chinese fetuses. METHODS:One hundred and fifty-one healthy Chinese fetuses were divided into five...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Peng QH,Zhou QC,Zeng S,Tian LQ,Zhang M,Tan Y,Pu DR

    更新日期:2009-12-01 00:00:00

  • Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure.

    abstract::We describe a fetus with a hypoplastic right ventricle detected by prenatal ultrasound examination. A possible causal relationship with prenatal valproate exposure is discussed. ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: ten Berg K,van Oppen AC,Nikkels PG,Gittenberger-de Groot AC,van der Voet GB,Brilstra EH,Lindhout D

    更新日期:2005-02-01 00:00:00

  • Metaphyseal chondrodysplasia McKusick type in a Chinese fetus, caused by novel compound heterozygosity 64T> A and 79G >T in RMRPgene.

    abstract::We present the first confirmed case by molecular analysis of a metaphyseal chondrodysplasia, McKusick type, in a 22-week fetus. Two novel compound heterozygous mutations, 64T> A and 79G > T, were found in the highly conserved regions of the RMRP gene. Twenty-two heterozygous g.1018 T> C mutations, two homozygous g.101...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Lam AC,Chan DH,Tong TM,Tang MH,Lo SY,Lo IF,Lam ST

    更新日期:2006-11-01 00:00:00

  • Prenatal detection of rubella-specific IgM in fetal sera.

    abstract::Serum specimens were obtained by fetoscopy at 19-25 weeks' gestation from four fetuses whose mothers had had confirmed rubella earlier in pregnancy. They were tested for rubella-specific IgM by antibody capture radioimmunoassay. No specific IgM was detected in one fetus and a healthy infant was delivered at term. Spec...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Morgan-Capner P,Rodeck CH,Nicolaides KH,Cradock-Watson JE

    更新日期:1985-01-01 00:00:00

  • The subarachnoid space: normal fetal development as demonstrated by transvaginal ultrasound.

    abstract::Enlargement of the subarachnoid spaces can be seen in the following conditions: communicating hydrocephalus, brain atrophy and benign enlargement of the subarachnoid spaces. These disorders may begin in utero. There are no established normograms for the fetal subarachnoid spaces. This study was conducted in order to d...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Malinger G,Lerman-Sagie T,Achiron R,Lipitz S

    更新日期:2000-11-01 00:00:00

  • Prenatal diagnosis of a 9q34.3 microdeletion by array-CGH in a fetus with an apparently balanced translocation.

    abstract:OBJECTIVES:Use high-resolution genome analysis to clarify the genomic integrity in a fetus with a cytogenetically balanced translocation t(2;9)(q11.2;q34.3). METHODS:High resolution molecular cytogenetic analyses including G-banded chromosome analysis, fluorescence in situ hybridization (FISH), and array-comparative g...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Simovich MJ,Yatsenko SA,Kang SH,Cheung SW,Dudek ME,Pursley A,Ward PA,Patel A,Lupski JR

    更新日期:2007-12-01 00:00:00

  • Fetal pyelectasis: comparison of postnatal renal pathology with unilateral and bilateral pyelectasis.

    abstract::The aim of this study was to determine the prenatal fetal pyelectasis which requires postnatal evaluation. This was a retrospective analysis involving 65 infants with complete urological follow-up; 59 had shown prenatal evidence of pyelectasis using previously published standards. Males were more common in both the no...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Wilson RD,Lynch S,Lessoway VA

    更新日期:1997-05-01 00:00:00

  • Prenatal diagnosis of focal nodular hyperplasia of the liver.

    abstract::A case of focal nodular hyperplasia of the liver presenting in a 36-week-old fetus is reported. The tumour appeared on antenatal ultrasound as a 4.0 cm x 3.0 cm x 2.7 cm hypoechoic mass at the periphery of the right lobe of the liver. Colour Doppler imaging showed it to have prominent vascularity. Postnatally, sonogra...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Petrikovsky BM,Cohen HL,Scimeca P,Bellucci E

    更新日期:1994-05-01 00:00:00

  • Predictors of perinatal outcome in early-onset fetal growth restriction: A study from an emerging economy country.

    abstract:OBJECTIVE:To identify antenatal predictors of adverse perinatal outcomes in a population of preterm fetuses with early placental insufficiency diagnosed by Doppler abnormalities. METHOD:In this cross-sectional study of a cohort of singleton pregnant women diagnosed with early placental insufficiency, relationships bet...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Baião AER,de Carvalho PRN,Moreira MEL,de Sá RAM,Junior SCG

    更新日期:2020-02-01 00:00:00

  • Pregnancy outcome after transcervical CVS with a flexible biopsy forceps: evaluation of risk factors.

    abstract::The pregnancy outcome of 1936 women who had transcervical chorionic villus sampling (CVS) with a flexible biopsy forceps was evaluated. Follow-up until 4 weeks after delivery was 99.4 per cent. Various patient- and procedure-related risk factors for spontaneous loss (fetal or neonatal death) were analysed using stepwi...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Lunshof S,Boer K,Leschot NJ,Pomp M,Wolf H

    更新日期:1995-09-01 00:00:00

  • High resolution chromosome analysis and in situ hybridization on amniotic fluid for diagnosis of a cryptic translocation.

    abstract::We report a cryptic translocation ascertained in a family after the birth of a mentally retarded proband. High resolution chromosome examination revealed that the father had a subtle translocation between chromosome 5 and chromosome 13, 46, XY, t(5;13) (q35.2;q34). Two specific, non-routine techniques were associated ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Guichet A,Briault S,Moraine C

    更新日期:1998-04-01 00:00:00

  • Quantitative real-time PCR technique for rapid prenatal diagnosis of Down syndrome.

    abstract:OBJECTIVES:To develop a reliable and specific technique for rapid prenatal diagnosis of Down syndrome. METHODS:High throughput real-time PCR technique was used to measure the DSCR3 gene dosage of genomic DNAs from uncultured amniocytes of fetuses, lymphocytes of trisomy 21 syndrome patients, and normal people, compare...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Hu Y,Zheng M,Xu Z,Wang X,Cui H

    更新日期:2004-09-01 00:00:00

  • The price of performance: a cost and performance analysis of the implementation of cell-free fetal DNA testing for Down syndrome in Ontario, Canada.

    abstract:OBJECTIVE:To examine the cost and performance implications of introducing cell-free fetal DNA (cffDNA) testing within modeled scenarios in a publicly funded Canadian provincial Down syndrome (DS) prenatal screening program. METHOD:Two clinical algorithms were created: the first to represent the current screening progr...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Okun N,Teitelbaum M,Huang T,Dewa CS,Hoch JS

    更新日期:2014-04-01 00:00:00

  • Mutation analysis for prenatal diagnosis and heterozygote detection of Gaucher disease type III (Norrbottnian type).

    abstract::A single base substitution in exon 10 of the glucocerebrosidase gene was detected in families affected by Gaucher disease (GD) type III. This mutation, which results in the substitution of proline for leucine in position 444 of glucocerebrosidase, has been shown to result in type III GD in a Swedish population. Three ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Dahl N,Wadelius C,Annerén G,Gustavson KH

    更新日期:1992-07-01 00:00:00

  • Maternoembryonic transfusion and congenital malformations.

    abstract::There is an increasing number of reports relating chorionic villus sampling (CVS) to transverse limb reduction defects or the oromandibular limb hypogenesis complex. In addition, a correlation has been established between the severity of the defect and the gestational age when CVS is performed. Several hypotheses have...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: van der Zee DC,Bax KM,Vermeij-Keers C

    更新日期:1997-01-01 00:00:00

  • Early prenatal diagnosis of ventricular diverticulum complicated by serous pericardial effusion.

    abstract::An unusual case of apical diverticulum complicated by serous pericardial effusion and diagnosed ultrasonographically at 13 weeks of gestation is described. A therapeutic abortion was induced at 14 weeks and the complete post-mortem examination did not show additional malformation. Cardiac diverticulum is a rare malfor...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Carles D,Maugey-Laulom B,Habboud H,Alberti EM,Weichhold W,Léger F

    更新日期:1995-08-01 00:00:00

  • Dilatation of the supra-pineal recess on prenatal imaging: early clue for obstructive ventriculomegaly downstream of the third ventricle.

    abstract:OBJECTIVE:The objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra-pineal recess (SPR) in cases of ventriculomegaly. METHOD:A retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our inst...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Azzi C,Giaconia MB,Lacalm A,Massoud M,Gaucherand P,Guibaud L

    更新日期:2014-04-01 00:00:00

  • Crown-rump length audit plots with the use of operator-specific PAPP-A and β-hCG median MoM.

    abstract:OBJECTIVE:Audit the crown-rump length (CRL) measurements taken at 11 to 13 weeks scan, using operator-specific median multiples of the median (MoM) for pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (β-hCG) plots, to identify deviations potentially related to a systematic CRL bia...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Sabria J,Guirado L,Miró I,Gómez-Roig MD,Borrell A

    更新日期:2017-03-01 00:00:00

  • Fetal cystic hygromata: insights gained from fetal blood sampling.

    abstract::Twelve second-trimester fetuses with cystic hygroma underwent fetal blood sampling for rapid karyotyping, haematologic evaluation, and blood gas analysis. An abnormal karyotype was found in seven cases: monosomy X in five, trisomy 21 in one, and trisomy 13 in the other. Eight of ten fetuses undergoing blood gas analys...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Tannirandorn Y,Nicolini U,Nicolaidis PC,Fisk NM,Arulkumaran S,Rodeck CH

    更新日期:1990-03-01 00:00:00

  • Immunoreactive trypsin level in fetoscopically-obtained cord sera of second trimester fetuses.

    abstract::Immunoreactive trypsin (IRT) has been assayed in cord blood collection by fetoscopy from fetuses with estimated gestational ages of between 16-24 weeks. Eighty per cent of the specimens contained more than 5 ng/ml of IRT indicating pancreatic synthesis of trypsin by mid-term. A prenatal test for cystic fibrosis based ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Ryley HC,Rodeck CH

    更新日期:1984-07-01 00:00:00

  • Proinflammatory macrophage migratory inhibition factor and interleukin-6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax.

    abstract:OBJECTIVES:To study the role of selected cytokines and growth factors involved in the pathogenesis of fetal chylous pleural effusion. METHODS:Seventeen fetuses with prenatal chylothorax at gestational age (GA) 17-29 weeks were enrolled as the study group during the period 2003-2005. Their pleural effusion (n = 17) and...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Chen M,Hsieh CY,Shih JC,Chou CH,Ma GC,Chen TH,Lee TH,Tsai HD,Cameron AD,Chen CP

    更新日期:2007-05-01 00:00:00

  • Fetal hypertension: an insight into the pathogenesis of the twin-twin transfusion syndrome.

    abstract:OBJECTIVES:To investigate if systemic hypertension occurs in fetuses with twin-to-twin transfusion syndrome (TTTS). METHODS:We conducted an observational cohort study in a tertiary care centre in 23 pregnant women with TTTS. Polyhydramnios stuck twin sequence occurred at a median gestational age of 22 weeks (range 15-...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Mahieu-Caputo D,Salomon LJ,Le Bidois J,Fermont L,Brunhes A,Jouvet P,Dumez Y,Dommergues M

    更新日期:2003-08-01 00:00:00