Effect of adenosine on cerebral blood flow as evaluated by single-photon emission computed tomography in normal subjects and in patients with occlusive carotid disease. A comparison with acetazolamide.


BACKGROUND AND PURPOSE:Acetazolamide is commonly used with single-photon CT to assess the cerebrovascular reserve in patients with internal carotid artery stenosis or occlusion. In this study we wanted to evaluate the effects of adenosine, a well-known vasodilatatory compound with a short biological half-life, on brain circulation in humans and compare the results with those of acetazolamide. METHODS:Acetazolamide (1 g) and adenosine (140 micrograms/kg per minute) were injected intravenously on different days in 6 normal subjects and 6 patients: 4 with unilateral stenosis, 1 with bilateral stenosis, and 1 with complete occlusion of the internal carotid artery. Changes in regional cerebral blood flow relative to that of the cerebellum (cortico/cerebellar ratios) from resting conditions were evaluated by 99mTc-hexamethylpropyleneamine oxime and single-photon emission CT. RESULTS:The measured blood flow ratios increased significantly in the normal group 20 minutes after acetazolamide injection in several cortical and subcortical regions, as well as at the 4th minute of a 6-minute adenosine infusion. Regional cerebral blood flow ratio values were higher after adenosine than after acetazolamide in both cortical (frontal and parietal) and subcortical (thalamus and basal ganglia) regions. In 4 of the 6 patients the side-to-side asymmetry increased from the basal resting condition after the injection of acetazolamide and even more so after the injection of adenosine. CONCLUSIONS:Adenosine infusion causes vasodilation of cerebral arteries and can be used for the investigation of cerebrovascular perfusion capacity in patients with carotid occlusive disease. One advantage in the use of adenosine over acetazolamide is the possibility of interrupting the test with reversal of clinical symptoms or patient discomfort within a few minutes.






Soricelli A,Postiglione A,Cuocolo A,De Chiara S,Ruocco A,Brunetti A,Salvatore M,Ell PJ




Has Abstract


1995-09-01 00:00:00














  • Thrombotic risk factors in primary antiphospholipid syndrome: a 5-year prospective study.

    abstract:BACKGROUND AND PURPOSE:Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes. METHODS:Fifty-six PAPS patients (mean age, 37+/-10 years) were prospectively studied for 5 years. The preliminary Sapporo classification cr...


    pub_type: 杂志文章


    authors: Turiel M,Sarzi-Puttini P,Peretti R,Rossi E,Atzeni F,Parsons W,Doria A

    更新日期:2005-07-01 00:00:00

  • Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population.

    abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...


    pub_type: 杂志文章,多中心研究


    authors: Khoury JC,Kleindorfer D,Alwell K,Moomaw CJ,Woo D,Adeoye O,Flaherty ML,Khatri P,Ferioli S,Broderick JP,Kissela BM

    更新日期:2013-06-01 00:00:00

  • Transcranial ultrasound brain perfusion assessment with a contrast agent-specific imaging mode: results of a two-center trial.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess brain perfusion with an ultrasound contrast-specific imaging mode and to prove if the results are comparable between 2 centers using a standardized study protocol. METHODS:A total of 32 individuals without known cerebrovascular disease were included in the...


    pub_type: 杂志文章,多中心研究


    authors: Hölscher T,Wilkening W,Draganski B,Meves SH,Eyding J,Voit H,Bogdahn U,Przuntek H,Postert T

    更新日期:2005-10-01 00:00:00

  • Apolipoprotein E, statins, and risk of intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Apolipoprotein E (ApoE) genotypes have been associated with lobar intracerebral hemorrhage (ICH). Although statins have been associated with an increased risk of ICH, meta-analyses have not consistently shown a statin-induced risk of ICH. Here, we test whether hypercholesterolemia (HC) and ApoE p...


    pub_type: 杂志文章


    authors: Woo D,Deka R,Falcone GJ,Flaherty ML,Haverbusch M,Martini SR,Greenberg SM,Ayres AM,Sauerbeck L,Kissela BM,Kleindorfer DO,Moomaw CJ,Anderson CD,Broderick JP,Rosand J,Langefeld CD,Woo JG

    更新日期:2013-11-01 00:00:00

  • Is there a future for endovascular treatment of intracranial atherosclerotic disease after Stenting and Aggressive Medical Management for Preventing Recurrent Stroke and Intracranial Stenosis (SAMMPRIS)?

    abstract::The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke and Intracranial Stenosis (SAMMPRIS) trial, a randomized clinical trial comparing aggressive medical management to stenting with aggressive medical management for symptomatic intracranial stenosis, was prematurely halted when a high rate of...


    pub_type: 杂志文章


    authors: Marks MP

    更新日期:2012-02-01 00:00:00

  • Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does

    abstract:BACKGROUND AND PURPOSE:Prophylactic administration of simvastatin has been shown to protect against brain damage and its long-lasting behavioral consequences in neonatal rats. To establish the drug treatment window, we evaluated the effectiveness of simvastatin administered at different intervals before and after strok...


    pub_type: 杂志文章


    authors: Balduini W,Mazzoni E,Carloni S,De Simoni MG,Perego C,Sironi L,Cimino M

    更新日期:2003-08-01 00:00:00

  • Synergistic Interaction Between Zinc and Reactive Oxygen Species Amplifies Ischemic Brain Injury in Rats.

    abstract::Background and Purpose- Although intracellular zinc accumulation has been shown to contribute to neuronal death after cerebral ischemia, the mechanism by which zinc keeps on accumulating to cause severe brain damage remains unclear. Herein the dynamic cause-effect relationships between zinc accumulation and reactive o...


    pub_type: 杂志文章


    authors: Zhao Y,Yan F,Yin J,Pan R,Shi W,Qi Z,Fang Y,Huang Y,Li S,Luo Y,Ji X,Liu KJ

    更新日期:2018-09-01 00:00:00

  • High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA.

    abstract:BACKGROUND AND PURPOSE:Severe cerebral edema is associated with poor outcome in patients with acute stroke. Experimental studies suggest that astrocytic endothelin-1 (ET-1) has deleterious effects on water homeostasis, cerebral edema, and blood brain barrier (BBB) integrity, which contribute to more severe ischemic bra...


    pub_type: 杂志文章


    authors: Moldes O,Sobrino T,Millán M,Castellanos M,Pérez de la Ossa N,Leira R,Serena J,Vivancos J,Dávalos A,Castillo J

    更新日期:2008-07-01 00:00:00

  • Reduction of diffusion-weighted MRI lesion volume after early moderate hypothermia in ischemic stroke.

    abstract:BACKGROUND:Large areas of restricted diffusion in the middle cerebral artery (MCA) territory are highly predictive of severe and potentially space-occupying MCA stroke. A reduction of diffusion-weighted MRI (DWI) lesions occurs in 20% to 40% of acute stroke patients with early reperfusion. METHODS:We report of a patie...


    pub_type: 杂志文章


    authors: Berger C,Schramm P,Schwab S

    更新日期:2005-06-01 00:00:00

  • Cerebral blood flow and ischemia-induced neurotransmitter release in the striatum of aged spontaneously hypertensive rats.

    abstract:BACKGROUND AND PURPOSE:We found age-related vulnerability to cerebral ischemia in the hippocampus and striatum in spontaneously hypertensive rats. Further study revealed that ischemia-induced release of hippocampal taurine, an inhibitory amino acid, was reduced by 40% in aged rats compared with adult rats, which sugges...


    pub_type: 杂志文章


    authors: Yao H,Ooboshi H,Ibayashi S,Uchimura H,Fujishima M

    更新日期:1993-04-01 00:00:00

  • Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease.

    abstract::Background and Purpose- Cerebral small vessel disease (cSVD) is the major vascular cause of cognitive decline and dementia. The pathogenesis of cSVD remains largely unknown, although several studies suggest a role for systemic inflammation. In certain pathophysiological situations, monocytes can reprogram toward a lon...


    pub_type: 杂志文章


    authors: Noz MP,Ter Telgte A,Wiegertjes K,Joosten LAB,Netea MG,de Leeuw FE,Riksen NP

    更新日期:2018-12-01 00:00:00

  • Montreal Cognitive Assessment 5-minute protocol is a brief, valid, reliable, and feasible cognitive screen for telephone administration.

    abstract:BACKGROUND AND PURPOSE:The National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening of vascular cognitive impairment. We investigated the validity, reliability, and feasibility of the Montr...


    pub_type: 杂志文章


    authors: Wong A,Nyenhuis D,Black SE,Law LS,Lo ES,Kwan PW,Au L,Chan AY,Wong LK,Nasreddine Z,Mok V

    更新日期:2015-04-01 00:00:00

  • Anticoagulant therapy in cerebrovascular disease: review and meta-analysis.

    abstract::Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control ...


    pub_type: 临床试验,杂志文章,评审


    authors: Jonas S

    更新日期:1988-08-01 00:00:00

  • Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke.

    abstract:BACKGROUND AND PURPOSE:In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-tr...


    pub_type: 临床试验,杂志文章


    authors: Montaner J,Alvarez-Sabín J,Molina CA,Anglés A,Abilleira S,Arenillas J,Monasterio J

    更新日期:2001-12-01 00:00:00

  • Age dependence of risk factors for stroke and death in young patients with atrial fibrillation: a nationwide study.

    abstract:BACKGROUND AND PURPOSE:The risk of stroke and death in patients with atrial fibrillation is strongly associated with age and concomitant comorbidities. The aim of this study was to examine the age dependence of risk factors for stroke and mortality in young patients with atrial fibrillation. METHODS:This study is a po...


    pub_type: 杂志文章


    authors: Melgaard L,Rasmussen LH,Skjøth F,Lip GY,Larsen TB

    更新日期:2014-05-01 00:00:00

  • Age of collagen in intracranial saccular aneurysms.

    abstract:BACKGROUND AND PURPOSE:The chronological development and natural history of cerebral aneurysms (CAs) remain incompletely understood. We used (14)C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries ...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Etminan N,Dreier R,Buchholz BA,Beseoglu K,Bruckner P,Matzenauer C,Torner JC,Brown RD Jr,Steiger HJ,Hänggi D,Macdonald RL

    更新日期:2014-06-01 00:00:00

  • Outcomes of intravenous recombinant tissue plasminogen activator therapy according to gender: a clinical registry study and systematic review.

    abstract:BACKGROUND AND PURPOSE:The natural history of stroke is worse in women than in men. Controversial data have been published on the efficacy of thrombolysis with recombinant tissue plasminogen activator (rtPA) according to gender. We evaluated gender differences in the efficacy and safety outcomes of intravenous rtPA usi...


    pub_type: 杂志文章,评审


    authors: Meseguer E,Mazighi M,Labreuche J,Arnaiz C,Cabrejo L,Slaoui T,Guidoux C,Olivot JM,Abboud H,Lapergue B,Raphaeli G,Klein IF,Lavallée PC,Amarenco P

    更新日期:2009-06-01 00:00:00

  • Sex differences in US mortality rates for stroke and stroke subtypes by race/ethnicity and age, 1995-1998.

    abstract:BACKGROUND AND PURPOSE:Ischemic stroke accounts for 70% to 80% of all strokes, but intracerebral and subarachnoid hemorrhagic strokes have greater fatality. Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/eth...


    pub_type: 杂志文章


    authors: Ayala C,Croft JB,Greenlund KJ,Keenan NL,Donehoo RS,Malarcher AM,Mensah GA

    更新日期:2002-05-01 00:00:00

  • Stroke and incontinence.

    abstract:BACKGROUND:Urinary incontinence in the acute stage of stroke is seen as a predictor of death, severe disability, and an important factor on hospital discharge destination. Therefore, it is an important measure of stroke severity that not only affects the lives of stroke survivors but also those of caregivers. SUMMARY ...


    pub_type: 杂志文章,评审


    authors: Brittain KR,Peet SM,Castleden CM

    更新日期:1998-02-01 00:00:00

  • Familial subarachnoid hemorrhage. Outcome study.

    abstract:BACKGROUND AND PURPOSE:The aim of our study was to compare outcome and its determinants in familial subarachnoid hemorrhage and in sporadic subarachnoid hemorrhage in a large and well-documented patient population. METHODS:Patients with aneurysmal subarachnoid hemorrhage (SAH) treated at the Department of Neurosurgery...


    pub_type: 杂志文章


    authors: Ronkainen A,Niskanen M,Piironen R,Hernesniemi J

    更新日期:1999-05-01 00:00:00

  • Role of carotid endarterectomy in asymptomatic carotid stenosis. A Veterans Administration Cooperative Study.

    abstract::A multi-centered cooperative study is being undertaken to determine the role of carotid endarterectomy in the treatment of asymptomatic carotid stenosis. The primary objective is to compare the incidence of transient ischemic attacks, stroke, and death in previously asymptomatic patients with arteriographically confir...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1986-05-01 00:00:00

  • Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA.

    abstract:BACKGROUND AND PURPOSE:20% of ischemic stroke is in the posterior circulation, but there is little prospective data on early recurrent stroke risk and whether vertebrobasilar stenosis predicts a high recurrence risk. This natural history data are important as it is technically possible to stent such lesions. Contrast e...


    pub_type: 杂志文章


    authors: Gulli G,Khan S,Markus HS

    更新日期:2009-08-01 00:00:00

  • Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Although insulin resistance and hyperinsulinemia play a crucial role in the pathogenesis of atherosclerosis, little is known about their roles in ischemic stroke. The purpose of this study was to clarify whether insulin resistance and hyperinsulinemia are causative factors in the pathogenesis of ...


    pub_type: 杂志文章


    authors: Shinozaki K,Naritomi H,Shimizu T,Suzuki M,Ikebuchi M,Sawada T,Harano Y

    更新日期:1996-01-01 00:00:00

  • Relationship between intima-media thickness in the common carotid artery and atherosclerosis in the carotid bifurcation.

    abstract:BACKGROUND AND PURPOSE:An increase in intima-media thickness (IMT) in the common carotid artery (CCA) is commonly used as a marker of atherosclerosis. The purpose of this study was to investigate the relationship between IMT in the CCA and atherosclerosis in the carotid bifurcation. METHODS:182 consecutive patients (m...


    pub_type: 杂志文章


    authors: Rosfors S,Hallerstam S,Jensen-Urstad K,Zetterling M,Carlström C

    更新日期:1998-07-01 00:00:00

  • Three-dimensional MRI analysis of individual volume of Lacunes in CADASIL.

    abstract:BACKGROUND AND PURPOSE:Three-dimensional MRI segmentation may be useful to better understand the physiopathology of lacunar infarctions. Using this technique, the distribution of lacunar infarctions volumes has been recently reported in patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts an...


    pub_type: 杂志文章


    authors: Hervé D,Godin O,Dufouil C,Viswanathan A,Jouvent E,Pachaï C,Guichard JP,Bousser MG,Dichgans M,Chabriat H

    更新日期:2009-01-01 00:00:00

  • Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis.

    abstract:BACKGROUND AND PURPOSE:Treatment of cerebral sinus thrombosis with heparin is controversial. We conducted a double-blind, placebo-controlled multicenter trial to examine whether anticoagulant treatment improves outcome in patients with sinus thrombosis. METHODS:Patients were randomized between body weight-adjusted sub...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: de Bruijn SF,Stam J

    更新日期:1999-03-01 00:00:00

  • Cigarette smoking and risk of stroke and its subtypes among middle-aged Japanese men and women: the JPHC Study Cohort I.

    abstract:BACKGROUND AND PURPOSE:We examined sex-specific relationships of smoking with risk of total stroke and stroke subtypes in Asian populations because of the limited data available. METHODS:A total of 19,782 men and 21,500 women aged 40 to 59 years who were free of prior diagnosis of stroke, coronary heart disease, or ca...


    pub_type: 杂志文章


    authors: Mannami T,Iso H,Baba S,Sasaki S,Okada K,Konishi M,Tsugane S,Japan Public Health Center-Based Prospective Study on Cancer and Cardiovascular Disease Group.

    更新日期:2004-06-01 00:00:00

  • To treat or not to treat? Pilot survey for minor and rapidly improving stroke.

    abstract:BACKGROUND AND PURPOSE:Minor strokes and rapidly improving stroke symptoms are frequent exclusions for intravenous tissue-type plasminogen activator. We explored factors influencing tissue-type plasminogen activator treatment decision for minor strokes/rapidly improving stroke symptoms. METHODS:A pilot survey, includi...


    pub_type: 杂志文章


    authors: Balucani C,Bianchi R,Feldmann E,Weedon J,Kolychev D,Levine SR

    更新日期:2015-03-01 00:00:00

  • Effect of intravenous dipyridamole on cerebral blood flow in humans. A PET study.

    abstract:BACKGROUND AND PURPOSE:Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. However, the effects of dipyridamole on cerebral circulation is not pronounced. This study invest...


    pub_type: 杂志文章


    authors: Ito H,Kinoshita T,Tamura Y,Yokoyama I,Iida H

    更新日期:1999-08-01 00:00:00

  • Cerebral ischemia in young patients: it is associated with mitral valve prolapse and abnormal platelet activity in vivo?

    abstract::The etiology of cerebrovascular disease (CDV) in young patients is difficult to establish if the common causes of a focal neurological deficit are excluded by appropriate investigations. Since in some observations prolapse of the mitral-valve (MVP), alterations of platelet function, or both have been linked with cereb...


    pub_type: 杂志文章


    authors: Scharf RE,Hennerici M,Bluschke V,Lueck J,Kladetzky RG

    更新日期:1982-07-01 00:00:00