Abstract:
:We review the current status as well as the risks and benefits of a recently developed DNA test of risk for Alzheimer's disease: the apolipoprotein E genotype. While apolipoprotein E genotypes may indicate a degree of susceptibility, the gene is neither necessary nor sufficient to cause the disease; thus, many questions remain. Because risk prediction is not straightforward, practical issues related to the testing of complex diseases like Alzheimer's and to the ethical, legal, and social implications of genetic tests require careful consideration and unambiguous answers. The use of apolipoprotein E genotyping in patients with Alzheimer's disease should be limited to research centers, and additional studies are strongly recommended. Apolipoprotein E genotypes should not be available to third parties such as insurers or employers until genotypic risks are fully understood. National policies that encourage scientific investigation while maintaining individual privacy and limiting unnecessary access to genetic information should be immediately developed.
journal_name
Am J Public Healthjournal_title
American journal of public healthauthors
Mayeux R,Schupf Ndoi
10.2105/ajph.85.9.1280subject
Has Abstractpub_date
1995-09-01 00:00:00pages
1280-4issue
9eissn
0090-0036issn
1541-0048journal_volume
85pub_type
杂志文章,评审abstract:OBJECTIVES:We examined changes in service use in a Housing First (HF) pilot program for adults who were homeless with medical illnesses and high prior acute-care use relative to a similar comparison group. METHODS:We used a 1-year pre-post comparison group design. The 29 participants and 31 comparison group members we...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2012.300867
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:We studied state-adopted bicycle guidelines to determine whether cycle tracks (physically separated, bicycle-exclusive paths adjacent to sidewalks) were recommended, whether they were built, and their crash rate. METHODS:We analyzed and compared US bicycle facility guidelines published between 1972 and 1999...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2012.301043
更新日期:2013-07-01 00:00:00
abstract::The soviet Union has experienced an increase in the incidence of coronary heart disease over the last 15 years sufficient to result in an overall deterioration in the health of adults. The distribution of coronary risk factors, and the secular trends in diet and cigarette consumption, provide a potential explanation f...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.72.5.431
更新日期:1982-05-01 00:00:00
abstract::This paper presents a comparison of prescribing habits for patients hospitalized in medical wards of university hospitals in America and Scotland. American patients received almost twice as many drugs both during and prior to hospitalization than did comparable Scots. The differences between the countries were consist...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.66.7.644
更新日期:1976-07-01 00:00:00
abstract:OBJECTIVES:We examined associations between premigration political violence exposure and past-year intimate partner violence (IPV) perpetration among immigrant men attending community health centers in Boston. METHODS:A convenience sample of immigrant men (N = 379; aged 18-35 years), largely from the Caribbean and Cap...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2007.120634
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:We examined whether Supplemental Nutrition Assistance Program (SNAP) participation changes associations between food insecurity, dietary quality, and weight among US adults. METHODS:We analyzed adult dietary intake data (n = 8333) from the 2003 to 2010 National Health and Nutrition Examination Survey. Bivar...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2015.302580
更新日期:2015-07-01 00:00:00
abstract::Sexual and reproductive health remains the contentious concept it was at the 1994 United Nations International Conference on Population and Development (ICPD), held in Cairo, Egypt. In light of the recent 15-year review of ICPD, we suggest several areas where advocates, practitioners, and researchers can inform future...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2009.177873
更新日期:2010-03-01 00:00:00
abstract::Interview data from a three-wave panel study of the impact of the residential environment upon the psychological well-being of 337 minority women were used to examine the effects of household infestation upon self-reported depression, phobic anxiety, somatization, hostility, and anomia. The findings of cross-sectional...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.75.11.1303
更新日期:1985-11-01 00:00:00
abstract::A sample of 745 gay men, ages 20 to 65, were interviewed in 1985 as part of an effort to determine the impact of the AIDS (acquired immunodeficiency syndrome) epidemic on the non-ill but at-risk community. Measured in terms of the number of different sexual partners, sexual activity was reported to have declined by 78...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.77.5.578
更新日期:1987-05-01 00:00:00
abstract::There is a high prevalence of oral disease in the Alaska Native population, much of which goes untreated, creating a large discrepancy between the level of their oral health and that of the general population. The causes of this discrepancy are multiple--a major cause being the lack of access to care, especially in re...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2004.053546
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:This study estimated the magnitude of health improvements resulting from a proposed living wage ordinance in San Francisco. METHODS:Published observational models of the relationship of income to health were applied to predict improvements in health outcomes associated with proposed wage increases in San Fr...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.91.9.1398
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVES:We sought to measure the difference in employment rates between HIV-seropositive and HIV-seronegative persons and to establish whether this difference varied according to the HIV-infected persons' socioeconomic position as defined by education level. METHODS:We used data from the VESPA (VIH: Enquête Sur les...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2005.081083
更新日期:2007-03-01 00:00:00
abstract::More than 100 years ago, public health began as an organized discipline, its purpose being to improve the health of populations rather than of individuals. Given its population-based focus, however, public health perennially faces dilemmas concerning the appropriate extent of its reach and whether its activities infri...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.91.11.1776
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVES:We sought to identify correlates of reported lifetime diagnoses of TB among injection drug users in the border city of Tijuana, Mexico. METHODS:Injection drug users in Tijuana were recruited into a prospective cohort study during 2006 and 2007. We used weighted multivariate logistic regression to identify c...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2008.142166
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:We identified courses of depressive symptoms in an epidemiological sample of emerging adults. METHODS:We used latent class growth modeling to identify trajectories of depressive symptoms measured by the 12-item Center for Epidemiological Studies Depression Scale (CES-D) during a 14-year follow-up of 2825 Ca...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2015.302817
更新日期:2015-11-01 00:00:00
abstract::This paper uses claims data from a universal health care system to describe physicians' hospitalization styles after adjusting for case-mix characteristics of their primary patients. Patients were uniquely assigned to that physician (general or family practitioners, internist, general surgeon, or obstetrician/gynecolo...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.76.1.45
更新日期:1986-01-01 00:00:00
abstract::We developed a theoretical framework to organize obesity prevention interventions by their likely impact on the socioeconomic gradient of weight. The degree to which an intervention involves individual agency versus structural change influences socioeconomic inequalities in weight. Agentic interventions, such as stand...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2014.302066
更新日期:2014-10-01 00:00:00
abstract::Men entering gay bars in three small southern cities were administered questionnaires to assess AIDS (acquired immunodeficiency syndrome) risk knowledge, perceived norms concerning the social acceptability of AIDS risk precautions, and personal sexual behavior. Seventy-seven percent (N = 355) of male patrons completed...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.80.4.416
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVES:Data from the Tecumseh Community Health Study were used to estimate excess morbidity owing to influenza, and results were compared with estimates made previously using different methodology for an Institute of Medicine report. METHODS:Study participants from Tecumseh, Michigan, were classified as infected o...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.83.12.1712
更新日期:1993-12-01 00:00:00
abstract::Public health clients in an Ontario community 65 years of age or older were randomly allocated to receive an intervention by a public health nurse during a home visit promoting either influenza immunization or safety measures. There was no statistically significant differences in influenza immunization rates between t...
journal_title:American journal of public health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2105/ajph.83.12.1751
更新日期:1993-12-01 00:00:00
abstract::The Italian death rates and years of potential life lost (YPLL) for all causes and for 12 selected aggregations of causes are reported for 1979 and 1983, with the latter compared to United States data. Cancer is the leading cause of YPLL in Italy (23.8 per cent of total YPLL), followed by unintentional injuries (16.3 ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.78.9.1202
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine the impact of personal and job characteristics on the time to employment loss after diagnosis of the acquired immunodeficiency syndrome (AIDS) and to examine how job loss affects patients' income. METHODS:Data were collected from 305 patients with AIDS at three sit...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.84.12.1976
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVES:We examined local public health agencies' involvement in community illicit drug policy advocacy and provision related to youths to determine the extent to which public health agencies were involved in local drug policy activities and could potentially provide an infrastructure for policy alternatives. METHO...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2007.112524
更新日期:2008-02-01 00:00:00
abstract::Food fortification is an effective public health tool for addressing micronutrient deficiencies. The mandatory fortification of enriched cereal grains (e.g., wheat flour) with folic acid, which began in the United States in 1998, is an example of a successful intervention that significantly reduced the rate of neural ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2011.300135
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:Message tailoring, based on individual needs and circumstances, is commonly used to enhance face-to-face patient counseling. Only recently has individual tailoring become feasible for printed messages. This study sought to determine whether printed tailored recommendations addressing women's specific screeni...
journal_title:American journal of public health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2105/ajph.84.1.43
更新日期:1994-01-01 00:00:00
abstract::In 1981, outbreaks of itchy skin rashes were reported accompanying the heavy infestation of gypsy moths (GM) in the Northeastern United States. The rash problem was widespread and a considerable public annoyance. In the spring of 1982, during the period of greatest contact with the caterpillars, a telephone survey was...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.74.8.799
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVES:We examined associations among 3 dimensions of sexual orientation (identity, behavior, and attraction) and key health-related indicators commonly studied among sexual minority populations: depressive symptoms, perceived stress, smoking, binge drinking, and victimization. METHODS:We analyzed data from the Na...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2011.300262
更新日期:2012-06-01 00:00:00
abstract::Use of the Freedom of Information Act can be potentially harmful to the security of research in progress. There is no protection from disclosure of information in grant applications; collected research data can be obtained and disclosed prematurely; and data supporting published research may be acquired and re-analyz...
journal_title:American journal of public health
pub_type: 社论
doi:10.2105/ajph.72.4.335
更新日期:1982-04-01 00:00:00
abstract::Public awareness of the risks of drinking during pregnancy was assessed in a Northwestern metropolitan county. Ninety per cent of respondents stated spontaneously that drinking might be harmful, and one-fourth of this group felt pregnant women should customarily abstain from alcohol. The balance of those who considere...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.71.3.312
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVES:This study examined the relationship of sociodemographic factors and use of substances other than cocaine to cocaine use from 1987 to 1992 in a cohort of Black and White men and women 20 to 32 years of age. METHODS:Data were collected as part of the Coronary Artery Risk Development in Young Adults study. Se...
journal_title:American journal of public health
pub_type: 杂志文章,多中心研究
doi:10.2105/ajph.86.12.1736
更新日期:1996-12-01 00:00:00