Impact of lifestyle factors on fracture risk in older patients with cardiovascular disease: a prospective cohort study of 26,335 individuals from 40 countries.

Abstract:

BACKGROUND:fractures are a major health concern among the elderly. People at risk for cardiovascular disease (CVD) are at an increased risk for fractures. The aim of this study was to assess the individual and combined effect of the CVD risk factors of smoking, alcohol consumption and physical activity on fracture risk in a large sample of older individuals with CVD or diabetes with end-organ damage. METHODS:we analysed data for 26,335 adults, aged 55 years or older, who participated in two large antihypertensive drug treatment trials and who had no previous fracture at baseline. Lifestyle factors were assessed by the standardised questionnaire and their individual and combined effects on incident fracture risk were modelled using Cox proportional hazard regression. RESULTS:during the 56-month follow-up, 1,079 incident fractures occurred; 508 (6.51%) among women and 571 (3.08%) among men. Smoking [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.27-1.82] and low physical activity (HR: 1.19, 95% CI: 1.05-1.36) were associated with an increased risk of any fracture, while high alcohol intake showed a directional, but non-significant, relationship with fracture risk (HR: 1.09, 95% CI: 0.64-1.84). Compared with participants with no lifestyle risk factors, those having one, two, or three risk factors had an increased risk of a future fracture (HR: 1.17, 95% CI: 1.03-1.34 for one risk factor; HR: 1.73, 95% CI: 1.38-2.16 for two risk factors; and HR: 2.37, 95% CI: 0.88-6.36 for three risk factors; P for trend <0.001). CONCLUSIONS:a healthier lifestyle advocated to reduce the risk of CVD is associated with a significant and graded reduction in fracture risk.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Khatib R,Yusuf S,Barzilay JI,Papaioannou A,Thabane L,Gao P,Joseph PG,Teo K,Mente A

doi

10.1093/ageing/afu009

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

629-35

issue

5

eissn

0002-0729

issn

1468-2834

pii

afu009

journal_volume

43

pub_type

杂志文章,多中心研究
  • Using dietetic assistants to improve the outcome of hip fracture: a randomised controlled trial of nutritional support in an acute trauma ward.

    abstract:OBJECTIVE:To examine how improved attention to nutritional status and dietary intake, achieved through the employment of dietetic assistants (DAs), will affect postoperative clinical outcome among elderly women with hip fracture. DESIGN:Open prospective randomised controlled trial, comparing conventional nursing care ...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/afj011

    authors: Duncan DG,Beck SJ,Hood K,Johansen A

    更新日期:2006-03-01 00:00:00

  • Chronic diseases in elderly men: underreporting and underdiagnosis.

    abstract:OBJECTIVE:prevalence estimates for chronic diseases and associated risk factors are needed for priority setting and disease prevention strategies. The aim of this cross-sectional study was to estimate the self-reported and clinical prevalence of common chronic disorders in elderly men. STUDY DESIGN AND SETTING:a quest...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afr153

    authors: Frost M,Wraae K,Gudex C,Nielsen T,Brixen K,Hagen C,Andersen M

    更新日期:2012-03-01 00:00:00

  • Upper gastro-intestinal endoscopy for Chinese elderly in an acute geriatric unit: a review.

    abstract::From December 1982 to August 1983, a total of 242 oesophago-gastro-duodenoscopies were performed for 208 elderly patients in the Geriatric Unit, Princess Margaret Hospital, Hong Kong. These were done as part of an investigatory procedure in the Geriatric Unit, the first of its kind in Hong Kong. In the 9-month survey,...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/13.5.285

    authors: Lee YC,Tam HC

    更新日期:1984-09-01 00:00:00

  • Defining 'recovery' for delirium research: a systematic review.

    abstract:BACKGROUND:Delirium is a common neuropsychiatric disorder. The natural course is of an acute, fluctuating and often transient condition; however, accumulating evidence suggests that delirium can be associated with incomplete recovery. Despite a growing body of research, a lack of clarity exists regarding definition and...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afu152

    authors: Adamis D,Devaney A,Shanahan E,McCarthy G,Meagher D

    更新日期:2015-03-01 00:00:00

  • Acute appendicitis in the elderly: a 5-year retrospective study.

    abstract::Acute appendicitis in elderly patients has not been studied extensively in the United Kingdom. Studies were performed prior to the regular use of broad spectrum antibiotics and tended to include younger patients. We studied retrospectively all elderly patients (n = 30, mean age = 72 years) who presented in the years 1...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.4.256

    authors: McCallion J,Canning GP,Knight PV,McCallion JS

    更新日期:1987-07-01 00:00:00

  • Socio-demographic differences in the onset and progression of disability in early old age: a longitudinal study.

    abstract:OBJECTIVES:to analyse socio-demographic differences in the onset and progression of disability. DESIGN:analysis of a cohort of people aged 55-69 in 1988-9 and in 1994. SUBJECTS:a representative sample of 3543 adults. METHODS:we measured severity of disability at baseline and follow-up. We analysed variations in inci...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/29.2.149

    authors: Grundy E,Glaser K

    更新日期:2000-03-01 00:00:00

  • Tuberculosis in older people--is it on the increase? Trends in notifications in Leeds from 1976 to 1996.

    abstract:OBJECTIVES:the absolute number of notifications for tuberculosis in older people appears to have increased in Scotland. To determine if these trends are present elsewhere in the UK, we have reviewed notifications in Leeds with particular reference to non-pulmonary disease, Asian subcontinent groups and older people. M...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/29.4.319

    authors: Phelan F,Teale C

    更新日期:2000-07-01 00:00:00

  • Review: abuse of elderly people in the domestic setting: a UK perspective.

    abstract::Interest in, and concern about, the abuse of elderly people is growing rapidly. A study of the literature shows little research in the UK, but valuable indicators about risk factors and interventions from North America. One of the major problems has been definition and this paper distinguishes between different kinds ...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/22.1.65

    authors: McCreadie C,Tinker A

    更新日期:1993-01-01 00:00:00

  • Polypharmacy including falls risk-increasing medications and subsequent falls in community-dwelling middle-aged and older adults.

    abstract:BACKGROUND:polypharmacy is an important risk factor for falls, but recent studies suggest only when including medications associated with increasing the risk of falls. DESIGN:a prospective, population-based cohort study. SUBJECTS:6,666 adults aged ≥50 years from The Irish Longitudinal study on Ageing. METHODS:partic...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afu141

    authors: Richardson K,Bennett K,Kenny RA

    更新日期:2015-01-01 00:00:00

  • Socio-demographic correlates of mobility disability in older Brazilians: results of the first national survey.

    abstract:INTRODUCTION:Socio-economic differences in mobility disability prevalence in old age have been reported from the US and Europe. Brazil is characterised by gross socio-economic inequalities, but there have been no previous national data on disability prevalence. AIM:This study aimed to estimate disability rates and exp...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afh075

    authors: Melzer D,Parahyba MI

    更新日期:2004-05-01 00:00:00

  • Metabolic effects of digitalis.

    abstract::In a study of two representative population samples of 70-year-olds, one of which was followed up at 75 years of age, digitalis treatment was associated with oestrogen-like metabolic effects, indicated by changes in the composition of the plasma phospholipid fraction. Digitalis treatment, at least at these ages, is re...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/11.4.261

    authors: Persson G,Landahl S,Svanborg A

    更新日期:1982-11-01 00:00:00

  • The usefulness of carotid sinus massage in different patient groups.

    abstract:AIM:to determine the positive yield of carotid sinus massage in different patient groups: unexplained syncope, falls, dizziness and controls. DESIGN:observational study. SETTING:teaching hospital. METHODS:we studied consecutive patients over the age of 60 years referred to the 'falls clinic' with a history of unexpl...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afg114

    authors: Kumar NP,Thomas A,Mudd P,Morris RO,Masud T

    更新日期:2003-11-01 00:00:00

  • Effects of a physiotherapist-led stroke training programme for nurses.

    abstract:AIM:to assess the effects of a physiotherapist-led stroke training programme for nurses working in a rehabilitation ward on clinical practice and patient outcome. METHOD:before and after group comparison with outcome assessment by observational and quantitative methods. Non-participant observation before and after the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/28.6.567

    authors: Forster A,Dowswell G,Young J,Sheard J,Wright P,Bagley P

    更新日期:1999-10-01 00:00:00

  • The association of ageing with calcium active hormone status in men.

    abstract::We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p < 0.01) together with a parallel increase in urinary (r = 0.46, p < 0.05) and nephrogenic cAMP (r = 0.63, p < 0....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.2.127

    authors: Ravaglia G,Forti P,Pratelli L,Maioli F,Scali CR,Bonini AM,Tedioli S,Marasti N,Pizzoferrato A,Gasbarrini G

    更新日期:1994-03-01 00:00:00

  • Cognitive decline with chronic meningitis secondary to a COX-2 inhibitor.

    abstract::Non-steroidal anti-inflammatory drugs are currently being investigated as agents to reduce the incidence and progression of Alzheimer's disease. Paradoxically they have also been reported to induce deleterious effects on the central nervous system, including aseptic meningitis and cognitive decline in the elderly. We ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afh112

    authors: Ashton D,Kim P,Griffiths N,Beran R

    更新日期:2004-07-01 00:00:00

  • Health conditions, health symptoms and driving difficulties in older adults.

    abstract:OBJECTIVES:Previous research has indicated that age-related medical or health conditions can affect driving performance in older adults but little, if any, research has examined the mechanisms through which health conditions affect driving difficulties in older adults. DESIGN:Cross-sectional, correlational study. SET...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afm032

    authors: Tuokko HA,Rhodes RE,Dean R

    更新日期:2007-07-01 00:00:00

  • Proximity to death is associated with frequency of GP contacts in the oldest old: the Leiden 85-plus study.

    abstract:BACKGROUND:the relationship between proximity to death and the amount of care provided by general practitioners (GPs) is largely unknown. OBJECTIVE:to examine the influence of the proximity to death on the frequency and length of GP contacts in the oldest old. STUDY DESIGN:this population-based follow-up study includ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs062

    authors: Blom JW,Lemmens SP,Assendelft WJ,Eekhof JA,Gussekloo J

    更新日期:2012-11-01 00:00:00

  • Comparative effectiveness of sitagliptin vs sulphonylureas in older people.

    abstract:BACKGROUND:two common anti-diabetic treatments used are sitagliptin and sulphonylureas however evidence examining their comparative effectiveness in older people is limited. OBJECTIVE:to evaluate effectiveness of sitagliptin vs sulphonylureas when added to metformin in older (aged ≥75) vs younger people (18-75). DESI...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afz078

    authors: Sharma M,Nazareth I,Petersen I

    更新日期:2019-09-01 00:00:00

  • Variability of response to thyroid-releasing hormone in normal elderly.

    abstract::The present study was undertaken to define the hormonal response to thyroid-releasing hormone (TRH) further in a large, healthy, ambulatory elderly group. Seventy-seven subjects over 60 years old, 30 males (MA) and 47 females (FA), and control subjects, 22 males (MC) and 42 females (FC) were studied. No difference in ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.6.345

    authors: Kaiser FE

    更新日期:1987-11-01 00:00:00

  • Effect of intravenous iron on functional outcomes in hip fracture: a randomised controlled trial.

    abstract:OBJECTIVES:to determine the safety and effect of intravenous iron sucrose on functional outcomes, delirium, nosocomial infections and transfusion requirements in older patients with hip fracture. DESIGN:single-centre randomised, double-blind, placebo-controlled clinical trial. SETTING AND PARTICIPANTS:orthogeriatric ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa107

    authors: Bielza R,Llorente J,Thuissard IJ,Andreu-Vázquez C,Blanco D,Sanjurjo J,López N,Herráez MR,Molano C,Morales A,Arias E,Neira M,Lung A,Escalera J,Portillo L,Larrubia Y,García C,Zambrana F,Gómez Cerezo J

    更新日期:2021-01-08 00:00:00

  • Warfarin sensitivity: be aware of genetic influence.

    abstract:BACKGROUND:avoidance of over anticoagulation in response to warfarin therapy would reduce risk of associated bleeding. SUBJECTS:two elderly patients with venous thromboembolism exhibited extreme anticoagulant response to warfarin. Both were noted to have variant CYP2C9 alleles, which reduce the metabolic capacity of c...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/32.2.226

    authors: Khan T,Kamali F,Daly A,King B,Wynne HA

    更新日期:2003-03-01 00:00:00

  • Tamoxifen and partial oestrogen agonism in postmenopausal women.

    abstract::The effect of tamoxifen on the vaginal mucosa and on serum oestrone, oestradiol and gonadotrophin concentrations was investigated in a group of nine postmenopausal women with non-metastatic breast cancer. Compared with fit age-matched controls, the vaginal pH in the tamoxifen-treated group was significantly lower and ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/20.1.52

    authors: Miodrag A,Ekelund P,Burton R,Castleden CM

    更新日期:1991-01-01 00:00:00

  • Long-term effect of community-based continence promotion on urinary symptoms, falls and healthy active life expectancy among older women: cluster randomised trial.

    abstract:BACKGROUND:The long-term effectiveness of group continence promotion delivered via community organisations on female urinary incontinence, falls and healthy life expectancy remains unknown. METHODS:A pragmatic cluster randomised trial was conducted among 909 women aged 65-98 years with urinary incontinence, recruited ...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/afz038

    authors: Tannenbaum C,Fritel X,Halme A,van den Heuvel E,Jutai J,Wagg A

    更新日期:2019-07-01 00:00:00

  • Regaining pre-fracture basic mobility status after hip fracture and association with post-discharge mortality and readmission-a nationwide register study in Denmark.

    abstract:BACKGROUND:early mobilization after hip fracture (HF) is an important predictor of outcome, but knowledge of the consequences of not achieving the pre-fracture basic mobility status in acute hospital recovery is sparse. OBJECTIVE:we examined whether the regain of pre-fracture basic mobility status evaluated with the c...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afy185

    authors: Kristensen MT,Öztürk B,Röck ND,Ingeman A,Palm H,Pedersen AB

    更新日期:2019-03-01 00:00:00

  • Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily?

    abstract::We present two cases of acute hepatotoxicity associated with elevated paracetamol (acetaminophen) levels in older patients. Both patients were receiving a standard European dose of oral paracetamol (2 × 500 mg QDS) with no risk factors for slowed metabolism (weight <50 kg, interacting medications, hepatic enzyme induc...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw067

    authors: Ging P,Mikulich O,O'Reilly KM

    更新日期:2016-07-01 00:00:00

  • Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees.

    abstract:Background:screening for cognitive impairment in Emergency Department (ED) requires short, reliable tools. Objective:to validate the 4AT and 6-Item Cognitive Impairment Test (6-CIT) for ED dementia and delirium screening. Design:diagnostic accuracy study. Setting/subjects:attendees aged ≥70 years in a tertiary care ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afx149

    authors: O'Sullivan D,Brady N,Manning E,O'Shea E,O'Grady S,O 'Regan N,Timmons S

    更新日期:2018-01-01 00:00:00

  • Will drugs help patients with Alzheimer's disease?

    abstract::Recent studies have shown a defect in the cholinergic system of the cerebral cortex of patients suffering from nonvascular senile dementia. This observation suggests the possibility of instituting some kind of replacement therapy and trial have been carried out. At this juncture it seem pertinent to ask what lessons c...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/8.2.86

    authors: Kendall MJ

    更新日期:1979-05-01 00:00:00

  • Reactive stepping behaviour in response to forward loss of balance predicts future falls in community-dwelling older adults.

    abstract:BACKGROUND:a fall occurs when an individual experiences a loss of balance from which they are unable to recover. Assessment of balance recovery ability in older adults may therefore help to identify individuals at risk of falls. The purpose of this 12-month prospective study was to assess whether the ability to recover...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afu054

    authors: Carty CP,Cronin NJ,Nicholson D,Lichtwark GA,Mills PM,Kerr G,Cresswell AG,Barrett RS

    更新日期:2015-01-01 00:00:00

  • Management of spasticity revisited.

    abstract::Spasticity is common after stroke and other neurological conditions and causes considerable limitations of movement, activities of daily living and participation. Interaction with other components of the upper motor neurone syndrome (UMNS) and the heterogeneity of patients' presentations together with limited tools fo...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/aft064

    authors: Graham LA

    更新日期:2013-07-01 00:00:00

  • Prevalence of biliary lithiasis in the elderly people of a small town in Sicily.

    abstract::The aim of the present study was to determine the prevalence of biliary lithiasis (BL) and its major associated factors in the elderly people of a small town in Sicily. All inhabitants over the age of 65 were interviewed and underwent a general physical examination, blood tests and ultrasonography of the gallbladder a...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/21.5.338

    authors: Montalto G,Soresi M,Carroccio A,Averna MR,Muratore R,Li Castri C,Barbagallo CM,Cavera G,Sapienza M,Notarbartolo A

    更新日期:1992-09-01 00:00:00