Effect of ventral noradrenergic bundle lesions on concentrations of monoamine neurotransmitters and metabolites in several discrete areas of the rat brain.

Abstract:

:1. The effects of radiofrequency lesions of the ventral noradrenergic bundle (VNB) on monoamine and metabolite concentrations in several discrete areas of the rat hypothalamus were examined. Monoamines and metabolites were analyzed utilizing high-performance liquid chromatography coupled with electrochemical detection. 2. VNB lesions decreased the concentrations of norepinephrine (NE) and 3-methoxy-4-hydroxyphenylethylene glycol in all areas examined except in the ventromedial nucleus (VMN). Dopamine and 3,4-dihydroxyphenylacetic acid concentrations were selectively decreased in the dorsomedial nucleus (DMN) and also slightly decreased in the medial forebrain bundle following VNB lesions. Serotonin and 5-hydroxyindole-3-acetic acid concentrations were not altered by VNB lesion in any area examined. 3. The results indicate that the NE innervation to the hypothalamus is extensive and that NE in the VMN may not be derived from the VNB. The source of the DA innervation to the DMN may be located in or pass through the area affected by the VNB lesion.

journal_name

Cell Mol Neurobiol

authors

Johnston CA,Mattiace LA,Negro-Vilar A

doi

10.1007/BF00733792

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

403-11

issue

4

eissn

0272-4340

issn

1573-6830

journal_volume

7

pub_type

杂志文章
  • Regulation of the biosynthesis of large dense-core vesicles in chromaffin cells and neurons.

    abstract::1. The proteins of large dense-core vesicles (LDV) in neuroendocrine tissues are well characterized. Secretory components comprise chromogranins and neuropeptides. Intrinsic membrane proteins include cytochrome b-561, transporters, SV2, synaptotagmin, and synaptobrevin. 2. The effects of stimulation and of second mess...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1022516919932

    authors: Winkler H,Fischer-Colbrie R

    更新日期:1998-04-01 00:00:00

  • RhoC involved in the migration of neural stem/progenitor cells.

    abstract::Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-014-0026-0

    authors: Zhang C,Ge X,Lok K,Zhao L,Yin M,Wang ZJ

    更新日期:2014-04-01 00:00:00

  • The role of nitric oxide in homocysteine thiolactone-induced seizures in adult rats.

    abstract::The role of NO in epileptogenesis has been studied in different experimental models, and the reported results have been highly contradictory. The current study aimed to determine the role of NO in mechanisms of D: ,L: -homocysteine-thiolactone (H) induced seizures by testing the action of L: -arginine (NO precursor) a...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-009-9444-9

    authors: Hrncić D,Rasić-Marković A,Krstić D,Macut D,Djuric D,Stanojlović O

    更新日期:2010-03-01 00:00:00

  • Autonomic nervous system function in rheumatoid arthritis.

    abstract::The sympathoneural and the adrenomedullary systems are involved in regulation of immune processes. Their impairment has been suggested in patients with rheumatoid arthritis (RA). In this study, sympathetic response to orthostasis was evaluated in 22 RA females with <40 years of age and in 15 matched healthy controls. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-012-9805-7

    authors: Vlcek M,Rovensky J,Eisenhofer G,Radikova Z,Penesova A,Kerlik J,Imrich R

    更新日期:2012-07-01 00:00:00

  • Alterations of glial cells in the mouse hippocampus during postnatal development.

    abstract::We investigated the postnatal alterations of neurons, astrocyte, oligodendrocyte, and microglia in the mouse hippocampal CA1 sector and dentate gyrus under the same conditions using immunohistochemistry. Neuronal nuclei (NeuN), Glial fibrillary acidic protein (GFAP), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPas...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-009-9412-4

    authors: Kimoto H,Eto R,Abe M,Kato H,Araki T

    更新日期:2009-12-01 00:00:00

  • Comparison of the neural differentiation potential of human mesenchymal stem cells from amniotic fluid and adult bone marrow.

    abstract::Human mesenchymal stem cells (MSCs) are considered a promising tool for cell-based therapies of nervous system diseases. Bone marrow (BM) has been the traditional source of MSCs (BM-MSCs). However, there are some limitations for their clinical use, such as the decline in cell number and differentiation potential with ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-013-9922-y

    authors: Yan ZJ,Hu YQ,Zhang HT,Zhang P,Xiao ZY,Sun XL,Cai YQ,Hu CC,Xu RX

    更新日期:2013-05-01 00:00:00

  • Kinetics of acetylcholine-activated cation channel blockade by the calcium antagonist D-600 in Aplysia neurons.

    abstract::The effects of the calcium channel blocker D-600 on the cation channels activated by acetylcholine (ACh) was studied in voltage-clamped Aplysia neurons by voltage-jump relaxation analysis. D-600 blocked the steady-state ACh current in a highly voltage-dependent manner, the degree of antagonism increasing with membrane...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00734714

    authors: Slater NT,Haas HL,Carpenter DO

    更新日期:1983-12-01 00:00:00

  • Involvement of RhoA/ROCK Signaling in Aβ-Induced Chemotaxis, Cytotoxicity and Inflammatory Response of Microglial BV2 Cells.

    abstract::Reactive microglia clustering around amyloid plaques in brain is a histopathological feature of Alzheimer's disease (AD) and reflects the contribution of neuroinflammation in AD pathogenesis. β-Amyloid peptide (Aβ) has been shown to induce a range of microglial responses including chemotaxis, cytotoxicity and inflamma...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-019-00668-6

    authors: Zhang X,Ye P,Wang D,Liu Y,Cao L,Wang Y,Xu Y,Zhu C

    更新日期:2019-07-01 00:00:00

  • Characterization of AT2 receptor expression in NIH 3T3 fibroblasts.

    abstract::1. A high expression of angiotensin II receptors and of angiotensin-converting enzyme (ACE) activity was detected in confluent NIH 3T3 fibroblasts. 2. Characterization with selective ligands, dithiothreitol, and GTP gamma S, indicated that only the AT2 subtype was expressed. 3. AT2 receptors and ACE expression were st...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1006985329240

    authors: Heemskerk FM,Zorad S,Xu N,Gutkind SJ,Saavedra JM

    更新日期:1999-04-01 00:00:00

  • Discovery of atrial natriuretic factor in the brain: its characterization and cardiovascular implication.

    abstract::1. We have devised a radioimmunoassay for atrial natriueretic factor (ANF). Its application to rat brain extract led to the discovery of ANF in the brain. In addition to the hypothalamus and the pontine medullary region, it was widely distributed. 2. ANF in the brain is stored in a low molecular weight form, in contra...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00711444

    authors: Inagami T,Tanaka I,McKenzie JC,Nakamaru M,Takayanagi R,Imada T,Pochet R,Resibois A,Naruse M,Naruse K

    更新日期:1989-03-01 00:00:00

  • Radioimmunochemical methods for the quantitative autoradiographic determination of antigens in brain and other tissues.

    abstract::1. We have used horseradish peroxidase-conjugated protein A- and 125I-protein A to develop immunohistochemical and radioimmunohistochemical methods for the localization of antigens in brain and other tissues of the rat. 2. We visualized methionine-enkephalin fibers in the rat brain by incubating tissue sections with a...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/BF00712912

    authors: Correa FM,Guilhaume SS,Saavedra JM

    更新日期:1988-03-01 00:00:00

  • Down-regulated GABAergic expression in the olfactory bulb layers of the mouse deficient in monoamine oxidase B and administered with amphetamine.

    abstract::This study explores primarily the role of the activity of monoamine oxidase B (MAOB) in the regulation of glutamic acid decarboxylase(67) (GAD(67)) expression in distinct layers of main olfactory bulb (OlfB), which links the limbic system. Moreover, the response of GAD(67) was investigated to amphetamine perturbation ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-009-9475-2

    authors: Yin HS,Chen K,Shih JC,Tien TW

    更新日期:2010-05-01 00:00:00

  • Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress.

    abstract::ERK pathway plays a critical role in the cellular adaptive responses to environmental changes. Stressful conditions can induce the activation of activate ERK, and its downstream targets, CREB and c-fos, in neural cells. Exposure to opioids has the same effect. In this study, we investigated the effects of morphine-ind...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-013-0011-z

    authors: Haghparast A,Fatahi Z,Alamdary SZ,Reisi Z,Khodagholi F

    更新日期:2014-03-01 00:00:00

  • Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats.

    abstract::The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Ma...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10571-008-9306-x

    authors: Bundzikova J,Pirnik Z,Zelena D,Mikkelsen JD,Kiss A

    更新日期:2008-12-01 00:00:00

  • Correction to: Pigment Epithelium-Derived Factor Improves Paracellular Blood-Brain Barrier Integrity in the Normal and Ischemic Mouse Brain.

    abstract::The original version of the article unfortunately contained an error in the unit of the protein concentrations under 'Stereotactic Intraparenchymal Injections' subsection in 'Methods' section. ...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10571-020-00872-9

    authors: Riabinska A,Zille M,Terzi MY,Cordell R,Nieminen-Kelhä M,Klohs J,Piña AL

    更新日期:2020-07-01 00:00:00

  • Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.

    abstract::Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypert...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9600-2

    authors: Chen Y,Rao F,Wen G,Gayen JR,Zhang K,Vaingankar SM,Biswas N,Mahata M,Friese RS,Fung MM,Salem RM,Nievergelt C,Bhatnagar V,Hook VY,Ziegler MG,Mahata SK,Hamilton BA,O'Connor DT

    更新日期:2010-11-01 00:00:00

  • Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain.

    abstract::Neuropathic pain occurs as a result of peripheral or central nervous system injury. Its pathophysiology involves mainly a central sensitization mechanism that may be correlated to many molecules acting in regions involved in pain processing, such as the spinal cord. It has been demonstrated that reactive oxygen specie...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-008-9279-9

    authors: Guedes RP,Araújo AS,Janner D,Belló-Klein A,Ribeiro MF,Partata WA

    更新日期:2008-12-01 00:00:00

  • Tailless-like (TLX) protein promotes neuronal differentiation of dermal multipotent stem cells and benefits spinal cord injury in rats.

    abstract::Spinal cord injury (SCI) remains a formidable challenge in the clinic. In the current study, we examined the effects of the TLX gene on the proliferation and neuronal differentiation of dermal multipotent stem cells (DMSCs) in vitro and the potential of these cells to improve SCI in rats in vivo. DMSCs were stably tra...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9642-5

    authors: Wang T,Ren X,Xiong J,Zhang L,Qu J,Xu W

    更新日期:2011-04-01 00:00:00

  • Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s).

    abstract::Glial cells have various important roles in regulation of brain functions. For such events, extracellular nucleotides/P2 receptors have central roles. Although there have been huge amount of literature about activation of P2 receptors and glial functions, little is known about what happens in glia or the brain if glia...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-012-9869-4

    authors: Kinoshita M,Nasu-Tada K,Fujishita K,Sato K,Koizumi S

    更新日期:2013-01-01 00:00:00

  • Protective role of glutathione synthesis on radiation-induced DNA damage in rabbit brain.

    abstract::1. Radiotherapy has attracted increasing interest in recent years. It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury. In this study, the metabolism of antioxidants in response to ionizing radiation to the...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1022525214871

    authors: Shimizu T,Iwanaga M,Yasunaga A,Urata Y,Goto S,Shibata S,Kondo T

    更新日期:1998-06-01 00:00:00

  • Intracellular localization of the HCS2 gene products in identified snail neurons in vivo and in vitro.

    abstract::1. The HCS2 (Helix command specific 2) gene expressed in giant command neurons for withdrawal behavior of the terrestrial snail Helix lucorum encodes a unique hybrid precursor protein that contains a Ca-binding (EF-hand motif) protein and four small peptides (CNP1-CNP4) with similar Tyr-Pro-Arg-X aminoacid sequence at...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-006-9025-0

    authors: Ivanova JL,Leonova OG,Popenko VI,Ierusalimsky VN,Korshunova TA,Boguslavsky DV,Malyshev AY,Balaban PM,Belyavsky AV

    更新日期:2006-03-01 00:00:00

  • Gonadal steroids do not affect apolipoprotein E expression in aging mouse cerebral cortex.

    abstract::The allelic variant of apolipoprotein (Apo) E4 is a known risk factor for the development of most common late onset form of Alzheimer's disease (AD). As aging is associated with reduced circulating level of gonadal steroid hormones, hormone replacement therapies have been used for the possible treatment of AD. Both es...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9631-8

    authors: Singh S,Thakur MK

    更新日期:2011-04-01 00:00:00

  • Standardised extract of Bacopa monniera (CDRI-08) improves contextual fear memory by differentially regulating the activity of histone acetylation and protein phosphatases (PP1α, PP2A) in hippocampus.

    abstract::Contextual fear conditioning is a paradigm for investigating cellular mechanisms involved in hippocampus-dependent memory. Earlier, we showed that standardised extract of Bacopa monniera (CDRI-08) improves hippocampus-dependent learning in postnatal rats by elevating the level of serotonin (5-hydroxytryptamine, 5-HT),...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-014-0042-0

    authors: Preethi J,Singh HK,Venkataraman JS,Rajan KE

    更新日期:2014-05-01 00:00:00

  • Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment in Acute Ischemic Stroke.

    abstract::Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental mode...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10571-020-00985-1

    authors: Liu C,Xie J,Sun S,Li H,Li T,Jiang C,Chen X,Wang J,Le A,Wang J,Li Z,Wang J,Wang W

    更新日期:2020-10-30 00:00:00

  • Intrinsic regulation of brain inflammatory responses.

    abstract::It is now well accepted that inflammatory responses in brain contribute to the genesis and evolution of damage in neurological diseases, trauma, and infection. Inflammatory mediators including cytokines, cell adhesion molecules, and reactive oxygen species including NO are detected in human brain and its animal models...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1025084415833

    authors: Galea E,Heneka MT,Dello Russo C,Feinstein DL

    更新日期:2003-10-01 00:00:00

  • LncRNA MEG8 Attenuates Cerebral Ischemia After Ischemic Stroke Through Targeting miR-130a-5p/VEGFA Signaling.

    abstract::MEG8 is involved in ischemia stroke, however, its role in ischemia stroke remains unknown. The current research aimed to investigate the effects and mechanisms of MEG8 in ischemic stroke. Mouse brain microvascular endothelial cells (BMECs) were treated by oxygen-glucose deprivation (OGD). Then, the expressions of MEG8...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-020-00904-4

    authors: Sui S,Sun L,Zhang W,Li J,Han J,Zheng J,Xin H

    更新日期:2020-07-05 00:00:00

  • Glial cells are involved in the exciting effects of doxapram on brainstem slices in vitro.

    abstract::This study tested whether the glial cells are involved in the exciting effects of doxapram on brainstem slice in vitro. Experiments were performed in brainstem slice preparations from neonatal rats. The medial area of nucleus retrofacialis (mNRF) and the hypoglossal nerve (XII nerve) were contained in the preparations...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-010-9500-5

    authors: Li GC,Zhang HT,Jiao YG,Wu ZH,Fang F,Cheng J

    更新日期:2010-07-01 00:00:00

  • Microarray analysis of neural stem cell differentiation in the striatum of the fetal rat.

    abstract::1. Gene expression profiles in neural stem cell differentiation in vitro were determined by cDNA microarray analysis. 2. Total RNA was extracted and reverse transcripted into cDNA from differentiated and undifferentiated neural stem cells. The 33P labeled cDNA was hybridized with a cDNA microarray consisting of 14,000...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1023/a:1021059520618

    authors: Wen T,Gu P,Minning TA,Wu Q,Liu M,Chen F,Liu H,Huang H

    更新日期:2002-08-01 00:00:00

  • Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion.

    abstract::Oxysophocarpine (OSC), an alkaloid isolated from Sophora flavescens Ait, has been traditionally used as a medicinal agent based on the observed pharmacological effects. In this study, the direct effect of OSC against neuronal injuries induced by oxygen and glucose deprivation (OGD) in neonatal rat primary-cultured hip...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-017-0501-5

    authors: Zhao P,Chang RY,Liu N,Wang J,Zhou R,Qi X,Liu Y,Ma L,Niu Y,Sun T,Li YX,He YP,Yu JQ

    更新日期:2018-03-01 00:00:00

  • The effect of nimodipine on calcium homeostasis and pain sensitivity in diabetic rats.

    abstract::1. The pathogenesis of diabetic neuropathy is a complex phenomenon, the mechanisms of which are not fully understood. Our previous studies have shown that the intracellular calcium signaling is impaired in primary and secondary nociceptive neurons in rats with streptozotocin (STZ)-induced diabetes. Here, we investigat...

    journal_title:Cellular and molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s10571-006-9107-z

    authors: Shutov L,Kruglikov I,Gryshchenko O,Khomula E,Viatchenko-Karpinski V,Belan P,Voitenko N

    更新日期:2006-10-01 00:00:00