Abstract：
:1. Experiments were designed to determine whether endothelium-dependent relaxing factor(s) released by acetylcholine from the canine femoral artery influences the membrane potential of coronary arterial smooth muscle. 2. The membrane potential was recorded in small canine coronary arteries (internal diameter less than or equal to 500 micron; without endothelium) by means of intracellular microelectrodes. The organ bath also contained a strip of left descending coronary artery without endothelium in which isometric force was measured to bioassay relaxing factor(s) as well as segments of femoral artery with endothelium, which served as the source of endothelium-derived relaxing factor(s). 3. Acetylcholine induced endothelium-dependent, transient hyperpolarizations and relaxations that were not affected by indomethacin. 4. Inhibition of the sodium-potassium pump by ouabain or potassium-free solution did not inhibit the relaxation to acetylcholine but prevented the corresponding hyperpolarization. 5. Activation of the sodium-potassium pump of the smooth muscle cells by readmission of potassium ions after incubation in potassium-free solution caused relaxation and marked hyperpolarization. 6. These results suggest that endothelium-derived relaxing factor(s) induces hyperpolarization of vascular smooth muscle of the canine coronary artery, possibly by activation of sodium-potassium pumping, but that this effect on the cell membrane may only partially explain endothelium-dependent relaxations evoked by acetylcholine.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Feletou M,Vanhoutte PMdoi
10.1111/j.1476-5381.1988.tb10306.xsubject
Has Abstractpub_date
1988-03-01 00:00:00pages
515-24issue
3eissn
0007-1188issn
1476-5381journal_volume
93pub_type
杂志文章abstract：:Opioid drugs such as morphine and meperidine are widely used in clinical pain management, although they can cause some adverse effects. A number of studies indicate that N-methyl-D-aspartate (NMDA) receptors may play a role in the mechanism of morphine analgesia, tolerance and dependence. Being an antitussive with NMD...
journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1969.tb07980.x
更新日期：1969-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Although trace amines (TAs) are historically considered 'false neurotransmitters' on the basis of their ability to induce catecholamine release, there is evidence that they directly affect neuronal activity via TA receptors, ligand-gated receptor channels and/or sigma receptors. Here, we have inv...
journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1981.tb09951.x
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abstract：:1. The convulsive effects of leptazol in the rat are potentiated by prior treatment with dexamphetamine.2. An intact dopamine synthesis is necessary for the potentiation of the convulsive action of leptazol.3. An intact noradrenaline synthesis is not necessary for this action of amphetamine, as long as the dopamine sy...
journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
pub_type： 杂志文章
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journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
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更新日期：1990-08-01 00:00:00
abstract：:1. Endothelial cell damage in glomeruli and kidney arterioles appears to play a pivotal role in glomerular inflammatory diseases. Glomerular endothelial cells, a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration, die by apoptosis in response to tumour necrosis factor-alpha (T...
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更新日期：1999-08-01 00:00:00
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journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
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doi：10.1038/sj.bjp.0706898
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更新日期：2004-07-01 00:00:00
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journal_title：British journal of pharmacology
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更新日期：2017-06-01 00:00:00
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journal_title：British journal of pharmacology
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更新日期：2013-12-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1973.tb08532.x
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更新日期：1988-05-01 00:00:00
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abstract：:1. The effects of dimethothiazine have been studied on the response of afferent fibres from primary and secondary endings of muscle spindles in the soleus muscle of the decerebrate cat during stretching of the muscle under controlled conditions.2. Dimethothiazine in doses of 1 to 4 mg/kg intravenously reduced the disc...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1970.tb10360.x
更新日期：1970-07-01 00:00:00
abstract：:1. We have investigated pre- and post-junctional responsiveness in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice. The response to a single stimulus was not significantly different between wild-type and knock-out mice. The isometric contraction to 10 Hz stimulation for 4 s was significantly lar...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0704791
更新日期：2002-07-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1995.tb13313.x
更新日期：1995-03-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/bph.13692
更新日期：2017-02-01 00:00:00
