Abstract:
:We studied the ultrastructural characteristics of 23 vascularized preretinal membranes removed from 22 eyes during pars plana vitrectomy for proliferative diabetic retinopathy. Traction detachment of the macula was the most frequent reason for surgery (15 of 22 eyes), followed by nonclearing vitreous hemorrhage (seven of 22 eyes). Vessels found in the membranes were studied by serial sectioning and categorized as having either developing, mature, or regressing characteristics. Developing vessels were seen in ten of 23 membranes (43%), mature vessels in 19 of 23 membranes (83%), and regressing vessels in 13 of 23 membranes (57%). Endothelial fenestrations and cell separations were rare. With three-dimensional reconstruction, we found that new vessels often extended cytoplasmic processes into the extracellular matrix and that lumina were present even at the distalmost tips of the vessels. Solid cords of endothelial cells were not seen. We concluded that in proliferative diabetic retinopathy, new vessels develop by a process of focal extracellular matrix degradation, generalized and exuberant extracellular matrix production, cytoplasmic microvillus extension into the extracellular matrix, and active lumen formation.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Williams JM Sr,de Juan E Jr,Machemer Rdoi
10.1016/0002-9394(88)90240-1subject
Has Abstractpub_date
1988-05-15 00:00:00pages
491-9issue
5eissn
0002-9394issn
1879-1891pii
0002-9394(88)90240-1journal_volume
105pub_type
杂志文章abstract:PURPOSE:To determine the effects of a second fluocinolone implant inserted in eyes with uveitis in which recurrent inflammation developed after the original implant was placed. DESIGN:Prospective, interventional trial. METHODS:Study subjects comprised all consecutive patients with noninfectious posterior uveitis who ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.11.008
更新日期:2008-04-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1991-03-15 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:1982-02-01 00:00:00
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更新日期:2003-03-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00
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journal_title:American journal of ophthalmology
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doi:10.1016/j.ajo.2004.12.024
更新日期:2005-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1989-03-15 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00543-9
更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-02-15 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.03.070
更新日期:2005-09-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1966-05-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-03-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.01.010
更新日期:2013-06-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1981-05-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.01.047
更新日期:2004-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1986-12-15 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(82)90002-2
更新日期:1982-11-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-11-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2007-10-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:2014-02-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1975-02-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.05.035
更新日期:2010-11-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1976-08-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/s0002-9394(00)00882-5
更新日期:2001-04-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00