Analysis of unconjugated morphine, codeine, normorphine and morphine as glucuronides in small volumes of plasma from children.

Abstract:

:A sensitive method for the analysis of unconjugated morphine, codeine, normorphine and total morphine after hydrolysis of glucuronide conjugates is described. The method was applicable to 50-microliters volumes of plasma. The analytes were converted to heptafluorobutyryl (HFB) derivatives before analysis by gas chromatography-negative ion chemical ionization mass spectrometry. Morphine and codeine were quantified against their [2H3]-isotopomers. Linearity, precision and accuracy were quite acceptable (in the 10(-10)-10(-9) g range), and the absolute limits of detection were < 1 pg.

journal_name

J Pharm Biomed Anal

authors

Watson DG,Su Q,Midgley JM,Doyle E,Morton NS

doi

10.1016/0731-7085(94)00121-h

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

27-32

issue

1

eissn

0731-7085

issn

1873-264X

pii

073170859400121H

journal_volume

13

pub_type

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