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New fiber formation in rat soleus muscle following administration of denervated muscle extract.

Abstract：

:A study was made of Wistar rat soleus muscle following intraperitoneal administration of denervated muscle extract over 1 and 2 days. Light microscopy revealed the appearance on fiber surfaces of basophilic satellite structures whose histochemical behaviour differed from that of the parent fiber. Small fibers showing regenerative characteristics were also detected, mainly in the extrafascicular spaces. At ultrastructural examination, activated satellite cells were visible, and there was evidence of splitting in subsarcolemmal regions of apparently hypertrophic muscle fibers. Interstitial cells were occasionally observed, containing structures like myofilaments. The hypothesis is advanced that denervated muscle extract contains substances able to stimulate new fiber formation in adult skeletal muscle.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Peña J,Jimena I,Luque E,Vaamonde R

doi

10.1016/0022-510x(94)00212-7

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

14-21

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(94)00212-7

journal_volume

128

pub_type

杂志文章

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