Abstract：
:Several murine monoclonal antibodies were raised against purified soluble Plasmodium falciparum antigens from the asexual blood stage. The monoclonal antibodies were purified from ascites by preparative agarose gel electrophoresis and tested for inhibitory activities against P. falciparum in vitro cultures. One monoclonal antibody, HATR 2-4, showed an isolate-specific growth inhibition of P. falciparum in vitro cultures. The antibody reacted in immunoblotting with bands of 250 and 57 kilo dalton (kdalton). Another monoclonal antibody, HATR 2-8, showed growth inhibition of several geographically distinct P. falciparum isolates. HATR 2-8 reacted in immunoblotting with bands of 250 and 74 kdalton. Heating of the antigens destroyed the reactivity of HATR 2-8. The monoclonal antibodies HATR 2-4 and HATR 2-8 probably recognize different epitopes on the same antigen. This antigen circulates in the plasma of some patients with P. falciparum parasitaemia.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Jakobsen PH,Jepsen S,Agger Rdoi
10.1007/BF00535326subject
Has Abstractpub_date
1987-01-01 00:00:00pages
518-23issue
6eissn
0932-0113issn
1432-1955journal_volume
73pub_type
杂志文章abstract：:Tungiasis is endemic in many countries in Latin America, the Caribbean and sub-Saharan Africa, and it is associated with severe morbidity. The pathophysiological and immunological characteristics of the ectoparasitosis are not well understood, and no effective therapy is currently available. The aim of this study was ...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-007-0731-4
更新日期：2007-12-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00436-017-5510-2
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931168
更新日期：1989-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931082
更新日期：1990-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2000-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Parasitology research
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2014-03-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2007-09-01 00:00:00
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更新日期：2007-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Parasitology research
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更新日期：2011-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2002-07-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
