Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.

Abstract:

:cDNA cloning revealed the presence of two related but distinct types of human interleukin-8 (IL-8) receptors, type I (type A) and type II (type B). By immunizing rabbits with glutathione-S-transferase fused with the NH2-terminal domain of each type of IL-8 receptor, we prepared polyclonal antibodies that specifically recognized the NH2-terminal domain of each type of IL-8 receptor. Immunofluorescence analysis of human peripheral blood leukocytes demonstrated that mature granulocytes except eosinophils express both types of IL-8 receptors. A majority of monocytes and CD16+ natural killer (NK) cells in peripheral blood were stained with both antibodies, whereas CD3+ T or CD20+ B lymphocytes in peripheral blood or CD34+ cells in cord blood were not stained with either antibody. These results suggest that both types of human IL-8 receptors were coordinately and selectively expressed in mature granulocytes, monocytes, and CD16+ NK cells.

journal_name

J Leukoc Biol

authors

Morohashi H,Miyawaki T,Nomura H,Kuno K,Murakami S,Matsushima K,Mukaida N

doi

10.1002/jlb.57.1.180

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

180-7

issue

1

eissn

0741-5400

issn

1938-3673

journal_volume

57

pub_type

杂志文章
  • Intravital imaging of eosinophils: Unwrapping the enigma.

    abstract::Eosinophils are traditionally associated with allergic and parasitic inflammation. More recently, eosinophils have also been shown to have roles in diverse processes including development, intestinal health, thymic selection, and B-cell survival with the majority of these insights being derived from murine models and ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.3HR0220-396R

    authors: Nguyen WNT,Jacobsen EA,Finney CAM,Colarusso P,Patel KD

    更新日期:2020-07-01 00:00:00

  • MERTK as negative regulator of human T cell activation.

    abstract::The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0714-334R

    authors: Cabezón R,Carrera-Silva EA,Flórez-Grau G,Errasti AE,Calderón-Gómez E,Lozano JJ,España C,Ricart E,Panés J,Rothlin CV,Benítez-Ribas D

    更新日期:2015-04-01 00:00:00

  • Cellular metabolism of myeloid cells in sepsis.

    abstract::In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial defenses (also described as immune tolerance o...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.4MR0216-066R

    authors: Arts RJ,Gresnigt MS,Joosten LA,Netea MG

    更新日期:2017-01-01 00:00:00

  • Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions.

    abstract::We have shown previously that homotypic interaction of resting memory CD4 T cells with activated T cells induces the production of cytokines with immunoregulatory potential (IL-10, IL-4) from the former. Here, we analyzed the effector functions of these T cells stimulated by homotypic T cell interaction. T cells induc...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0310122

    authors: Thümmler K,Leipe J,Ramming A,Schulze-Koops H,Skapenko A

    更新日期:2010-11-01 00:00:00

  • Culture of ovine bone marrow-derived macrophages and evidence for serum factors distinct from M-CSF contributing to their propagation in vitro.

    abstract::An in vitro system allowing the culture of ovine bone marrow-derived macrophages (BMMs) is described. Bone marrow (BM) cells from the sternum of 4- to 9-month-old sheep were cultured in liquid suspension in hydrophobic bags with medium containing 20% autologous serum and 20% fetal calf serum (FCS). Cells with macropha...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.51.6.525

    authors: Francey T,Jungi TW,Rey O,Peterhans E

    更新日期:1992-06-01 00:00:00

  • Induction of macrophage growth by effete cells.

    abstract::When mouse peritoneal cells in early phase-inflammatory exudates were cultured in vitro, the number of polymorphonuclear leukocytes (PMNs) rapidly decreased, whereas the number of macrophages gradually increased during culture. Macrophage growth was also induced by addition of effete PMNs or their debris to macrophage...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.39.5.489

    authors: Yui S,Yamazaki M

    更新日期:1986-05-01 00:00:00

  • Monitoring of neutrophil priming in whole blood by antibodies isolated from a synthetic phage antibody library.

    abstract::Neutrophil activation is a multistep process. In vitro activation of neutrophils with semiphysiological activators is optimal only after preactivation or priming with cytokines, chemotaxins, and/or bacterial products. Until now, no antibodies have been developed that can distinguish between resting and (cytokine) prim...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Koenderman L,Kanters D,Maesen B,Raaijmakers J,Lammers JW,de Kruif J,Logtenberg T

    更新日期:2000-07-01 00:00:00

  • MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation.

    abstract::As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor beta (TGF-beta) superfamily designated macrophage inhibitory cytokine 1 (MIC-1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.65.1.2

    authors: Fairlie WD,Moore AG,Bauskin AR,Russell PK,Zhang HP,Breit SN

    更新日期:1999-01-01 00:00:00

  • Protein kinase C agonists enhance phagocytosis of P. aeruginosa by murine alveolar macrophages.

    abstract::Pulmonary alveolar macrophages (AMphis) are incompetent to phagocytose unopsonized Pseudomonas aeruginosa, but ingestion by other macrophage phenotypes (i.e., peritoneal macrophages) occurs efficiently. The purpose of this study was to explore factors that might control such phenotypic differences. Our laboratory has ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Heale JP,Speert DP

    更新日期:2001-01-01 00:00:00

  • Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines.

    abstract::Human activated T cells adhere to synovial fibroblast-like cells in vitro. The present study was conducted to investigate the consequences of T cell-synovial fibroblast interactions with regard to induction of adhesion molecules and proinflammatory cytokines. A sensitive Western blot technique, polymerase chain reacti...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.54.5.399

    authors: Bombara MP,Webb DL,Conrad P,Marlor CW,Sarr T,Ranges GE,Aune TM,Greve JM,Blue ML

    更新日期:1993-11-01 00:00:00

  • No detectable NO synthesis from L-arginine or N(G)-hydroxy-L-arginine in fMLP-stimulated human blood neutrophils despite production of nitrite, nitrate, and citrulline from N(G)-hydroxy-L-arginine.

    abstract::Nitric oxide (NO) is a well-documented effector molecule in rodent phagocytes but its synthesis in human neutrophils has been controversial. In this study, NO production in human neutrophils activated by chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) was measured in the presence of L-arginine (L-Ar...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.66.1.127

    authors: Holm P,Kankaanranta H,Oja SS,Knowles RG,Moilanen E

    更新日期:1999-07-01 00:00:00

  • Stimulus-specific regulation of chemokine expression involves differential activation of the redox-responsive transcription factors AP-1 and NF-kappaB.

    abstract::The promoters of the IL-8, MCP-1, and RANTES genes contain binding sites for the redox-responsive transcription factors AP-1 and NF-kappaB, which have been shown to be important for their expression. In this overview, we present evidence from our laboratories that the stimulus-specific regulation of these chemokines b...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.65.3.291

    authors: Roebuck KA,Carpenter LR,Lakshminarayanan V,Page SM,Moy JN,Thomas LL

    更新日期:1999-03-01 00:00:00

  • Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor.

    abstract::ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer metastasis. The present studies now show that ADAM23 expression on DCs p...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.2HI1115-525R

    authors: Elizondo DM,Andargie TE,Marshall KM,Zariwala AM,Lipscomb MW

    更新日期:2016-11-01 00:00:00

  • C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue.

    abstract::C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the m...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJ

    更新日期:2001-11-01 00:00:00

  • The significance of carbohydrates on G-CSF: differential sensitivity of G-CSFs to human neutrophil elastase degradation.

    abstract::It has been reported recently that granulocyte-colony stimulating factor (G-CSF) is degraded upon exposure to human neutrophil elastase (HNE), and this has a negative effect on the ability of the cytokine to promote the in vitro proliferation and maturation of CD34+ cells. This has important implications on the possib...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0803378

    authors: Carter CR,Whitmore KM,Thorpe R

    更新日期:2004-03-01 00:00:00

  • ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis.

    abstract::ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory sti...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/JLB.2MR0220-549R

    authors: Bui TM,Wiesolek HL,Sumagin R

    更新日期:2020-09-01 00:00:00

  • Macrophage-elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88-dependent TNF-α production.

    abstract::Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.04111185

    authors: Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

    更新日期:2012-02-01 00:00:00

  • Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation.

    abstract::CD163 is a member of the group B scavenger receptor cysteine-rich (SRCR) superfamily. This study describes aspects of the tissue distribution, the regulation of expression, and signal transduction after cross-linking of this receptor at the cell surface of macrophages. CD163 showed an exclusive expression on resident ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.66.5.858

    authors: Van den Heuvel MM,Tensen CP,van As JH,Van den Berg TK,Fluitsma DM,Dijkstra CD,Döpp EA,Droste A,Van Gaalen FA,Sorg C,Högger P,Beelen RH

    更新日期:1999-11-01 00:00:00

  • GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells.

    abstract::During B-cell differentiation, the gene expression of B-cell differentiation-related transcription factors must be strictly controlled by epigenetic mechanisms including histone acetylation and deacetylation, to complete the differentiation pathway. GCN5, one of the most important histone acetyltransferases, is involv...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0413232

    authors: Kikuchi H,Nakayama M,Kuribayashi F,Imajoh-Ohmi S,Nishitoh H,Takami Y,Nakayama T

    更新日期:2014-03-01 00:00:00

  • Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells.

    abstract::We show that interleukin-18 is constitutively produced by dendritic cells; synthesis and secretion are poorly affected by maturative stimuli. Challenge of dendritic cells with autologous anti-tetanus toxoid T lymphocytes results in a secretory switch, with induction of secretion of biologically active interleukin-18 a...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Gardella S,Andrei C,Costigliolo S,Poggi A,Zocchi MR,Rubartelli A

    更新日期:1999-08-01 00:00:00

  • Nitric oxide (.NO)-induced mitochondrial injury among chicken .NO-generating and target leukocytes.

    abstract::In an analysis of nitric oxide (.NO) production and toxicity, chicken macrophage-generated .NO inhibited mitochondrial activity in both .NO-producing macrophages themselves and lymphoid tumor targets. However, differences in targeting of mitochondrial toxicity were observed among these cells. Two chicken macrophage ce...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.56.1.52

    authors: Sung YJ,Dietert RR

    更新日期:1994-07-01 00:00:00

  • Chemokine decoy receptor D6 mimicking trap (D6MT) prevents allosensitization and immune rejection in murine corneal allograft model.

    abstract::Although corneal allotransplantation is performed in the immune-privileged cornea, many grafts are still rejected after transplantation. This study examined the role of chemokine receptor D6 expression in a corneal allograft rejection, investigated the modulation of D6 expression in cells, and determined the effect of...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.5A0414-233RR

    authors: Choi W,Byun YJ,Jung E,Noh H,Hajrasouliha AR,Sadrai Z,Chang E,Lee JH,Lee HK

    更新日期:2015-02-01 00:00:00

  • Effect of lidocaine on production of migration inhibitory factor and on macrophage motility: in vitro exposure of guinea pig lymphocytes and macrophages.

    abstract::Exposure of lymphocytes from guinea pigs sensitized to keyhole limpet hemocyanin and of macrophages from nonsensitized animals to noncytotoxic doses of lidocaine (10(-4) to 10(-6) M) resulted in the inhibition of the production of macrophage migration inhibitory factor and of macrophage motility. The inhibition of bot...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.36.5.621

    authors: Dickstein RA,Kiremidjian-Schumacher L,Stotzky G

    更新日期:1984-11-01 00:00:00

  • Trogocytic CD137 transfer causes an internalization of CD137 ligand on murine APCs leading to reduced T cell costimulation.

    abstract::CD137 ligand (CD137L) is expressed on APCs and crosslinks CD137, a powerful costimulatory molecule on T cells during cognate interactions, and thereby greatly enhances immune responses. We report that CD137 can be transferred from activated T cells and from tumor cells that express CD137 to other cells via trogocytosi...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0213-079RRR

    authors: Shao Z,Harfuddin Z,Pang WL,Nickles E,Koh LK,Schwarz H

    更新日期:2015-05-01 00:00:00

  • Prostaglandin E2 and thromboxane B2 release from human monocytes treated with bacterial lipopolysaccharide.

    abstract::We investigated the capacity of counterflow-isolated human monocytes to independently synthesize thromboxane B2 (TxB2) and prostaglandin E2 (PGE2) when stimulated with bacterial lipopolysaccharide (LPS). Independent metabolism was confirmed by establishing different specific activities (dpm/ng) of TxB2 and PGE2 releas...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.44.5.376

    authors: Nichols FC,Garrison SW,Davis HW

    更新日期:1988-11-01 00:00:00

  • Transcriptional profiling of human monocytes reveals complex changes in the expression pattern of inflammation-related genes in response to the annexin A1-derived peptide Ac1-25.

    abstract::Annexin A1 is a glucocorticoid-regulated, anti-inflammatory protein, which plays an important role as an endogenous regulator of the inflammatory response. Many of these anti-inflammatory properties are retained in the N-terminal annexin A1 peptide Ac1-25, which is released from the full-length protein by a neutrophil...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0307158

    authors: Lange C,Starrett DJ,Goetsch J,Gerke V,Rescher U

    更新日期:2007-12-01 00:00:00

  • Potential role of cyclophilin A in regulating cytokine secretion.

    abstract::Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface vi...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.3RU0317-090RR

    authors: Dawar FU,Xiong Y,Khattak MNK,Li J,Lin L,Mei J

    更新日期:2017-10-01 00:00:00

  • Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.

    abstract::Life stress is a major risk factor in the onset and exacerbation of mast cell-associated diseases, including allergy/anaphylaxis, asthma, and irritable bowel syndrome. Although it is known that mast cells are highly activated upon stressful events, the mechanisms by which stress modulates mast cell function and diseas...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.2HI0317-088RR

    authors: Ayyadurai S,Gibson AJ,D'Costa S,Overman EL,Sommerville LJ,Poopal AC,Mackey E,Li Y,Moeser AJ

    更新日期:2017-12-01 00:00:00

  • Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.

    abstract::Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down-regulation of TLR4 activation-driven immune responses in mice, i.t.-treated with LPS, using the specific Mer-blocking antibody. At 4 h and 24 h after LPS tre...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0611289

    authors: Lee YJ,Han JY,Byun J,Park HJ,Park EM,Chong YH,Cho MS,Kang JL

    更新日期:2012-06-01 00:00:00

  • The bone marrow: a site of neutrophil clearance.

    abstract::Neutrophils, an essential component of the innate immune system, are produced at a rate 10(11) cells/day and are consequently the most abundant leukocyte in the blood. These granulocytes have a relatively short half-life (6-8 h) in the blood, and as a result of the cytotoxic nature of their contents, it is critical th...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.0210112

    authors: Rankin SM

    更新日期:2010-08-01 00:00:00