Activation of deoxycholic acid by the lipid peroxy radical and its covalent binding to nucleic acids.

Abstract:

:Deoxycholic acid, a colon tumor promoter, was found to bind covalently to DNA and RNA in the presence of methyl linoleate hydroperoxide and ferrous ion. This binding was shown to occur specifically with guanine residues and its covalent nature was demonstrated by analysis of hydrolysates of nucleic acid adducts. These findings are discussed in connection with the increased risk of colon cancer associated with a high fat and meat diet.

journal_name

Arch Biochem Biophys

authors

Kodama M,Inoue F,Nakayama T,Nagata C

doi

10.1016/0003-9861(87)90379-1

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

574-8

issue

2

eissn

0003-9861

issn

1096-0384

pii

0003-9861(87)90379-1

journal_volume

258

pub_type

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