Fungal endophthalmitis associated with compounded products.

Abstract:

:Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck's Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products.

journal_name

Emerg Infect Dis

authors

Mikosz CA,Smith RM,Kim M,Tyson C,Lee EH,Adams E,Straif-Bourgeois S,Sowadsky R,Arroyo S,Grant-Greene Y,Duran J,Vasquez Y,Robinson BF,Harris JR,Lockhart SR,Török TJ,Mascola L,Park BJ,Fungal Endophthalmitis Outbreak Resp

doi

10.3201/eid2002.131257

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

248-56

issue

2

eissn

1080-6040

issn

1080-6059

journal_volume

20

pub_type

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