Abstract:
:Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck's Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Mikosz CA,Smith RM,Kim M,Tyson C,Lee EH,Adams E,Straif-Bourgeois S,Sowadsky R,Arroyo S,Grant-Greene Y,Duran J,Vasquez Y,Robinson BF,Harris JR,Lockhart SR,Török TJ,Mascola L,Park BJ,Fungal Endophthalmitis Outbreak Respdoi
10.3201/eid2002.131257subject
Has Abstractpub_date
2014-02-01 00:00:00pages
248-56issue
2eissn
1080-6040issn
1080-6059journal_volume
20pub_type
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