Hepatic ALECT-2 amyloidosis causing portal hypertension and recurrent variceal bleeding: a case report and review of the literature.

Abstract:

OBJECTIVES:To examine laser microdissection and mass spectrometry (LMD-MS), which has emerged as a new tool to aid in typing amyloid proteins. RESULTS:ALECT-2 is a potential cause of hepatic amyloidosis best detected by LMD-MS. METHODS:One of the more recently reported proteins is ALECT-2 (leukocyte cell-derived chemotaxin 2) amyloid, found in renal specimens of Hispanic patients. Here we report the first case of hepatic ALECT-2 amyloidosis diagnosed by LMD-MS from a liver biopsy specimen of a 52-year-old Hispanic man and causing portal hypertension with recurrent esophageal variceal bleeding. CONCLUSIONS:ALECT-2 can cause amyloidosis in organs other than the kidneys. It should be strongly considered in Hispanic patients and in those with a globular pattern of amyloid deposition. The incidence of ALECT-2 amyloidosis is likely underreported.

journal_name

Am J Clin Pathol

authors

Damlaj M,Amre R,Wong P,How J

doi

10.1309/AJCPCLK54RKXTRDI

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

288-91

issue

2

eissn

0002-9173

issn

1943-7722

pii

141/2/288

journal_volume

141

pub_type

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