Therapeutic implications of the prostaglandin pathway in Alzheimer's disease.


:An important pathologic hallmark of Alzheimer's disease (AD) is neuroinflammation, a process characterized in AD by disproportionate activation of cells (microglia and astrocytes, primarily) of the non-specific innate immune system within the CNS. While inflammation itself is not intrinsically detrimental, a delicate balance of pro- and anti-inflammatory signals must be maintained to ensure that long-term exaggerated responses do not damage the brain over time. Non-steroidal anti-inflammatory drugs (NSAIDs) represent a broad class of powerful therapeutics that temper inflammation by inhibiting cyclooxygenase-mediated signaling pathways including prostaglandins, which are the principal mediators of CNS neuroinflammation. While historically used to treat discrete or systemic inflammatory conditions, epidemiologic evidence suggests that protracted NSAID use may delay AD onset, as well as decrease disease severity and rate of progression. Unfortunately, clinical trials with NSAIDs have thus far yielded disappointing results, including premature discontinuation of a large-scale prevention trial due to unexpected cardiovascular side effects. Here we review the literature and make the argument that more targeted exploitation of downstream prostaglandin signaling pathways may offer significant therapeutic benefits for AD while minimizing adverse side effects. Directed strategies such as these may ultimately help to delay the deleterious consequences of brain aging and might someday lead to new therapies for AD and other chronic neurodegenerative diseases.


Biochem Pharmacol


Biochemical pharmacology


Cudaback E,Jorstad NL,Yang Y,Montine TJ,Keene CD




Has Abstract


2014-04-15 00:00:00














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    abstract::Cannabis and cannabinoids are known to affect female reproduction. However, the role of the endocannabinoid system in mouse uterine contractility in the dioestrus and oestrus phases has not been previously investigated. The present study aimed at filling this gap. Endocannabinoid (anandamide and 2-arachidonoylglycerol...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Pagano E,Orlando P,Finizio S,Rossi A,Buono L,Iannotti FA,Piscitelli F,Izzo AA,Di Marzo V,Borrelli F

    更新日期:2017-01-15 00:00:00

  • Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine.

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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Nirthanan S

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  • Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101, a multi-acting inhibitor of histone deacetylase, epidermal growth factor receptor and human epidermal growth factor receptor 2.

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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Mostafa MH,El-Sewedy SM,El-Bassiouni EA,Abdel-Tawab GA

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    更新日期:1985-05-01 00:00:00