Heterotrimeric G proteins involved in the modulation of voltage-dependent calcium channels of neuroendocrine cells.

Abstract:

:Various mechanisms have been identified by which hormones and neurotransmitters, interacting with heptahelical receptors, modulate the intracellular Ca2+ concentration in neuronal, endocrine, and neuroendocrine cells. All of them involve heterotrimeric G proteins. Best documented are hormonal stimulations and inhibitions of voltage-dependent Ca2+ channels. Stimulation is caused by agonists interacting with receptors known to induce phosphatidylinositol 4,5-bisphosphate hydrolysis, that is, a PI response. Although the PI response triggers a transient secretion by fast Ca2+ release, the stimulation of Ca2+ channels is assumed to be responsible for prolonged cell responses and for refilling of IP3-sensitive Ca2+ pools after repeated stimulations. Using antisense oligonucleotide microinjection in rat pituitary GH3 cells, Gi2 has been identified as the pertussis toxin-sensitive G protein stimulating Ca2+ channels, whereas Gq/G11 are involved in the concurrent PI response with subsequent protein kinase C activation, which is required for Ca2+ channel stimulation. Inhibitory modulations of Ca2+ channels are assumed to be the basis of inhibitions of transmitter or hormone secretion. Experiments in GH3 cells have revealed that Go subforms composed of alpha o1 x beta 3 x gamma 4 and alpha o2 x beta 1 x gamma 3 are the active G-protein heterotrimers transferring inhibitory signals from muscarinic M4 and somatostatin receptors to the Ca2+ channel, respectively.

journal_name

Ann N Y Acad Sci

authors

Hescheler J,Schultz G

doi

10.1111/j.1749-6632.1994.tb17280.x

subject

Has Abstract

pub_date

1994-09-15 00:00:00

pages

306-12

eissn

0077-8923

issn

1749-6632

journal_volume

733

pub_type

杂志文章,评审
  • The relationship between surface charge (potential characteristics) of the vascular interface and thrombosis.

    abstract::Thus, it can be shown that highly theoretical experiments carried out to evaluate the electrochemistry of thrombosis can also be shown to have significance in the generation of new products, which relates the scientific findings to successful modern prosthesis and medically useful devices. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1983.tb35212.x

    authors: Sawyer PN

    更新日期:1983-01-01 00:00:00

  • Homing of long-term and short-term engrafting cells in vivo.

    abstract::Long-term repopulating hematopoietic stem cells can be separated from cells which provided radioprotection (short-term repopulating cells) on the basis of size. This might be a result of the quiescent nature of long-term repopulating cells. To define the activity of these populations we utilized a dye, PKH26, which in...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08452.x

    authors: Lanzkron SM,Collector MI,Sharkis SJ

    更新日期:1999-04-30 00:00:00

  • Beyond heart rate variability: vagal regulation of allostatic systems.

    abstract::The autonomic nervous system (ANS) plays a role in a wide range of somatic and mental diseases. Whereas the role of the ANS in the regulation of the cardiovascular system seems evident, its role in the regulation of other systems associated with allostasis is less clear. Using a model of neurovisceral integration we d...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1366.014

    authors: Thayer JF,Sternberg E

    更新日期:2006-11-01 00:00:00

  • Hepatic metabolism and carcinogenesis. Its role in hepatoma and adenocarcinoma.

    abstract::The effect of carcinogenesis on various hepatic microsomal parameters and related cell functions was studied in two tumor models. Hepatocarcinoma was produced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) (Solt-Farber model) and mammary adenocarcinoma using R3230 AC cancer cell line. In these models th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1988.tb30145.x

    authors: Feuer G

    更新日期:1988-01-01 00:00:00

  • Advances in lupus and Sjögren's syndrome: a tribute to Josep Font.

    abstract::Dr. Josep Font (Barcelona, 1953-2006) devoted his professional career to the care of patients with systemic autoimmune diseases (SAD). In 1995, he created the Department of Autoimmune Diseases at the Hospital Clinic in Barcelona, a pioneering unit in Europe specifically dedicated to the clinical management of these pa...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 传,历史文章,杂志文章,评审

    doi:10.1196/annals.1422.006

    authors: Ramos-Casals M,Khamashta MA

    更新日期:2007-06-01 00:00:00

  • Balance before reason in rats and humans.

    abstract::Considerable clinical and experimental evidence indicates that loss of vestibular function results in cognitive deficits, especially deficits in spatial memory. These studies demonstrate the importance of balance for the most fundamental of cognitive processes and suggest that information about head acceleration and o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03726.x

    authors: Smith PF,Brandt T,Strupp M,Darlington CL,Zheng Y

    更新日期:2009-05-01 00:00:00

  • Statins and neuroprotection: a prescription to move the field forward.

    abstract::There is growing interest in the use of statins, HMG-CoA reductase inhibitors, for treating specific neurodegenerative diseases (e.g., cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis) and possibly traumatic brain injury. Neither is there a consensus on the efficacy of statins in t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05359.x

    authors: Wood WG,Eckert GP,Igbavboa U,Müller WE

    更新日期:2010-06-01 00:00:00

  • Autoregulation of the immune response in autoimmune disease and cardiac transplantation by photoinactivated autologous lymphocytes.

    abstract::These studies demonstrate that photochemotherapy can be successfully evaluated in animal models. The therapy mediates specific suppression of immune responses and appears to operate at the level of the effector T cells. Future studies will focus on isolation and characterization of the host response to photochemothera...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb33457.x

    authors: Berger CL,Edelson RL,Edwards N,Sanchez J,Coppey L,He X,Marboe C,Rose E

    更新日期:1991-12-30 00:00:00

  • Binocular coordination in fore/aft motion.

    abstract::Stabilization of images on the fovea during either fore/aft translation of a subject or fore/aft movement of a visual target in front of a stationary observer imposes complex geometrical requirements that depend upon the eccentricity of the object of interest with respect to the eyes. Each eye needs to be rotated inde...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.005

    authors: Ramat S,Zee DS

    更新日期:2005-04-01 00:00:00

  • Dispersion and surface characteristics of nanosilica suspensions.

    abstract::Nanofluids consisting of nanometer-sized particles dispersed in base liquids are known to be effective in extending the saturated boiling regime and critical heat flux in pool boiling. The heat transfer characteristics of nanosilica suspensions with particle sizes of 10 and 20 nm in pool boiling with a suspended heati...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.04334.x

    authors: Kumar R,Milanova D

    更新日期:2009-04-01 00:00:00

  • Discovery of ligands for the nuclear peroxisome proliferator-activated receptors.

    abstract::The identification of high-affinity ligands for PPAR gamma has revealed the role of this receptor as the molecular target for the antidiabetic activity of the thiazolidinediones. The surprising observation that agonists of an adipogenic transcription factor reverse the obesity-associated disease of diabetes highlights...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb18622.x

    authors: Willson TM,Lehmann JM,Kliewer SA

    更新日期:1996-12-27 00:00:00

  • Interleukin-6-type cytokine-induced changes in acute phase protein glycosylation.

    abstract::The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb32336.x

    authors: Van Dijk W,Mackiewicz A

    更新日期:1995-07-21 00:00:00

  • Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.

    abstract::Consumers of marijuana typically feel a strong, compulsive desire to consume food. Although past research revealed that the CB1 cannabinoid receptor is a potent regulator of food intake, the functional presence of neuronal CB2 cannabinoid receptors in the brain has been controversial. The role of CB2 receptors in food...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1432.035

    authors: Onaivi ES,Carpio O,Ishiguro H,Schanz N,Uhl GR,Benno R

    更新日期:2008-10-01 00:00:00

  • Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy.

    abstract::Despite the documented association between apolipoprotein E genotype and cerebral amyloid angiopathy (CAA), a substantial proportion of CAA-related hemorrhages occur in patients without known risks for this disorder. Two other factors implicated in the pathogenesis of CAA are the amyloid-beta peptide (preferentially d...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06361.x

    authors: Greenberg SM,Cho HS,O'Donnell HC,Rosand J,Segal AZ,Younkin LH,Younkin SG,Rebeck GW

    更新日期:2000-04-01 00:00:00

  • Quantification of total IgM and IgG and specific IgM and IgG to a thymus-independent (LPS) and a thymus-dependent (tetanus toxoid) antigen in the rat by enzyme-linked immunosorbent assay (ELISA).

    abstract::Rat IgM and IgG was determined by mechanized "sandwich" enzyme-linked immunosorbent assay (ELISA) using peroxidase labeled anti-rat-IgM and -IgG. Linear ranges in standard curves of a reference rat serum had a slope similar to the slopes found with sera of 25 rats of various age. IgM and IgG measurements by ELISA in t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:

    authors: Vos JG,Buys J,Beekhof P,Hagenaars AM

    更新日期:1979-05-31 00:00:00

  • Phenotypic flexibility of skeletal muscles during long-distance migration of garden warblers: muscle changes are differentially related to body mass.

    abstract::Mass changes of skeletal muscles occur in a variety of species during the migratory period. Phenotypic flexibility of flight muscle mass is considered to represent adaptations of the flight muscle to changing power requirements associated with changes in body mass. We analyzed the relationship between muscle masses an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1343.025

    authors: Bauchinger U,Biebach H

    更新日期:2005-06-01 00:00:00

  • Confronting mortality: faith and meaning across cultures.

    abstract::Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.12474

    authors: Paulson S,Kellehear A,Kripal JJ,Leary L

    更新日期:2014-11-01 00:00:00

  • Prospects for single-molecule information-processing devices for the next paradigm.

    abstract::Present information technologies use semiconductor devices and magnetic/optical disks; however, they are all foreseen to face fundamental limitations within a decade. Therefore, superceding devices are required for the next paradigm of high-performance information technologies. The paper first describes architectures ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb03024.x

    authors: Wada Y

    更新日期:2002-04-01 00:00:00

  • Negative regulation of placental fibronectin expression by glucocorticoids and cyclic adenosine 3',5'-monophosphate.

    abstract::Fibronectin is a ubiquitous extracellular matrix (ECM) protein known to play a critical role in cell adhesion. In the present study we dissected the effects of glucocorticoids and cyclic adenosine 3',5'-monophosphate (cAMP) on FN expression in cultures of cytotrophoblasts isolated from human term placentas to identify...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb21741.x

    authors: Guller S,Wozniak R,Leibman MI,Lockwood CJ

    更新日期:1994-09-30 00:00:00

  • Clinical correlates of 24-h cortisol and norepinephrine excretion among subjects seeking treatment following the world trade center attacks on 9/11.

    abstract:UNLABELLED:Whereas trauma-associated arousal has been linked fairly consistently with elevations in both glucocorticoids and catecholamines, neuroendocrine correlates of hyperarousal in the context of posttraumatic stress disorder (PTSD) have been more variable. Further, neuroendocrine predictors of the development of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1364.055

    authors: Bierer LM,Tischler L,Labinsky E,Cahill S,Foa E,Yehuda R

    更新日期:2006-07-01 00:00:00

  • Genes, cognition, and communication: insights from neurodevelopmental disorders.

    abstract::Twin and family studies have demonstrated that most cognitive traits are moderately to highly heritable. Neurodevelopmental disorders such as dyslexia, autism, and specific language impairment (SLI) also show strong genetic influence. Nevertheless, it has proved difficult for researchers to identify genes that would e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04419.x

    authors: Bishop DV

    更新日期:2009-03-01 00:00:00

  • Closing the gaps between genotype and phenotype in Rickettsia rickettsii.

    abstract::Rocky Mountain spotted fever (RMSF) caused by Rickettsia rickettsii is a severe rickettsiosis that occurs in nearly every state of the continental USA. RMSF is endemic in Central and Southern America, with recent well-documented cases in Mexico, Costa Rica, Panama, Colombia, Brazil, and Argentina. RMSF is the most mal...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04526.x

    authors: Eremeeva ME,Dasch GA

    更新日期:2009-05-01 00:00:00

  • Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies.

    abstract::Tight junctions (TJs) regulate paracellular barriers and claudins (Cld) form the backbone of TJ strands. To elucidate the molecular mechanism of claudin polymer formation, TJs were reconstituted by claudin transfection of TJ-free HEK293 cells. Therewith, typical TJ stands can be found at cell-cell contacts. In additio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2012.06546.x

    authors: Rossa J,Lorenz D,Ringling M,Veshnyakova A,Piontek J

    更新日期:2012-06-01 00:00:00

  • Sequence patterns observed in 5' flanking regions of primate Alu elements.

    abstract::Retrotransposons have generally been known to integrate randomly into host genomes. Jurka, however, showed some consensus sequence patterns at insertion sites of some mammalian retrotransposons and proposed enzymatic involvement that mediates integration. Jurka used about 400 complete human Alu and rodent ID sequences...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08905.x

    authors: Toda Y,Saito R,Tomita M

    更新日期:1999-05-18 00:00:00

  • Effects of modified low-density lipoproteins on human retinal pericyte survival.

    abstract::According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heav...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1333.045

    authors: Song W,Barth JL,Lu K,Yu Y,Huang Y,Gittinger CK,Argraves WS,Lyons TJ

    更新日期:2005-06-01 00:00:00

  • Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis.

    abstract::Recent work in the field of atherosclerosis has greatly expanded our knowledge of the pathogenesis of this disease. Scavenger receptors, including CD36, are thought to be most important early in the disease progression during macrophage uptake of modified LDL and foam cell formation. Genetically engineered murine mode...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03944.x

    authors: Nicholson AC,Han J,Febbraio M,Silversterin RL,Hajjar DP

    更新日期:2001-12-01 00:00:00

  • Blood lipid peroxides and muscle damage increased following intensive resistance training of female weightlifters.

    abstract::The aim of this study was to examine changes in muscle cell injury and antioxidant capacity of weightlifters following a 1-week intensive resistance-training regimen. Thirty-six female subjects participated in this study, and their ages ranged from 18 to 25 years. The sample group included 19 elite weightlifters with ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1338.029

    authors: Liu JF,Chang WY,Chan KH,Tsai WY,Lin CL,Hsu MC

    更新日期:2005-05-01 00:00:00

  • Peripheral neuropathy caused by proteolipid protein gene mutations.

    abstract::Pelizaeus-Merzbacher disease (PMD) is a dysmyelinating disorder of the central nervous system typically caused by duplications or missense mutations of the proteolipid protein (PLP) gene. Most investigators have found that peripheral nerve function and structure is normal in PMD patients. We have found that null mutat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:

    authors: Garbern JY,Cambi F,Lewis R,Shy M,Sima A,Kraft G,Vallat JM,Bosch EP,Hodes ME,Dlouhy S,Raskind W,Bird T,Macklin W,Kamholz J

    更新日期:1999-09-14 00:00:00

  • Development of a hybrid liver support system.

    abstract::Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03843.x

    authors: Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

    更新日期:2001-11-01 00:00:00

  • The neuropeptide alpha-MSH in HIV infection and other disorders in humans.

    abstract::We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09622.x

    authors: Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

    更新日期:1998-05-01 00:00:00