Effects of tetracycline-containing gel and a mixture of tetracycline and citric acid-containing gel on non-surgical periodontal therapy.

Abstract:

:The purpose of this study was to assess the clinical and microbiological effects of a newly developed root conditioning gel system containing tetracycline or a mixture of tetracycline and citric acid on non-surgical periodontal therapy. Sixty-four (64) single-rooted teeth with a probing depth of 4 to 6 mm were randomly subjected to one of the following four treatments; 1) root planing alone (RP group); 2) tetracycline-containing gel alone (TCG group); 3) root planing plus tetracycline-containing gel (RP + TCG group); or 4) root planing plus a mixture of tetracycline and citric acid-containing gel (RP + TC-CAG group). Probing depth, attachment level, and tooth mobility were measured and the presence of dental plaque and gingival inflammation was recorded at baseline and after 2, 4, 8, and 12 weeks. Subgingival plaque samples from each site were collected at the same visits and examined with phase contrast microscopy for proportions of motile rods and spirochetes. Plaque index, gingival sulcus bleeding index (SBI), probing depth, and attachment level decreased significantly in all groups compared to the baseline values (P < 0.05). A significant decrease in probing pocket depth was noted after 12 weeks in RP + TC-CAG group compared to the other groups (P < 0.05). Significantly more gain in attachment was detected in the RP + TC-CAG group compared to the TCG group (P < 0.05). Tooth mobility scores also decreased later in the study. A significant decrease in the proportion of motile rods was found primarily in the RP + TC-CAG group.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Periodontol

authors

Jeong SN,Han SB,Lee SW,Magnusson I

doi

10.1902/jop.1994.65.9.840

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

840-7

issue

9

eissn

0022-3492

issn

1943-3670

journal_volume

65

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:BACKGROUND:There are no specific bacterial profiles or diagnostic tests capable of identifying refractory periodontitis patients before a treatment regimen is initiated. Therefore, in this high-risk cohort of patients who do not respond appropriately, host factors that might be partly under genetic control may play a c...

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    pub_type: 杂志文章

    doi:10.1902/jop.2006.050254

    authors: Kim DM,Ramoni MF,Nevins M,Fiorellini JP

    更新日期:2006-06-01 00:00:00

  • Efficacy of acellular dermal matrix and coronally advanced flaps for the treatment of induced gingival recession defects: a histomorphometric study in dogs.

    abstract:BACKGROUND:Gingival recession (GR) defects can be treated by various methods, including acellular dermal matrix (ADM) or coronally advanced flaps (CAFs). The aim of this histomorphometric experiment is to compare the efficacy of ADM and CAF for treating GR defects in dogs. METHODS:In eight beagle dogs, a critical-size...

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    pub_type: 杂志文章

    doi:10.1902/jop.2012.120380

    authors: Al-Hezaimi K,Rudek I,Al-Hamdan KS,Javed F,Iezzi G,Piattelli A,Wang HL

    更新日期:2013-08-01 00:00:00

  • The long-term effectiveness of periodontal therapy in a clinical practice.

    abstract::A retrospective study was conducted of 620 patients in a periodontal practice over the years 1960 to 1982. Various periodontal therapies were assessed by using careful office protocols, meticulous record-keeping and well-defined outcome criteria. Four treatment outcome categories were used: two representing satisfacto...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.5.253

    authors: Meador HL,Lane JJ,Suddick RP

    更新日期:1985-05-01 00:00:00

  • Boric acid irrigation as an adjunct to mechanical periodontal therapy in patients with chronic periodontitis: a randomized clinical trial.

    abstract:BACKGROUND:The purpose of this single-masked, randomized, controlled clinical trial was to evaluate the effects of boric acid irrigation as an adjunct to scaling and root planing (SRP) on clinical and microbiologic parameters and compare this method with chlorhexidine irrigation and SRP alone in patients with chronic p...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2012.120467

    authors: Sağlam M,Arslan U,Buket Bozkurt Ş,Hakki SS

    更新日期:2013-09-01 00:00:00

  • A network meta-analysis of interproximal oral hygiene methods in the reduction of clinical indices of inflammation.

    abstract:BACKGROUND:A wide selection of Interdental Oral Hygiene (IOH) aids is available to consumers. Recommendations for selection are, however, limited by the lack of direct comparisons in available studies. We aimed to assess the comparative efficacy of IOH aids using Bayesian Network Meta-Analysis (BNMA). METHODS:Two inde...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/JPER.17-0368

    authors: Kotsakis GA,Lian Q,Ioannou AL,Michalowicz BS,John MT,Chu H

    更新日期:2018-05-01 00:00:00

  • Periodontal surgery for a patient with paroxysmal nocturnal hemoglobinuria.

    abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon blood stem cell disorder. The acquired defect is in the cell membrane of the precursor of the affected clone, which renders erythrocytes, platelets and granulocytes unusually sensitive to the hemolytic effects of complement. It is characterized by chronic hemoly...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.2.115

    authors: Cohen CI,Zimmerman DR

    更新日期:1988-02-01 00:00:00

  • Demineralization of the contacting surfaces in autologous onlay bone grafts improves bone formation and bone consolidation.

    abstract:BACKGROUND:Autologous bone grafts are usually well consolidated after 4 to 5 months but can be incompletely interlocked with the native bone. This study investigated the effect of acid demineralization of the graft-bed interface on graft consolidation. METHODS:Onlay bone grafts were performed on the calvaria of 36 gui...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.130298

    authors: Rezende ML,Consolaro A,Sant'Ana AC,Damante CA,Greghi SL,Passanezi E

    更新日期:2014-05-01 00:00:00

  • Immunohistochemical expression of extracellular matrix components of normal and healing periodontal tissues in the beagle dog.

    abstract::Periodontal regeneration requires formation of periodontal tissues lost due to periodontal disease. To better understand the formation of new periodontal tissues during periodontal repair and regeneration, immunohistochemical expression of extracellular matrix components of normal as well as healing periodontal tissue...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1995.66.7.579

    authors: Matsuura M,Herr Y,Han KY,Lin WL,Genco RJ,Cho MI

    更新日期:1995-07-01 00:00:00

  • Subgingival microflora of advanced periodontitis in the Dominican Republic.

    abstract::A study of the predominant subgingival microflora was carried out in 24 periodontitis patients, 18 to 60 years of age, in Santo Domingo, Dominican Republic. Paper point sampling, transport in VMGA III, and conventional microbiological techniques were utilized. Direct microscopic examination revealed that cocci and non...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1991.62.9.543

    authors: Slots J,Rams TE,Feik D,Taveras HD,Gillespie GM

    更新日期:1991-09-01 00:00:00

  • The effect of a supragingival plaque-control regimen on the subgingival microbiota in smokers and never-smokers: evaluation by real-time polymerase chain reaction.

    abstract:BACKGROUND:The aim of the present study was to evaluate the effect of strict supragingival plaque control on the subgingival microbiota in smokers and never-smokers. Research into the impact of supragingival plaque control on the number of subgingival bacteria has resulted in contradictory findings. Real-time polymeras...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2008.070558

    authors: Gomes SC,Nonnenmacher C,Susin C,Oppermann RV,Mutters R,Marcantonio RA

    更新日期:2008-12-01 00:00:00

  • A radiographic evaluation of bone healing around submerged and non-submerged dental implants in beagle dogs.

    abstract:BACKGROUND:The rehabilitation of the oral cavity with dental implants has become a predictable treatment modality. However, there have been only a few direct comparisons evaluating the submerged and nonsubmerged placement techniques. The purpose of this study was to characterize radiographic peri-implant bone changes f...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.3.248

    authors: Fiorellini JP,Buser D,Paquette DW,Williams RC,Haghighi D,Weber HP

    更新日期:1999-03-01 00:00:00

  • Suggested solutions for common problems in clinical periodontics.

    abstract::This short report offers solutions for three common clinical problems. Based on their experience, the authors suggest using a "spoon" type partial denture for the temporary replacement of maxillary anterior teeth. The denture is unique in that it has no clasps and does not contact the marginal gingiva. Also, conventio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.6.341

    authors: O'Leary TJ,Kepic TJ,Detamore RJ

    更新日期:1984-06-01 00:00:00

  • Early intervention of peri-implantitis and periodontitis using a mouse model.

    abstract:BACKGROUND:Peri-implantitis is an inflammatory response to bacterial biofilm resulting in bone loss and can ultimately lead to implant failure. Because of the lack of predictable treatments available, a thorough understanding of peri-implantitis's pathogenesis is essential. The objective of this study is to evaluate an...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.17-0541

    authors: Wong RL,Hiyari S,Yaghsezian A,Davar M,Casarin M,Lin YL,Tetradis S,Camargo PM,Pirih FQ

    更新日期:2018-06-01 00:00:00

  • A novel approach to the use of subgingival controlled-release chlorhexidine delivery in chronic periodontitis: a randomized clinical trial.

    abstract:BACKGROUND:We aimed to analyze clinical, microbiologic, and serologic effects of chlorhexidine (CHX) chips used as a subgingival controlled-release delivery device before and immediately after scaling and root planing (SRP). METHODS:Twenty-four patients presenting with ≥12 teeth with probing depth (PD) ≥5 mm and bleed...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2011.100287

    authors: Gonzales JR,Harnack L,Schmitt-Corsitto G,Boedeker RH,Chakraborty T,Domann E,Meyle J

    更新日期:2011-08-01 00:00:00

  • Collinin reduces Porphyromonas gingivalis growth and collagenase activity and inhibits the lipopolysaccharide-induced macrophage inflammatory response and osteoclast differentiation and function.

    abstract:BACKGROUND:Collinin is a secondary plant metabolite belonging to the class of geranyloxycoumarins. We explored the potential beneficial impact of collinin on periodontal health by investigating its effect on Porphyromonas gingivalis (P. gingivalis), lipopolysaccharide (LPS)-induced inflammatory response of macrophages,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.120118

    authors: Santos J,Marquis A,Epifano F,Genovese S,Curini M,Grenier D

    更新日期:2013-05-01 00:00:00

  • Comparative study of ultrasonic instrumentation for the non-surgical treatment of interproximal and non-interproximal furcation involvements.

    abstract:BACKGROUND:The aim of this clinical trial was to compare the outcome of non-surgical treatment of interproximal and non-interproximal Class II furcation involvements. METHODS:Thirty-eight patients presenting at least one Class II furcation involvement that bled on probing with a probing depth (PD) > or = 5 mm were rec...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2007.060312

    authors: Del Peloso Ribeiro E,Bittencourt S,Nociti FH Jr,Sallum EA,Sallum AW,Casati MZ

    更新日期:2007-02-01 00:00:00

  • Proximal caries in juvenile periodontitis patients.

    abstract:BACKGROUND:Caries is recognized as the prevalent proximal dental disease in adolescents, while proximal bone loss is minimal to non-existent in this population. Adolescents demonstrating an inverse disease pattern, i.e., minimal caries and active periodontitis, could provide powerful clues with regard to both diseases....

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.5.710

    authors: Sioson PB,Furgang D,Steinberg LM,Fine DH

    更新日期:2000-05-01 00:00:00

  • Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis.

    abstract:BACKGROUND:Bacterial constituents, such as Gram-negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host-derived inflammatory cytokines. The aim of this study was to establish a model of aggressive inflammatory alveolar bone loss in rats using LPS derived from the periodo...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060321

    authors: Rogers JE,Li F,Coatney DD,Rossa C,Bronson P,Krieder JM,Giannobile WV,Kirkwood KL

    更新日期:2007-03-01 00:00:00

  • Surgical crown lengthening: a 12-month clinical wound healing study.

    abstract:BACKGROUND:Surgical crown lengthening has been proposed as a means of facilitating restorative procedures and preventing periodontal injuries in teeth with structurally inadequate clinical crowns or exposing tooth structure in the presence of deep, subgingival pathologies which may hamper the access for proper restorat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.7.841

    authors: Pontoriero R,Carnevale G

    更新日期:2001-07-01 00:00:00

  • Enhancing effects of areca nut extracts on the production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells.

    abstract:BACKGROUND:The habit of chewing areca quid (AQ) has been implicated in oral pathogenesis, including periodontal disease. Little is understood about the roles of AQ in the cytokine secretion by immune cells. The study examined the effects of areca nut, the major ingredient of AQ, on the production of interleukin (IL)-6 ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.060039

    authors: Chang LY,Wan HC,Lai YL,Liu TY,Hung SL

    更新日期:2006-12-01 00:00:00

  • The presence of bacteria in the oral epithelium in periodontal disease. II. Immunohistochemical identification of bacteria.

    abstract::Serial histological sections of gingiva obtained from each of six advanced adult periodontitis, two localized juvenile periodontitis and two periodontally healthy patients were used for specific identification of bacteria within the oral epithelium and adjacent connective tissue. Healthy gingival biopsies served as co...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1986.57.8.492

    authors: Saglie FR,Smith CT,Newman MG,Carranza FA Jr,Pertuiset JH,Cheng L,Auil E,Nisengard RJ

    更新日期:1986-08-01 00:00:00

  • Gingival crevicular fluid matrix metalloproteinase-8 levels following adjunctive use of meloxicam and initial phase of periodontal therapy.

    abstract:BACKGROUND:The purpose of the present study was to assess the effects of adjunctive meloxicam on the matrix metalloproteinase-8 (MMP-8) levels of gingival crevicular fluid (GCF) in chronic periodontitis patients following the initial phase of periodontal therapy. METHODS:Twelve chronic periodontitis patients received ...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2002.73.1.103

    authors: Buduneli N,Vardar S,Atilla G,Sorsa T,Luoto H,Baylas H

    更新日期:2002-01-01 00:00:00

  • Enamel matrix protein adsorption to root surfaces in the presence or absence of human blood.

    abstract:BACKGROUND:The clinical use of an enamel matrix derivative (EMD) has been shown to promote formation of new cementum, periodontal ligament (PDL), and bone and to significantly enhance the clinical outcomes after regenerative periodontal surgery. It is currently unknown to what extent the bleeding during periodontal sur...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.110404

    authors: Miron RJ,Bosshardt DD,Laugisch O,Katsaros C,Buser D,Sculean A

    更新日期:2012-07-01 00:00:00

  • The role of IgE in the release of histamine from human gingival mast cells.

    abstract::Twelve gingival samples removed from 6 human volunteers were sectioned in small pieces, parts of which served as uncultured pieces. The remaining pieces were organ cultured for 5 hours in control, compound 48/80, and antihuman IgE media. Uncultured tissues, cultured tissues, and cultured spent media were analyzed spec...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1975.46.3.171

    authors: Schwartz J,Dibblee M

    更新日期:1975-03-01 00:00:00

  • Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone.

    abstract:BACKGROUND:Purified recombinant human platelet-derived growth factor BB (rhPDGF-BB) is a potent wound healing growth factor and stimulator of the proliferation and recruitment of both periodontal ligament (PDL) and bone cells. The hypothesis tested in this study was that application of rhPDGF-BB incorporated in bone al...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2003.74.9.1282

    authors: Nevins M,Camelo M,Nevins ML,Schenk RK,Lynch SE

    更新日期:2003-09-01 00:00:00

  • Parameter on "Refractory" Periodontitis.

    abstract::The American Academy of Periodontology has developed the following parameter on the treatment of "refractory" periodontitis. Patients should be informed of the disease process, therapeutic alternatives, potential complications, expected results, and their responsibility in treatment. Consequences of no treatment shoul...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.5-S.859

    authors:

    更新日期:2000-05-01 00:00:00

  • Healing of the oral mucosa with the use of collagen artificial skin.

    abstract::Wounds were prepared in the oral cavity of 15 rabbits and five dogs, and an enzyme-solubilized calfskin collagen was placed over the surgery sites on one side. The contralateral sides acted as controls. Results indicated that the membrane was biologically acceptable to the oral mucosa of rabbits and dogs. Th collagen ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1979.50.5.250

    authors: Levin MP,Tsaknis PJ,Cutright DE

    更新日期:1979-05-01 00:00:00

  • A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis.

    abstract:BACKGROUND:This review addresses the ability of a commercially available genetic susceptibility test to determine the risk of developing severe chronic periodontitis. The test is used to detect the simultaneous occurrence of allele 2 at the IL-1A+4845 and IL-1B+3954 loci. If both of these polymorphisms are present, pat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,meta分析

    doi:10.1902/jop.2002.73.2.231

    authors: Greenstein G,Hart TC

    更新日期:2002-02-01 00:00:00

  • Comparison of two differently processed acellular dermal matrix products for root coverage procedures: a prospective, randomized multicenter study.

    abstract:BACKGROUND:The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession defects. METHODS:Eig...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1902/jop.2014.140198

    authors: Wang HL,Romanos GE,Geurs NC,Sullivan A,Suárez-López Del Amo F,Eber RM

    更新日期:2014-12-01 00:00:00

  • The healing of gingival wounds in miniature swine.

    abstract::Standard wounds of simple incision and partial excision of the dentogingival junction were made in miniature swine. The healing from the 1st to the 14th day were described clinically and histologically, and the standardization of the wounds permitted quantitative and statistical analysis. In wounds that are closely ad...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1980.51.6.318

    authors: Wirthlin MR,Yeager JE,Hancock EB,Gaugler RW

    更新日期:1980-06-01 00:00:00