Biased cell migration of fibroblasts exhibiting contact guidance in oriented collagen gels.

abstract：:The combination of gene therapy and chemotherapy has showed increased therapeutic efficacy in the treatment of cancers, but it is not well investigated about the actual coordination pattern between therapeutic gene and chemical drug. In this work, p53/BPEI-β-CD/AD-dox complex was fabricated and employed to investigate...

journal_title：Annals of biomedical engineering

authors： Xie B,Peng J,Wang S,Zhang X,Nie H

更新日期：2016-11-01 00:00:00

abstract：:A progressive reduction in muscle fiber conduction velocity is typically observed during fatiguing muscle contraction. Although the exact causes of the conduction velocity decrease have not yet been fully established, increasing evidence suggests that changes in extracellular potassium concentration may be largely res...

journal_title：Annals of biomedical engineering

authors： Fortune E,Lowery MM

更新日期：2009-10-01 00:00:00

abstract：:For treatment of complex congenital heart disease, computer simulation using a three-dimensional heart model may help to improve outcomes by enabling detailed preoperative evaluations. However, no highly integrated model that accurately reproduces a patient's pathophysiology, which is required for this simulation has ...

journal_title：Annals of biomedical engineering

authors： Kariya T,Washio T,Okada JI,Nakagawa M,Watanabe M,Kadooka Y,Sano S,Nagai R,Sugiura S,Hisada T

更新日期：2020-06-01 00:00:00

abstract：:Dendritic cells (DCs) are crucial components of the immune response, strategically positioned as immune sentinels. Complex trafficking and accurate positioning of DCs are indispensable for both immunity and tolerance. This is particularly evident for their therapeutic application where an unmet clinical need exists fo...

journal_title：Annals of biomedical engineering

authors： Silva Z,Konstantopoulos K,Videira PA

更新日期：2012-04-01 00:00:00

abstract：:This paper reports the design, manufacturing, and characterization of a new bioreactor dedicated to the development of tissue-engineered heart valve substitutes. First, a comprehensive review of the state of the art in bioreactors is presented and a rigorous classification is put forward. The existing bioreactors foun...

journal_title：Annals of biomedical engineering

authors： Ruel J,Lachance G

更新日期：2009-04-01 00:00:00

abstract：:The most widely implanted prosthetic valve is the mechanical bileaflet. Recent clinical experiences suggest that some designs are more prone to thromboembolic episodes than others. This study evaluated the hinge flow and near-field forward flow of the new St. Jude Medical Regent bileaflet mechanical heart valve. Laser...

journal_title：Annals of biomedical engineering

authors： Ellis JT,Travis BR,Yoganathan AP

更新日期：2000-05-01 00:00:00

abstract：:Experimental and diagnostic procedures like distension of a balloon catheter, bougie, and esophagogastroduodenoscopy can induce shear deformation in the esophageal wall. However, the shear modulus of the esophagus is yet unknown. The aim of this study was to determine the esophageal shear modulus and its dependence on...

journal_title：Annals of biomedical engineering

authors： Yang J,Liao D,Zhao J,Gregersen H

更新日期：2004-09-01 00:00:00

abstract：:Our 3-D model for a junctional complex (JC) in the erythrocyte membrane skeleton proposed that the helical actin protofilament functions as a mechanical axis for three pairs of αβ spectrin (Sp), and each pair wraps around the protofilament in a back-to-back fashion. The distal end of each Sp is further associated with...

journal_title：Annals of biomedical engineering

authors： Sche P,Vera C,Sung LA

更新日期：2011-07-01 00:00:00

abstract：:Most non-invasive blood pressure measurements are based on either the auscultatory or the oscillometric technique. In this study, we performed an extensive analysis of the signals, i.e., responses of a microphone implanted in the cuff and pressure changes in the cuff, which can be recorded during such measurements. We...

journal_title：Annals of biomedical engineering

authors： Jazbinsek V,Luznik J,Mieke S,Trontelj Z

更新日期：2010-03-01 00:00:00

abstract：:This paper reviews the applications of accelerometers on the detection of physiological acoustic signals such as heart sounds, respiratory sounds, and gastrointestinal sounds. These acoustic signals contain a rich reservoir of vital physiological and pathological information. Accelerometer-based systems enable continu...

journal_title：Annals of biomedical engineering

authors： Hu Y,Kim EG,Cao G,Liu S,Xu Y

更新日期：2014-11-01 00:00:00

abstract：:Although diagnostic testing with auditory evoked potentials (EPs) has become routine, quantitative measurements of signal and noise are still lacking. In this study, current signal, power, noise power, and signal-to-noise ratio (SNR) estimation formulas are reviewed and applied to auditory brainstem response averaging...

journal_title：Annals of biomedical engineering

authors： Ozdamar O,Delgado RE

更新日期：1996-11-01 00:00:00

abstract：:Thorax injuries mainly due to rib fractures have been associated with high rates of morbidity and mortality in motor vehicle crashes. Thoracic biomechanics has been studied extensively, but there are no robust biomechanical response targets for ribs that consider age, sex, body size, and vulnerability factors. The obj...

journal_title：Annals of biomedical engineering

authors： Kang YS,Kwon HJ,Stammen J,Moorhouse K,Agnew AM

更新日期：2021-02-01 00:00:00

abstract：:Glaucoma is a common optic neuropathy characterized by retinal ganglion cell death. Elevated intraocular pressure (IOP), a key risk factor for glaucoma, leads to significant biomechanical deformation of optic nerve head (ONH) cells and tissues. ONH astrocytes respond to this deformation by transforming to a reactive, ...

journal_title：Annals of biomedical engineering

authors： Mulvihill JJE,Raykin J,Snider EJ,Schildmeyer LA,Zaman I,Platt MO,Kelly DJ,Ethier CR

更新日期：2018-02-01 00:00:00

abstract：:The field of percutaneous coronary intervention has witnessed many progressions over the last few decades, more recently with the advancement of fully degradable bioabsorbable stents. Bioabsorbable materials, such as metallic alloys and aliphatic polyesters, have the potential to yield stents which provide temporary s...

journal_title：Annals of biomedical engineering

authors： Boland EL,Shine R,Kelly N,Sweeney CA,McHugh PE

更新日期：2016-02-01 00:00:00

abstract：:Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) ...

journal_title：Annals of biomedical engineering

authors： Abubacker S,Dorosz SG,Ponjevic D,Jay GD,Matyas JR,Schmidt TA

更新日期：2016-04-01 00:00:00

abstract：:In this study, cell-material adhesive strength and cellular mechanical properties were measured using atomic force microscopy (AFM) to track cell attachment and osteogenic differentiation. First, chitosan substrates were treated with simulated body fluid (SBF) for various periods, resulting in substrates with differen...

journal_title：Annals of biomedical engineering

authors： Ho MH,Li CH,Hsiao SW,Thien DV

更新日期：2015-04-01 00:00:00

abstract：:This paper presents the bispectral analysis of the ontogeny of the hippocampal EEG recorded from the dentate gyrus and CA1, the primary sites that generate theta (theta) rhythm. The hippocampal EEG was collected during the vigilance state of rapid eye movement (REM) sleep of freely moving rats at 15, 30 and 90 days of...

journal_title：Annals of biomedical engineering

authors： Ning T,Bronzino JD

更新日期：1998-07-01 00:00:00

abstract：:The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation...

journal_title：Annals of biomedical engineering

authors： Whittingslow DC,Jeong HK,Ganti VG,Kirkpatrick NJ,Kogler GF,Inan OT

更新日期：2020-01-01 00:00:00

abstract：:The effect of hemodynamic shear stress on endothelial gene expression was investigated in the porcine iliac arteries. A novel statistical approach was applied to computational fluid dynamics simulations of the iliac artery flow field to identify three anatomical regions likely to experience high, medium, and low level...

journal_title：Annals of biomedical engineering

authors： LaMack JA,Himburg HA,Zhang J,Friedman MH

更新日期：2010-07-01 00:00:00

abstract：:High mechanical stress in atherosclerotic plaques at vulnerable sites, called critical stress, contributes to plaque rupture. The site of minimum fibrous cap (FC) thickness (FC(MIN)) and plaque shoulder are well-documented vulnerable sites. The inherent weakness of the FC material at the thinnest point increases the s...

journal_title：Annals of biomedical engineering

authors： Teng Z,Sadat U,Li Z,Huang X,Zhu C,Young VE,Graves MJ,Gillard JH

更新日期：2010-10-01 00:00:00

abstract：:An MR image-based computational model of a murine KHT sarcoma is presented that allows the calculation of plasma fluid and solute transport within tissue. Such image-based models of solid tumors may be used to optimize patient-specific therapies. This model incorporates heterogeneous vasculature and tissue porosity to...

journal_title：Annals of biomedical engineering

authors： Pishko GL,Astary GW,Mareci TH,Sarntinoranont M

更新日期：2011-09-01 00:00:00

abstract：:While considerable efforts have been expended to develop snore-driven markers for detecting obstructive sleep apnea (OSA), there is little emphasis on the relationship between the human upper airway (UA) dimensions and the attributes of snores. This paper aims to investigate the acoustical and perceptual impacts of ch...

journal_title：Annals of biomedical engineering

authors： Ng AK,Koh TS,Baey E,Puvanendran K

更新日期：2009-09-01 00:00:00

abstract：:In this study, we have developed an integrated microfluidic platform for actively patterning mammalian cells, where poly(ethylene glycol) (PEG) hydrogels play two important roles as a non-fouling layer and a dielectric structure. The developed system has an embedded array of PEG microwells fabricated on a planar indiu...

journal_title：Annals of biomedical engineering

authors： Tsutsui H,Yu E,Marquina S,Valamehr B,Wong I,Wu H,Ho CM

更新日期：2010-12-01 00:00:00

abstract：:3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped ...

journal_title：Annals of biomedical engineering

authors： Mahdavi SS,Abdekhodaie MJ,Kumar H,Mashayekhan S,Baradaran-Rafii A,Kim K

更新日期：2020-07-01 00:00:00

abstract：:Mechanical interactions during angiogenesis, i.e., traction applied by neovessels to the extracellular matrix and the corresponding deformation, are important regulators of growth and neovascularization. We have previously designed, implemented, and validated a coupled model of angiogenesis in which a discrete microve...

journal_title：Annals of biomedical engineering

authors： Edgar LT,Hoying JB,Weiss JA

更新日期：2015-07-01 00:00:00

abstract：:This paper discusses the dynamics of the circus movement around a one-dimensional continuous and uniform loop of model cardiac cells. The membrane ionic currents are represented by a modified Beeler-Reuter formulation. The description of the quasiperiodic regimes initiated in a previous paper is completed and their eq...

journal_title：Annals of biomedical engineering

authors： Vinet A

更新日期：2000-07-01 00:00:00

abstract：:Typical inverse dynamics approaches to the calculation of muscle, ligament, and joint contact forces are based on a step-wise solution of the equations of motion. This approach is therefore limited in its ability to provide insight as to the muscular, ligamentous, and articular interactions that create joint stability...

journal_title：Annals of biomedical engineering

authors： Cleather DJ,Bull AM

更新日期：2011-07-01 00:00:00

abstract：:A solid tumor is composed of a population of cells that is expanding as a result of cell division. With dense cell packing, the solid matrix of the interstitial tissue is subject to residual stress. In addition, elevated interstitial fluid pressure (IFP) has been reported by researchers for a number of solid tumors. T...

journal_title：Annals of biomedical engineering

authors： Sarntinoranont M,Rooney F,Ferrari M

更新日期：2003-03-01 00:00:00

abstract：:This experimental work focused on the sensor selection for the development of a needle-like instrument to treat small isolated cartilage defects with hydrogels. The aim was to identify the most accurate and sensitive imaging method to determine the location and size of defects compared to a gold standard (µCT). Only i...

journal_title：Annals of biomedical engineering

authors： Horeman T,Buiter EC,Pouran B,Stijntjes M,Dankelman J,Tuijthof GJM

更新日期：2018-11-01 00:00:00

abstract：:Knowledge of strain-rate sensitivity of soft tissue viscoelastic and nonlinear elastic properties is important for accurate predictions of biomechanical behavior and for quantitative assessment of the effects of disease or surgical/pharmaceutical intervention. Soft tissues are known to exhibit mild rate sensitivity, b...

journal_title：Annals of biomedical engineering

authors： Doehring TC,Carew EO,Vesely I

更新日期：2004-02-01 00:00:00