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Prime-boost vaccination with plasmid DNA followed by recombinant vaccinia virus expressing BgGARP induced a partial protective immunity to inhibit Babesia gibsoni proliferation in dogs.

Abstract：

:A heterologous prime-boost vaccination regime with DNA and recombinant vaccinia virus (rvv) vectors expressing relevant antigens has been shown to induce effective immune responses against several infectious pathogens. In this study, we describe the effectiveness of the prime-boost strategy by immunizing dogs with a recombinant plasmid followed by vaccinia virus, both of which expressed the glutamic acid-rich protein (BgGARP) of Babesia gibsoni. The dogs immunized with the prime-boost regime developed a significantly high level of specific antibodies against BgGARP when compared with the control groups. The antibody level was strongly increased after a booster immunization with a recombinant vaccinia virus. Two weeks after the booster immunization with a recombinant vaccinia virus expressing BgGARP, the dogs were challenged with B. gibsoni parasite. The dogs immunized with the prime-boost regime showed partial protection, manifested as a significantly low level of parasitemia. These results indicated that this type of DNA/rvv prime-boost immunization approach may have use against B. gibsoni infection in dogs.

journal_name

Acta Parasitol

journal_title

Acta parasitologica

authors

Cao S,Mousa AA,Aboge GO,Kamyingkird K,Zhou M,Moumouni PF,Terkawi MA,Masatani T,Nishikawa Y,Suzuki H,Fukumoto S,Xuan X

doi

10.2478/s11686-013-0183-1

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

619-23

issue

4

eissn

1230-2821

issn

1896-1851

journal_volume

58

pub_type

杂志文章

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