Childhood leukemia: diagnostic accuracy of bedside chest radiography for severe pulmonary complications.

Abstract:

PURPOSE:To determine the diagnostic accuracy of bedside chest radiography in patients who develop severe pulmonary complications while undergoing therapy for leukemia. MATERIALS AND METHODS:The authors studied 45 patients, aged 21 years and younger, who died of leukemia or of treatment complications and for whom autopsy findings were available. Pulmonary findings at autopsy comprised pneumonia (n = 25), adult respiratory distress syndrome (ARDS) (n = 16), hemorrhage (n = 38), infarction (n = 18), and leukemic cellular infiltration (n = 11). Four radiologists who were unaware of the autopsy diagnoses independently rated antemortem bedside chest radiographs. RESULTS:Diagnostic accuracy for each disease was as follows: ARDS, 0.81 +/- .03 (standard error); all pneumonias, 0.56 +/- .04; hemorrhage, 0.47 +/- .07; infarction, 0.50 +/- .12; and pulmonary leukemic cellular infiltration, 0.38 +/- .12. CONCLUSION:The specific radiographic appearance of ARDS permits excellent diagnostic accuracy.

journal_name

Radiology

journal_title

Radiology

authors

Winer-Muram HT,Rubin SA,Fletcher BD,Kauffman WM,Jennings SG,Arheart KL,Bozeman PM

doi

10.1148/radiology.193.1.8090880

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

127-33

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

193

pub_type

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