Frequent biomarker analysis in the isolated perfused heart reveals two distinct phases of reperfusion injury.

Abstract:

BACKGROUND:Reperfusion injury and its modulation are incompletely characterized. The purpose of the present study was to characterize the dynamics of reperfusion injury by portraying the temporal release of lactate dehydrogenase (LDH) during ischemia-reperfusion injury in an isolated heart model. METHODS:We studied infarct size and LDH release in the following groups: I) Effect of reperfusion length was evaluated in 79 rats subjected to 40 minute ischemia and 60, 90, 120 or 180 minute reperfusion and a) ischemic preconditioning (IPC) or b) No IPC (control). II) LDH release kinetics was studied in 6 rats subjected to calcium-paradox to verify the applicability of LDH as a dynamic marker of cellular injury. III) Ischemia-reperfusion injury modification was studied in 36 rats subjected to: a) ischemic postconditioning, b) prolonged ischemia, c) Reperfusion Injury Salvage Kinase (RISK) pathway inhibition with wortmannin in IPC hearts, d) RISK activation with insulin or e) mitochondrial permeability transition pore (mPTP) inhibition with cyclosporine A. RESULTS:Infarct size increased from 60 to 180 minute reperfusion in control hearts. LDH was released in two separate peaks from 2 to 20 and 30 to 120 min of reperfusion. IPC attenuated both peaks. Postconditioning and agents known to modify reperfusion injury attenuated the second peak. CONCLUSIONS:Frequent measurement of myocardial ischemia markers for 120 min of reperfusion allows identification of two phases of reperfusion injury that are affected by cardioprotective stimuli. The second phase contributes significantly to final infarct size, which is modifiable and a potential target for cardioprotective interventions.

journal_name

Int J Cardiol

authors

Povlsen JA,Løfgren B,Dalgas C,Jespersen NR,Johnsen J,Bøtker HE

doi

10.1016/j.ijcard.2013.11.035

subject

Has Abstract

pub_date

2014-01-15 00:00:00

pages

9-14

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(13)02053-6

journal_volume

171

pub_type

杂志文章
  • Immunoglobulin E, mast cell-specific tryptase and the complement system in sudden death from coronary artery thrombosis.

    abstract::We tested the hypothesis of anaphylaxis as a pathogenic factor in acute myocardial infarction. Mast cells were counted in the myocardium, coronary arteries and airways. Total serum IgE, mast cell tryptase, complements C3, C4, and factor B, were measured in 29 cases of sudden death from coronary artery thrombosis and i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(95)02448-6

    authors: Edston E,van Hage-Hamsten M

    更新日期:1995-11-10 00:00:00

  • Metamorphosis: the natural history of coronary heart disease. Sudden death is common. Unexpected death is not.

    abstract::It is a common practice to perform percutaneous or open coronary artery revascularisation in CHD to prevent sudden or unexpected death. Such a practice assumes that sudden and unexpected death is common in stable patients with uncomplicated CHD. This is a retrospective analysis of 248 patients (199, 80% men, 49, 20% w...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2006.05.031

    authors: Jelinek M,Santamaria J

    更新日期:2007-05-16 00:00:00

  • Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan.

    abstract::The molecular background of the Ca(2+)-sensitizing effect of levosimendan relates to its specific interaction with the Ca(2+)-sensor troponin C molecule in the cardiac myofilaments. Over the years, significant preclinical and clinical evidence has accumulated and revealed a variety of beneficial pleiotropic effects of...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijcard.2011.07.022

    authors: Papp Z,Édes I,Fruhwald S,De Hert SG,Salmenperä M,Leppikangas H,Mebazaa A,Landoni G,Grossini E,Caimmi P,Morelli A,Guarracino F,Schwinger RH,Meyer S,Algotsson L,Wikström BG,Jörgensen K,Filippatos G,Parissis JT,Gonzále

    更新日期:2012-08-23 00:00:00

  • Effect of diltiazem on norepinephrine-induced acute left ventricular dysfunction.

    abstract::The present study has examined the role of diltiazem as a protective agent in a canine model of norepinephrine cardiotoxicity. Effects of diltiazem, 20 micrograms/kg/min x 5 min pretreatment followed by 10 micrograms/kg/min x 90 min, or saline infusion were examined at baseline and 1 h after infusion of norepinephrine...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(92)90105-c

    authors: Jolly SR,Reeves WC,Mozingo S,Mehta P,Gilliland MG,Wilson E,Movahed A

    更新日期:1992-07-01 00:00:00

  • Hemodynamic effects of celiprolol in patients with ischemic and non-ischemic cardiomyopathy.

    abstract::In this study, the effect of celiprolol (beta-1-antagonist with beta-2-agonistic activity) on hemodynamic and electrocardiographic parameters of patients with congestive heart failure due to ischemic (iCMP) and non-ischemic (niCMP) origin should be evaluated. Sixteen patients were included into the study, nine with iC...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0167-5273(98)00377-5

    authors: Hennersdorf MG,Perings C,Vester EG

    更新日期:1999-03-15 00:00:00

  • Isoproterenol enhancement of I(Ks) current in amiodarone-induced long QT syndrome.

    abstract::The response over time of the QT interval and the Transmural Dispersion of Repolarization (TDR) to Isoproterenol infusion (ISO) in an 85 year-old-man with severe and syntomatic bradycardia, in the setting of an Amiodarone-induced Long QT Syndrome (LQTS) is the subject of this communication. ISO shortened the QT and de...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2007.07.175

    authors: Raviña T,Raviña M,Gutierrez J

    更新日期:2009-04-17 00:00:00

  • Impact of race on morbidity and mortality in patients with congestive heart failure: a study of the multiracial population in Singapore.

    abstract:AIM:We assessed the impact of race on clinical outcome in the multiracial Singapore congestive heart failure (CHF) population. METHODS:668 CHF patients (Age 66+/-12 years, Ejection fraction 29+/-13%), consisting of Chinese (72%), Malays (17.1%) and Indians (10.9%) were prospectively followed up for 24+/-12 months. Pri...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2007.12.107

    authors: Lee R,Chan SP,Chan YH,Wong J,Lau D,Ng K

    更新日期:2009-05-29 00:00:00

  • A decrease of ATP production steered by PEDF in cardiomyocytes with oxygen-glucose deprivation is associated with an AMPK-dependent degradation pathway.

    abstract:AIMS:The activated AMP activated protein kinase (AMPK) serves as a transient protective cardiovascular kinase via preserving adenosine triphosphate (ATP) production under ischemic conditions. However, recent studies reveal that inhibition of AMPK in stroke is neuroprotection. Pigment epithelium derived factor (PEDF) is...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2018.01.034

    authors: Qiu F,Zhang H,Yuan Y,Liu Z,Huang B,Miao H,Liu X,Zhao Q,Zhang H,Dong H,Zhang Z

    更新日期:2018-04-15 00:00:00

  • Transmural distribution of myocardial blood perfusion and phasic coronary blood flow pattern in a canine model of acute ischemia.

    abstract:BACKGROUND:Although several investigators have analyzed coronary artery blood flow under various conditions, almost all these studies have measured only some branches of the left anterior descending (LAD), left circumflex (LCX), or right coronary (RCA) artery. METHODS:In a canine model of acute ischemia (n = 5), we si...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2005.03.056

    authors: Ootaki Y,Kamohara K,Schenk S,Kopcak MW Jr,Dessoffy R,Schoenhagen P,Fukamachi K

    更新日期:2006-03-08 00:00:00

  • QTc interval prolongation during infusion with dipyridamole or adenosine.

    abstract::The aim of our study was to discover whether there was a relationship between the QTc interval prolongation on the standard 12-lead electrocardiogram (ECG) and provoked myocardial ischemia. Since the increase of adenosine plasma levels, obtained either with adenosine or dipyridamole (an adenosine reuptake inhibitor) i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(94)02209-2

    authors: Guideri F,Ferber D,Galgano G,Isidori S,Blardi P,Pasini FL,Di Perri T

    更新日期:1995-01-27 00:00:00

  • Clinical significance of fecal occult blood screening in patients before percutaneous coronary intervention.

    abstract:BACKGROUND:The most common reason for premature discontinuation of dual anti-platelet therapy (DAPT) after coronary stenting is the manifestation of gastrointestinal bleeding. Before percutaneous coronary interventions (PCIs), we screened patients who tested positive for fecal occult blood (fecOB). METHODS AND RESULTS...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2014.12.143

    authors: Sueta D,Hokimoto S,Tayama S,Tsujita K,Sakamoto K,Yamamoto E,Tanaka T,Izumiya Y,Yamamuro M,Yamanaga K,Akasaka T,Tababa N,Arima Y,Kaikita K,Ogawa H

    更新日期:2015-03-01 00:00:00

  • Pediatric cardiac surgery after exclusively echocardiography-based diagnostic work-up.

    abstract::This study was performed to evaluate the accuracy of exclusively non-invasive preoperative diagnostic work-up based on echocardiography and to assess the safety of cardiac surgery using this diagnostic approach in children with heart disease. During a 3. 5-year period, accuracy of preoperative (invasive and non-invasi...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0167-5273(00)00278-3

    authors: Pfammatter JP,Berdat P,Hämmerli M,Carrel T

    更新日期:2000-07-31 00:00:00

  • Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease.

    abstract:BACKGROUND:Inflammation plays a major role in the pathogenesis of coronary artery disease (CAD). METHODS:We hypothesized, that quantifying inflammation by measuring circulating interleukin-6 concentrations help in the diagnosis and/or prediction of functionally relevant CAD. Among consecutive patients with symptoms su...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2018.10.029

    authors: Walter J,Tanglay Y,du Fay de Lavallaz J,Strebel I,Boeddinghaus J,Twerenbold R,Doerflinger S,Puelacher C,Nestelberger T,Wussler D,Amrein M,Badertscher P,Todd J,Rentsch K,Fahrni G,Jeger R,Kaiser C,Reichlin T,Mueller C

    更新日期:2019-01-15 00:00:00

  • Successful treatment of primary cardiac lymphoma and pulmonary tumor embolism with chemotherapy.

    abstract::A 72-year-old man with a large mass in the right atrium and the pulmonary embolism by chest computed tomography was diagnosed as the primary cardiac B-cell lymphoma (PCL) with pulmonary tumor embolism and pericardial effusion. Upon completion of initial chemotherapy, the mass was markedly reduced, and the pulmonary em...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2005.06.054

    authors: Kosugi M,Ono T,Yamaguchi H,Sato N,Dan K,Tanaka K,Takano T

    更新日期:2006-07-28 00:00:00

  • Homocysteine-lowering vitamins and cardiovascular mortality: are they really effective?

    abstract::In the light of current data obtained from prospective outcome studies, we believe that it is premature to support the use of homocysteine-lowering vitamins including folic acid in patients with established coronary artery disease in order to improve cardiovascular outcomes. We think that future large-scale epidemiolo...

    journal_title:International journal of cardiology

    pub_type: 评论,信件

    doi:10.1016/j.ijcard.2007.05.044

    authors: Celik T,Iyisoy A,Yuksel UC,Isik E

    更新日期:2008-08-29 00:00:00

  • Hypereosinophilic syndrome associated with multiple coronary aneurysms.

    abstract::Aneurysmal coronary artery disease occurring in the absence of stenotic atherosclerotic plaques is extremely rare and the pathophysiology of focal aneurysm formation is poorly understood. Whilst clinical-histological correlates exist linking spontaneous coronary artery dissection and perivascular eosinophilic infiltra...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2007.08.136

    authors: Puri R,Dundon BK,Leong DP,Khurana S,Worthley MI

    更新日期:2009-03-20 00:00:00

  • Abnormal exercise electrocardiogram in an asymptomatic person--what next?

    abstract::No reasonable guidelines exist for evaluating an asymptomatic individual (without evidence for ischemic heart disease on history or electrocardiography) with a positive exercise ECG. Available data indicate that persons with a strongly positive test should undergo a coronary angiography. In persons with mild to modera...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-5273(94)90084-1

    authors: Juneja R,Wasir HS

    更新日期:1994-01-01 00:00:00

  • What do we do when thrombolysis fails? A United Kingdom survey.

    abstract::We conducted a postal survey amongst members of the British Cardiac Society to determine current strategies for the detection and management of failed thrombolysis for acute myocardial infarction. The response rate was 290/387 (75%). On-site cardiac catheterisation facilities are available to 162 (60%), 112 (41%) of w...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/s0167-5273(97)00116-2

    authors: Prendergast BD,Shandall A,Buchalter MB

    更新日期:1997-08-29 00:00:00

  • Effects of angiotensin receptor blocker at discharge in patients with heart failure with reduced ejection fraction: Korean Acute Heart Failure (KorAHF) registry.

    abstract:BACKGROUND:After introduction of up-titration strategy, there are limited data on comparison between the effects of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocker (ARB) in patients with heart failure with reduced ejection fraction (HFrEF). The study sought to investigate the associatio...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2017.12.002

    authors: Choi KH,Lee GY,Choi JO,Jeon ES,Lee HY,Cho HJ,Lee SE,Kim MS,Kim JJ,Hwang KK,Chae SC,Baek SH,Kang SM,Choi DJ,Yoo BS,Kim KH,Park HY,Cho MC,Oh BH

    更新日期:2018-04-15 00:00:00

  • The size of infarction as judged enzymatically in 1974 patients with acute myocardial infarction. Relation with symptomatology, infarct localization and type of infarction.

    abstract::A common data base of six coronary care units containing personal and clinical data of 17462 patients was used to investigate the relation between clinical symptoms of patients with acute myocardial infarction and size of infarction. In 1974 of the 5110 patients, in whom a final diagnosis of infarction was made, size ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(88)90080-0

    authors: van der Laarse A,van Leeuwen FT,Krul R,Tuinstra CL,Lie KI

    更新日期:1988-05-01 00:00:00

  • Low density lipoprotein particles are small in patients with coronary vasospasm.

    abstract::Increased lipid oxidative stress has been recently implicated in the pathogenesis of coronary artery spasm. Small, dense LDL with high susceptibility to oxidation may be linked to the genesis of coronary vasospasm. The relative migratory distance of the predominant densitometric peak of LDL from that of VLDL to that o...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0167-5273(02)00250-4

    authors: Miwa K

    更新日期:2003-02-01 00:00:00

  • Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension.

    abstract:BACKGROUND/OBJECTIVES:Several studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.06.010

    authors: Sakao S,Daimon M,Voelkel NF,Miyauchi H,Jujo T,Sugiura T,Ishida K,Tanabe N,Kobayashi Y,Tatsumi K

    更新日期:2016-09-15 00:00:00

  • A recurrent patent ductus arteriosus.

    abstract::Patent ductus arteriosus (PDA) can occur as part of more congenital cardiac malformations or as an isolate finding. Spontaneous, transcatheter, surgical closure, and pharmacological treatment have been reported. We present a case of recurrent PDA after the initial course of a pharmacological treatment. Also this case ...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2009.02.017

    authors: Tulino V,Dattilo G,Tulino D,Marte F,Patanè S

    更新日期:2011-05-05 00:00:00

  • Capecitabine induced vasospastic angina.

    abstract::Cardiotoxicity is a recognised side effect of intravenous 5-fluorouracils. In the two case reports described we demonstrate similar cardiotoxic side effects seen with the use of capecitabine. With the increasing use of oral adjuvant chemotherapeutic agents, capecitabine should be used with caution in those patients wi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2007.06.152

    authors: Coughlin S,Das S,Lee J,Cooper J

    更新日期:2008-10-30 00:00:00

  • Mid-term clinical outcomes of ABSORB bioresorbable vascular scaffold versus everolimus-eluting stent for coronary bifurcation lesions.

    abstract:BACKGROUND:Data regarding bioresorbable vascular scaffolds (BVS) use in coronary bifurcation lesions are limited. The aim of this study was to compare mid-term clinical outcomes of all-comer patients treated with BVS versus everolimus-eluting stents (EES) for bifurcation lesions. METHODS:A total of 351 non-left-main b...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2017.03.123

    authors: Naganuma T,Kawamoto H,Panoulas VF,Latib A,Tanaka A,Mitomo S,Ruparelia N,Jabbour RJ,Chieffo A,Carlino M,Montorfano M,Colombo A

    更新日期:2017-11-01 00:00:00

  • Direct versus conventional stent implantation in patients with acute coronary syndrome just before the era of drug-eluting stents.

    abstract:BACKGROUND:Direct stent implantation in patients, who undergo elective percutaneous coronary intervention (PCI) can be performed with a high success rate and clinical results that are comparable to those after predilatation. It was the aim of this prospective study to compare clinical, angiographic and procedural param...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2005.01.007

    authors: Süselbeck T,Türkoglu A,Lang S,Krause B,Kralev S,Haghi D,Poerner T,Kaden J,Borggrefe M,Haase KK

    更新日期:2005-10-20 00:00:00

  • Acute myocardial infarction following scrub typhus infection.

    abstract::Up to recently, a few cases of myocarditis in the cardiac manifestations of scrub typhus have been reported. However, acute myocardial infarction (AMI) associated with scrub typhus has not been previously reported. We presented a case of AMI ensued on scrub typhus, which were successfully treated by percutaneous coron...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2006.07.131

    authors: Kim DG,Kim JW,Choi YS,Kim SH,Kim SM,Park CG,Seo HS,Oh DJ

    更新日期:2007-01-02 00:00:00

  • PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells.

    abstract:BACKGROUND:Chronic endoplasmic reticulum (ER) stress contributes to the apoptotic cell death in the myocardium, thereby playing a critical role in the development of cardiomyopathy. ER stress has been reported to be induced after high-fat diet feeding in mice and also after saturated fatty acid treatment in vitro. Ther...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2014.03.176

    authors: Palomer X,Capdevila-Busquets E,Botteri G,Salvadó L,Barroso E,Davidson MM,Michalik L,Wahli W,Vázquez-Carrera M

    更新日期:2014-06-01 00:00:00

  • Non-vitamin K antagonist oral anticoagulants compared with warfarin at different levels of INR control in atrial fibrillation: A meta-analysis of randomized trials.

    abstract:BACKGROUND:The efficacy and safety of warfarin for stroke prevention in atrial fibrillation (AF) depend on the time in the therapeutic range (TTR) with an international normalised ratio (INR) of 2.0-3.0. This meta-analysis focused the relative efficacy and safety of non-VKA oral anticoagulants (NOAC) compared with warf...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.ijcard.2017.06.004

    authors: Carmo J,Ferreira J,Costa F,Carmo P,Cavaco D,Carvalho S,Morgado F,Adragão P,Mendes M

    更新日期:2017-10-01 00:00:00

  • The fall and rise of rheumatic fever in the United States: a commentary.

    abstract::After a documented decline in the incidence of acute rheumatic fever in the United States during the past three decades, an apparent resurgence has occurred in the mid-1980s. Although standards of living have continued to improve with concomitant decrease in crowding and easier accessibility to medical care, the preci...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-5273(88)90003-4

    authors: Kaplan EL,Markowitz M

    更新日期:1988-10-01 00:00:00