Abstract:
:Characteristic changes in vimentin were studied in 9L rat brain tumor cells treated at 45 degrees C. During heat-shock treatment, vimentin molecules were rapidly phosphorylated and reorganized from a filamentous form into a perinuclear higher-order structure that was less extractable by nonionic detergent. These effects were found to be highly transient, peaked at 30 min after the onset of heat-shock treatment, and subsided thereafter. Simultaneously, the solubility of the constitutively expressed heat-shock protein 70 (HSC70) was also temporarily decreased and the kinetics was identical to that of vimentin. The results indicated that HSC70 and vimentin were co-insolubilized during the heat-shock treatment. We propose that the reorganization of the intermediate filaments resulted from enhanced phosphorylation of vimentin leads to the concurrent association of HSC70 to the intermediate filaments. This process may play an essential role in regulating heat-shock genes.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Cheng TJ,Lai YKdoi
10.1002/jcb.240540111subject
Has Abstractpub_date
1994-01-01 00:00:00pages
100-9issue
1eissn
0730-2312issn
1097-4644journal_volume
54pub_type
杂志文章abstract::The interaction of cancer cells with extracellular matrix (ECM) is important in metastasization. Here we identified the molecules of the ECM expressed by sarcomatous malignant mesothelioma, and their effect on adhesion and spreading. In addition, by analyzing the relationship between translation and attachment to matr...
journal_title:Journal of cellular biochemistry
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Journal of cellular biochemistry
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journal_title:Journal of cellular biochemistry
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更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of cellular biochemistry
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journal_title:Journal of cellular biochemistry
pub_type: 杂志文章
doi:
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journal_title:Journal of cellular biochemistry
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of cellular biochemistry
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更新日期:2016-08-01 00:00:00
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journal_title:Journal of cellular biochemistry
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journal_title:Journal of cellular biochemistry
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journal_title:Journal of cellular biochemistry
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更新日期:2003-08-01 00:00:00
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更新日期:2019-11-13 00:00:00
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journal_title:Journal of cellular biochemistry
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更新日期:2017-12-01 00:00:00