Actions of acromelic acid on nervous system L-glutamate receptors.

Abstract:

:Acromelic acid, a naturally occurring kainoid, isolated from the mushroom Clitocybe acromelalga, is a weak displacer of [3H]L-glutamate binding to cockroach (Periplaneta americana) nerve cord membranes. Acromelic acid (1 mM) displaces approximately 60% of specifically bound [3H]L-glutamate. When applied by bath perfusion to the cell body membrane of the cockroach fast coxal depressor motor neurone, acromelic acid generated slow, prolonged, dose-dependent depolarizations at concentrations of 0.3 microM and above. Thus acromelic acid is among the most potent of the excitatory amino acids tested to date on insect neurones.

authors

Sattelle DB,Sepúlveda MI,Shinozaki H,Ishida M

doi

10.1002/arch.940250202

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

87-94

issue

2

eissn

0739-4462

issn

1520-6327

journal_volume

25

pub_type

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