Abstract:
:With increasing longevity and cardiovascular events, chronic kidney disease may also become a significant problem in older people with intellectual disability (ID). We studied prevalence and associations of chronic kidney disease as part of the Healthy Ageing and Intellectual Disability (HA-ID) study, a large Dutch cross-sectional study among people with ID aged 50 years and over, using creatinine and cystatin-C measurement in plasma. Glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Equations based on creatinine (as the MDRD equation) may underestimate kidney dysfunction in people with sarcopenia, because low muscle mass leads to a low creatinine production. Therefore, also prevalence of chronic kidney disease was studied in the sarcopenic group, using different GFR equations. Prevalence of chronic kidney disease, among 635 participants, was 15.3%, which equals prevalence in the general Dutch population. In the group of participants with sarcopenia (n=82), the CKD-EPI equation based on creatinine and cystatin-C gave a higher prevalence of chronic kidney disease than did the MDRD equation, but confidence intervals were very wide. Chronic kidney disease was associated with higher age, Down syndrome, obesity, hypercholesterolemia and hypothyroid disease. GFR should be measured in all older people with ID and polypharmacy, and in older people with ID and Down syndrome as part of the regular health checks. Moreover, if sarcopenia is present and information on GFR is required, this should not be measured based on creatinine only, but additional measures, such as cystatin-C, should be taken into account.
journal_name
Res Dev Disabiljournal_title
Research in developmental disabilitiesauthors
de Winter CF,Echteld MA,Evenhuis HMdoi
10.1016/j.ridd.2013.11.005subject
Has Abstractpub_date
2014-03-01 00:00:00pages
726-32issue
3eissn
0891-4222issn
1873-3379pii
S0891-4222(13)00492-7journal_volume
35pub_type
杂志文章abstract::Children's developmental problems vary, with some easier to identify than others. The accuracy of caregivers' initial identification of children's developmental problems is important in the timely treatment of those problems by medical professionals. In this study, we investigated the degree to which caregivers' initi...
journal_title:Research in developmental disabilities
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journal_title:Research in developmental disabilities
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journal_title:Research in developmental disabilities
pub_type: 临床试验,杂志文章
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2011.04.004
更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/0891-4222(89)90029-2
更新日期:1989-01-01 00:00:00
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journal_title:Research in developmental disabilities
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journal_title:Research in developmental disabilities
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doi:10.1016/j.ridd.2012.07.001
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
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journal_title:Research in developmental disabilities
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