Abstract:
:Perfluoroalkyl acids (PFAAs) are persistent, synthetic compounds that are used in a number of consumer products. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have been associated with cardiovascular risk factors, and changes in gene expression and DNA methylation in animals and cellular systems. However, whether PFAA exposure is associated with LINE-1 DNA methylation, a potential marker of cardiovascular risk, in humans remains unknown. We sought to evaluate the cross-sectional associations between serum PFAAs and LINE-1 DNA methylation in a population highly exposed to PFOA. We measured serum PFAAs twice four to five years apart in 685 adult participants (47% male, mean age±SD=42±11years). We measured percent LINE-1 DNA methylation in peripheral blood leukocytes at the second time point (follow-up), and estimated absolute differences in LINE-1 methylation associated with an interquartile (IQR) shift in mean PFAA serum levels. IQR increases in mean serum PFOA, PFOS, perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) were associated with differences of -0.04 (p=0.16), 0.20 (p=0.001), 0.06 (p=0.19), and 0.02 (p=0.57), respectively, in % LINE-1 methylation at follow-up after adjustment for potential confounders. We observed a monotonic increase in LINE-1 DNA methylation across tertiles of PFOS and PFNA (ptrend=0.02 for both associations), but not across tertiles of PFOA or PFHxS (ptrend=0.71 and 0.44, respectively). In summary, serum PFOS was associated with LINE-1 methylation, while serum PFOA, PFHxS, and PFNA were not. Additional research is needed to more precisely determine whether these compounds are epigenetically active.
journal_name
Environ Intjournal_title
Environment internationalauthors
Watkins DJ,Wellenius GA,Butler RA,Bartell SM,Fletcher T,Kelsey KTdoi
10.1016/j.envint.2013.10.018subject
Has Abstractpub_date
2014-02-01 00:00:00pages
71-6eissn
0160-4120issn
1873-6750pii
S0160-4120(13)00249-3journal_volume
63pub_type
杂志文章abstract:OBJECTIVE:To assess the association between estimated whole-brain and lobe-specific radiofrequency electromagnetic fields (RF-EMF) doses, using an improved integrated RF-EMF exposure model, and brain volumes in preadolescents at 9-12 years old. METHODS:Cross-sectional analysis in preadolescents aged 9-12 years from th...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105808
更新日期:2020-09-01 00:00:00
abstract::The content, behaviour and significance of heavy metals in composted waste materials is important from two potentially conflicting aspects of environmental legislation in terms of: (a) defining end-of-waste criteria and increasing recycling of composted residuals on land and (b) protecting soil quality by preventing c...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2008.06.009
更新日期:2009-01-01 00:00:00
abstract::The discovery of antibiotics is considered one of the most significant scientific achievements of the 20th century, revolutionizing both human and veterinary medicine. However, antibiotics have been recently recognized as an emerging class of environmental contaminants since they have been massively administrated in h...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2016.06.025
更新日期:2016-09-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are infamous industry by-products or additives, and increasing evidences demonstrated that their exposure is associate with adverse effects on human health. Liver, as the dominate site for xenobiotic metabolism, is apt to be the primary target of PCBs insult. Although PCBs' hepatic tox...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105701
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Exposure to environmental phenols including parabens, bisphenols (BPs), oxybenzone/benzophenone-3 (BP-3) and triclosan (TCS) is ubiquitous. Due to evidence of their estrogenic activity, they have been considered as chemicals of concern. The exposure of the Norwegian population to these compounds is presently...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.02.037
更新日期:2018-05-01 00:00:00
abstract::The occurrence of viable but non-culturable (VBNC) bacteria will result in significant underestimation of viable bacterial counts in drinking water. Whereas, much is unknown in characterizing their viability. In this study, two environmental isolates (Aeromonas sp. and Pseudomonas sp.) and two model strains (E. coli a...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.05.077
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:Tobacco presence in outdoor children's playgrounds is concerning not only because it leads to secondhand smoke (SHS) exposure, but also cigarette butt pollution and tobacco normalization. OBJECTIVES:This study aimed to assess SHS exposure in children's playgrounds, according to area-level socioeconomic st...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105775
更新日期:2020-11-20 00:00:00
abstract::Recently, PM2.5 (atmospheric fine particulate matter with aerodynamic diameter ≤ 2.5 μm) have received so much attention that the observations, source appointment and countermeasures of it have been widely studied due to its harmful impacts on visibility, mood (mental health), physical health, traffic safety, construc...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2015.10.016
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In the context of global warming, most researches have been conducted on health influences of heat waves, with limited understanding of health impacts of cold spells, especially for developing countries. METHODS:We collected daily mortality and meteorological data for 31 capital cities across China during t...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.04.049
更新日期:2019-07-01 00:00:00
abstract::It is well known that dissolved organic matter in soil solution may affect the toxicity or bioavailability of heavy metals to plants, but existing information on various organic substances is insufficient for treating problems with heavy metal-contaminated soils. To clarify how dissolved organic matter alters the toxi...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2004.10.017
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:A growing number of epidemiologic studies have estimated associations between type 2 diabetes mellitus and exposure to metals. However, studies on the associations of internal assessments of metal exposure and gestational diabetes mellitus (GDM) are limited in scope and have inconsistent outcomes. OBJECTIVE...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105370
更新日期:2020-02-01 00:00:00
abstract::A major incident of phthalate-contaminated foodstuffs happened in Taiwan between April and July, 2011. Phthalates were deliberately added to foodstuffs as a substitute of emulsifier. We describe the course of this incident, government response and management of the crisis, and its future implications. Five major food ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2012.01.014
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The inconsistent epidemiological results of the endocrine disrupting effects of DDT fuel a harsh debate on its global ban. OBJECTIVES:We tested the hypothesis that occupational exposure to dichloro-diphenyl-trichloroethane (DDT) causes impairment in male fertility in a cohort of DDT exposed workers, in Sard...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2015.01.010
更新日期:2015-04-01 00:00:00
abstract::Internationally publicized impacts upon human health associated with potentially harmful element (PHE) exposure have been reported amongst internally displaced populations (IDPs) in Mitrovica, Kosovo, following the Kosovan War. Particular concern has surrounded the exposure to Pb indicated by the presence of highly el...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.07.014
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Dyslipidemia is a major risk factor for cardiovascular disease. Several studies have explored the associations of greenness with blood lipids. However, the evidence is still limited and mixed, especially in rural areas. METHODS:From May to September 2016, we recruited 4735 Uyghur adults from rural areas of ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105903
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Ambient fine particulate matter (PM2.5) pollution is currently a serious environmental problem in China, but evidence of health effects with higher resolution and spatial coverage is insufficient. OBJECTIVE:This study aims to provide a better overall understanding of long-term mortality effects of PM2.5 pol...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.10.015
更新日期:2018-01-01 00:00:00
abstract::The main objective of this study was to investigate compositional changes in a range of source- and weathering-dependent molecular parameters in oil residues in the arid terrestrial environment of Al-Alamein, Egypt. The results of aromatic hydrocarbon analysis demonstrated the stability of several aromatic hydrocarbon...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(01)00060-5
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested that phthalates might disrupt fetal steroidogenesis. However, the evidence of the effects of prenatal phthalate exposure across pregnancy on fetal glucocorticoids was insufficient. OBJECTIVE:We investigated the associations between urinary phthalate metabolites across pregnan...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.09.037
更新日期:2018-12-01 00:00:00
abstract::Studies of the effects on pregnancy outcomes of in utero exposure to phthalates, contaminants that are widely present in the environment, have yielded conflicting results. In addition, the mode of assessment of exposure varies between studies. The aim of this review was therefore to establish a current state of knowle...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2015.06.003
更新日期:2015-10-01 00:00:00
abstract::Antimicrobial resistance (AMR) is a major global concern, especially in India where the burden of infectious diseases is high and health care spending is low. Here we quantified total coliform, faecal coliforms (FC), carbapenem-resistant enteric bacteria (CRE), blaNDM-1, and three integron genes in samples collected f...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.07.004
更新日期:2018-10-01 00:00:00
abstract::Bisphenol A (BPA) is commonly manufactured to make polycarbonate plastics and epoxy resins for use in consumer products and packaged goods. BPA has been found in several different types of environmental media (e.g., food, dust, and air). Many cross-sectional studies have frequently detected BPA concentrations in adult...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.12.014
更新日期:2018-03-01 00:00:00
abstract::The cabin of an automobile can be considered to be a part of the living environment because many people spend long periods of time during business, shopping, recreation or travel activities. However, little is known about the interior air contamination due to organic compounds diffusing from the interior materials use...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2005.04.009
更新日期:2006-01-01 00:00:00
abstract::Globally, many of our urban agriculture sites (UAS) contain high levels of lead (Pb), a contaminant of toxicological concern to humans. To improve the derivation of soil assessment criteria at UAS, and avoid inappropriate closure of these valuable community spaces, we sampled nearly 280 paired soil and crop samples ac...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.10.054
更新日期:2019-01-01 00:00:00
abstract::Waterborne and shellfish-borne enteric viruses associated with wastewater-polluted coastal waters (e.g. Norovirus, Hepatitis A/E viruses, Adenovirus) represent a major threat to human health. Improved understanding of the locations and periods of heightened risks can help target mitigation measures and improve public ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.02.042
更新日期:2019-05-01 00:00:00
abstract::Giant reed (Arundo donax L.) was grown on surface soil and irrigated with mixed heavy metal solutions of Cd(II) and Ni(II) to study the impact of these heavy metals on its growth and photosynthesis. The tested concentrations were 5, 50, and 100 ppm for each heavy metal against the control and resulted in high cadmium ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2004.09.022
更新日期:2005-02-01 00:00:00
abstract::In recent years there has been an increased interest from the European Union (EU) in the development of large Human Bio-monitoring (HBM) studies across Europe, especially biomonitoring toxic metals. In Spain, most studies using hair as a biomarker have been conducted to determine occupational or industrial exposures, ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.03.010
更新日期:2014-11-01 00:00:00
abstract::The effect of environmental factors affecting the population dynamic of phytoplankton population was studied seasonally in a closed freshwater pond with the natural water of Lake Kasumigaura, Japan. The predominant phytoplankton species in the pond were classified as Oscillatoria tenuis, Synedra ulna, Chlamydomonas ci...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(01)00087-3
更新日期:2001-11-01 00:00:00
abstract::This study focuses on characterising the risk of exposure to volatile organic compounds (VOCs) by means of inhalation in people living in the vicinity of the largest chemical production site in the Mediterranean area. Eighty-six VOCs were initially selected for this study based on their adverse environmental and healt...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2011.11.002
更新日期:2012-02-01 00:00:00
abstract::Multiple classes of environmental contaminants have been found in aquatic environments, globally. Understanding internalised concentrations in the organism could further improve the risk assessment process. The present study is concerned with the determination of several contaminant classes (107 compounds) in Gammarus...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.04.038
更新日期:2019-08-01 00:00:00
abstract::Bisphenol-A (BPA) is one of the highest volume chemicals produced worldwide, with over 6billion pounds produced and over 100t released into the atmosphere each year. Recent extensive literature has raised concerns about its possible implication in the etiology of some human chronic diseases such as diabetes, obesity, ...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2013.12.007
更新日期:2014-03-01 00:00:00