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Use of 'very low-dose phenobarbital' to investigate compliance in patients on reducing doses of methadone (detoxification).

Abstract：

:Incorporation of very low doses of phenobarbital into a methadone linctus has enabled us to monitor the compliance of 7 patients receiving a reducing dose of methadone (detoxification) for treatment for opioid addiction. By measuring both plasma phenobarbital and methadone we detected 4 patients who consumed extra illicitly obtained methadone during the detoxification regime. Treatment outcome was poor; 11 of the original 18 patients dropped out of treatment within 14 days and of those who remained, 4 patients relapsed and reabused illicit drugs and 2 returned to a fixed dose of methadone. Laboratory measurements were successfully used to detect poor methadone compliance.

journal_name

J Subst Abuse Treat

journal_title

Journal of substance abuse treatment

authors

Wolff K,Hay AA,Raistrick D,Feely M

doi

10.1016/0740-5472(93)90006-n

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

453-8

issue

5

eissn

0740-5472

issn

1873-6483

journal_volume

10

pub_type

杂志文章

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