Stable lead isotope profiles in smelter and general urban communities: a comparison of environmental and blood measures.

Abstract:

:High-precision lead isotope ratios and lead concentrations have been compared statistically and graphically in women of child-bearing age (n = 77) from two smelter communities and one general urban community to evaluate the relative contributions to blood lead of tissue lead stores and lead from the contemporaneous environment (soil, floor dust, indoor airborne dust, water, food). Blood lead (PbB) contents were generally low (e.g. <10 μg dL(-1)). Statistically significant isotopic differences in blood and environmental samples were observed between the three cities although isotopic differences in blood for individual subjects living in close proximity (∼200 m radius) was as large as the differences within a city. No single environmental measure dominated the biological isotope profile and in many cases the low levels of blood lead meant that their isotopic profiles could be easily perturbed by relatively small changes of environmental exposure. Apportioning of sources using lead isotopes is possibly not feasible, nor cost effective, when blood lead levels are <5 μg dL(-1). Interpretations based on statistical analyses of city-wide data do not give the same conclusions as when the houses are considered individually. Aggregating data from multiple subjects in a study such as this obscures potentially useful information. Most of the measures employed in this study, and many other similar studies, are markers of only short-to-medium integration of lead exposure. Serial sampling of blood and longer sampling times, especially for household variables, should provide more meaningful information.

journal_name

Environ Geochem Health

authors

Gulson BL,Pisaniello D,McMichael AJ,Mizon KJ,Korsch MJ,Luke C,Ashbolt R,Pederson DG,Vimpani G,Mahaffey KR

doi

10.1007/BF01771238

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

147-63

issue

4

eissn

0269-4042

issn

1573-2983

journal_volume

18

pub_type

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