Abstract:
BACKGROUND:The optimal timing for changing intravenous (IV) administration sets that contain total parenteral nutrition (TPN), with and without lipids, in neonates remains unknown. OBJECTIVE:To determine whether decreasing the frequency of changing IV administration sets (>24 h versus every 24 h) in neonates increases the incidence of sepsis within seven days of discontinuation of TPN and microbial contamination of the infusate. METHODS:The databases searched to identify studies that evaluated the frequency of IV administration sets on sepsis and microbial contamination of the infusate included MEDLINE, EMBASE, CINAHL, Cochrane Library, Scopus and Web of Science. The Evidence Evaluation Worksheet adapted from the American Heart Association's International Liaison Committee on Resuscitation was used to evaluate eligible studies for quality, level of evidence and direction of support. RESULTS:Two studies were reviewed; however, neither of the studies reported on the outcome of sepsis. One study reported that changing IV administration sets every 48 h did not increase the rate of infusate (amino acid or lipid) contamination compared with change every 24 h, while the other study reported an increase in the lipid infusate contamination rate when IV administration sets were changed every 72 h. CONCLUSIONS:There is insufficient evidence to support or refute routinely changing IV administration sets every 48 h or that decreasing the frequency of set changes increases the incidence of sepsis. HISTORIQUE:On ne connaît pas le moment optimal pour changer les dispositifs de transfusion intraveineuse (IV) de l’alimentation parentérale totale (APT), avec et sans lipides, chez les nouveau-nés. OBJECTIF:Déterminer si le fait de réduire la fréquence des changements de dispositif de transfusion IV (plus de 24 heures plutôt que toutes les 24 heures) chez les nouveau-nés accroît l’incidence de septicémie dans les sept jours suivant l’arrêt de l’APT ainsi que la contamination microbienne du soluté. MÉTHODOLOGIE:Les chercheurs ont consulté les bases de données MEDLINE, EMBASE, CINAHL, Bibliothèque Cochrane, Scopus et Web of Science pour repérer les études qui évaluaient la fréquence des changements de dispositif de transfusion IV sur la septicémie et la contamination microbienne du soluté. Ils ont utilisé la feuille d’évaluation des données probante adaptée de l’International Liaison Committee on Resuscitation de l’American Heart Association pour déterminer les études admissibles en matière de qualité, de qualité des preuves et d’orientation du soutien. RÉSULTATS:Les chercheurs ont analysé deux études, mais aucune des deux ne signalait l’issue de la septicémie. Une étude a établi que le fait de changer le dispositif de transfusion IV toutes les 48 heures n’accroissait pas le taux de contamination du soluté (acide aminé ou lipide) par rapport à un changement toutes les 24 heures, tandis que l’autre étude indiquait une augmentation du taux de contamination du soluté de lipide lorsque le dispositif de transfusion IV était changé toutes les 72 heures. CONCLUSIONS:Les données probantes sont insuffisantes pour étayer ou réfuter les changements systématiques de dispositif de transfusion IV toutes les 48 heures ou établir que la diminution de la fréquence des changements de dispositif de transfusion accroît l’incidence de septicémie.
journal_name
Paediatr Child Healthjournal_title
Paediatrics & child healthauthors
Chirinian N,Shah Vsubject
Has Abstractpub_date
2012-11-01 00:00:00pages
501-4issue
9eissn
1205-7088issn
1918-1485journal_volume
17pub_type
杂志文章,评审abstract:OBJECTIVE:To determine whether reminder notices would improve the timeliness of toddler-age vaccinations. DESIGN:Prospective, randomized, controlled trial. POPULATION STUDIED:Two convenience cohorts of 320 children due to receive either measles-mumps-rubella (MMR) vaccine (at 12 months of age) or diphtheria-pertussis...
journal_title:Paediatrics & child health
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abstract::[This corrects the article DOI: 10.1093/pch/pxy072.]. ...
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pub_type: 杂志文章,已发布勘误
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journal_title:Paediatrics & child health
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journal_title:Paediatrics & child health
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journal_title:Paediatrics & child health
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