Abstract:
BACKGROUND:We studied stagnation of the blood in hepatic metastatic lesions of colorectal cancer. METHODS:Twenty-two hepatic tumors in 11 patients with liver metastases of colorectal cancers were investigated in this study. With a catheter inserted into the roots of the proper hepatic artery, 5 to 10 mCi 133Xe was injected. The half-time (t1/2) was calculated for the tumor region based on the washout curve by the compartmental method and expressed as the intratumor retention time of the blood. RESULTS:Transcatheter arterial chemoembolization with iodized oil (Lipiodol) and cisplatin was effective in eight (50%) of 16 tumors that were hypervascular but in only one (17%) of six tumors that were hypovascular (p < 0.05). Regardless of the hypervascular tumor, transcatheter arterial chemoembolization was not effective in tumors that had shown a t1/2 of less than 80 seconds. Seven of eight good-responding lesions that were hypervascular and had a long t1/2 (187 +/- 74.6 seconds) revealed characteristic fireworks-shaped accumulation of Lipiodol. CONCLUSIONS:Transarterial infusion chemotherapy for liver metastasis of colorectal cancer was considered effective for hypervascular hepatic tumors with a long t1/2.
journal_name
Surgeryjournal_title
Surgeryauthors
Kameyama M,Imaoka S,Fukuda I,Nakamori S,Sasaki Y,Fujita M,Hasegawa Y,Iwanaga Tsubject
Has Abstractpub_date
1993-07-01 00:00:00pages
97-101issue
1eissn
0039-6060issn
1532-7361journal_volume
114pub_type
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