Abstract:
PURPOSE:Streptococcus pneumoniae and Neisseria meningitidis are major causes of severe invasive bacterial infections in some individuals. Apparently the genetic is a major susceptibility determinant to these infectious diseases. We study if the functional polymorphisms within genes of the innate immune system (TLR2-TLR4 and CD14) are related to the predisposition to severe invasive infections caused by S. pneumoniae and N. meningitidis. MATERIAL AND METHODS:Prospective descriptive study. Sixty-six Caucasian healthy children and 173 consecutive Caucasian children with invasive bacterial infections by N. meningitidis (n=59) and S. pneumoniae (n=114) were enrolled between January 1, 2008 and December 31, 2010. All blood samples were genotyped with description of the coding polymorphisms in p.R753Q of TLR2 gene and p.D299G of TLR4 gene as well as the promotor polymorphism c.-159C>T of the CD14 gene. RESULTS:Compared to the controls the p.753Q allele of TLR2 and the allele c.-159T of CD14 were more frequent in patients with S. pneumoniae (p<0.0001 and p=0.0167) and meningococcal infections (p=0.0003 and p=0.0276 respectively). CONCLUSIONS:Genetical variations in the innate immune system by polymorphisms in the TLR2 and CD14, could be related with an increases susceptibility to severe invasive infections by S. pneumoniae and N. meningitidis.
journal_name
Med Intensivajournal_title
Medicina intensivaauthors
Tellería-Orriols JJ,García-Salido A,Varillas D,Serrano-González A,Casado-Flores Jdoi
10.1016/j.medin.2013.08.006subject
Has Abstractpub_date
2014-08-01 00:00:00pages
356-62issue
6eissn
0210-5691issn
1578-6749pii
S0210-5691(13)00187-3journal_volume
38pub_type
杂志文章abstract:OBJECTIVE:To identify factors related to mortality in adult trauma patients, analyzing the clinical, epidemiological and therapeutic characteristics at the pre-hospital levels, in the Emergency Care Department and in Intensive Care. DESIGN:A retrospective, longitudinal descriptive study was carried out. Statistical an...
journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2014.06.004
更新日期:2015-10-01 00:00:00
abstract::A narrative review is presented on the diagnosis, treatment and management of accidental hypothermia. Although all these processes form a continuum, for descriptive purposes in this manuscript the recommendations are organized into the prehospital and in-hospital settings. At prehospital level, it is advised to: a) pe...
journal_title:Medicina intensiva
pub_type: 杂志文章,评审
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abstract::Severe acute pancreatitis (SAP) causes local and systemic complications leading to high catabolic, hypermetabolic and hyperdynamic stress states with marked morbidity and mortality. In the last decade, nutritional support has become a key element in the treatment of SAP. Thus, specialized nutrition is indicated from a...
journal_title:Medicina intensiva
pub_type: 共识发展会议,杂志文章,实务指引
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abstract:OBJECTIVE:Apply a sedoanalgesic (SA) protocol for invasive procedures (PI) in pediatric patients and evaluate its effectiveness and safety. DESIGN:Prospective observational study. SCOPE:Pediatric Intensive Care Unit (PICU) of third level hospital. PATIENTS:A total of 110 children subjected to invasive procedures und...
journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/s0210-5691(07)74851-9
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abstract::The intensive care units must be prepared for a possible disaster, whether internal or external, in case it becomes necessary to evacuate the in-patients. They must have an Emergency and Self-protection Plan that includes the patient evacuation criteria and this must be known by all the personnel who work in the servi...
journal_title:Medicina intensiva
pub_type: 杂志文章
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abstract:OBJECTIVES:This study has aimed to establish the intensivist physician's concepts and practices in this region regarding the diagnosis, management and prevention of delirium in intensive care units (ICU). DESIGN:A survey was distributed among the FEPIMCTI member societies for distribution among its medical members. R...
journal_title:Medicina intensiva
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journal_title:Medicina intensiva
pub_type: 杂志文章,实务指引
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journal_title:Medicina intensiva
pub_type: 共识发展会议,杂志文章,实务指引
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journal_title:Medicina intensiva
pub_type: 杂志文章
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journal_title:Medicina intensiva
pub_type: 杂志文章,实务指引
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journal_title:Medicina intensiva
pub_type: 杂志文章
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2014.02.006
更新日期:2014-12-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,评审
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journal_title:Medicina intensiva
pub_type: 共识发展会议,杂志文章
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2012.07.010
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2010.09.010
更新日期:2011-06-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,meta分析
doi:10.1016/j.medin.2011.11.014
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Describe the frequency of high degree atrioventricular block (HDAVB) in patients with unstable angina (UA), analyze the variables associated with their appearance and evaluate whether HDAVB is independently associated with increased mortality or increased length of ICU stay. DESIGN:Retrospective descriptive ...
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journal_title:Medicina intensiva
pub_type: 杂志文章,多中心研究
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journal_title:Medicina intensiva
pub_type: 杂志文章,多中心研究
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journal_title:Medicina intensiva
pub_type: 杂志文章,评审
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journal_title:Medicina intensiva
pub_type: 杂志文章,评审
doi:10.1016/j.medin.2009.10.003
更新日期:2010-05-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,评审
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更新日期:2009-06-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
abstract::The use of neuromuscular blockers (NMB) is a frequent practice in Intensive Care Units. However most of the experience with the use of these agents come from the operating room used to deal with patients with different characteristics from those admitted in the ICU. Recent advances on neuromonitoring and the commercia...
journal_title:Medicina intensiva
pub_type: 杂志文章,评审
doi:
更新日期:2008-02-01 00:00:00
abstract::Patients with cardiac disease can develop two types of malnutrition: cardiac cachexia, which appears in chronic congestive heart failure, and malnutrition due to the complications of cardiac surgery or any other type of surgery in patients with heart disease. Early enteral nutrition should be attempted if the oral rou...
journal_title:Medicina intensiva
pub_type: 共识发展会议,杂志文章,实务指引
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更新日期:2011-11-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,多中心研究
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更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To determine the clinical characteristics and prognostic factors of patients with severe sepsis/septic shock admitted to the Intensive Care Unit of Donostia University Hospital (Guipuzcoa, Spain). DESIGN:A prospective, observational study was carried out during a consecutive 6-year period (1st February 2008-...
journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2012.04.010
更新日期:2013-01-01 00:00:00
abstract::After an introduction that summarizes the new definitions and risk classification of acute kidney injury, along with the consequences on its epidemiology, available evidence in the literature is reviewed in order to compare intermittent and continuous renal replacement therapy in terms of survival, renal function reco...
journal_title:Medicina intensiva
pub_type: 杂志文章,评审
doi:10.1016/s0210-5691(09)70688-6
更新日期:2009-03-01 00:00:00