TLR2-TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae.

Abstract:

PURPOSE:Streptococcus pneumoniae and Neisseria meningitidis are major causes of severe invasive bacterial infections in some individuals. Apparently the genetic is a major susceptibility determinant to these infectious diseases. We study if the functional polymorphisms within genes of the innate immune system (TLR2-TLR4 and CD14) are related to the predisposition to severe invasive infections caused by S. pneumoniae and N. meningitidis. MATERIAL AND METHODS:Prospective descriptive study. Sixty-six Caucasian healthy children and 173 consecutive Caucasian children with invasive bacterial infections by N. meningitidis (n=59) and S. pneumoniae (n=114) were enrolled between January 1, 2008 and December 31, 2010. All blood samples were genotyped with description of the coding polymorphisms in p.R753Q of TLR2 gene and p.D299G of TLR4 gene as well as the promotor polymorphism c.-159C>T of the CD14 gene. RESULTS:Compared to the controls the p.753Q allele of TLR2 and the allele c.-159T of CD14 were more frequent in patients with S. pneumoniae (p<0.0001 and p=0.0167) and meningococcal infections (p=0.0003 and p=0.0276 respectively). CONCLUSIONS:Genetical variations in the innate immune system by polymorphisms in the TLR2 and CD14, could be related with an increases susceptibility to severe invasive infections by S. pneumoniae and N. meningitidis.

journal_name

Med Intensiva

journal_title

Medicina intensiva

authors

Tellería-Orriols JJ,García-Salido A,Varillas D,Serrano-González A,Casado-Flores J

doi

10.1016/j.medin.2013.08.006

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

356-62

issue

6

eissn

0210-5691

issn

1578-6749

pii

S0210-5691(13)00187-3

journal_volume

38

pub_type

杂志文章
  • Prognostic factors associated with mortality in patients with severe trauma: from prehospital care to the Intensive Care Unit.

    abstract:OBJECTIVE:To identify factors related to mortality in adult trauma patients, analyzing the clinical, epidemiological and therapeutic characteristics at the pre-hospital levels, in the Emergency Care Department and in Intensive Care. DESIGN:A retrospective, longitudinal descriptive study was carried out. Statistical an...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2014.06.004

    authors: González-Robledo J,Martín-González F,Moreno-García M,Sánchez-Barba M,Sánchez-Hernández F

    更新日期:2015-10-01 00:00:00

  • Management of accidental hypothermia: A narrative review.

    abstract::A narrative review is presented on the diagnosis, treatment and management of accidental hypothermia. Although all these processes form a continuum, for descriptive purposes in this manuscript the recommendations are organized into the prehospital and in-hospital settings. At prehospital level, it is advised to: a) pe...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审

    doi:10.1016/j.medin.2018.11.008

    authors: Avellanas Chavala ML,Ayala Gallardo M,Soteras Martínez Í,Subirats Bayego E

    更新日期:2019-12-01 00:00:00

  • [Guidelines for specialized nutritional and metabolic support in the critically ill-patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): sever

    abstract::Severe acute pancreatitis (SAP) causes local and systemic complications leading to high catabolic, hypermetabolic and hyperdynamic stress states with marked morbidity and mortality. In the last decade, nutritional support has become a key element in the treatment of SAP. Thus, specialized nutrition is indicated from a...

    journal_title:Medicina intensiva

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1016/S0210-5691(11)70007-9

    authors: Bordejé Laguna L,Lorencio Cárdenas C,Acosta Escribano J,Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE).

    更新日期:2011-11-01 00:00:00

  • [Safety and effectiveness of the sedoanalgesia with fentanyl and propofol. Experience in a pediatric intensive medicine unit].

    abstract:OBJECTIVE:Apply a sedoanalgesic (SA) protocol for invasive procedures (PI) in pediatric patients and evaluate its effectiveness and safety. DESIGN:Prospective observational study. SCOPE:Pediatric Intensive Care Unit (PICU) of third level hospital. PATIENTS:A total of 110 children subjected to invasive procedures und...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/s0210-5691(07)74851-9

    authors: López JM,Valerón M,Pérez O,Consuegra E,Urquía L,Morón A,González R

    更新日期:2007-11-01 00:00:00

  • [Evacuation plan of an intensive care unit: a new quality indicator?].

    abstract::The intensive care units must be prepared for a possible disaster, whether internal or external, in case it becomes necessary to evacuate the in-patients. They must have an Emergency and Self-protection Plan that includes the patient evacuation criteria and this must be known by all the personnel who work in the servi...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2009.05.005

    authors: Sánchez-Palacios M,Lorenzo Torrent R,Santana-Cabrera L,Martín García JA,Campos SG,Carrasco de Miguel V,Grupo de Trabajo del Plan de Autoprotección para el Servicio de Medicina Intensiva.

    更新日期:2010-04-01 00:00:00

  • [Latin American survey on delirium in critical patients].

    abstract:OBJECTIVES:This study has aimed to establish the intensivist physician's concepts and practices in this region regarding the diagnosis, management and prevention of delirium in intensive care units (ICU). DESIGN:A survey was distributed among the FEPIMCTI member societies for distribution among its medical members. R...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2010.04.003

    authors: Ceraso DH,Dueñas-Castel C,Raimondi N,Celis E,Carrillo R,Ugarte Ubiergo S,Rodriguez F

    更新日期:2010-11-01 00:00:00

  • [Recommendations of the Infectious Diseases Work Group (GTEI) of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) and the Infections in Critically Ill Patients Study Group (GEIPC) of the Spanish Society of Infectio

    abstract::The diagnosis of influenza A/H1N1 is mainly clinical, particularly during peak or seasonal flu outbreaks. A diagnostic test should be performed in all patients with fever and flu symptoms that require hospitalization. The respiratory sample (nasal or pharyngeal exudate or deeper sample in intubated patients) should be...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.medin.2011.11.020

    authors: Rodríguez A,Alvarez-Rocha L,Sirvent JM,Zaragoza R,Nieto M,Arenzana A,Luque P,Socías L,Martín M,Navarro D,Camarena J,Lorente L,Trefler S,Vidaur L,Solé-Violán J,Barcenilla F,Pobo A,Vallés J,Ferri C,Martín-Loeches I,

    更新日期:2012-03-01 00:00:00

  • [Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection].

    abstract::Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, that was first recognized in Wuhan, China, in December 2019. Currently, the World Health Organization (WHO) has defined the infection as a global pandemic and there is a health and social emergency for the mana...

    journal_title:Medicina intensiva

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1016/j.medin.2020.03.005

    authors: Cinesi Gómez C,Peñuelas Rodríguez Ó,Luján Torné M,Egea Santaolalla C,Masa Jiménez JF,García Fernández J,Carratalá Perales JM,Heili-Frades SB,Ferrer Monreal M,de Andrés Nilsson JM,Lista Arias E,Sánchez Rocamora JL,Garrote JI,Zam

    更新日期:2020-10-01 00:00:00

  • Advances in immunosuppression after lung transplantation.

    abstract::Immunosuppression in transplantation has experienced changes in recent years as a result of the introduction of new drugs that act upon the different pathways of the host immune response with the purpose of securing more individualized immune suppression, with fewer side effects. Although following in the steps of oth...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2012.05.011

    authors: Borro JM

    更新日期:2013-01-01 00:00:00

  • [Analgesia in critical cares].

    abstract::Pain is a problem in critically ill patients. The diagnosis of the intensity of is more simple when the patient is conscious (using ad hoc scales) than in unconscious or sedated patients. In these cases the study of the physiological responses to pain can be the best way of pain monitoring. The pain management in ICU ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,实务指引

    doi:

    authors: Alfaro CG,Roldán JM,González PI,Hazaña FH,Grupo de Trabajo de Analgesia y Sedación de la SEMICYUC.

    更新日期:2008-02-01 00:00:00

  • [Acute renal function deterioration in a Coronary Unit in Spain].

    abstract:OBJECTIVE:To assess the incidence and prognostic value of acute renal function deterioration (ARFD) in patients with acute heart disease. SETTING:Coronary Care Unit in a tertiary university hospital. DESIGN:Retrospective study. PARTICIPANTS:One hundred consecutive patients admitted during 2004. INTERVENTIONS:No ran...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/s0210-5691(08)70932-x

    authors: Martí D,Escobar C,Dedieu N,Liaño F,Jiménez Mena M,Asín E

    更新日期:2008-05-01 00:00:00

  • Temporary internal pacing.

    abstract::Technology and insertion techniques for cardiac temporary internal pacing have experienced a remarkable development over the last few years. Despite this fact, the procedure continues to have potentially fatal associated complications. Temporary internal pacing is indicated for the treatment of bradyarrhythmias or tac...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2014.02.006

    authors: Ortiz Díaz-Miguel R,Gómez Grande ML

    更新日期:2014-12-01 00:00:00

  • [Takotsubo cardiomyopathy: transient apical dysfunction of the left ventricle].

    abstract::Transient apical dysfunction syndrome, ballooning or Takotsubo cardiomyopathy is a recently described syndrome. It is a disease with a partially known mechanism, characterized by the morphology adopted by the left ventricle secondary to hypokinesis and dyskinesis of the apical segments and hypercontractibility of the ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审

    doi:10.1016/s0210-5691(07)74793-9

    authors: Obón Azuara B,Ortas Nadal MR,Gutiérrez Cía I,Villanueva Anadón B

    更新日期:2007-04-01 00:00:00

  • The American-European Consensus Conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure!

    abstract::In 1994, an American-European Consensus Conference (AECC) formalized the criteria for the diagnosis of the acute respiratory distress syndrome (ARDS). Although that definition is simple to apply in the clinical setting, it has been challenged over the years in several studies since the assessment of the oxygenation de...

    journal_title:Medicina intensiva

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.medin.2012.08.010

    authors: Villar J,Kacmarek RM

    更新日期:2012-11-01 00:00:00

  • [Analysis of organ failure and mortality in sepsis due to secondary peritonitis].

    abstract:OBJECTIVES:To identify the organs most susceptible to develop multiorgan dysfunction syndrome (MODS) in patients with sepsis due to secondary peritonitis, and to determine the outcome and mortality predicting utility of the SOFA (Sequential Organ Failure Assessment) system. DESIGN:A prospective, observational cohort s...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2012.07.010

    authors: Hernández-Palazón J,Fuentes-García D,Burguillos-López S,Domenech-Asensi P,Sansano-Sánchez TV,Acosta-Villegas F

    更新日期:2013-10-01 00:00:00

  • [Tako-tsubo syndrome. Transient left ventricular dyskinesia. Presentation of our casuistics].

    abstract::This syndrome was described in 1990. It is characterized by chest pain that simulates an acute coronary syndrome (ACS), with alterations in the ECG, but with normal coronary arteries. We present 16 patients admitted in our ICU, who met the criteria of transient left ventricular dysfunction syndrome (TLVDS). All but 1 ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2010.09.010

    authors: Del Nogal Sáez F,Meyer García-Sípido E,Villar Molina M,Blasco Navalpotro MA,Díaz Abad R,Grande Ingelmo JM

    更新日期:2011-06-01 00:00:00

  • Comparison of values in critically ill patients for global end-diastolic volume and extravascular lung water measured by transcardiopulmonary thermodilution: a meta-analysis of the literature.

    abstract:INTRODUCTION:Hemodynamic parameters such as the global end-diastolic volume index (GEDVI) and extravascular lung water index (EVLWI), derived by transpulmonary thermodilution, have gained increasing interest for guiding fluid therapy in critically ill patients. The proposed normal values (680-800ml/m(2) for GEDVI and 3...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.medin.2011.11.014

    authors: Eichhorn V,Goepfert MS,Eulenburg C,Malbrain ML,Reuter DA

    更新日期:2012-10-01 00:00:00

  • [Atrioventricular block in unstable angina. Results of the ARIAM registry].

    abstract:OBJECTIVE:Describe the frequency of high degree atrioventricular block (HDAVB) in patients with unstable angina (UA), analyze the variables associated with their appearance and evaluate whether HDAVB is independently associated with increased mortality or increased length of ICU stay. DESIGN:Retrospective descriptive ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/s0210-5691(06)74566-1

    authors: Ruiz-Bailén M,Pola Gallego MD,Expósito Ruiz M,Pintor Mármol A,Issa-Khozouz Z,Aguayo De Hoyos E,Rucabado-Aguilar L,Castillo-Rivera AM,Morante-Valle A,Rodríguez-Puche JA,García-Alcántara A,Gómez Jiménez FJ,Grupo ARIAM.

    更新日期:2006-12-01 00:00:00

  • [Prolonged mechanical ventilation probability model].

    abstract:OBJECTIVE:To design a probability model for prolonged mechanical ventilation (PMV) using variables obtained during the first 24 hours of the start of MV. DESIGN:An observational, prospective, multicenter cohort study. SCOPE:Thirteen Spanish medical-surgical intensive care units. PATIENTS:Adult patients requiring mec...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.medin.2012.01.003

    authors: Añón JM,Gómez-Tello V,González-Higueras E,Oñoro JJ,Córcoles V,Quintana M,López-Martínez J,Marina L,Choperena G,García-Fernández AM,Martín-Delgado C,Gordo F,Díaz-Alersi R,Montejo JC,Lorenzo AG,Pérez-Arriaga M,Madero R

    更新日期:2012-10-01 00:00:00

  • Brain death organ donation potential and life support therapy limitation in neurocritical patients.

    abstract:OBJECTIVE:To analyze the profile, incidence of life support therapy limitation (LSTL) and donation potential in neurocritical patients. STUDY DESIGN:A multicenter prospective study was carried out. SETTING:Nine hospitals authorized for organ harvesting for transplantation. PATIENTS:All patients consecutively admitte...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.medin.2014.07.010

    authors: Bodí MA,Pont T,Sandiumenge A,Oliver E,Gener J,Badía M,Mestre J,Muñoz E,Esquirol X,Llauradó M,Twose J,Quintana S

    更新日期:2015-08-01 00:00:00

  • [Brain death diagnosis].

    abstract::Brain death has been recognized by the scientific community as the person's death, and accepted in the legislation of different countries. Brain death is defined as the irreversible ending of the functions of all the intracranial neurological structure in both the brain and brain stem. This clinical situation appears ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审

    doi:10.1016/s0210-5691(09)71215-x

    authors: Escudero D

    更新日期:2009-05-01 00:00:00

  • [Stress hyperglycemia and its control with insulin in critically ill patients: current evidence].

    abstract:OBJECTIVE:To analyze the current evidence on glycemic control with insulin therapy in the critically ill. RECENT FINDINGS:Stress hyperglycemia in critically ill patients has been associated with increased morbidity and mortality. Furthermore, current evidence suggests that glucose variability has a predictive value fo...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审

    doi:10.1016/j.medin.2009.10.003

    authors: Manzanares W,Aramendi I

    更新日期:2010-05-01 00:00:00

  • [Hormone modulation of organ donor. Utility of the steroids].

    abstract::Recently, the work group made up of the National Transplant Organization (Organización Nacional de Trasplantes, ONT), Spanish Society of Intensive, Critical Medicine and Coronary Units (Sociedad Española de Medicina Intensiva, Crítica y de Unidades Coronarias, SEMICYUC) and other Scientific Societies have recommended ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审

    doi:10.1016/s0210-5691(09)71760-7

    authors: Michelena JC,Chamorro C,Falcón JA,Garcés S

    更新日期:2009-06-01 00:00:00

  • Perioperative management in thoracic surgery.

    abstract::Thoracic surgery has undergone significant advances in recent years related to anesthetic and surgical techniques and the prevention and management of complications related to the procedure. This has allowed improvements in patient clinical outcomes in surgeries of this kind. Despite the above, thoracic surgery, espec...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2019.10.012

    authors: Muñoz de Cabo C,Hermoso Alarza F,Cossio Rodriguez AM,Martín Delgado MC

    更新日期:2020-04-01 00:00:00

  • [Use of neuromuscular blockers in the critical patient].

    abstract::The use of neuromuscular blockers (NMB) is a frequent practice in Intensive Care Units. However most of the experience with the use of these agents come from the operating room used to deal with patients with different characteristics from those admitted in the ICU. Recent advances on neuromonitoring and the commercia...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审

    doi:

    authors: Sandiumenge A,Anglés R,Martínez-Melgar JL,Torrado H,Grupo de Trabajo de Analgesia y Sedación de la SEMICYUC.

    更新日期:2008-02-01 00:00:00

  • [Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): cardi

    abstract::Patients with cardiac disease can develop two types of malnutrition: cardiac cachexia, which appears in chronic congestive heart failure, and malnutrition due to the complications of cardiac surgery or any other type of surgery in patients with heart disease. Early enteral nutrition should be attempted if the oral rou...

    journal_title:Medicina intensiva

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1016/S0210-5691(11)70017-1

    authors: Jiménez Jiménez FJ,Cervera Montes M,Blesa Malpica AL,Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE).

    更新日期:2011-11-01 00:00:00

  • Gender gap in medical care in ST segment elevation myocardial infarction networks: Findings from the Catalan network Codi Infart.

    abstract:OBJECTIVE:To assess the impact of gender upon the prognosis and medical care in a regional acute ST-elevation myocardial infarction management network. DESIGN:An observational study was made of consecutive patients entered in a prospective database. SCOPE:The Catalan acute ST-elevation myocardial infarction managemen...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.medin.2016.06.008

    authors: Fernández-Rodríguez D,Regueiro A,Cevallos J,Bosch X,Freixa X,Trilla M,Brugaletta S,Martín-Yuste V,Sabaté M,Bosa-Ojeda F,Masotti M,en representación de los investigadores del Registro Codi Infart.

    更新日期:2017-03-01 00:00:00

  • Epidemiology and prognostic factors in severe sepsis/septic shock. Evolution over six years.

    abstract:OBJECTIVE:To determine the clinical characteristics and prognostic factors of patients with severe sepsis/septic shock admitted to the Intensive Care Unit of Donostia University Hospital (Guipuzcoa, Spain). DESIGN:A prospective, observational study was carried out during a consecutive 6-year period (1st February 2008-...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2015.01.006

    authors: Azkárate I,Choperena G,Salas E,Sebastián R,Lara G,Elósegui I,Barrutia L,Eguibar I,Salaberria R

    更新日期:2016-01-01 00:00:00

  • Alcohol and/or drug abuse favors trauma recurrence and reduces the trauma-free period.

    abstract:AIM:A study is made of the influence of alcohol and/or drug abuse upon traumatismo recurrence, with an analysis of the influence of such abuse upon the time to appearance of first injury in patients without antecedents of trauma. DESIGN:A prospective observational study was made. SETTING:Trauma patients admitted to t...

    journal_title:Medicina intensiva

    pub_type: 杂志文章

    doi:10.1016/j.medin.2012.04.010

    authors: Cordovilla Guardia S,Rodríguez-Bolaños S,Guerrero López F,Lara-Rosales R,Pino Sánchez F,Rayo A,Fernández-Mondéjar E

    更新日期:2013-01-01 00:00:00

  • [Intermittent versus continuous renal replacement techniques: pro intermittent].

    abstract::After an introduction that summarizes the new definitions and risk classification of acute kidney injury, along with the consequences on its epidemiology, available evidence in the literature is reviewed in order to compare intermittent and continuous renal replacement therapy in terms of survival, renal function reco...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审

    doi:10.1016/s0210-5691(09)70688-6

    authors: Barrio V

    更新日期:2009-03-01 00:00:00