Eruptive squamous cell carcinomas after vemurafenib therapy.

Abstract:

BACKGROUND:Vemurafenib is an oral BRAF inhibitor recently approved for the treatment of metastatic melanoma. Patients treated with this medication have been reported to have the occurrence of squamous cell carcinoma (SCC) and/or actinic keratosis (AK). OBJECTIVE:We report the case of a patient treated with vemurafenib for papillary thyroid carcinoma who subsequently developed multiple SCCs and AK of the skin. The lesions were deemed related to the medication and treated with excision. In addition, subsequent development of SCCs and AK was successfully prevented with a combination of isotretinoin and 5-fluorouracil in this patient. We discuss postulated mechanisms for these findings, as well as potential preventive therapy with the aforementioned combination regimen in patients undergoing treatment with vemurafenib.

journal_name

J Cutan Med Surg

authors

Mays R,Curry J,Kim K,Tsai K,Arora A,Khan F,Ramirez-Fort M,Ciurea A

doi

10.2310/7750.2013.12092

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

419-22

issue

6

eissn

1203-4754

issn

1615-7109

journal_volume

17

pub_type

杂志文章
  • Successful treatment of refractory aquagenic pruritus with naltrexone.

    abstract:BACKGROUND:Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. It is most commonly associated with polycythemia rubra vera. Common but often ineffective treatments include anticholinergics and antihistamines. Other moderatel...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/s10227-005-0144-x

    authors: Ingber S,Cohen PD

    更新日期:2005-10-01 00:00:00

  • Strongyloidiasis presenting as larva currens 38 years after presumed exposure.

    abstract:BACKGROUND:We present a case of strongyloidiasis presenting as larva currens 38 years after potential exposure in a country with what is typically thought of as low epidemiologic risk. CONCLUSION:This case highlights several important features of strongyloidiasis, including its varied epidemiology, long incubation per...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347541201600613

    authors: Showler A,Boggild AK

    更新日期:2012-11-01 00:00:00

  • Therapeutic options for external genital warts.

    abstract::The primary goal of treatment for external genital warts (EGWs) is to eradicate visible lesions and address symptoms that may accompany them, but it does not address the underlying virus. Left untreated, warts may grow, remain the same, or spontaneously regress as a result of being cleared by the immune system. Howeve...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:

    authors: Vender R,Bourcier M,Bhatia N,Lynde C

    更新日期:2013-12-01 00:00:00

  • A clinical evaluation of tazarotene 0.1% gel, with and without a high- or mid-high-potency corticosteroid, in patients with stable plaque psoriasis.

    abstract:BACKGROUND:Several clinical trials have established the benefit of using a topical corticosteroid in conjunction with tazarotene gel in the treatment of plaque psoriasis. However, there is little information comparing the relative benefits of different corticosteroids, or different formulations of corticosteroids, when...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s10227-001-0031-z

    authors: Green L,Sadoff W

    更新日期:2002-03-01 00:00:00

  • Maintenance of Certification: What's to Know.

    abstract::The Maintenance of Certification (MOC) Program administered by the Royal College of Physicians and Surgeons applies to all Fellows of the Royal College including dermatologists. It is mandatory for those who wish to maintain their fellowship in the Royal College and can be critical for maintaining licensure requiremen...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475417709194

    authors: Rich P

    更新日期:2017-07-01 00:00:00

  • Multiple cutaneous granular cell tumors: case report of a 19-year-old African American female.

    abstract:BACKGROUND AND OBJECTIVE:This is a somewhat rare case of a 19-year-old African American female with multiple cutaneous granular cell tumors. Granular cell tumors are of neural origin, except in rare cases, and are considered benign, with a low incidence of malignancy. The clinical presentation varies greatly, but these...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2011.10088

    authors: Henry M,Perry A

    更新日期:2011-11-01 00:00:00

  • Epidermodysplasia verruciformis associated with myelodysplastic syndrome: an intriguing association.

    abstract:BACKGROUND:Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by massive infection with human papillomaviruses (HPVs) and development of skin cancer. Myelodysplastic syndromes (MDSs) are a group of chronic conditions that involve dysplastic hematopoiesis, peripheral blood cytopenias, and a high...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2009.08049

    authors: Oliveira WR,Ferreira GN,Rady PL,Festa C,Tyring SK

    更新日期:2009-11-01 00:00:00

  • Cellulitis Secondary to Liquid Nitrogen Cryotherapy: Case Report and Literature Review.

    abstract:BACKGROUND:Liquid nitrogen cryotherapy is a commonly used technique to treat a wide variety of dermatologic conditions including actinic keratoses, non-melanoma skin cancers, verrucae, and seborrheic keratoses. The risks associated with liquid nitrogen cryotherapy are important to know and discuss with patients prior t...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475417702152

    authors: Huang CM,Lu EY,Kirchhof MG

    更新日期:2017-07-01 00:00:00

  • Cutaneous cryptococcosis mimicking basal cell carcinoma in a patient with AIDS.

    abstract:BACKGROUND:Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans. This ubiquitous organism has emerged as a frequent finding in immunosuppressed patients, especially those with underlying malignancies, organ transplants, and the acquired immune deficiency syndrome (AIDS)....

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347549800300112

    authors: Ingleton R,Koestenblatt E,Don P,Levy H,Szaniawski W,Weinberg JM

    更新日期:1998-07-01 00:00:00

  • Rationale and Argument for Subunit Mohs Excision in Nasal Reconstruction.

    abstract:BACKGROUND:Optimal aesthetic results are achieved when nasal defects after Mohs micrographic surgery (MMS) are reconstructed as entire nasal subunits. OBJECTIVE:To illustrate the importance of reconstructing the nose in entire subunits and explore the possibilities of expanding the principles of subunit reconstruction...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416629594

    authors: Jergensen ZR,Pezeshk RA,Thornton JF

    更新日期:2016-07-01 00:00:00

  • Genital Ulcer Disease: A Review of Pathogenesis and Clinical Features.

    abstract::Genital ulcer disease can be caused by a wide variety of sources. Most commonly, genital ulcer disease is grouped into infectious and noninfectious causes. HSV, syphilis, lymphogranuloma venereum, and chancroid represent some common infectious ulcers. Noninfectious causes on the other hand can be inflammatory, noninfl...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475419858955

    authors: Maliyar K,Mufti A,Syed M,Selk A,Dutil M,Bunce PE,Alavi A

    更新日期:2019-11-01 00:00:00

  • Antepartum intravenous immunoglobulin therapy in refractory pemphigoid gestationis: case report and literature review.

    abstract:BACKGROUND:pemphigoid gestationis is an autoimmune blistering disease affecting pregnant women. Treatment often consists of topical corticosteroids, oral antihistamines, and oral prednisone followed by immunosuppressants. Refractory cases in antepartum patients present a particular therapeutic challenge as the majority...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.2310/7750.2009.09001

    authors: Doiron P,Pratt M

    更新日期:2010-07-01 00:00:00

  • Mycobacterium marinum with associated bursitis.

    abstract:BACKGROUND:Mycobacterium marinum infections have been reported for over 50 years, mostly in association with trauma in the setting of water exposure. OBJECTIVE:The differential diagnosis for nodules in a sporotrichoid distribution with simultaneous bursitis is discussed. Mycobacterium marinum treatment regimens for sk...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347549900300413

    authors: Saadatmand B,Poulton JK,Kauffman CL

    更新日期:1999-04-01 00:00:00

  • Unusual case of proximal calciphylaxis without renal failure.

    abstract:BACKGROUND:Calciphylaxis is a rare syndrome of vascular calcification with subsequent cutaneous and tissue necrosis. It usually manifests as a complication of end-stage renal failure, affecting 1 to 4% of long-term dialysis patients. Very exceptionally, it can occur without chronic renal failure. OBJECTIVE:The goal of...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2011.10046

    authors: Stanciu M,Gagné-Henley A,Thérien G

    更新日期:2011-09-01 00:00:00

  • Prospective Case Series of Cutaneous Adverse Effects Associated With Dabrafenib and Trametinib.

    abstract:BACKGROUND:Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416670368

    authors: Lacroix JP,Wang B

    更新日期:2017-01-01 00:00:00

  • The Accuracy of Measurements of Nonmelanoma Skin Cancer Sizes Referred to the Mohs Surgery Clinic.

    abstract:BACKGROUND:Tumour size is a crucial factor used to plan Mohs procedures. Larger tumours require more time and stages of excision, and they need to be triaged as a higher priority. Therefore, the accuracy in measurement of tumour size is critical. OBJECTIVE:To investigate if there is a significant difference in accurac...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416683391

    authors: To D,Macdonald J

    更新日期:2017-05-01 00:00:00

  • Supernumerary nipples and renal malformations: a family study.

    abstract::We describe a family with supernumerary nipples and kidney and urinary tract malformations. The proband is a 59-year-old man with a supernumerary nipple and recently identified hypoplastic kidney, bladder diverticulum, and hypotonic bladder. His mother also has a supernumerary nipple and a recently identified hypoplas...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s10227-003-0166-1

    authors: Brown J,Schwartz RA

    更新日期:2004-05-01 00:00:00

  • Lymphangiosarcoma of the scalp.

    abstract:BACKGROUND:Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its clinical and histologic features are often indistinguishable from angiosarcoma. OBJECTIVE:We sought to better characterize the clinical and hist...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2013.13025

    authors: Mamelak AJ,Collie MR,Kroll R,Hanson ML,Harris HM

    更新日期:2014-03-01 00:00:00

  • Keratoelastoidosis marginalis.

    abstract:BACKGROUND:Keratoelastoidosis marginalis is a rare disease that is a variant of solar elastosis. Long-term ultraviolet radiation exposure and chronic trauma secondary to manual labor are considered to be inciting factors. OBJECTIVE:To outline the clinical and histological features of this disorder. METHODS:We report ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/s10227-001-0025-x

    authors: Mengesha YM,Kayal JD,Swerlick RA

    更新日期:2002-01-01 00:00:00

  • Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification.

    abstract::Juvenile xanthogranuloma (JXG) is a member of the non-Langerhans cell group of proliferative disorders of mononuclear phagocytes. JXG is a benign tumour of histiocytic cells. Classic JXG is divided into 2 main clinical subtypes: dome-shaped papules (<0.5 cm) and single/multiple nodules (<2.0 cm). A rare variant is ref...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475418777734

    authors: Ladha MA,Haber RM

    更新日期:2018-09-01 00:00:00

  • Olanzapine may be an effective adjunctive therapy in the management of acne excoriée: a case report.

    abstract:BACKGROUND:The self-inflicted dermatoses such as acne excorieé and neurotic excoriations are often chronic, recurring, and resistant to standard dermatologic therapies. OBJECTIVE:We present a 28-year-old woman with longstanding acne excorieé, whose acne started at age 14 years and was followed by acne excorieé at age ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347540100500106

    authors: Gupta MA,Gupta AK

    更新日期:2001-01-01 00:00:00

  • Improvement in both Raynaud disease and hyperhidrosis in response to botulinum toxin type A treatment.

    abstract:BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in c...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2008.07044

    authors: Kossintseva I,Barankin B

    更新日期:2008-07-01 00:00:00

  • A Systematic Review on Oral Isotretinoin Therapy and Clinically Observable Wound Healing in Acne Patients.

    abstract::The association between isotretinoin and atypical wound healing remains controversial. It is common practice to delay elective procedures for 6 to 24 months after oral isotretinoin therapy. The studies supporting common practices (SCP) recommend extending this period to include the 6 to 24 months preceding treatment. ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475417701419

    authors: McDonald KA,Shelley AJ,Alavi A

    更新日期:2017-07-01 00:00:00

  • A Bullous Flare of a Hyperkeratotic Affair: A Case Report.

    abstract:BACKGROUND:Darier's disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution. The vesiculo-bullous variant of Darier's disease is rare. Several previously reported cases have demonstrated clinical and microscopic features resembling famili...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416660295

    authors: Klimas N,West C,Tarbox M

    更新日期:2016-11-01 00:00:00

  • Crohn Disease of the Vulva without Gastrointestinal Manifestations in a 16-Year-Old Girl.

    abstract:BACKGROUND:Crohn disease of the vulva is a rare disease that is difficult to diagnose. There are limited reports describing treatment of this condition. OBJECTIVE:To describe the diagnosis and treatment of a 16-year-old girl with Crohn disease of the vulva, without onset of intestinal symptoms. METHODS:Crohn disease ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2014.14005

    authors: Zhang AJ,Zhan SH,Chang H,Gao YQ,Li YQ

    更新日期:2015-01-01 00:00:00

  • Managing Patients With Psoriasis in the Busy Clinic: Practical Tips for Health Care Practitioners.

    abstract::Psoriasis is a common inflammatory disease with significant comorbidities, whose management can be challenging given the variety of treatment options. It is critical for nurse practitioners, physician assistants, general practitioners, and dermatology trainees to have useful information about the treatment and monitor...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475415623508

    authors: Armstrong AW,Aldredge L,Yamauchi PS

    更新日期:2016-05-01 00:00:00

  • Multiple symmetric lipomatosis.

    abstract:BACKGROUND:Multiple symmetric lipomatosis (MSL) is a relatively uncommon entity of unknown etiology characterized by symmetrically subcutaneous accumulation of nonencapsulated adipose tissue. Approximately 200 to 300 cases have been published. OBJECTIVES:The aims of this article are to report the case of a 58-year-old...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.2310/7750.2011.10026

    authors: Gomes da Silva R,Detoffol Bragança R,Ribeiro Costa C,Torres de Melo L,Weiss Telles R,Costa Silva L

    更新日期:2011-07-01 00:00:00

  • Primary Cutaneous Peripheral T-Cell Lymphoma in a Sporotrichoid Pattern: A Case Report.

    abstract::We present the extraordinary case of a 72-year-old man with a history of primary cutaneous peripheral T-cell lymphoma not otherwise specified (pcPTCL-NOS) previously controlled with topical agents who developed tumours in a sporotrichoid pattern. Culture of the tumours was negative, and histopathology showed findings ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475417721425

    authors: Lewis DJ,Vin H,Hinojosa T,Tetzlaff MT,Dabaja BS,Duvic M

    更新日期:2017-11-01 00:00:00

  • Cutaneous Adverse Events in Chronic Hepatitis C Patients Treated With New Direct-Acting Antivirals: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Direct-acting antivirals (DAAs) are known to present with additional dermatological events over pegylated-interferon/ribavirin (Peg-IFN/RBV). OBJECTIVE:A systematic review and meta-analysis was conducted to assess the incidence/risk of cutaneous adverse events (AEs) for simeprevir, sofosbuvir, ABT450/r-ombi...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/1203475415595775

    authors: Patel P,Malik K,Krishnamurthy K

    更新日期:2016-01-01 00:00:00

  • Schnitzler Syndrome Without a Monoclonal Gammopathy: A Case Report.

    abstract:BACKGROUND:Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leuk...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416657999

    authors: Urbanski M,Holfeld K,Milne A,Abbas M

    更新日期:2016-11-01 00:00:00