The effects of heparin and dietary fish oil on embolic events and the microcirculation downstream from a small-artery repair.

Abstract:

:In recent studies we demonstrated that platelet emboli induced by arterial injury impair the microcirculation. The present study was performed to determine if heparin or dietary cod liver oil reduces the incidence of emboli following the same arterial injury and, in turn, whether these agents prevent the associated decrease in microcirculatory blood flow. The cremaster muscle of 29 male Sprague-Dawley rats was isolated on a single neurovascular bundle consisting of the iliac artery and vein and the genitofemoral nerve. Emboli were generated by a thrombogenic injury of the iliac artery, and their number and their subsequent effect on capillary perfusion in the downstream microcirculation were measured. Nine animals received heparin (10-unit IV bolus plus 10 units/hour IV infusion), 10 were fed cod liver oil (10 percent by weight of food) for 3 weeks prior to the experiment, and 9 animals receiving no treatment served as controls. The number of emboli was significantly reduced in the heparin group, but there was no accompanying improvement in capillary perfusion. In contrast, in the cod liver oil group, the number of emboli was not reduced, but there was significant improvement in capillary perfusion. These findings suggest that the harmful effect that platelet emboli have on the microcirculation is probably biochemical in nature (vasoconstriction) rather than related to simple mechanical obstruction to flow.

journal_name

Plast Reconstr Surg

authors

Barker JH,Gu JM,Anderson GL,O'Shaughnessy M,Pierangeli S,Johnson P,Galletti G,Acland RD

doi

10.1097/00006534-199302000-00020

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

335-43

issue

2

eissn

0032-1052

issn

1529-4242

journal_volume

91

pub_type

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