Mn-DPDP in MR imaging of pancreatic adenocarcinoma: initial clinical experience.

Abstract:

:Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP) was tested as a contrast agent for magnetic resonance imaging of pancreatic adenocarcinoma in 15 patients. At enhanced T1-weighted spin-echo (SE) and enhanced T1-weighted gradient-echo (GRE) imaging, statistically significant increases in signal-to-noise ratio (S/N) for the pancreas (21% and 92%, respectively) and contrast-to-noise ratio (C/N) (91% and 209%, respectively) were found. The C/N at enhanced T1-weighted SE imaging was superior to that at unenhanced imaging, including T2-weighted SE imaging (P = .001). Subjective image analysis showed that delineation of the pancreas and pancreatic tumors was clearly improved (P = .05) on enhanced T1-weighted SE and GRE images compared with on unenhanced T1- and T2-weighted images. The liver enhanced 19% at T1-weighted SE imaging and 90% at T1-weighted GRE imaging. There was a significantly higher S/N increase in hepatic parenchyma than in pancreatic tissue at enhanced T1-weighted GRE imaging (P = .0026) but not at enhanced T1-weighted SE imaging.

journal_name

Radiology

journal_title

Radiology

authors

Gehl HB,Urhahn R,Bohndorf K,Klever P,Hauptmann S,Lodemann KP,Matern S,Schumpelick V,Günther RW

doi

10.1148/radiology.186.3.8430190

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

795-8

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

186

pub_type

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