Abstract:
OBJECTIVES:The aim of this study was to analyze the relation between anomalies of the heart and aortic arch arteries in near-term rat fetuses exposed to the chemical bis-diamine. BACKGROUND:Bis-diamine is known to induce cardiovascular anomalies. METHODS:Bis-diamine was given orally to normal pregnant rats, and the 65 fetuses were examined under a dissecting microscope after formalin fixation. RESULTS:There were 26 rat fetuses (40%) with a ventricular septal defect in the perimembranous portion, of which 14 (22%) had tetralogy of Fallot, 4 (6%) had truncus arteriosus and 8 (12%) had a relatively small defect with no other major anomalies. In 44 fetuses (68%) the middle latitudinal muscle bundle of the ventricular septum was continuous with the right ventricular free wall. There were, isolated or in association, a double- or right aortic arch in 6 fetuses (9%), aberrant subclavian arteries in 9 (14%), right ductus arteriosus in 12 (18%) and agenetic ductus in 4 (6%). The cross-sectional area of the ductus, as corrected by that of the aortic isthmus, was abnormally small in 47 rats (72%). The rat fetuses with a septal defect or abnormal myocardial architecture, or both, usually had a small ductus; it was very small or absent in those fetuses with tetralogy of Fallot. Of the four fetuses with truncus arteriosus, two had a vestigial vasculature on the truncus root and three had a rudimentary infundibulum. CONCLUSIONS:The cardinal defect may be the anomalous and reduced development of the sixth arch arteries, which by imposing pressure overload on the fetal right ventricle, may have led to either or both the persistence of ventricular septal defect as a vent or the formation of myocardial architecture favorable for the generation of pressure in the right ventricle.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Kuribayashi T,Roberts WCdoi
10.1016/0735-1097(93)90111-dsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
768-76issue
3eissn
0735-1097issn
1558-3597pii
0735-1097(93)90111-Djournal_volume
21pub_type
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journal_title:Journal of the American College of Cardiology
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更新日期:2008-01-15 00:00:00
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doi:10.1016/j.jacc.2008.08.024
更新日期:2008-11-11 00:00:00
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doi:10.1016/j.jacc.2010.10.035
更新日期:2011-03-15 00:00:00
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doi:10.1016/s0735-1097(84)80323-x
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Familial hypercholesterolemia is typically caused by LDL receptor (LDLR) mutations that result in elevated levels of LDL cholesterol (LDL-C). In homozygous FH, the prevalence of aortic valve calcification (AoVC) reaches 100% and is often symptomatic. OBJECTIVES:The objective of this study was to investigate...
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更新日期:2015-12-22 00:00:00
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更新日期:2010-04-20 00:00:00
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更新日期:2015-12-15 00:00:00
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更新日期:2011-12-13 00:00:00
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更新日期:2000-07-01 00:00:00
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更新日期:1986-10-01 00:00:00
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更新日期:1994-03-15 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1999-07-01 00:00:00
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更新日期:2016-07-19 00:00:00
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更新日期:1988-06-01 00:00:00
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更新日期:2020-12-01 00:00:00
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更新日期:2015-12-08 00:00:00
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更新日期:2006-07-18 00:00:00
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更新日期:2018-02-13 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2010.04.068
更新日期:2010-11-30 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jacc.2014.06.1205
更新日期:2014-10-21 00:00:00
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更新日期:1991-09-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(97)00276-3
更新日期:1997-11-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jacc.2015.11.055
更新日期:2016-02-23 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1989-03-01 00:00:00
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更新日期:1998-06-01 00:00:00