Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.

Abstract:

:A phylogenetic analysis of sex-chromosomal zinc-finger genes (Zfx and Zfy) indicates that the genes have not evolved completely independently since their initial separation. The sequence similarities suggest gene conversion in the last exon between the duplicated Y-chromosomal genes Zfy-1 and Zfy-2 in the mouse. There are also indications of conversion (or recombination) between the X- and Y-chromosomal genes in the crab-eating fox and in the mouse. The method for estimating synonymous and nonsynonymous substitutions is modified by incorporating the substitutions in the twofold-degenerate sites in a novel way. The estimates of synonymous substitutions support the generation-time hypothesis in that the obtained rates are higher in mice (by a factor of 4.7) than in humans and higher in the Y-chromosomal genes (by a factor of 1.9) than in the X-chromosomal genes.

journal_name

Mol Biol Evol

authors

Pamilo P,Bianchi NO

doi

10.1093/oxfordjournals.molbev.a040003

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

271-81

issue

2

eissn

0737-4038

issn

1537-1719

journal_volume

10

pub_type

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