Abstract:
:Mitoplasts from rabbit bone marrow cells in vitro incubated with benzene metabolites showed a concentration-dependent inhibition of mitochondrial RNA synthesis. The 50% molar inhibitory concentration for each metabolite was determined to be p-benzoquinone, 2 X 10(-6); phenol, 2.5 X 10(-5); hydroquinone, 5 X 10(-5); catechol, 2 X 10(-3); benzene, 1.6 X 10(-2). Activated metabolites of radiolabeled benzene covalently bound to mitochondrial DNA in vitro. Labeled deoxynucleosides, enzymatically produced from DNA isolated from mitoplasts prelabeled in DNA with [3H]dGTP and exposed to [14C]benzene in vitro, were chromatographed on a Sephadex LH-20 column to obtain deoxynucleoside-adducts. The elution profiles indicated that mtDNA contained seven deoxyguanosine-adducts. A similar experiment in which the mtDNA was prelabeled with [3H]dATP indicated that two deoxyadenosine-adducts of mtDNA were formed from benzene in vitro. Tentative identification of several deoxyguanosine-adducts indicates that p-benzoquinone, hydroquinone, phenol, and 1,2,4-benzenetriol produced from benzene form adducts with guanine.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Kalf GF,Snyder R,Rushmore THdoi
10.1002/ajim.4700070512subject
Has Abstractpub_date
1985-01-01 00:00:00pages
485-92issue
5-6eissn
0271-3586issn
1097-0274journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Occupational eye injuries have been recognized as a serious health risk to workers and are in need of further investigation to develop effective interventions. METHODS:Rhode Island workers' compensation claims of ocular injury between 1998 through 2002 (n=8,877) were examined. The Current Population Survey ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20234
更新日期:2006-01-01 00:00:00
abstract::The Editorial Board of the American Journal of Industrial Medicine strongly supports the "Call for an International Ban on Asbestos". We concur with the Collegium Ramazzini that a ban is necessary, overdue and essential for public health. To eliminate the burden of disease and death that is caused worldwide by exposur...
journal_title:American journal of industrial medicine
pub_type: 指南,杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Following a work refusal at a plant manufacturing ice cream novelties in Ontario, we were asked to document cases of cumulative trauma disorders (CTDs) and carpal tunnel syndrome (CTS) in this workplace. There were 17 employees with possible hand and wrist problems identified from Workers Compensation Board (WCB) Form...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700220312
更新日期:1992-01-01 00:00:00
abstract::Fact-finding surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of silk thread or of paint were carried out. Some of the workers showed higher PCB levels in the plasma than typical yusho patients. Gas chromatographic patterns of their PCBs were shown to match the pattern of...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::The objectives of this study were 1) to summarize in a clinically meaningful way information on occupational risk factors for carpal tunnel syndrome (CTS), and 2) to test a questionnaire on risk factors that could be used by physicians with their patients. For the two objectives, a systematic literature review was per...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0274(199803)33:3<224::aid-ajim3
更新日期:1998-03-01 00:00:00
abstract::This study measured the validity of work histories obtained by interview with 84 female workers and examined specific factors which influence such validity. This is the first validation of work histories collected by interviews with women. The validity of each interview was assessed over a period of 29 years, from 195...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700190409
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Assess the national prevalence of current workplace exposure to potential skin hazards, secondhand smoke (SHS), and outdoor work among various industry and occupation groups. Also, assess the national prevalence of chronic workplace exposure to vapors, gas, dust, and fumes (VGDF) among these groups. METHODS:...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22089
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:A medical surveillance program of benzene-exposed workers has to be established in such a way as to observe early signs of benzene-induced cytopenia, pancytopenia, or leukemia. This study evaluates the utility of routine medical survey applied to benzene-exposed workers by analyzing the hematological, immuno...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10296
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Use of surrogate responders often needs to be considered in case-control studies with a high case fatality. METHODS:Agreement between 98 colon cancer patients and their closest relative was expressed as a percentage of the exact agreement and by Kappa coefficients and intra-class correlation coefficients. ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10266
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:The risk of breast cancer was investigated in a large dynamic population-based cohort of all 1.1 million economically active women in Norway with potential exposure to 50 Hz magnetic fields at the censuses of 1960, 1970, and 1980. METHODS:The follow-up period for the cohort was 1961-1992. For each woman, da...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199907)36:1<147::aid-ajim2
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Thoroughbred horse farm workers self-report a high frequency of work-related injuries and pain. However, an analysis of Thoroughbred horse farm workers' compensation injury claims is absent from the literature, yet may benefit worker safety. METHODS:We analyzed workers' compensation insurance firm data cont...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23159
更新日期:2020-10-01 00:00:00
abstract::Chest radiographs, taken at a 9-year interval for 1,261 U.S. coal miners, were read for pneumoconiosis side-by-side by six readers in a controlled trial. Incidence and progression of small, rounded opacities were consistent with levels predicted from dose-response curves developed by the British Pneumoconiosis Field R...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700060604
更新日期:1984-01-01 00:00:00
abstract::Exposure to grain dust has been associated with a neutrophilic bronchitis. In vitro studies suggest several possible mechanisms for recruitment of neutrophils, including direct chemotaxis to aqueous grain dust extracts and release of chemotactic activity by bronchial epithelial cells in response to challenge with grai...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700250122
更新日期:1994-01-01 00:00:00
abstract::Semen analysis has proven useful in the clinical diagnosis of infertility and is the most widely used method of monitoring the effects of occupational exposure on male fertility. Collection and analysis of semen samples in a field setting, however, require a highly motivated population and excellent technical resource...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700200209
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Deaths due to occupational disease and injury place a heavy burden on society in terms of economic costs and human suffering. METHODS:We estimate the annual deaths due to selected diseases for which an occupational association is reasonably well established and quantifiable, by calculation of attributable f...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.10216
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to determine whether cross-shift changes in peak expiratory flow rate (PEFR) were related to respirable dust exposure in South African coalminers. METHODS:Fifty workers were randomly selected from a cohort of 684 miners from 3 bituminous coalmines in Mpumalanga, South Afric...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20513
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compile nationally representative statistics describing inpatient hospital care for patients with work-related injuries and illnesses covered under workers' compensation (WC) insurance in the United States. METHODS:Three years of data (1997-1999) from the Nationwide Inpatient Sa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10273
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:A 5-year longitudinal study examined nonmalignant respiratory effects of wood processing dust exposure. METHODS:Ten study plants, investigator selected from 447 candidate plants, included 1 sawmill-planing-plywood, 1 plywood, 1 milling, 3 cabinet and 4 furniture facilities. Personal dust samples (2363) were...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20594
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Continuous increase in male incidence of malignant mesothelioma of the pleura (MMP) despite the drop of asbestos production since 1980 in Québec motivated this study aiming to assess when the rates of MMP will decline. METHODS:Age-standardized rates and trends were estimated over the 1984-2007 period by sex...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22442
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Case reports have identified hydrofluoric acid (HF) as causing fatal work injury, and HF has both local and systemic toxicity. Surveillance for HF-related mortality is problematic because of the lack of unique coding for this acid in hospital records and vital statistics. METHODS:We identified HF-related fa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1090
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Nearly one of every three workers in the United States is low-income. Low-income populations have a lower life expectancy and greater rates of chronic diseases compared to those with higher incomes. Low- income workers face hazards in their workplaces as well as in their communities. Developing integrated pu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22174
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Engineering or administrative methods are often insufficient or impractical to control exposure to chemicals in anatomy laboratories. This study explored the feasibility of wearing one or a combination of respirators and goggles used as personal protective equipment (PPE) to control exposure in one such labo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10180
更新日期:2003-03-01 00:00:00
abstract::Pressure from the vinyl chloride (VC) industry on researchers involved in industry-sponsored studies and on regulatory agencies has been documented since 1970s. This commentary describes the influence of a lawsuit pursued by workers of an Italian VC plant on the recent scientific debate on VC exposure and risk of hepa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20941
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The rate of lost-time sprains and strains in private nursing homes is over three times the national average, and for back injuries, almost four times the national average. The Ohio Bureau of Workers' Compensation (BWC) has sponsored interventions that were preferentially promoted to nursing homes in 2000-200...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20731
更新日期:2009-09-01 00:00:00
abstract::Long-term exposure to lead is known to cause a variety of neurotoxic manifestations, including symptoms of depression. Dimercaptosuccinic acid (DMSA), a recently approved oral chelating agent, can diminish the body burden of lead, but few cases of documented clinical improvement following treatment have been reported....
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700240606
更新日期:1993-12-01 00:00:00
abstract::This study examines the determinants of susceptibility to the irritant effects of sodium borate in 18 responsive workers identified through repeated self-reports of nasal irritation. For each worker, susceptibility was characterized by two features; reactivity and sensitivity, as estimated from the slope and intercept...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199812)34:6<614::aid-ajim1
更新日期:1998-12-01 00:00:00
abstract::This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal me...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700160405
更新日期:1989-01-01 00:00:00
abstract::The oil and gas extraction industry is rapidly growing due to horizontal drilling and high volume hydraulic fracturing (HVHF). This growth has provided new jobs and economic stimulus. The industry occupational fatality rate is 2.5 times higher than the construction industry and 7 times higher than general industry; ho...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.22316
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Opioid use is rising in the US and may cause special problems in workers compensation cases, including addiction and preventing a return to work after an injury. OBJECTIVE:This study evaluates a physician-level intervention to curb opioid usage. An insurer identified patients with out-of-guideline opioid ut...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22779
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Asthma has been found to be among the most common conditions in the working age population and is among the most common causes of work limitation, but we could find no longitudinal studies of employment among persons with this condition. METHODS:A panel of 601 persons with a diagnosis of asthma from random ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199905)35:5<472::aid-ajim4
更新日期:1999-05-01 00:00:00