Modulation of cell death in age-related diseases.

Abstract:

:Aging is a stage of life of all living organisms. According to the free-radical theory, aging cells gradually become unable to maintain cellular homeostasis due to the adverse effects of reactive oxygen species (ROS). ROS can cause irreversible DNA mutations, protein and lipid damage which are increasingly accumulated in the course of time if cells could not overcome these effects by the antioxidant defence system. Accrued damaged molecules in cells may either induce cellular death or contribute to develop various pathologies. Hence, programmed cell death mechanisms, apoptosis and autophagy, play a vital role in the aging process. Although they are strictly controlled by various interconnected signalling pathways, alterations in their regulations may contribute to severe pathologies including cancer, Alzheimer's and Parkinson's diseases. In this review, we summarized our current understanding and hypotheses regarding oxidative stress and age-related dysregulation of cell death signalling pathways.

journal_name

Curr Pharm Des

authors

Tezil T,Basaga H

doi

10.2174/13816128113196660702

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

3052-67

issue

18

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-56420

journal_volume

20

pub_type

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