The carboxy-terminal domain is essential for stability and not for virion incorporation of HIV-1 Vpr into virus particles.

abstract：:Identification of regulators of p53 expression is a crucial step in understanding the diverse functions of p53 and its role in cellular homeostasis and responsiveness to insult. Several viral proteins inactivate p53 as a modulator of cell cycle progression and apoptosis. Here, we report that a unique leporipoxviral tr...

journal_title：Virology

authors： Wali A,Strayer DS

更新日期：1996-10-01 00:00:00

abstract：:The human parvovirus B19 causes aplastic crises in sickle cell anemia patients and the disease erythema infectiosum. So far, it has not been possible to grow B19 virus in cultured cells. Here we report the use of in vitro transcription in HeLa cell extracts and transient expression of cloned DNA transfected into HeLa ...

journal_title：Virology

authors： Doerig C,Beard P,Hirt B

更新日期：1987-04-01 00:00:00

abstract：:Twelve avian reovirus strain 176 proteins, 10 structural (lambda 1, lambda 2, lambda 3, mu 1, mu 2/mu 2C, sigma 1, sigma 2, sigma 3, and sigma 4), and 2 nonstructural (mu NS and sigma NS) were identified and characterized by electrophoretic analysis of purified virions and infected cell lysates. Three of the identifie...

journal_title：Virology

authors： Ni Y,Ramig RF,Kemp MC

更新日期：1993-03-01 00:00:00

abstract：:Significant economic losses in the poultry industries have resulted from H9N2 low pathogenic avian influenza virus infections across North Africa, the Middle East and Asia. The present study investigated the evolutionary dynamics of H9N2 viruses circulating in Korea from 1996 to 2012. Our analysis of viral population ...

journal_title：Virology

authors： Lee DH,Fusaro A,Song CS,Suarez DL,Swayne DE

更新日期：2016-01-15 00:00:00

abstract：:Human papilllomaviruses (HPVs) are common human pathogens that infect cutaneous or mucosal epithelia in which they cause warts, self-contained benign lesions that commonly regress. The HPV life cycle is intricately tied to the differentiation of the host epithelium it infects. Mucosotropic HPVs are the most common sex...

journal_title：Virology

authors： Johannsen E,Lambert PF

更新日期：2013-10-01 00:00:00

abstract：:Expression of Kaposi's sarcoma herpesvirus vFLIP, a potent activator of NFkB signaling, promotes latency. Inhibition of NFkB signaling promotes lytic reactivation. We previously reported that lytic inducer, RTA, inhibits vFLIP induced NFkB signaling by inducing the degradation of vFLIP via the proteasome. Here we repo...

journal_title：Virology

authors： Chmura JC,Herold K,Ruffin A,Atuobi T,Fabiyi Y,Mitchell AE,Choi YB,Ehrlich ES

更新日期：2017-01-15 00:00:00

abstract：:Human enteric adenovirus Ad41 is associated with children gastroenteritis. To infect gastrointestinal cells, the invading virus must be acid-stable and resistant to inactivation by bile salts and proteases. In addition, it has to cross the mucus barrier before it infects mucosa cells. We show that Ad41 infectivity is ...

journal_title：Virology

authors： Favier AL,Burmeister WP,Chroboczek J

更新日期：2004-04-25 00:00:00

abstract：:One of the newest niches for baculoviruses-based technologies is their use as vectors for mammalian cell transduction and gene therapy applications. However, an outstanding safety issue related to such use is the residual expression of viral genes in infected mammalian cells. Here we show that infectious baculoviruses...

journal_title：Virology

authors： Efrose R,Swevers L,Iatrou K

更新日期：2010-10-25 00:00:00

abstract：:Activation of interferon regulatory factors (IRFs) 3 and 7 is essential for the induction of Type I interferons (IFN) and innate antiviral responses, and herpesviruses have evolved mechanisms to evade such responses. We previously reported that Epstein-Barr virus BZLF1, an immediate-early (IE) protein, inhibits the fu...

journal_title：Virology

authors： Bentz GL,Liu R,Hahn AM,Shackelford J,Pagano JS

更新日期：2010-06-20 00:00:00

abstract：:Sequence variants of the Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) have been reported in association with EBV-linked malignancies but little is known about their effects on signalling pathways and phenotype. We have examined the ability of the nasopharyngeal carcinoma (NPC)-derived variant, CAO...

journal_title：Virology

authors： Blake SM,Eliopoulos AG,Dawson CW,Young LS

更新日期：2001-04-10 00:00:00

abstract：:While trying to generate a site-directed deletion in the ORF63 latency-associated gene of varicella-zoster virus (VZV) Oka, we constructed a virus with an unexpected rearrangement. The virus has a small deletion in both copies of ORF63 and two copies of a cassette inserted between ORFs 64/65 and 68/69 containing (a) t...

journal_title：Virology

authors： Ambagala AP,Krogmann T,Qin J,Pesnicak L,Cohen JI

更新日期：2010-04-10 00:00:00

abstract：:The rep gene of the defective human parvovirus, adeno-associated virus, (AAV) mediates several trans-acting functions important to virus replication, transcription, and gene expression. At least four overlapping polypeptides are expressed from the rep gene. We have constructed a prokaryotic vector which expressed in E...

journal_title：Virology

authors： Trempe JP,Mendelson E,Carter BJ

更新日期：1987-11-01 00:00:00

abstract：:L83V-related variants of human papillomavirus (HPV) 16 E6, exemplified by the Asian-American variant Q14H/H78Y/L83V, were shown to be more prevalent than E6 prototype in progressing lesions and cervical cancer. We evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as w...

journal_title：Virology

authors： Zehbe I,Richard C,DeCarlo CA,Shai A,Lambert PF,Lichtig H,Tommasino M,Sherman L

更新日期：2009-01-05 00:00:00

abstract：:Infection of eukaryotic cells in culture with herpes simplex virus type-1 (HSV-1) or HSV-2 increased the mutation frequency of the supF gene carried on the shuttle vector pZ189 by around sixfold. The increase was apparent 2 hr postinfection and reached a peak after 8 hr. To investigate this mutagenesis, plasmids pCKRR...

journal_title：Virology

authors： Clarke P,Clements JB

更新日期：1991-06-01 00:00:00

abstract：:Human CD4 was expressed on a range of mammalian cell lines. CD4+ non-primate cells, derived from rat, hamster, mink, cat, and rabbit, bind recombinant gp120 of human immunodeficiency virus type 1 (HIV-1) but are resistant to HIV-1 infection. CD4 expression on various human, rhesus, and African green monkey cell lines ...

journal_title：Virology

authors： Clapham PR,Blanc D,Weiss RA

更新日期：1991-04-01 00:00:00

abstract：:During Herpes simplex virus envelopment, capsids, tegument polypeptides, and membrane proteins assemble at the site of budding and a cellular lipid bilayer becomes refashioned into a spherical envelope. Though the molecular interactions driving these events are poorly understood, several lines of evidence suggest that...

journal_title：Virology

authors： Gross ST,Harley CA,Wilson DW

更新日期：2003-12-05 00:00:00

abstract：:PO-1-Lu, the endogenous type D retrovirus of langurs (Trachypithecus obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis. This study reevaluates this hypothesis t...

journal_title：Virology

authors： Sommerfelt MA,Harkestad N,Hunter E

更新日期：2003-10-25 00:00:00

abstract：:DI7 is a defective interfering RNA derived from RNA 2 of tobacco rattle tobravirus (TRV) isolate PpK20. Tobacco was transformed with DI7 cDNA fused to the CaMV 35S promoter. Upon infection of the transgenic plants with TRV isolate PpK20 or the serologically unrelated isolate PaY4, the transgenic DI7 RNA started to acc...

journal_title：Virology

authors： Visser PB,Brown DJ,Brederode FT,Bol JF

更新日期：1999-10-10 00:00:00

abstract：:Previously different authors described various flavivirus mutants with high affinity to cell glycosaminoglycans and low neuroinvasiveness in mice that were obtained consequently passages in cell cultures or in ticks. In present study the analysis of TBEV isolates has shown existence of GAG-binding variants in natural ...

journal_title：Virology

authors： Kozlovskaya LI,Osolodkin DI,Shevtsova AS,Romanova LIu,Rogova YV,Dzhivanian TI,Lyapustin VN,Pivanova GP,Gmyl AP,Palyulin VA,Karganova GG

更新日期：2010-03-15 00:00:00

abstract：:Recently, we reported that PrP(Sc), a surrogate marker for prion disease, is associated with the cellular fraction of blood from scrapie-infected sheep using a ligand-based immunoassay. In the study reported here, we found that a subset of peripheral blood mononuclear cells is most likely to sequester PrP(Sc) during b...

journal_title：Virology

authors： Edwards JC,Moore SJ,Hawthorn JA,Neale MH,Terry LA

更新日期：2010-09-15 00:00:00

abstract：:Monoclonal antibodies specific for eight antigenic sites on the G1 glycoprotein of La Crosse virus were studied in a kinetics of neutralization assay. When examined at the same protein concentration, there were differences in the rates and degree of neutralization induced by these antibodies. The maximum amount of neu...

journal_title：Virology

authors： Kingsford L

更新日期：1984-07-30 00:00:00

abstract：:Purification of the putative cowpea mosaic virus (CPMV) RNA replicase previously started with an RNA-dependent RNA polymerase activity which had been solubilized from a crude membrane fraction of CPMV-infected cowpea leaves by extraction with a Mg2+-deficient buffer. This led to the identification of a host-encoded, 1...

journal_title：Virology

authors： Dorssers L,van der Meer J,Van Kammen A,Zabel P

更新日期：1983-02-01 00:00:00

abstract：:Sequence analysis of the murine gamma-herpesvirus 68 (gammaHV68) genome previously identified several open reading frames (ORFs) located at the left end of the viral genome that do not share homology with other known herpesvirus or cellular genes. Here, we show that one of these ORFs, M4, encodes a secreted glycoprote...

journal_title：Virology

authors： Evans AG,Moorman NJ,Willer DO,Speck SH

更新日期：2006-01-20 00:00:00

abstract：:The major and minor nucleoprotein components in turnip yellow mosaic virus (TYMV) preparations have been fractionated by four cycles of CsCl gradient equilibrium centrifugations. RNAs isolated from the various fractions were translated in a rabbit reticulocyte cell-free system. Three classes of RNAs were studied: geno...

journal_title：Virology

authors： Mellema JR,Benicourt C,Haenni AL,Noort A,Pleij CW,Bosch L

更新日期：1979-07-15 00:00:00

abstract：:Barley stripe mosaic virus (BSMV) has a tripartite genome comprising RNAs designated alpha, beta, and gamma, which collectively encode seven polypeptides. We show here that an antiserum raised against an abundant disease-specific protein from BSMV-infected plants reacts specifically with the viral beta b gene product ...

journal_title：Virology

authors： Petty IT,Jackson AO

更新日期：1990-08-01 00:00:00

abstract：:Immunization with heat-inactivated herpes simplex virus type 1 (HSV-1) 2-5 days before ocular infection reduced the frequency of establishment of latent HSV-1 infection in the trigeminal ganglion (TG); this induction of resistance coincided with reduced expression of IFN-gamma mRNA in the TG. Immunization with unrelat...

journal_title：Virology

authors： Halford WP,Veress LA,Gebhardt BM,Carr DJ

更新日期：1997-09-29 00:00:00

abstract：:Many plant virus coat proteins have binding sites for divalent cations, particularly calcium. It has been speculated that the purpose of such sites is to ensure that plant viruses release their RNA only in the host cytoplasm which has a low calcium concentration. By comparison to tomato bushy stunt virus, two of the a...

journal_title：Virology

authors： Laakso MM,Heaton LA

更新日期：1993-12-01 00:00:00

abstract：:The parvovirus-encoded nonstructural (NS) proteins have been implicated in the cytopathogenicity of these agents. Although protein NS-1 of minute virus of mice (MVM) has been shown to be toxic, little is known about the role of NS-2 in this process. In order to determine the contribution of NS-1 and NS-2 to cytotoxici...

journal_title：Virology

authors： Legrand C,Rommelaere J,Caillet-Fauquet P

更新日期：1993-07-01 00:00:00

abstract：:Influenza A H1N2 viruses, which emerged during 2001, are genetic reassortants between H1N1 and H3N2 subtype viruses which have cocirculated in the human population since 1977. They possess a H1 hemagglutinin antigenically and genetically similar to contemporary A/New Caledonia/20/99 (H1N1)-like viruses and seven genes...

journal_title：Virology

authors： Gregory V,Bennett M,Orkhan MH,Al Hajjar S,Varsano N,Mendelson E,Zambon M,Ellis J,Hay A,Lin YP

更新日期：2002-08-15 00:00:00

abstract：:Various lectins were tested for blocking rotavirus infection of MA104 cells and it was observed that galactose-specific lectins were the most inhibitory. Of these Ricinus agglutinin was able to inhibit infection (by human and animal strains) at concentrations as low as 10(-9) M. In addition, in a virus overlay protein...

journal_title：Virology

authors： Jolly CL,Beisner BM,Holmes IH

更新日期：2000-09-15 00:00:00