Role of hepatitis B surface antigen (HBsAg) in identifying true inactive HBsAg carriers infected with genotype C hepatitis B virus.

Abstract:

BACKGROUND:Inactive and active phases of hepatitis B e antigen-negative chronic hepatitis B virus (HBV) infection are diagnosed by serum HBV DNA levels, with cutoff at 2000 IU/mL. However, it is difficult to distinguish inactive carriers at a single time point because HBV DNA levels can transiently decrease to <2000 IU/mL even in noninactive carriers. GOALS:We aimed to establish the role of serum hepatitis B surface antigen (HBsAg) in identifying "true inactive carriers" among treatment-naive genotype C HBV-infected patients with low viremia. STUDY:A total of 133 hepatitis B e antigen-negative carriers with serum HBV DNA levels of <2000 IU/mL and normal alanine aminotransferase levels were enrolled and followed up for >12 months. RESULTS:Forty patients (30.1%) were classified as noninactive carriers (HBV DNA ≥2000 IU/mL and/or alanine aminotransferase >40 IU/L) during 12 months from enrollment. No baseline serum HBV DNA levels could identify true inactive carriers with 100% specificity, whereas baseline serum HBsAg levels (50 IU/mL) identified true inactive carriers with 100% specificity and 29% detection rate. Detection rate increased when different cutoff levels were applied to different age groups according to median age (46 y). It was comparable in both younger and older groups (37.2% vs. 38%) even when HBsAg cutoff level was increased in the former (400 vs. 50 IU/mL). Furthermore, none reversed to noninactive phase during long-term follow-up when these cutoff levels were applied. CONCLUSIONS:Baseline serum HBsAg levels at a single time point can identify persistently true inactive carriers, with different cutoff levels according to age.

journal_name

J Clin Gastroenterol

authors

Yim SY,Um SH,Jung JY,Seo YS,Yim HJ,Ryu HS,Chun HJ,Jeen YT,Kim CD,Keum B,Lee HS

doi

10.1097/MCG.0b013e3182a4711d

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

166-71

issue

2

eissn

0192-0790

issn

1539-2031

journal_volume

48

pub_type

杂志文章
  • Anorectal and pelvic pain in women: diagnostic considerations and treatment.

    abstract::Functional anorectal and pelvic pain disorders may cause considerable morbidity and frustration in many women. This article reviews current concepts of these often poorly understood disorders and provides suggestions for evaluating and managing women who may come to the attention of the practicing gastroenterologist. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200110000-00005

    authors: Wald A

    更新日期:2001-10-01 00:00:00

  • Treating Budd-Chiari Syndrome: making rational choices from a myriad of options.

    abstract::Budd-Chiari syndrome represents a spectrum of disorders characterized by obstruction to hepatic venous drainage. Originally described as an "obliterating endophlebitis of the hepatic veins," this condition has come to refer to the manifestations of hepatic venous outflow obstruction anywhere above the level of the hep...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200003000-00007

    authors: Olzinski AT,Sanyal AJ

    更新日期:2000-03-01 00:00:00

  • The efficacy of intravenous contrast-enhanced 16-raw multidetector CT colonography for detecting patients with colorectal polyps in an asymptomatic population in Korea.

    abstract:PURPOSE:The purpose of this study is to compare the sensitivity of computed tomography (CT) colonography (CTC) with that of colonoscopy for detecting patients with colorectal polyps in an asymptomatic screening population in Korea, thus to evaluate a possibility, whether CTC could be used as a screening tool for colore...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31811edcb7

    authors: Kim YS,Kim N,Kim SH,Park MJ,Lim SH,Yim JY,Cho KR,Kim SS,Kim DH,Eun HW,Cho KS,Kim JH,Choi BI,Jung HC,Song IS,Shin CS,Cho SH,Oh BH

    更新日期:2008-08-01 00:00:00

  • Granular cell myoblastoma of the esophagus.

    abstract::Granular cell myoblastoma, a rare, but generally benign tumor, is being encountered with increasing frequency in the digestive tract. Seventy-two cases have been described in the esophagus; we report two additional cases. A follow-up, available in 13 patients (including ours), reveals a low likelihood of malignant tra...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198404000-00003

    authors: Subramanyam K,Shannon CR,Patterson M,Davis M,Gourley WK

    更新日期:1984-04-01 00:00:00

  • Endoscopic Treatment of Gastrointestinal Perforations, Leaks, and Fistulae.

    abstract::Gastrointestinal leaks and fistulae are common postoperative complications, whereas intestinal perforation more commonly complicates advanced endoscopic procedures. Although these complications have classically been managed surgically, there exists an ever-expanding role for endoscopic therapy and the involvement of a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000409

    authors: Rustagi T,McCarty TR,Aslanian HR

    更新日期:2015-11-01 00:00:00

  • Irritable bowel syndrome subtypes defined by Rome II and Rome III criteria are similar.

    abstract:BACKGROUND:The implications of the Rome III recommendations to change the irritable bowel syndrome (IBS) subtype criteria for stool pattern are unknown. AIM:(1) Determine the level of agreement between Rome II and Rome III subtypes and (2) compare the behaviors of Rome II and Rome III subtypes over time. METHODS:Fema...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31815bd749

    authors: Dorn SD,Morris CB,Hu Y,Toner BB,Diamant N,Whitehead WE,Bangdiwala SI,Drossman DA

    更新日期:2009-03-01 00:00:00

  • Importance of Patients' Knowledge of Their Prescribed Medication in Improving Treatment Adherence in Inflammatory Bowel Disease.

    abstract:GOALS:To investigate the association between treatment nonadherence and patients' knowledge of the prescribed medication among individuals with inflammatory bowel disease (IBD), and evaluate the impact of nonadherence on relapse. BACKGROUND:The patient's knowledge of the prescribed medication has been identified as an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000431

    authors: Tae CH,Jung SA,Moon HS,Seo JA,Song HK,Moon CM,Kim SE,Shim KN,Jung HK

    更新日期:2016-02-01 00:00:00

  • A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis.

    abstract:BACKGROUND:Guidelines recommend upper endoscopic screening of cirrhotic patients for gastroesophageal varices. Cirrhosis is not always distinguishable from chronic hepatitis. GOALS:To identify low-risk patients who can be spared upper endoscopy irrespective of a diagnosis of cirrhosis. STUDY:We evaluated 13 nonendosc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318157464b

    authors: Gentile I,Viola C,Graf M,Liuzzi R,Quarto M,Cerini R,Piazza M,Borgia G

    更新日期:2009-01-01 00:00:00

  • Endoscopic diagnosis and treatment of pancreatic neuroendocrine tumors.

    abstract::Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms comprising only 1% to 2% of all pancreatic tumors. In recent years, the number of incidentally discovered PNETs has greatly increased given the widespread use of axial imaging. However, a significant proportion of PNETs may not be visualized on con...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000152

    authors: Rustagi T,Farrell JJ

    更新日期:2014-11-01 00:00:00

  • Density of Helicobacter pylori infection evaluated semiquantitatively in gastric cancer.

    abstract::Helicobacter pylori infection may play a role in the development of gastric cancer; however, a quantitative evaluation of the density of H. pylori infection has not been reported previously in relation to the histologic stage and type of cancer. This study was designed to compare the density of H. pylori infection to ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200010000-00006

    authors: Tokunaga Y,Shirahase H,Hoppou T,Kitaoka A,Tokuka A,Ohsumi K

    更新日期:2000-10-01 00:00:00

  • Hepatitis C virus RNA assays: a comparison of SuperQuant and Monitor.

    abstract::Hepatitis C RNA testing has been used extensively to assess the efficacy of antiviral therapy and has increasingly become an integral part of clinical management of patients with chronic hepatitis C. A variety of commercially available hepatitis C virus (HCV) RNA tests are used to detect HCV RNA qualitatively or quant...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200107000-00011

    authors: Hadziyannis E,Hadziyannis A,Yen-Lieberman B,Kiwi ML,Hodnick S,Spanou F,Starkey C,Younossi ZM

    更新日期:2001-07-01 00:00:00

  • Barrett esophagus: endoscopic findings and what to biopsy.

    abstract::Barrett esophagus (BE) is considered the precursor for nearly all cases of esophageal adenocarcinoma. The potential sequence from intestinal metaplasia to dysplasia to cancer can best be monitored by careful endoscopic observation and surveillance biopsies. The ability to diagnose BE, biopsy accurately, and appropriat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200305001-00003

    authors: Boyce HW

    更新日期:2003-05-01 00:00:00

  • The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans.

    abstract:BACKGROUND AND GOALS:Chronic inflammation associated with Helicobacter pylori infection is a risk factor of gastric adenocarcinoma. Interleukin-8 (IL-8) plays an important role in gastric mucosal inflammation induced by H. pylori infection. Recently, studies on the association of genetic polymorphisms of various proinf...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181646701

    authors: Ye BD,Kim SG,Park JH,Kim JS,Jung HC,Song IS

    更新日期:2009-03-01 00:00:00

  • Aortoesophageal fistula after perigraft abscess with characteristic CT findings.

    abstract::Aortoesophageal fistula is a rare cause of massive gastrointestinal hemorrhage, and may occur as a sequela to prosthetic replacement of the thoracic aorta. Esophageal compression necrosis with leakage of microorganisms into the proximal suture line is probably central to pathogenesis. Like the more common aortoduodena...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198412000-00009

    authors: Tierney LM Jr,Wall SD,Jacobs RA

    更新日期:1984-12-01 00:00:00

  • Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.

    abstract::A 79-year-old woman visiting our hospital with chief complaints of epigastric pain and jaundice was emergently admitted. Her alpha-fetoprotein (AFP) level was as high as 2265 ng/mL at admission. Her abdominal computed tomography scan revealed dilation of the intrahepatic bile duct and a tumorlike lesion protruding int...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200607000-00016

    authors: Miyazawa M,Torii T,Toshimitsu Y,Kamizasa N,Suzuki T,Shinozuka N,Ishizawa K,Koyama I

    更新日期:2006-07-01 00:00:00

  • The Dieulafoy's Lesion: An Update on Evaluation, Diagnosis, and Management.

    abstract::Dieulafoy's lesion (DL) is a persistently wide caliber artery that is observed more frequently at the fifth decade of life in the male population with multiple comorbidities. There are a variety of endoscopic therapies that have been used to treat DL; however, there are no clear guidelines on the best treatment modali...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000321

    authors: Nguyen DC,Jackson CS

    更新日期:2015-08-01 00:00:00

  • Endoscopy in the evaluation of patients with upper gastrointestinal symptoms: indications, expectations, and interpretation.

    abstract::Upper gastrointestinal endoscopy is the most sensitive diagnostic test in patients with upper gastrointestinal symptoms. Endoscopy performed by trained examiners, however, still misses lesions. Single-contrast upper gastrointestinal x-ray adds little new information to a complete endoscopic examination by a trained en...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Tedesco FJ

    更新日期:1981-01-01 00:00:00

  • Endoscopic ultrasound-guided endotherapy.

    abstract::Over the last 2 decades, endoscopic ultrasound (EUS) has evolved from a noninvasive diagnostic tool to a combined diagnostic and therapeutic modality. The use of EUS complementary to endoscopic retrograde cholangiopancreatography (ERCP) has made possible biliary and pancreatic drainage in situations where conventional...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000276

    authors: Gavini H,Lee JH

    更新日期:2015-03-01 00:00:00

  • Patient outcomes related to percutaneous endoscopic gastrostomy placement.

    abstract::Although many aspects of percutaneous endoscopic gastrostomy (PEG) have been addressed in the literature, attention to psychologic and social outcomes of PEG has been limited. Our goal was to assess a range of physical, psychologic, and social outcomes related to PEG feeding. This study is a follow-up survey of patien...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200101000-00012

    authors: Verhoef MJ,Van Rosendaal GM

    更新日期:2001-01-01 00:00:00

  • Corset liver.

    abstract::We describe four patients with a benign hepatic malformation most consistent with the rarely described anomaly known as corset liver. Three of these patients were extensively evaluated to rule out a malignancy because of an abdominal mass. These patients illustrate several features which may help in making the diagnos...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198508000-00019

    authors: Philips DM,LaBrecque DR,Shirazi SS

    更新日期:1985-08-01 00:00:00

  • Current Management of Patients With Diverticulosis and Diverticular Disease: A Survey From the 2nd International Symposium on Diverticular Disease.

    abstract:BACKGROUND:Management of diverticular disease (DD) remains a point of debate. GOALS:To investigate the current opinion of participants of the 2nd International Symposium on Diverticular Disease, on real-life management of patients with DD of the colon. STUDY:Twelve questions were aimed at the diagnosis, treatment, an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000645

    authors: Tursi A,Picchio M,Elisei W,Di Mario F,Scarpignato C,Brandimarte G

    更新日期:2016-10-01 00:00:00

  • The parathyroids and the gut.

    abstract::This review discusses gastrointestinal manifestations of parathyroid diseases. Parathyroid hormone is the primary regulator of calcium physiology. Hypoparathyroidism can be idiopathic, hereditary, or secondary to surgery in the neck. Hyperparathyroidism is usually from adenomas or hyperplasia. Hypoparathyroidism is as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181cd9d4c

    authors: Ebert EC

    更新日期:2010-08-01 00:00:00

  • A case of cyclosporine-sensitive, steroid-resistant, autoimmune chronic active hepatitis.

    abstract::Few alternative treatments are available for those patients with autoimmune chronic active hepatitis who fail to respond to the conventional treatment of corticosteroids. Such patients have a poor prognosis and frequently require liver transplantation. We report a patient with autoimmune hepatitis who failed treatment...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199312000-00012

    authors: Person JL,McHutchison JG,Fong TL,Redeker AG

    更新日期:1993-12-01 00:00:00

  • Endoscopic diagnosis of duodenal neoplasms causing upper gastrointestinal bleeding.

    abstract::Duodenal neoplasms are a rare and not often considered cause of massive upper gastrointestinal bleeding. During a 4-year period, 859 endoscopies in patients with upper gastrointestinal bleeding revealed a duodenal tumor to be the cause of bleeding in eight patients. Three patients had a primary duodenal neoplasm, two ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198202000-00006

    authors: Sharon P,Stalnikovicz R,Rachmilewitz D

    更新日期:1982-02-01 00:00:00

  • Comparison of magnetic resonance imaging and endoscopy in distinguishing the type and severity of inflammatory bowel disease.

    abstract::Twenty consecutive patients with first-time presentation of suspected inflammatory bowel disease underwent both endoscopy with biopsy and magnetic resonance imaging (MRI) within a 3-day period; the relative abilities of endoscopy and MRI to distinguish ulcerative colitis (UC) from Crohn's disease (CD) and to determine...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199407000-00009

    authors: Shoenut JP,Semelka RC,Magro CM,Silverman R,Yaffe CS,Micflikier AB

    更新日期:1994-07-01 00:00:00

  • Rapid growth of untreated esophageal squamous-cell carcinoma in 10 patients.

    abstract::We documented the natural history of esophageal carcinoma and its rapid growth by measuring the change in tumor diameter radiographically in 10 patients during an observation period because the diagnosis had been missed. Nine men and one woman (age range, 48-74 years; mean, 60 years) were included in the study. Eight ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199104000-00003

    authors: Haruma K,Tokutomi T,Yoshihara M,Sumii K,Kajiyama G

    更新日期:1991-04-01 00:00:00

  • Malignancy in Peutz-Jeghers syndrome? The pitfall of pseudo-invasion.

    abstract::Peutz-Jeghers syndrome is a malignancy-associated polyposis syndrome. We describe a histopathologic phenomenon easily encountered when examining the nature of Peutz-Jeghers polyps but that is underreported in the literature. This phenomenon of "pseudo-invasion" may mimic invasive carcinoma due to epithelial displaceme...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199707000-00023

    authors: Westerman AM,van Velthuysen ML,Bac DJ,Schouten WR,Wilson JH

    更新日期:1997-07-01 00:00:00

  • Exclusion of the meal period improves the clinical reliability of esophageal pH monitoring.

    abstract::Meal period exclusion from 24-h pH testing allows better separation between controls and patients with gastroesophageal reflux disease. We reviewed the results of 24-h pH studies of 350 patients with reflux symptoms. They were divided into two groups based on the 95th percentile of the total percentage of time when pH...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199707000-00003

    authors: Ter RB,Johnston BT,Castell DO

    更新日期:1997-07-01 00:00:00

  • Wound sepsis after cholecystectomy. Influence of incidental appendectomy.

    abstract::We undertook a prospective study of the effect of incidental appendectomy on the safety of cholecystectomy in patients under the age of 50 years. One hundred twenty patients were randomized to have either cholecystectomy alone or cholecystectomy and appendectomy. All patients received preoperative antibiotic cover. Bo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198608000-00010

    authors: O'Malley VP,Finch DR,Powley PH

    更新日期:1986-08-01 00:00:00

  • Pathogenesis and therapy of peptic ulcer disease.

    abstract::The epithelial cells of the stomach and duodenum are normally protected from the damaging effects of acid and pepsin by a balancing mechanism of mucosal resistance. If an imbalance occurs, peptic ulcer may result. Traditional teaching has emphasized the importance of acid (and pepsin) as the cause of this imbalance; h...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199000000-00002

    authors: Peterson WL

    更新日期:1990-01-01 00:00:00