Abstract：
:This work compares two accelerated partial breast irradiation modalities, MammoSite brachytherapy and three dimensional conformal radiotherapy (3D-CRT), to a new method, SAVI brachytherapy, following NSABP B-39 guidelines. A total of 21 patients treated at UC San Diego with the SAVI device were evaluated in this comparison. 9 of the 21 patients were eligible for all three modalities and were dosimetrically compared evaluating V90, V150, V200, total target volume, maximum skin, lung, and chestwall/rib dose. The target volumes (PTV_EVAL) differed with SAVI having the least total volume at 59.9 cc vs. 71.5 cc and 351.6 cc for MammoSite and 3D-CRT, respectively. The median V90, V150 and V200 for the three modalities were 97.7%, 25.0 cc, 10.4 cc (SAVI) vs. 97.6%, 23.9 cc, 5.0 cc (MammoSite) vs. 100% (V90 3D-CRT). The maximum dose for SAVI, MammoSite, and 3D-CRT, respectively, relative to the prescribed dose, for the: lung was 80.0%, 150.0%, and 104.9%; for rib 108.8%, 225.0%, and 114.7%: for skin 75.0%, 135.0%, and 108.6%. Comparing modalities, PTV coverage varied between 97.6% - 100.0% with more breast tissue covered by 3D-CRT, as expected, given the differences between external beam and brachytherapy. The maximum lung, skin and rib doses were lowest for the SAVI, highlighting its ability to conform to exclude normal tissues. In offering partial breast radiation, the availability of a variety of techniques allows for maximal patient eligibility, and comparison of individual method pros and cons may guide the most appropriate choice for each patient.
journal_name
J Appl Clin Med Physjournal_title
Journal of applied clinical medical physicsauthors
Scanderbeg D,Yashar C,White G,Rice R,Pawlicki Tdoi
10.1120/jacmp.v11i1.3021subject
Has Abstractpub_date
2009-12-03 00:00:00pages
3021issue
1issn
1526-9914journal_volume
11pub_type
杂志文章abstract：:Two patients with multiple lung metastases (≥ 5) were treated using frameless stereotactic body radiation therapy (SBRT) on an Elekta Axesse linear accelerator equipped with an interdigitation-capable multileaf collimator and four-dimensional cone-beam CT (4D CBCT). The technique and the early clinical outcomes were e...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v15i4.4737
更新日期：2014-07-08 00:00:00
abstract：:We retrospectively generated IMRT plans for 14 NSCLC patients who had experienced grade 2 or 3 esophagitis (CTCAE version 3.0). We generated 11-beam and reduced esophagus dose plan types to compare changes in the volume and length of esophagus receiving doses of 50, 55, 60, 65, and 70 Gy. Changes in planning target vo...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v14i4.4248
更新日期：2013-07-08 00:00:00
abstract：:Our institution performs in vivo verification measurement for each of our total body irradiation (TBI) patients with optically stimulated luminescent dosimeters (OSLD). The lung block verification measurements were commonly higher than expected. The aim of this work is to understand this discrepancy and improve the ac...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i3.6128
更新日期：2016-05-08 00:00:00
abstract：:The purpose of this study was to develop and evaluate filmless quality assurance (QA) tools for helical tomotherapy by using the signals from the on-board megavoltage computed tomography (MVCT) detector and applying a dedicated step-wedge phantom. The step-wedge phantom is a 15 cm long step-like aluminum block positio...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v13i1.3585
更新日期：2012-01-05 00:00:00
abstract：:The purpose of this study is to evaluate the accuracy of the electron Monte Carlo (eMC) dose calculation algorithm included in a commercial treatment planning system and compare its performance against an electron pencil beam algorithm. Several tests were performed to explore the system's behavior in simple geometries...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v16i3.4636
更新日期：2015-05-08 00:00:00
abstract：:Optimal choice of beam energy in radiation therapy is easy in many well-documented cases, but less obvious in some others. Low-energy beams may provide better conformity around the target than their high-energy counterparts due to reduced lateral scatter, but they also contribute to overdosage of peripheral normal tis...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v10i4.3012
更新日期：2009-09-03 00:00:00
abstract：:To estimate the lung tumor position from multiple anatomical features on four-dimensional computed tomography (4D-CT) data sets using single regression analysis (SRA) and multiple regression analysis (MRA) approach and evaluate an impact of the approach on internal target volume (ITV) for stereotactic body radiotherap...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12121
更新日期：2017-09-01 00:00:00
abstract：:Precise radiation therapy (RT) for abdominal lesions is complicated by respiratory motion and suboptimal soft tissue contrast in 4D CT. 4D MRI offers improved con-trast although long scan times and irregular breathing patterns can be limiting. To address this, visual biofeedback (VBF) was introduced into 4D MRI. Ten v...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i3.6017
更新日期：2016-05-08 00:00:00
abstract：:The purpose of this study was to perform comprehensive measurements and testing of a Novalis Tx linear accelerator, and to develop technical guidelines for com-missioning from the time of acceptance testing to the first clinical treatment. The Novalis Tx (NTX) linear accelerator is equipped with, among other features,...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v13i3.3729
更新日期：2012-05-10 00:00:00
abstract：:Shewhart control charts have previously been suggested as a process control tool for use in routine linear accelerator (linac) output verifications. However, a comprehensive approach to process control has not been investigated for linac output verifications. The purpose of this work is to investigate a comprehensive ...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v14i1.4032
更新日期：2013-01-07 00:00:00
abstract：:The assessment of the coincidence of imaging and radiation isocenters is an important task of regular quality assurance of medical linear accelerators (linacs) as recommended in national and international quality assurance guidelines. A previously reported investigation of the accuracy of the Elekta XVI software to lo...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12861
更新日期：2020-05-01 00:00:00
abstract：:Magnetic Resonance Imaging (MRI) simulation differs from diagnostic MRI in purpose, technical requirements, and implementation. We propose a semiautomatic method for image acceptance and commissioning for the scanner, the radiofrequency (RF) coils, and pulse sequences for an MRI simulator. The ACR MRI accreditation la...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12311
更新日期：2018-05-01 00:00:00
abstract：:This paper aims to evaluate the impact of spectral filtration on image quality in a microcomputed tomography (micro-CT) system. A mouse phantom comprising 11rods for modeling lung, muscle, adipose, and bones was scanned with 17 s and 2min, respectively. The current (μA) for each scan was adjusted to achieve identical ...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i1.5714
更新日期：2016-01-08 00:00:00
abstract：PURPOSE:To determine if the gamma knife icon (GKI) can provide superior stereotactic radiotherapy (SRT) dose distributions for appropriately selected meningioma and post-resection brain tumor bed treatments to volumetric modulated arc therapy (VMAT). MATERIALS AND METHODS:Appropriately selected targets were not proxim...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.13100
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:To investigate the daily setup, interfraction motion, variability in the junction areas, and dosimetric effect in craniospinal irradiation (CSI) patients. METHODS:Fifteen CSI patients who had undergone split-field IMRT were followed in the study. Previous, middle, and posttreatment, each target volume position...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12909
更新日期：2020-08-01 00:00:00
abstract：:The objective of this work is the investigation of intense pulsed light (IPL) photoepilation using Monte Carlo simulation to model the effect of the output dosimetry with millisecond exposure used by typical commercial IPL systems. The temporal pulse shape is an important parameter, which may affect the biological tis...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v13i5.3702
更新日期：2012-09-06 00:00:00
abstract：BACKGROUND AND PURPOSE:The purpose of this study of pancreatic cancer patients treated with respiratory-guided stereotactic body radiotherapy (SBRT) on a standard linac was to investigate (a) the intrafractional relationship change (IRC) between a breathing signal and the tumor position, (b) the impact of IRC on the de...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12841
更新日期：2020-03-01 00:00:00
abstract：:Remote afterloading devices used for high-dose-rate (HDR) brachytherapy may be supplied with different sources, and these sources typically have differing initial source strengths. In addition, the proposed frequency for source changes may also vary, depending upon the source type. Dosimetric parameters unique to each...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v14i6.4239
更新日期：2013-11-04 00:00:00
abstract：:We investigate the role of adaptive radiation therapy in pediatric patients with diffuse pontine glioma and the impact of steroid-related weight gain on treatment parameters utilizing cone-beam CT. Fifteen patients with diffuse pontine glioma were treated with three-dimensional conformal radiation therapy and enrolled...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：
更新日期：2011-01-30 00:00:00
abstract：:The goal of the present study was to develop a new dose-volume histogram (DVH)- based homogeneity index for effectively evaluating the dose homogeneity of intensity-modulated radiotherapy plans. The new index, called the sigma-index ("S-index") is defined as the standard deviation of the normalized differential DVH cu...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v8i2.2390
更新日期：2007-03-20 00:00:00
abstract：:Atlas-based autosegmentation is an established tool for segmenting structures for CT-planned head and neck radiotherapy. MRI is being increasingly integrated into the planning process. The aim of this study is to assess the feasibility of MRI-based, atlas-based autosegmentation for organs at risk (OAR) and lymph node ...
journal_title：Journal of applied clinical medical physics
pub_type： 临床试验,杂志文章
doi：10.1120/jacmp.v17i4.6051
更新日期：2016-07-08 00:00:00
abstract：PURPOSE:Multiple metrics are proposed to characterize and compare the complexity of helical tomotherapy (HT) plans created for different treatment sites. METHODS:A cohort composed of 208 HT plans from head and neck (105), prostate (51) and brain (52) tumor sites was considered. For each plan, 14 complexity metrics wer...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12895
更新日期：2020-07-01 00:00:00
abstract：:The purpose of this study is to find the uncertainties in the reconstruction of MR compatible ring-tandem intracavitary applicators of high-dose rate image-based brachytherapy treatment planning using rigid registration of 3D MR and CT image fusion. Tandem and ring reconstruction in MR image based brachytherapy planni...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v15i2.4206
更新日期：2014-03-06 00:00:00
abstract：PURPOSE:To evaluate the quality of patient-specific complicated treatment plans, including commercialized treatment planning systems (TPS) and commissioned beam data, we developed a process of quality assurance (QA) using a Monte Carlo (MC) platform. Specifically, we constructed an interface system that automatically c...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12718
更新日期：2019-10-01 00:00:00
abstract：:A patient with a cardiac ventricular assist device (VAD) with computer-controlled driver presented to our department for radiation therapy. The treatment plan was 4500 cGy to the rectum over 25 fractions with 15MV photon beams. All beams avoided the pump and leads. The response to electromagnetic interference (EMI) wa...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v9i4.2851
更新日期：2008-10-29 00:00:00
abstract：:The purpose of this study is to simulate random and systematic RapidArc delivery errors for external beam prostate radiotherapy plans in order to determine the dose sensitivity for each error type. Ten prostate plans were created with a single 360° arc. The DICOM files for these treatment plans were then imported into...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v12i3.3409
更新日期：2011-05-20 00:00:00
abstract：:The aim of this study was to compare image noise properties of GE Discovery HD 750 and Toshiba Aquilion ONE. The uniformity section of a Catphan 600 image quality assurance phantom was scanned with both scanners, at different dose levels and with extension rings simulating patients of different sizes. 36 datasets were...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i3.5900
更新日期：2016-05-08 00:00:00
abstract：PURPOSE/OBJECTIVES:To present our linac-based SRS procedural technique for medically and/or surgically refractory trigeminal neuralgia (TN) treatment and simultaneously report our clinical outcomes. MATERIALS AND METHODS:Twenty-seven refractory TN patients who were treated with a single fraction of 80 Gy to TN. Treatm...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12057
更新日期：2017-03-01 00:00:00
abstract：:The use of a radioactive check device containing Strontium 90 was investigated to carry out the redundancy checks of Farmer-type ionization chambers. It was not possible to meet the recommended tolerance limits of the redundancy checks without taking into account the angular response of the ionization chambers. The io...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v1i4.2636
更新日期：2000-10-01 00:00:00
abstract：:The impact of the treatment couch on a radiotherapy plan is rarely fully assessed during the treatment planning process. Incorporating a couch model into the treatment planning system (TPS) enables the planner to avoid or dosimetrically evaluate beam-couch intersections. In this work, we demonstrate how existing TPS t...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v11i2.3171
更新日期：2010-04-19 00:00:00
